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156 results on '"Shi, Ya-Jun"'

18. Targeted Drug Delivery Systems for Curcumin in Breast Cancer Therapy

Author

Huang,Mian, Zhai,Bing-Tao, Fan,Yu, Sun,Jing, Shi,Ya-Jun, Zhang,Xiao-Fei, Zou,Jun-Bo, Wang,Jia-Wen, Guo,Dong-Yan, Huang,Mian, Zhai,Bing-Tao, Fan,Yu, Sun,Jing, Shi,Ya-Jun, Zhang,Xiao-Fei, Zou,Jun-Bo, Wang,Jia-Wen, and Guo,Dong-Yan

Abstract

Mian Huang,1 Bing-Tao Zhai,1,2 Yu Fan,3 Jing Sun,1 Ya-Jun Shi,1 Xiao-Fei Zhang,1 Jun-Bo Zou,1 Jia-Wen Wang,1 Dong-Yan Guo1,4 1School of Pharmacy, Shaanxi University of Chinese Medicine, Xi’an, 712046, People’s Republic of China; 2State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi University of Chinese Medicine, Xi’an, 712046, People’s Republic of China; 3School of Basic Medicine, Shaanxi University of Chinese Medicine, Xi’an, 712046, People’s Republic of China; 4Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Research, Shaanxi University of Chinese Medicine, Xi’an, 712046, People’s Republic of ChinaCorrespondence: Dong-Yan Guo, Email 2051080@sntcm.edu.cnAbstract: Breast cancer (BC) is the most prevalent type of cancer in the world and the main reason women die from cancer. Due to the significant side effects of conventional treatments such as chemotherapy and radiotherapy, the search for supplemental and alternative natural drugs with lower toxicity and side effects is of interest to researchers. Curcumin (CUR) is a natural polyphenol extracted from turmeric. Numerous studies have demonstrated that CUR is an effective anticancer drug that works by modifying different intracellular signaling pathways. CUR’s therapeutic utility is severely constrained by its short half-life in vivo, low water solubility, poor stability, quick metabolism, low oral bioavailability, and potential for gastrointestinal discomfort with high oral doses. One of the most practical solutions to the aforementioned issues is the development of targeted drug delivery systems (TDDSs) based on nanomaterials. To improve drug targeting and efficacy and to serve as a reference for the development and use of CUR TDDSs in the clinical setting, this review describes the physicochemical properties and bioavailability of CUR and its mechanism of action on BC, with emphasis on recent studies on TDDSs for B

Published
2023

23. Exploring the Scientific Rationality of the Phenomenon of 'Different Dosage Forms of the Same Prescription' of Chinese Proprietary Medicine Based on Biopharmaceutical Properties of Powder and Pill of Chuanxiong Chatiao Prescription

Author

Qu, Zhong-huan, Liu, Lin, Zhang, Xiao-fei, Guo, Dong-yan, Zhai, Bing-tao, Zou, Jun-bo, and Shi, Ya-jun

Subjects
Pharmacology, Pharmacology (medical)
Abstract

Background: The 2020 edition of the Pharmacopoeia of the People’s Republic of China (Chinese Pharmacopoeia 2020 edition) has 255 Chinese prescriptions with different dosage forms, accounting for 21.09% of the total prescriptions (1,209) in Chinese Pharmacopoeia 2020 edition. However, the scientific rationality of the phenomenon of “Different Dosage Forms of the Same Prescription” of Chinese proprietary medicine has been less explored. Based on the dosage form theory of “components in pills release slowly and take effect in slow-acting manner, while in powders release quickly and take effect in fast-acting way,” we provided the in vitro dissolution experiment and in vivo pharmacokinetics of Chuanxiong Chatiao powders and pills in order to rationalize the phenomenon of “Different Dosage Forms of the Same Prescription” of Chuanxiong Chatiao prescription.Materials and Methods: Chuanxiong Chatiao powders and pills were prepared in the laboratory referring to the preparation methods in the Chinese Pharmacopoeia 2020 edition, and the contents of tetramethylpyrazine, ferulic acid, nodakenin, and isoimperatorin were determined by the external standard method. We measured the in vitro dissolution of four analytes of Chuanxiong Chatiao powders and pills according to the second method for dissolution determination (paddle method) in the Chinese Pharmacopoeia 2020 edition, and their corresponding contents in each sampling point were determined by LC-MS/MS. We also provided a pharmacokinetic study of Chuanxiong Chatiao powders and pills. Six female domestic rabbits were divided into two groups (powder and pill groups) and given Chuanxiong Chatiao powders and pills (9.85 g/kg) by surgical administration separately. Blood samples were collected at 5, 15, 30, 45, 60, 90, 120, 150, 180, 240, 360, 480, 720, and 1,440 min after drug administration to measure the plasma concentration of the four analytes by LC-MS/MS.Results: The results of in vitro dissolution experiment showed that the dissolution rate of four analytes in the powder group was greater than that of the pill group. However, the solubilities of tetramethylpyrazine and isoimperatorin were very low in the powder and pill, which may be related to their low solubility properties. The results of the in vivo pharmacokinetic study of Chuanxiong Chatiao powders and pills showed that Tmax (h) of ferulic acid and nodakenin in the powder group was 0.420 and 0.053 times that of the pill group and t1/2 (h) of ferulic acid, nodakenin, and isoimperatorin of the powder group was 0.910, 0.262, and 0.661 times that of the pill group, respectively.Conclusion: The in vitro dissolution rate and in vivo pharmacokinetic parameters of four analytes in CXCTF could partly explain the scientific rationality of the classic theory of “丸者缓也, 散者散也” as in Chinese, which is helpful for providing a basis for the comparison of subsequent dosage forms. The results of our studies also suggest the complexity of the design of dosage forms of Chinese proprietary medicines and imply that we should pay more attention to the scientific rationality of the phenomenon of “Different Dosage Forms of the Same Prescription.”

