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2. A phase II randomized trial of sodium oligomannate in Alzheimer’s dementia

Author

Wang, Tao, Kuang, Weihong, Chen, Wei, Xu, Wenwei, Zhang, Liming, Li, Yingjie, Li, Hailin, Peng, Ying, Chen, Yangmei, Wang, Baojun, Xiao, Jinsong, Li, Honghua, Yan, Chuanzhu, Du, Yifeng, Tang, Mouni, He, Zhiyi, Chen, Haibo, Li, Wei, Lin, Hong, Shi, Shugui, Bi, Jianzhong, Zhou, Huadong, Cheng, Yan, Gao, Xiaoping, Guan, Yihui, Huang, Qiu, Chen, Kewei, Xin, Xianliang, Ding, Jian, Geng, Meiyu, and Xiao, Shifu

Published
2020
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3. Association of Stroke Subtype With Hemorrhagic Transformation Mediated by Thrombectomy Pass: Data From the ANGEL-ACT Registry

Author

Tong, Xu, primary, Burgin, W. Scott, additional, Ren, Zeguang, additional, Jia, Baixue, additional, Zhang, Xuelei, additional, Huo, Xiaochuan, additional, Luo, Gang, additional, Wang, Anxin, additional, Zhang, Yijun, additional, Ma, Ning, additional, Gao, Feng, additional, Song, Ligang, additional, Sun, Xuan, additional, Liu, Lian, additional, Deng, Yiming, additional, Li, Xiaoqing, additional, Wang, Bo, additional, Ma, Gaoting, additional, Wang, Yilong, additional, Wang, Yongjun, additional, Miao, Zhongrong, additional, Mo, Dapeng, additional, Gui, Liqiang, additional, Song, Cunfeng, additional, Peng, Ya, additional, Wu, Jin, additional, Zhao, Shijun, additional, Zhao, Junfeng, additional, Zhou, Zhiming, additional, Li, Yongli, additional, Jing, Ping, additional, Yang, Lei, additional, Liu, Yajie, additional, Zhao, Qingshi, additional, Liu, Yan, additional, Peng, Xiaoxiang, additional, Gao, Qingchun, additional, Guo, Zaiyu, additional, Chen, Wenhuo, additional, Li, Weirong, additional, Cheng, Xiaojiang, additional, Xu, Yun, additional, Zhang, Yongqiang, additional, Zhang, Guilian, additional, Lu, Yijiu, additional, Lu, Xinyu, additional, Wang, Dengxiang, additional, Wang, Yan, additional, Li, Hao, additional, Hua, Yang, additional, Geng, Deqin, additional, Yuan, Haicheng, additional, Wang, Hongwei, additional, Yang, Haihua, additional, Wang, Zengwu, additional, Wei, Liping, additional, Liufu, Xuancong, additional, Shi, Xiangqun, additional, Li, Juntao, additional, Yang, Wenwu, additional, Jing, Wenji, additional, Yong, Xiang, additional, Wang, Leyuan, additional, Li, Chunlei, additional, Cao, Yibin, additional, Zhu, Qingfeng, additional, Zhang, Peng, additional, Luo, Xiang, additional, Chen, Shengli, additional, Peng, WenWu, additional, Wang, Lixin, additional, Wen, Xue, additional, Shi, Shugui, additional, Wang, Wanming, additional, Bo, Wang, additional, Yuan, Pu, additional, Wang, Dong, additional, Guan, Haitao, additional, Liang, Wenbao, additional, Ma, Daliang, additional, Chen, Long, additional, Xiao, Yan, additional, Xie, Xiangdong, additional, Shi, Zhonghua, additional, Zeng, Xiangjun, additional, Su, Fanfan, additional, Chang, MingZe, additional, Yin, Jijun, additional, Sun, Hongxia, additional, Li, Chong, additional, Bi, Yong, additional, Xie, Gang, additional, Zhao, Yuwu, additional, Wang, Chao, additional, Wang, Xianjun, additional, Li, Dongqun, additional, Liang, Hui, additional, Chen, Zhonglun, additional, Wang, Yuxin, additional, Yin, Lin, additional, Qiu, HongKai, additional, Wei, Jun, additional, Sun, Yaxuan, additional, Feng, Xiaoya, additional, Wu, Weihua, additional, Gao, Lianbo, additional, Ai, Zhibing, additional, Tan, Lan, additional, Ding, Li, additional, Liang, Qilong, additional, Wang, Zhimin, additional, Yang, Jianwen, additional, Xu, Ping, additional, Dong, Wei, additional, Zheng, Quanle, additional, Zhu, Zhenyun, additional, Zhao, Liyue, additional, Meng, Qingbo, additional, Wei, Yuqing, additional, Chen, Xianglin, additional, Wang, Wei, additional, Sun, Dong, additional, Yan, Yongxing, additional, Yuan, Guangxiong, additional, Yang, Yadong, additional, Zhou, Jianfeng, additional, Yang, Zhi, additional, Zhang, Zhenzhong, additional, Guan, Ning, additional, and Wang, Huihong, additional

