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561 results on '"Shi, Ying‐Hong"'

2. Application of a single-cell-RNA-based biological-inspired graph neural network in diagnosis of primary liver tumors

Author

Zhang, Dao-Han, Liang, Chen, Hu, Shu-Yang, Huang, Xiao-Yong, Yu, Lei, Meng, Xian-Long, Guo, Xiao-Jun, Zeng, Hai-Ying, Chen, Zhen, Zhang, Lv, Pei, Yan-Zi, Ye, Mu, Cai, Jia-Bin, Huang, Pei-Xin, Shi, Ying-Hong, Ke, Ai-Wu, Chen, Yi, Ji, Yuan, Shi, Yujiang Geno, Zhou, Jian, Fan, Jia, Yang, Guo-Huan, Sun, Qi-Man, Shi, Guo-Ming, and Lu, Jia-Cheng

Published
2024
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3. Macro CD5L+ deteriorates CD8+T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma

Author

Lu, Jia-Cheng, Wu, Lei-Lei, Sun, Yi-Ning, Huang, Xiao-Yong, Gao, Chao, Guo, Xiao-Jun, Zeng, Hai-Ying, Qu, Xu-Dong, Chen, Yi, Wu, Dong, Pei, Yan-Zi, Meng, Xian-Long, Zheng, Yi-Min, Liang, Chen, Zhang, Peng-Fei, Cai, Jia-Bin, Ding, Zhen-Bin, Yang, Guo-Huan, Ren, Ning, Huang, Cheng, Wang, Xiao-Ying, Gao, Qiang, Sun, Qi-Man, Shi, Ying-Hong, Qiu, Shuang-Jian, Ke, Ai-Wu, Shi, Guo-Ming, Zhou, Jian, Sun, Yi-Di, and Fan, Jia

Published
2024
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9. Single-cell and spatial architecture of primary liver cancer

Author

Zhou, Pei-Yun, Zhou, Cheng, Gan, Wei, Tang, Zheng, Sun, Bao-Ye, Huang, Jin-Long, Liu, Gao, Liu, Wei-Ren, Tian, Meng-Xin, Jiang, Xi-Fei, Wang, Han, Tao, Chen-Yang, Fang, Yuan, Qu, Wei-Feng, Huang, Run, Zhu, Gui-Qi, Huang, Cheng, Fu, Xiu-Tao, Ding, Zhen-Bin, Gao, Qiang, Zhou, Jian, Shi, Ying-Hong, Yi, Yong, Fan, Jia, and Qiu, Shuang-Jian

Published
2023
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18. SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer

Author

Chen, Xiu‐Fei, Tian, Meng‐Xin, Sun, Ren‐Qiang, Zhang, Meng‐Li, Zhou, Li‐Sha, Jin, Lei, Chen, Lei‐Lei, Zhou, Wen‐Jie, Duan, Kun‐Long, Chen, Yu‐Jia, Gao, Chao, Cheng, Zhou‐Li, Wang, Fang, Zhang, Jin‐Ye, Sun, Yi‐Ping, Yu, Hong‐Xiu, Zhao, Yu‐Zheng, Yang, Yi, Liu, Wei‐Ren, Shi, Ying‐Hong, Xiong, Yue, Guan, Kun‐Liang, and Ye, Dan

Subjects
Rare Diseases, Liver Cancer, Liver Disease, Digestive Diseases, Cancer, Prevention, Aetiology, 2.1 Biological and endogenous factors, Acyl-CoA Oxidase, Animals, Carcinoma, Hepatocellular, DNA Damage, Down-Regulation, Female, Gene Knockdown Techniques, HEK293 Cells, HeLa Cells, Hep G2 Cells, Humans, Hydrogen Peroxide, Liver Neoplasms, Male, Mice, Mice, Knockout, Middle Aged, Oxidation-Reduction, Oxidative Stress, Peroxisomes, Prognosis, Sirtuins, ACOX1, liver cancer, oxidative stress, SIRT5, succinylation, Hela Cells, Biochemistry and Cell Biology, Developmental Biology
Abstract