Published
2022

25. Predictors of adherence to home-based cardiac rehabilitation program among coronary artery disease outpatients in China

Author

Ge, Cheng, Ma, Jing, Xu, Yong, Shi, Ya-Jun, Zhao, Cheng-Hui, Gao, Ling, Bai, Jing, Wang, Yu, Sun, Zhi-Jun, Guo, Jun, and Chen, Yun-Dai

Subjects
Adherence, Cardiac rehabilitation, Coronary artery disease, Research Article
Abstract

Background Cardiac rehabilitation (CR) has proven beneficial for patients with coronary artery disease. However, adherence to CR programs is the key to the health improvement in those patients. Identifying predictors for adherence, which is very much unknown in China, would be valuable for effective rehabilitation. This study aims to determine the adherence to home-based CR programs in Chinese coronary artery disease patients and determine predictors of adherence. Methods The current study included 1033 outpatients with coronary heart disease in the First Medical Center of Chinese PLA General Hospital in Beijing from July 2015 to June 2017. Participants were given an exercise prescription and took part in home-based exercise training lasting for 3–24 months. A questionnaire was used to evaluate the completion of the CR program, understanding of the program, motivation of the patients, and family/peer support. Results Two thirds of the patients adhered well to the home-based CR program. Elder patients (≥ 65-year-old) adhere to the program better, while men adhered better than women. Patients who used to exercise (B = 6.756, P < 0.001), understood the program (B = 0.078, P = 0.002), with stronger motivation to participate (B = 0.376, P < 0.001), and received better family support (B = 0.487, P < 0.001) also adhere better to the program. Conclusions Understanding the program, self-motivation of patients, and family support help to keep patients engaged in a home-based CR program. Improvement of family support by educating both patients and families may be helpful in improving adherence to home-based CR programs.

Published
2019

27. Chinese expert consensus on the non-invasive imaging examination pathways of stable coronary artery disease

Author

Chen, Yun-Dai, Fang, Wei-Yi, Chen, Ji-Yan, Fan, Zhan-Ming, Gao, Chuan-Yu, Ge, Jun-Bo, He, Zuo-Xiang, Huo, Yong, Li, Lang, Li, Si-Jin, Lu, Xi-Lie, Lv, Bin, Qian, Ju-Ying, Shi, Ya-Jun, Shen, Zhu-Jun, Wang, Jing, Wang, Yi-Ning, Xu, Lei, Yang, Li, Yu, Bo, Zhang, Mei, Yang, Jun-Jie, Zhang, Shu-Yang, Zhang, Xiao-Li, Zhao, Shi-Hua, Zheng, Yang, Han, Yu-Chi, and Zhi, Guang

Subjects
Special Article, Clinical pathway, Non-invasive imaging examination, Expert consensus, Pre-test probabilities, Coronary artery disease
Published
2018

31. Therapeutic Efficacy of Kangfuxin Liquid Combined with PPIs in Gastric Ulcer

Author

Zou, Jun-Bo, Zhang, Xiao-Fei, Shi, Ya-Jun, Tai, Jia, Wang, Yu, Liang, Yu-Lin, Wang, Fang, Cheng, Jiang-Xue, Wang, Jing, and Guo, Dong-Yan