Published
2022
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4. Combined Approach to Eptifibatide and Thrombectomy in Acute Ischemic Stroke Because of Large Vessel Occlusion: A Matched-Control Analysis

Author

Ma, Gaoting, primary, Sun, Xuan, additional, Cheng, Huiran, additional, Burgin, W. Scott, additional, Luo, Weiliang, additional, Jia, Weihua, additional, Liu, Yajie, additional, He, Wenlong, additional, Geng, Xiaokun, additional, Zhu, Liangfu, additional, Chen, Xingyu, additional, Shi, Huaizhang, additional, Xu, Haowen, additional, Zhang, Litong, additional, Wang, Anxin, additional, Mo, Dapeng, additional, Ma, Ning, additional, Gao, Feng, additional, Song, Ligang, additional, Huo, Xiaochuan, additional, Deng, Yiming, additional, Liu, Lian, additional, Luo, Gang, additional, Jia, Baixue, additional, Tong, Xu, additional, Liu, Liping, additional, Ren, Zeguang, additional, Miao, Zhongrong, additional, Gui, Liqiang, additional, Wang, Tianyu, additional, Ma, Xiang, additional, Yang, Chunshui, additional, Song, Cunfeng, additional, Peng, Ya, additional, Wu, Jin, additional, Zhao, Shijun, additional, Zhao, Junfeng, additional, Zhou, Zhiming, additional, Li, Yongli, additional, Jing, Ping, additional, Yang, Lei, additional, Zhao, Qingshi, additional, Liu, Yan, additional, Peng, Xiaoxiang, additional, Gao, Qingchun, additional, Guo, Zaiyu, additional, Chen, Wenhuo, additional, Li, Weirong, additional, Cheng, Xiaojiang, additional, Xu, Yun, additional, Zhang, Yongqiang, additional, Zhang, Guilian, additional, Lu, Yijiu, additional, Lu, Xinyu, additional, Wang, Dengxiang, additional, Wang, Yan, additional, Li, Hao, additional, Hua, Yang, additional, Geng, Deqin, additional, Yuan, Haicheng, additional, Wang, Hongwei, additional, Yang, Haihua, additional, Wang, Zengwu, additional, Wei, Liping, additional, Liufu, Xuancong, additional, Shi, Xiangqun, additional, Li, Juntao, additional, Yang, Wenwu, additional, Jing, Wenji, additional, Yong, Xiang, additional, Wang, Leyuan, additional, Li, Chunlei, additional, Cao, Yibin, additional, Zhu, Qingfeng, additional, Zhang, Peng, additional, Luo, Xiang, additional, Chen, Shengli, additional, Peng, WenWu, additional, Wang, Lixin, additional, Wen, Xue, additional, Shi, Shugui, additional, Wang, Wanming, additional, Bo, Wang, additional, Yuan, Pu, additional, Wang, Dong, additional, Guan, Haitao, additional, Liang, Wenbao, additional, Ma, Daliang, additional, Chen, Long, additional, Xiao, Yan, additional, Xie, Xiangdong, additional, Shi, Zhonghua, additional, Zeng, Xiangjun, additional, Su, Fanfan, additional, Chang, MingZe, additional, Yin, Jijun, additional, Sun, Hongxia, additional, Li, Chong, additional, Bi, Yong, additional, Xie, Gang, additional, Zhao, Yuwu, additional, Wang, Chao, additional, Wang, Xianjun, additional, Li, Dongqun, additional, Liang, Hui, additional, Chen, Zhonglun, additional, Wang, Yu Xin, additional, Yin, Lin, additional, Qiu, HongKai, additional, Wei, Jun, additional, Sun, Yaxuan, additional, Feng, Xiaoya, additional, Wu, Weihua, additional, Gao, Lianbo, additional, Ai, Zhibing, additional, Lan, Tan, additional, Ding, Li, additional, Liang, Qilong, additional, Wang, Zhimin, additional, Yang, Jianwen, additional, Xu, Ping, additional, Dong, Wei, additional, Zheng, Quanle, additional, Zhu, Zhenyun, additional, Zhao, Liyue, additional, Meng, Qingbo, additional, Wei, Yuqing, additional, Chen, Xianglin, additional, Wang, Wei, additional, Sun, Dong, additional, Yan, Yongxing, additional, Yuan, Guangxiong, additional, Yang, Yadong, additional, Zhou, Jianfeng, additional, Yang, Zhi, additional, Zhang, Zhenzhong, additional, Guan, Ning, additional, and Wang, Huihong, additional