Peroxisomes account for ~35% of total H2O2 generation in mammalian tissues. Peroxisomal ACOX1 (acyl-CoA oxidase 1) is the first and rate-limiting enzyme in fatty acid β-oxidation and a major producer of H2O2 ACOX1 dysfunction is linked to peroxisomal disorders and hepatocarcinogenesis. Here, we show that the deacetylase sirtuin 5 (SIRT5) is present in peroxisomes and that ACOX1 is a physiological substrate of SIRT5. Mechanistically, SIRT5-mediated desuccinylation inhibits ACOX1 activity by suppressing its active dimer formation in both cultured cells and mouse livers. Deletion of SIRT5 increases H2O2 production and oxidative DNA damage, which can be alleviated by ACOX1 knockdown. We show that SIRT5 downregulation is associated with increased succinylation and activity of ACOX1 and oxidative DNA damage response in hepatocellular carcinoma (HCC). Our study reveals a novel role of SIRT5 in inhibiting peroxisome-induced oxidative stress, in liver protection, and in suppressing HCC development.

Published
2018

19. Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma

Author

Liu, Meng-Xi, Jin, Lei, Sun, Si-Jia, Liu, Peng, Feng, Xu, Cheng, Zhou-Li, Liu, Wei-Ren, Guan, Kun-Liang, Shi, Ying-Hong, Yuan, Hai-Xin, and Xiong, Yue

Subjects
Cancer, Liver Disease, Digestive Diseases, Rare Diseases, Liver Cancer, Aetiology, 2.1 Biological and endogenous factors, Animals, Apoptosis, Carcinoma, Hepatocellular, Cells, Cultured, Cellular Reprogramming, Citric Acid Cycle, Genes, Tumor Suppressor, Gluconeogenesis, HEK293 Cells, Hep G2 Cells, Humans, Intracellular Signaling Peptides and Proteins, Liver Neoplasms, MCF-7 Cells, Male, Mice, Mice, Inbred ICR, Mice, Nude, Oxidative Stress, Phosphoenolpyruvate Carboxykinase (GTP), Clinical Sciences, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Phosphoenolpyruvate carboxykinase (PEPCK or PCK) catalyzes the first rate-limiting step in hepatic gluconeogenesis pathway to maintain blood glucose levels. Mammalian cells express two PCK genes, encoding for a cytoplasmic (PCPEK-C or PCK1) and a mitochondrial (PEPCK-M or PCK2) isoforms, respectively. Increased expressions of both PCK genes are found in cancer of several organs, including colon, lung, and skin, and linked to increased anabolic metabolism and cell proliferation. Here, we report that the expressions of both PCK1 and PCK2 genes are downregulated in primary hepatocellular carcinoma (HCC) and low PCK expression was associated with poor prognosis in patients with HCC. Forced expression of either PCK1 or PCK2 in liver cancer cell lines results in severe apoptosis under the condition of glucose deprivation and suppressed liver tumorigenesis in mice. Mechanistically, we show that the pro-apoptotic effect of PCK1 requires its catalytic activity. We demonstrate that forced PCK1 expression in glucose-starved liver cancer cells induced TCA cataplerosis, leading to energy crisis and oxidative stress. Replenishing TCA intermediate α-ketoglutarate or inhibition of reactive oxygen species production blocked the cell death caused by PCK expression. Taken together, our data reveal that PCK1 is detrimental to malignant hepatocytes and suggest activating PCK1 expression as a potential treatment strategy for patients with HCC.

Published
2018

23. Metabolism Archetype Tumor Cells Induce Protumor TREM2 Macrophages via Oxidized LDL-Mediated Metabolic Interplay in Hepatocellular Carcinoma

Author

Chu, Tianhao, primary, Zhu, Guiqi, additional, Qu, Weifeng, additional, Tang, Zheng, additional, Yang, Rui, additional, Pan, Haiting, additional, Wang, Yi, additional, Tian, Ruilin, additional, Chen, Leilei, additional, Guan, Zhiqi, additional, Bu, Yichao, additional, Zhao, Qianfu, additional, Chen, Jiafeng, additional, Mao, Shengwei, additional, Fang, Yuan, additional, Gao, Jun, additional, Wu, Xiao-Ling, additional, Zhou, Jian, additional, Liu, Wei-Ren, additional, Fan, Jia, additional, Ye, Dan, additional, and Shi, Ying-Hong, additional

Published
2024
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24. Destabilization of Fatty Acid Synthase by Acetylation Inhibits De Novo Lipogenesis and Tumor Cell Growth