Subjects
Article Subject
Abstract

Objective. To evaluate the clinical efficacy and safety of Kangfuxin liquid (KFX) combined with proton pump inhibitors (PPIs) in the treatment of gastric ulcer (GU). Materials and Methods. Electronic databases including PubMed, Wanfang, CNKI, VIP, Embase, Cochrane Library, and CBM were examined for appropriate articles without language limitations on key words before March 10, 2019. RevMan 5.3 software was applied to execute outcome assessment and finish the meta-analysis. Results. 22 articles involving 2,024 patients with a gastric ulcer were selected. Total efficacy rate and efficacy rate of gastroscopy were significantly enhanced for the combination of KFX with PPIs compared to those of PPI treatment alone (OR = 6.95, 95% CI: 4.87, 9.91, P

Published
2019
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34. Exploring the Mechanism of Lingzhu San in Treating Febrile Seizures by Using Network Pharmacology

Author

Zhou, Xiao, Zhang, Xiao-Fei, Guo, Dong-Yan, Yang, Yan-Jun, Liu, Lin, Wang, Lin, Zhang, Xue, Cheng, Jiang-Xue, Zou, Jun-Bo, and Shi, Ya-Jun

Abstract

Objective: Lingzhu San (LZS) is a traditional Chinese medicine (TCM) prescription that can be effective in treating febrile seizures (FS) and there are few research works conducted on its mechanisms. In order to better guide the clinical use of LZS, we used the research ideas and methods of network pharmacology to find the potential core compounds, targets and pathways of LZS in the complex TCM system for the treatment of FS, and predict the mechanism. Materials and Methods: Databases such as BATMAN, TCMSP, TCMID, and SWISS TARGET are used to mine the active compounds and targets of LZS, and the target information of FS is obtained through GENECARDS and OMIM. Using Venny2.1.0 and Cytoscape software, the potential core compounds and targets of FS were obtained. The R language and ClusterProfiler software package are adopted to enrich and analyze the KEGG and GO pathways of the core targets and the biological processes and potential mechanisms of the core targets are also revealed. Results: 187 active compounds and 2113 target proteins of LZS were collected. And 38 potential core compounds, 35 core targets and 775 metabolic and functional pathways were screened, which were involved in mediating FS. Finally, the role of the core compounds, targets and pivotal pathways of LZS in regulating FS in the pathogenesis and the therapeutic mechanism of FS were discussed and clarified. Conclusion: In this paper, the multi-compounds, multi-targets and multi-pathways mechanism of LZS in the treatment of FS were preliminarily screened through the analysis of network pharmacology data, which are consistent with the principle of multi-compounds’ compatibility with TCM prescriptions and a unified treatment of diseases from multiple aspects, and it provides a new way for TCM to treat complex diseases caused by multiple factors.

Published
2021
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35. Inhibitive Effects of FGF2/FGFR1 Pathway on Astrocyte-Mediated Inflammation in vivo and in vitro After Infrasound Exposure

Author

Shi, Ya-Jun, primary, Shi, Ming, additional, Xiao, Li-Jun, additional, Li, Li, additional, Zou, Lin-Hui, additional, Li, Chao-Yang, additional, Zhang, Qin-Jun, additional, Zhou, Lin-Fu, additional, Ji, Xin-Chao, additional, Huang, Huan, additional, Xi, Ye, additional, Liu, Ling, additional, Zhang, Hong-Ya, additional, Zhao, Gang, additional, and Ma, Lei, additional

Published
2018
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37. Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia

Author

Pang, Han-Qing, primary, Yue, Shi-Jun, additional, Tang, Yu-Ping, additional, Chen, Yan-Yan, additional, Tan, Ya-Jie, additional, Cao, Yu-Jie, additional, Shi, Xu-Qin, additional, Zhou, Gui-Sheng, additional, Kang, An, additional, Huang, Sheng-Liang, additional, Shi, Ya-Jun, additional, Sun, Jing, additional, Tang, Zhi-Shu, additional, and Duan, Jin-Ao, additional

Published
2018
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39. Pharmacokinetic Comparison of Seven Major Bio-Active Components in Normal and Blood Stasis Rats after Oral Administration of Herb Pair Danggui-Honghua by UPLC-TQ/MS

Author

Jin, Yi, primary, Tang, Yu-Ping, additional, Zhu, Zhen-Hua, additional, Shang, Er-Xin, additional, Pang, Han-Qing, additional, Shi, Xu-Qin, additional, Chen, Yan-Yan, additional, Wang, Jin, additional, Chang, Xing, additional, Kang, An, additional, Zhou, Gui-Sheng, additional, Shi, Ya-Jun, additional, Sun, Jin, additional, Tang, Zhi-Shu, additional, Li, Shao-Ping, additional, and Duan, Jin-Ao, additional

Published
2017
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