Published
2022
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5. Identification of novel FUS and TARDBP gene mutations in Chinese amyotrophic lateral sclerosis patients with HRM analysis

Author

Wang, Feng, Fu, Shengyu, Lei, Jiafan, Wu, Hongchen, Shi, Shugui, Chen, Kangning, Hu, Jun, and Xu, Xueqing

Subjects
Adult, Male, amyotrophic lateral sclerosis, China, Middle Aged, Pedigree, DNA-Binding Proteins, Young Adult, Asian People, Mutation, Humans, RNA-Binding Protein FUS, Female, HRM analysis, TARDBP, Research Paper, FUS
Abstract

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive loss of motor neurons. More than 30 genes have been linked to ALS to date, including FUS and TARDBP, which exhibit similar roles in RNA metabolism. This study explored the use of high-resolution melting (HRM) analysis to screen for FUS and TARDBP mutation hotspot regions in 146 Chinese ALS patients, which achieved 100% detection. Two FUS mutations were observed in two different familial ALS probands, a missense mutation (p.R521H) and a novel splicing mutation (c.1541+1G>A). Five TARDBP mutations were identified in six ALS patients, including a novel 3’UTR mutation (c.*731A>G) and four missense mutations (p.G294V, p.M337V, p.G348V, and p.I383V). We found that FUS mutations were present in 1.4% of Chinese ALS patients, whereas TARDBP mutations were responsible for 4.1% of Chinese ALS cases. Here, we describe the accuracy of using highly sensitive HRM analysis to identify two novel FUS and TARDBP mutations in Chinese sporadic and familial ALS cases. Our study contributes to the further understanding of the genetic and phenotypic diversity of ALS.

Published
2020

8. Sex-Related Differences in Outcomes of Endovascular Treatment for Anterior Circulation Large Vessel Occlusion

Author

Sun, Dapeng, Raynald, Huo, Xiaochuan, Jia, Baixue, Tong, Xu, Ma, Gaoting, Wang, Anxin, Ma, Ning, Gao, Feng, Mo, Dapeng, Nguyen, Thanh N., Miao, Zhongrong, Miao, Zhongrong, Gui, Liqiang, Song, Cunfeng, Peng, Ya, Wu, Jin, Zhao, Shijun, Zhao, Junfeng, Zhou, Zhiming, Li, Yongli, Jing, Ping, Yang, Lei, Liu, Yajie, Zhao, Qingshi, Liu, Yan, Peng, Xiaoxiang, Gao, Qingchun, Guo, Zaiyu, Chen, Wenhuo, Li, Weirong, Cheng, Xiaojiang, Xu, Yun, Zhang, Yongqiang, Zhang, Guilian, Lu, Yijiu, Lu, Xinyu, Wang, Dengxiang, Wang, Yan, Li, Hao, Hua, Yang, Geng, Deqin, Yuan, Haicheng, Wang, Hongwei, Yang, Haihua, Wang, Zengwu, Wei, Liping, Liufu, Xuancong, Shi, Xiangqun, Li, Juntao, Yang, Wenwu, Jing, Wenji, Yong, Xiang, Wang, Leyuan, Li, Chunlei, Cao, Yibin, Zhu, Qingfeng, Zhang, Peng, Luo, Xiang, Chen, Shengli, Peng, WenWu, Wang, Lixin, Wen, Xue, Shi, Shugui, Wang, Wanming, Bo, Wang, Yuan, Pu, Wang, Dong, Guan, Haitao, Liang, Wenbao, Ma, Daliang, Chen, Long, Xiao, Yan, Xie, Xiangdong, Shi, Zhonghua, Zeng, Xiangjun, Su, Fanfan, Chang, MingZe, Yin, Jijun, Sun, Hongxia, Li, Chong, Bi, Yong, Xie, Gang, Zhao, Yuwu, Wang, Chao, Zhang, Peng, Wang, Xianjun, Li, Dongqun, Liang, Hui, Chen, Zhonglun, Wang, Yan, Wang, Yuxin, Yin, Lin, Qiu, HongKai, Wei, Jun, Sun, Yaxuan, Feng, Xiaoya, Wu, Weihua, Gao, Lianbo, Ai, Zhibing, Tan, Lan, Ding, Li, Liang, Qilong, Wang, Zhimin, Yang, Jianwen, Xu, Ping, Dong, Wei, Zheng, Quanle, Zhu, Zhenyun, Zhao, Liyue, Meng, Qingbo, Wei, Yuqing, Chen, Xianglin, Wang, Wei, Sun, Dong, Yan, Yongxing, Yuan, Guangxiong, Yang, Yadong, Zhou, Jianfeng, Yang, Zhi, Zhang, Zhenzhong, Guan, Ning, and Wang, Huihong