Author

Lin, Huai-Peng, Cheng, Zhou-Li, He, Ruo-Yu, Song, Lei, Tian, Meng-Xin, Zhou, Li-Sha, Groh, Beezly S, Liu, Wei-Ren, Ji, Min-Biao, Ding, Chen, Shi, Ying-Hong, Guan, Kun-Liang, Ye, Dan, and Xiong, Yue

Subjects
Cancer, 2.1 Biological and endogenous factors, Aetiology, Acetylation, Cell Growth Processes, Cell Proliferation, Fatty Acid Synthases, Humans, Lipogenesis, Signal Transduction, Tumor Microenvironment, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Fatty acid synthase (FASN) is the terminal enzyme in de novo lipogenesis and plays a key role in cell proliferation. Pharmacologic inhibitors of FASN are being evaluated in clinical trials for treatment of cancer, obesity, and other diseases. Here, we report a previously unknown mechanism of FASN regulation involving its acetylation by KAT8 and its deacetylation by HDAC3. FASN acetylation promoted its degradation via the ubiquitin-proteasome pathway. FASN acetylation enhanced its association with the E3 ubiquitin ligase TRIM21. Acetylation destabilized FASN and resulted in decreased de novo lipogenesis and tumor cell growth. FASN acetylation was frequently reduced in human hepatocellular carcinoma samples, which correlated with increased HDAC3 expression and FASN protein levels. Our results suggest opportunities to target FASN acetylation as an anticancer strategy. Cancer Res; 76(23); 6924-36. ©2016 AACR.

Published
2016

28. Dissecting spatial heterogeneity and the immune-evasion mechanism of CTCs by single-cell RNA-seq in hepatocellular carcinoma

Author

Sun, Yun-Fan, Wu, Liang, Liu, Shi-Ping, Jiang, Miao-Miao, Hu, Bo, Zhou, Kai-Qian, Guo, Wei, Xu, Yang, Zhong, Yu, Zhou, Xiao-Rui, Zhang, Ze-Fan, Liu, Geng, Liu, Sheng, Shi, Ying-Hong, Ji, Yuan, Du, Min, Li, Nan-Nan, Li, Gui-Bo, Zhao, Zhi-Kun, Huang, Xiao-Yun, Xu, Li-Qin, Yu, Qi-Chao, Peng, David H., Qiu, Shuang-Jian, Sun, Hui-Chuan, Dean, Michael, Wang, Xiang-Dong, Chung, Wen-Yuan, Dennison, Ashley R., Zhou, Jian, Hou, Yong, Fan, Jia, and Yang, Xin-Rong

Published
2021
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41. Supplementary tables and figures from Circulating Tumor Cells with Stem-Like Phenotypes for Diagnosis, Prognosis, and Therapeutic Response Evaluation in Hepatocellular Carcinoma

Author

Guo, Wei, primary, Sun, Yun-Fan, primary, Shen, Min-Na, primary, Ma, Xiao-Lu, primary, Wu, Jiong, primary, Zhang, Chun-Yan, primary, Zhou, Yan, primary, Xu, Yang, primary, Hu, Bo, primary, Zhang, Min, primary, Wang, Gang, primary, Chen, Wei-Qin, primary, Guo, Lin, primary, Lu, Ren-Quan, primary, Zhou, Chao-Hui, primary, Zhang, Xin, primary, Shi, Ying-Hong, primary, Qiu, Shuang-jian, primary, Pan, Bai-shen, primary, Cao, Ya, primary, Zhou, Jian, primary, Yang, Xin-Rong, primary, and Fan, Jia, primary

Published
2023
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42. Supplementary Tables 1-2 from Autophagy Activation in Hepatocellular Carcinoma Contributes to the Tolerance of Oxaliplatin via Reactive Oxygen Species Modulation

Author

Ding, Zhen-Bin, primary, Hui, Bo, primary, Shi, Ying-Hong, primary, Zhou, Jian, primary, Peng, Yuan-Fei, primary, Gu, Cheng-Yu, primary, Yang, Hua, primary, Shi, Guo-Ming, primary, Ke, Ai-Wu, primary, Wang, Xiao-Ying, primary, Song, Kang, primary, Dai, Zhi, primary, Shen, Ying-Hao, primary, and Fan, Jia, primary

Published
2023
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43. Supplementary Figure 1 from Margin-Infiltrating CD20+ B Cells Display an Atypical Memory Phenotype and Correlate with Favorable Prognosis in Hepatocellular Carcinoma