Published
2023
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9. Thrombectomy Versus Combined Thrombolysis and Thrombectomy in Patients With Acute Stroke

Author

Tong, Xu, primary, Wang, Yilong, additional, Fiehler, Jens, additional, Bauer, Clayton T., additional, Jia, Baixue, additional, Zhang, Xuelei, additional, Huo, Xiaochuan, additional, Luo, Gang, additional, Wang, Anxin, additional, Pan, Yuesong, additional, Ma, Ning, additional, Gao, Feng, additional, Mo, Dapeng, additional, Song, Ligang, additional, Sun, Xuan, additional, Liu, Lian, additional, Deng, Yiming, additional, Li, Xiaoqing, additional, Wang, Bo, additional, Ma, Gaoting, additional, Wang, Yongjun, additional, Ren, Zeguang, additional, Miao, Zhongrong, additional, Gui, Liqiang, additional, Song, Cunfeng, additional, Peng, Ya, additional, Wu, Jin, additional, Zhao, Shijun, additional, Zhao, Junfeng, additional, Zhou, Zhiming, additional, Li, Yongli, additional, Jing, Ping, additional, Yang, Lei, additional, Liu, Yajie, additional, Zhao, Qingshi, additional, Liu, Yan, additional, Peng, Xiaoxiang, additional, Gao, Qingchun, additional, Guo, Zaiyu, additional, Chen, Wenhuo, additional, Li, Weirong, additional, Cheng, Xiaojiang, additional, Xu, Yun, additional, Zhang, Yongqiang, additional, Zhang, Guilian, additional, Lu, Yijiu, additional, Lu, Xinyu, additional, Wang, Dengxiang, additional, Wang, Yan, additional, Li, Hao, additional, Hua, Yang, additional, Geng, Deqin, additional, Yuan, Haicheng, additional, Wang, Hongwei, additional, Yang, Haihua, additional, Wang, Zengwu, additional, Wei, Liping, additional, Liufu, Xuancong, additional, Shi, Xiangqun, additional, Li, Juntao, additional, Yang, Wenwu, additional, Jing, Wenji, additional, Yong, Xiang, additional, Wang, Leyuan, additional, Li, Chunlei, additional, Cao, Yibin, additional, Zhu, Qingfeng, additional, Zhang, Peng, additional, Luo, Xiang, additional, Chen, Shengli, additional, Peng, WenWu, additional, Wang, Lixin, additional, Wen, Xue, additional, Shi, Shugui, additional, Wang, Wanming, additional, Bo, Wang, additional, Yuan, Pu, additional, Wang, Dong, additional, Guan, Haitao, additional, Liang, Wenbao, additional, Ma, Daliang, additional, Chen, Long, additional, Xiao, Yan, additional, Xie, Xiangdong, additional, Shi, Zhonghua, additional, Zeng, Xiangjun, additional, Su, Fanfan, additional, Chang, MingZe, additional, Yin, Jijun, additional, Sun, Hongxia, additional, Li, Chong, additional, Bi, Yong, additional, Xie, Gang, additional, Zhao, Yuwu, additional, Wang, Chao, additional, Wang, Xianjun, additional, Li, Dongqun, additional, Liang, Hui, additional, Chen, Zhonglun, additional, Xin, Yu, additional, Yin, Lin, additional, Qiu, HongKai, additional, Wei, Jun, additional, Sun, Yaxuan, additional, Feng, Xiaoya, additional, Wu, Weihua, additional, Gao, Lianbo, additional, Ai, Zhibing, additional, Lan, Tan, additional, Ding, Li, additional, Liang, Qilong, additional, Wang, Zhimin, additional, Yang, Jianwen, additional, Xu, Ping, additional, Dong, Wei, additional, Zheng, Quanle, additional, Zhu, Zhenyun, additional, Zhao, Liyue, additional, Meng, Qingbo, additional, Wei, Yuqing, additional, Chen, Xianglin, additional, Wang, Wei, additional, Sun, Dong, additional, Yan, Yongxing, additional, Yuan, Guangxiong, additional, Yang, Yadong, additional, Zhou, Jianfeng, additional, Yang, Zhi, additional, Zhang, Zhenzhong, additional, Guan, Ning, additional, and Wang, Huihong, additional