Author

Shi, Jie-Yi, primary, Gao, Qiang, primary, Wang, Zhi-Chao, primary, Zhou, Jian, primary, Wang, Xiao-Ying, primary, Min, Zhi-Hui, primary, Shi, Ying-Hong, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Ke, Ai-Wu, primary, Dai, Zhi, primary, Qiu, Shuang-Jian, primary, Song, Kang, primary, and Fan, Jia, primary

Published
2023
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44. Supplementary Figure 3 from Margin-Infiltrating CD20+ B Cells Display an Atypical Memory Phenotype and Correlate with Favorable Prognosis in Hepatocellular Carcinoma

Author

Shi, Jie-Yi, primary, Gao, Qiang, primary, Wang, Zhi-Chao, primary, Zhou, Jian, primary, Wang, Xiao-Ying, primary, Min, Zhi-Hui, primary, Shi, Ying-Hong, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Ke, Ai-Wu, primary, Dai, Zhi, primary, Qiu, Shuang-Jian, primary, Song, Kang, primary, and Fan, Jia, primary

Published
2023
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45. Supplementary Figure 4 from Margin-Infiltrating CD20+ B Cells Display an Atypical Memory Phenotype and Correlate with Favorable Prognosis in Hepatocellular Carcinoma

Author

Shi, Jie-Yi, primary, Gao, Qiang, primary, Wang, Zhi-Chao, primary, Zhou, Jian, primary, Wang, Xiao-Ying, primary, Min, Zhi-Hui, primary, Shi, Ying-Hong, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Ke, Ai-Wu, primary, Dai, Zhi, primary, Qiu, Shuang-Jian, primary, Song, Kang, primary, and Fan, Jia, primary

Published
2023
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46. Supplementary Data from CD24 Is a Novel Predictor for Poor Prognosis of Hepatocellular Carcinoma after Surgery

Author

Yang, Xin-Rong, primary, Xu, Yang, primary, Yu, Bin, primary, Zhou, Jian, primary, Li, Jia-Chu, primary, Qiu, Shuang-Jian, primary, Shi, Ying-Hong, primary, Wang, Xiao-Ying, primary, Dai, Zhi, primary, Shi, Guo-Ming, primary, Wu, Bin, primary, Wu, Li-Ming, primary, Yang, Guo-Huan, primary, Zhang, Bo-Heng, primary, Qin, Wen-Xin, primary, and Fan, Jia, primary

Published
2023
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47. Supplementary Figure Legend, Tables 1 - 2 from Margin-Infiltrating CD20+ B Cells Display an Atypical Memory Phenotype and Correlate with Favorable Prognosis in Hepatocellular Carcinoma

Author

Shi, Jie-Yi, primary, Gao, Qiang, primary, Wang, Zhi-Chao, primary, Zhou, Jian, primary, Wang, Xiao-Ying, primary, Min, Zhi-Hui, primary, Shi, Ying-Hong, primary, Shi, Guo-Ming, primary, Ding, Zhen-Bin, primary, Ke, Ai-Wu, primary, Dai, Zhi, primary, Qiu, Shuang-Jian, primary, Song, Kang, primary, and Fan, Jia, primary

Published
2023
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49. Supplementary Data from Overexpression of PD-L1 Significantly Associates with Tumor Aggressiveness and Postoperative Recurrence in Human Hepatocellular Carcinoma

Author

Gao, Qiang, primary, Wang, Xiao-Ying, primary, Qiu, Shuang-Jian, primary, Yamato, Ichiro, primary, Sho, Masayuki, primary, Nakajima, Yoshiyuki, primary, Zhou, Jian, primary, Li, Bai-Zhou, primary, Shi, Ying-Hong, primary, Xiao, Yong-Sheng, primary, Xu, Yang, primary, and Fan, Jia, primary

Published
2023
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50. Supplementary Figure 1 from Autophagy Activation in Hepatocellular Carcinoma Contributes to the Tolerance of Oxaliplatin via Reactive Oxygen Species Modulation

Author

Ding, Zhen-Bin, primary, Hui, Bo, primary, Shi, Ying-Hong, primary, Zhou, Jian, primary, Peng, Yuan-Fei, primary, Gu, Cheng-Yu, primary, Yang, Hua, primary, Shi, Guo-Ming, primary, Ke, Ai-Wu, primary, Wang, Xiao-Ying, primary, Song, Kang, primary, Dai, Zhi, primary, Shen, Ying-Hao, primary, and Fan, Jia, primary

Published
2023
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