Published
2021
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10. Current Status of Endovascular Treatment for Acute Large Vessel Occlusion in China

Author

Jia, Baixue, primary, Ren, Zeguang, additional, Mokin, Maxim, additional, Burgin, W. Scott, additional, Bauer, Clayton T., additional, Fiehler, Jens, additional, Mo, Dapeng, additional, Ma, Ning, additional, Gao, Feng, additional, Huo, Xiaochuan, additional, Luo, Gang, additional, Wang, Anxin, additional, Pan, Yuesong, additional, Song, Ligang, additional, Sun, Xuan, additional, Zhang, Xuelei, additional, Gui, Liqiang, additional, Song, Cunfeng, additional, Peng, Ya, additional, Wu, Jin, additional, Zhao, Shijun, additional, Zhao, Junfeng, additional, Zhou, Zhiming, additional, Li, Yongli, additional, Jing, Ping, additional, Yang, Lei, additional, Liu, Yajie, additional, Zhao, Qingshi, additional, Liu, Yan, additional, Peng, Xiaoxiang, additional, Gao, Qingchun, additional, Guo, Zaiyu, additional, Chen, Wenhuo, additional, Li, Weirong, additional, Cheng, Xiaojiang, additional, Xu, Yun, additional, Zhang, Yongqiang, additional, Zhang, Guilian, additional, Lu, Yijiu, additional, Lu, Xinyu, additional, Wang, Dengxiang, additional, Wang, Yan, additional, Li, Hao, additional, Ling, Li, additional, Peng, Guangge, additional, Zhang, Jingyu, additional, Zhang, Kai, additional, Li, Shuo, additional, Qi, Zhongqi, additional, Xu, Haifeng, additional, Tong, Xu, additional, Ma, Gaoting, additional, Liu, Raynald, additional, Guo, Xu, additional, Deng, Yiming, additional, Leng, Xinyi, additional, Leung, Thomas W., additional, Liebeskind, David S., additional, Wang, Yilong, additional, Wang, Yongjun, additional, Miao, Zhongrong, additional, Hua, Yang, additional, Geng, Deqin, additional, Yuan, Haicheng, additional, Wang, Hongwei, additional, Yang, Haihua, additional, Wang, Zengwu, additional, Wei, Liping, additional, Liufu, Xuancong, additional, Shi, Xiangqun, additional, Li, Juntao, additional, Yang, Wenwu, additional, Jing, Wenji, additional, Yong, Xiang, additional, Wang, Leyuan, additional, Li, Chunlei, additional, Cao, Yibin, additional, Zhu, Qingfeng, additional, Zhang, Peng, additional, Luo, Xiang, additional, Chen, Shengli, additional, Peng, WenWu, additional, Wang, Lixin, additional, Wen, Xue, additional, Shi, Shugui, additional, Wang, Wanming, additional, Bo, Wang, additional, Yuan, Pu, additional, Wang, Dong, additional, Guan, Haitao, additional, Liang, Wenbao, additional, Ma, Daliang, additional, Chen, Long, additional, Xiao, Yan, additional, Xie, Xiangdong, additional, Shi, Zhonghua, additional, Zeng, Xiangjun, additional, Su, Fanfan, additional, Chang, MingZe, additional, Yin, Jijun, additional, Sun, Hongxia, additional, Li, Chong, additional, Bi, Yong, additional, Xie, Gang, additional, Zhao, Yuwu, additional, Wang, Chao, additional, Wang, Xianjun, additional, Li, Dongqun, additional, Liang, Hui, additional, Chen, Zhonglun, additional, Wang, Yu Xin, additional, Yin, Lin, additional, Qiu, HongKai, additional, Wei, Jun, additional, Sun, Yaxuan, additional, Feng, Xiaoya, additional, Wu, Weihua, additional, Gao, Lianbo, additional, Ai, Zhibing, additional, Lan, Tan, additional, Ding, Li, additional, Liang, Qilong, additional, Wang, Zhimin, additional, Yang, Jianwen, additional, Xu, Ping, additional, Dong, Wei, additional, Zheng, Quanle, additional, Zhu, Zhenyun, additional, Zhao, Liyue, additional, Meng, Qingbo, additional, Wei, Yuqing, additional, Chen, Xianglin, additional, Wang, Wei, additional, Sun, Dong, additional, Yan, Yongxing, additional, Yuan, Guangxiong, additional, Yang, Yadong, additional, Zhou, Jianfeng, additional, Yang, Zhi, additional, Zhang, Zhenzhong, additional, Guan, Ning, additional, and Wang, Huihong, additional

Published
2021
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13. A phase II randomized trial of sodium oligomannate in Alzheimer's dementia

Author

Wang, Tao, primary, Kuang, Weihong, additional, Chen, Wei, additional, Zhang, Liming, additional, Xu, Wenwei, additional, Li, Yingjie, additional, Li, Hailin, additional, Peng, Ying, additional, Chen, Yangmei, additional, Wang, Baojun, additional, Xiao, Jinsong, additional, Li, Honghua, additional, Yan, Chuanzhu, additional, Du, Yifeng, additional, Tang, Mouni, additional, He, Zhiyi, additional, Chen, Haibo, additional, Li, Wei, additional, Lin, Hong, additional, Shi, Shugui, additional, Bi, Jianzhong, additional, Zhou, Huadong, additional, Cheng, Yan, additional, Gao, Xiaoping, additional, Guan, Yihui, additional, Huang, Qiu, additional, Chen, Kewei, additional, Xin, Xianliang, additional, Ding, Jian, additional, Geng, Meiyu, additional, and Xiao, Shifu, additional

Published
2020
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14. Middle cerebral artery occlusion following autologous bitemporal fat injection

Author

Hu, Jun, Chen, Wei, Wu, Yaguang, Chen, Kangning, Luo, Chunxia, Liang, Yong, and Shi, Shugui

Subjects
Magnetic resonance imaging -- Usage, Angiography -- Usage, Blood circulation disorders -- Risk factors -- Diagnosis -- Case studies -- Care and treatment, Health
Abstract

Byline: Jun. Hu, Wei. Chen, Yaguang. Wu, Kangning. Chen, Chunxia. Luo, Yong. Liang, Shugui. Shi Sir, Fat embolism syndrome (FES) manifests more frequently in closed fractures of the pelvis or [...]

Published
2011

15. Five-year follow-up of stenting for a symptomatic posterior cerebral artery stenosis

Author

Hu, Jun, Chen, Wei, Zhang, Xiaofei, Chen, Kangning, and Shi, Shugui

Subjects
Arteries -- Stenosis, Stent (Surgery) -- Usage, Angiography -- Usage, CT imaging -- Usage, Health
Abstract

Byline: Jun. Hu, Wei. Chen, Xiaofei. Zhang, Kangning. Chen, Shugui. Shi Angioplasty and stenting in symptomatic intracranial stenosis is technically possible and may reduce the risk of stroke in patients [...]

Published
2011

25. Stent Placement for Treatment of Long Segment (≥80mm) Carotid Artery Stenosis in Patients with Takayasu Disease.

Author

Hu, Jun, Huang, Heqing, Zhang, Xiaofei, Li, Guangjian, Liu, Qu, Wu, Min, Li, Gui, Chen, Kangning, and Shi, Shugui

Abstract

Abstract: Purpose: To evaluate the effectiveness and safety of carotid artery stent (CAS) placement for treatment of long segment stenosis in patients with Takayasu arteritis. Materials and Methods: Between January 2002 and February 2012, all patients with Takayasu arteritis found to have long segment (≥80mm) carotid artery stenoses at a single institution were retrospectively analyzed. Five patients treated by CAS placement with either long or multiple self-expandable stents were included. All patients had focal neurologic symptoms, including three strokes and two transient ischemic attacks (TIAs). Six self-expanding stents were used in five patients. The mean follow-up period was 19.2 months (range, 6–30 mo); all patients had clinical evaluation, laboratory examination, and vascular imaging follow-up. Results: Improvement in clinical symptoms was shown after successful angioplasty. There were no perioperative or in-hospital deaths. Four patients exhibited persistent relief, and repeated angiography or computed tomography (CT) angiography showed normal flow. One patient stopped taking her medications after CAS placement and became symptomatic 8 months later as a result of a severe in-stent stenosis. Conclusions: CAS placement was shown to be a feasible option for treating long segment (≥80mm) stenosis of carotid arteries in patients with Takayasu arteritis with encouraging results. [Copyright &y& Elsevier]

Published
2012
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26. A novel SOD1 mutation in amyotrophic lateral sclerosis with a distinct clinical phenotype.

Author

Hu, Jun, Chen, Kangning, Ni, Bing, Li, Lusi, Chen, Guisheng, and Shi, Shugui

Subjects
AMYOTROPHIC lateral sclerosis, AMINO acids, GENETIC mutation, PHENOTYPES, GENES, PATIENTS
Abstract

Familial amyotrophic lateral sclerosis (FALS) accounts for about 5% of cases of the neurodegenerative disorder ALS. At least 100 Cu/Zn superoxide dismutase (SOD1) genetic mutations have been associated with FALS. We identified a FALS family in China with an atypical clinical phenotype. To investigate the SOD1 gene mutations in this family, five exons of the SOD1 gene from each living patient were amplified by PCR and screened by SSCP and direct DNA sequencing. SSCP analysis demonstrated a mutation in exon 2 of SOD1, and DNA sequencing demonstrated the presence of an insertion mutation in exon 2 that has not been reported previously. The mutant SOD1 gene encodes a truncated protein of 35 amino acid residues compared to the normal SOD1 protein of 153 amino acids. In conclusion, The SOD1 exon 2 mutation is likely to be the etiological factor of ALS in this family. [ABSTRACT FROM AUTHOR]

Published
2012
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27. Influences of cerebral stent implantation on CD4+CD25+FOXP3+Treg, Th1 and Th17 cells.

Author

Wang, Sijia, Ni, Bing, Chen, Kangning, and Shi, Shugui

Subjects
*SURGICAL stents, *CD antigens, *FORKHEAD transcription factors, *T helper cells, *ARTERIAL stenosis treatment, *INFLAMMATION
Abstract

Abstract: Stent implantation is primarily used for the treatment of artery stenosis. However, the application and use of stent struts induces local and systemic inflammation, leading to intractable neointimal hyperplasia. CD4+ T cells are involved in artery stenosis diseases, but little is known about the influence of the CD4+ T cells on the inflammation reaction after stent implantation. In this study, we analyzed the frequency of signature transcription factors and proinflammatory cytokine expression from each subtype of CD4+ T cells in 50 patients receiving intracranial or cervical stent implantations from December 2011 to June 2012. The results showed that the frequency of signature transcription factor/cytokine production in Treg cells was reduced in the first week and returned to control levels at 3months after stent implantation. However, we observed opposite trends for Th17 cells, showing increased signature transcription factor/cytokine production during the acute phase, which returned to control levels after 3months. No significant difference in the frequency of signature transcription factor/cytokine expression was observed in Th1 cells from patients before and after stent implantation. We speculate that the maintenance of the frequency and function of Tregs controls the inflammatory response, which otherwise induces acute inflammation after stent implantation. [Copyright &y& Elsevier]

Published
2013
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28. Stent placement for treatment of long-segment (≥40 mm) carotid atherosclerotic stenosis: results and long-term follow-up in a single-center experience.

Author

Hu J, Shi S, Xie S, Liang Y, Tang X, and Chen K

Subjects
Adult, Aged, Angioplasty adverse effects, Carotid Stenosis etiology, Cerebral Hemorrhage etiology, Female, Follow-Up Studies, Humans, Male, Middle Aged, Myocardial Infarction etiology, Treatment Outcome, Angioplasty methods, Atherosclerosis complications, Carotid Stenosis therapy, Stents
Abstract

Background: Treatment of long segment carotid stenosis (≥40 mm) with carotid artery stenting (CAS) has rarely been reported. In randomized trials, use of longer stents (>40 mm) has been associated with adverse clinical events. Here, we report our preliminary experience on the stent length and outcome in treating long segment carotid arterial stenosis., Methods and Results: Between August 2003 and February 2013, 22 patients with long segment stenosis of the carotid artery were treated by CAS. The mean stent length was 58.5 mm (50-60 mm). The procedures were successful in all patients, and all reported remarkable relief of symptoms immediately after stent placement. Complications included 1 case of cerebral hemorrhage and one death from myocardial infarction at 10 months. The mean follow up was 27.3 months (10-60 months). One follow-up was lost. 2 patients had late stent thrombosis at 22 and 36 months by CTA follow-up. 18 patients had persistent relief, and angiography/CTA showed normal carotid flow., Conclusions: Our study showed that stenting for long carotid stenosis (≥40 mm) can be beneficial. Large scale clinical trial is needed to further evaluate its efficacy and safety., (Copyright © 2014. Published by Elsevier B.V.)

Published
2014
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29. Influences of cerebral stent implantation on CD4+ CD25+ FOXP3+ Treg, Th1 and Th17 cells.

Author

Wang S, Ni B, Chen K, and Shi S

Subjects
Aged, Constriction, Pathologic immunology, Female, Forkhead Transcription Factors immunology, Humans, Interleukin-2 Receptor alpha Subunit immunology, Male, Middle Aged, Carotid Stenosis immunology, Stents, T-Lymphocytes, Regulatory immunology, Th1 Cells immunology, Th17 Cells immunology
Abstract

Stent implantation is primarily used for the treatment of artery stenosis. However, the application and use of stent struts induces local and systemic inflammation, leading to intractable neointimal hyperplasia. CD4(+) T cells are involved in artery stenosis diseases, but little is known about the influence of the CD4(+) T cells on the inflammation reaction after stent implantation. In this study, we analyzed the frequency of signature transcription factors and proinflammatory cytokine expression from each subtype of CD4(+) T cells in 50 patients receiving intracranial or cervical stent implantations from December 2011 to June 2012. The results showed that the frequency of signature transcription factor/cytokine production in Treg cells was reduced in the first week and returned to control levels at 3 months after stent implantation. However, we observed opposite trends for Th17 cells, showing increased signature transcription factor/cytokine production during the acute phase, which returned to control levels after 3 months. No significant difference in the frequency of signature transcription factor/cytokine expression was observed in Th1 cells from patients before and after stent implantation. We speculate that the maintenance of the frequency and function of Tregs controls the inflammatory response, which otherwise induces acute inflammation after stent implantation., (© 2013.)

Published
2013
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30. Development of transgenic endothelial progenitor cell-seeded stents.

Author

Zhou Z, Shi S, Song M, Huang H, Chen K, Mi J, Li L, Chen G, Hou C, Huang G, and Zhu C

Subjects
Antigens, CD34 chemistry, Cell Adhesion, Cell Proliferation, Cells, Cultured, Collagen chemistry, DNA-Binding Proteins, Humans, Immobilized Proteins chemistry, Transfection, Tumor Necrosis Factor alpha-Induced Protein 3, Endothelial Cells cytology, Intracellular Signaling Peptides and Proteins genetics, Nuclear Proteins genetics, Stem Cells cytology, Stents
Abstract

Endothelial progenitor cell (EPC)-seeded intravascular stents may reduce or prevent in-stent restenosis. A20 can play an important role for preventing vascular restenosis. Therefore, it is very important how to enhance the seeding efficiency of A20-modified EPCs on the stent for preventing in-stent restenosis. To approach this problem, we developed a novel transgenic EPC-seeded stent and evaluated its feasibility and efficiency. EPCs were isolated and purified from umbilical blood using immunomagnetic beads and then transfected with the A20 gene. One stent type (type 1) was coated with EDC cross-linked collagen, and another stent type (type 2) was coated with EDC cross-linked collagen and bound to the CD34 antibody using the bifunctional coupling agent N-succinmidyl3-(2-pyridyldithio) propionate (SPDP). Then, the stents were seeded with EPCs transfected with the A20 gene. The stents were implanted in biological artificial vessels, and cell adhesion was determined in a flow chamber. Cell growth was also measured. EPCs were transfected successfully with the A20 gene. The cells covered both types of stents with favorable biological function. After placement in a flow chamber, the number of cells attached to type 1 stents significantly dropped and their distribution was scattered. Type 2 stents were basically covered with cells and there were more cells on type 2 stents than on type 1 stents (p < 0.01). Collagen-coupled antibody effectively improves the seeding of transgenic EPCs, offering a new choice of stents to prevent restenosis caused by vascular disease after interventional treatment., ((c) 2008 Wiley Periodicals, Inc.)

Published
2009
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