Search

Your search keyword '"Shi, Mingchao"' showing total 38 results
Start Over Author "Shi, Mingchao"
38 results on '"Shi, Mingchao"'

20. Role of Adaptive Immune and Impacts of Risk Factors on Adaptive Immune in Alzheimer's Disease: Are Immunotherapies Effective or Off-Target?

Author

Shi, Mingchao, Chu, Fengna, Tian, Xiaoping, Aerqin, Qiaolifan, Zhu, Feiqi, and Zhu, Jie

Subjects
*ALZHEIMER'S disease, *APOLIPOPROTEIN E4, *B cells, *CEREBROSPINAL fluid, *T cells, *IMMUNOTHERAPY
Abstract

The pathogenesis of Alzheimer's disease (AD) is complex. Still it remains unclear, which resulted in all efforts for AD treatments with targeting the pathogenic factors unsuccessful over past decades. It has been evidenced that the innate immune is strongly implicated in the pathogenesis of AD. However, the role of adaptive immune in AD remains mostly unknown and the results obtained were controversial. In the review, we summarized recent studies and showed that the molecular and cellular alterations in AD patients and its animal models involving T cells and B cells as well as immune mediators of adaptive immune occur not only in the peripheral blood but also in the brain and the cerebrospinal fluid. The risk factors that cause AD contribute to AD progress by affecting the adaptive immune, indicating that adaptive immunity proposes a pivotal role in this disease. It may provide a possible basis for applying immunotherapy in AD and further investigates whether the immunotherapies are effective or off-target? [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

23. Gut Microbiota in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Current Applications and Future Perspectives

Author

Chu, Fengna, Shi, Mingchao, Lang, Yue, Shen, Donghui, Jin, Tao, Zhu, Jie, and Cui, Li

Subjects
Article Subject, digestive system
Abstract

The gut environment and gut microbiome dysbiosis have been demonstrated to significantly influence a range of disorders in humans, including obesity, diabetes, rheumatoid arthritis, and multiple sclerosis (MS). MS is an autoimmune disease affecting the central nervous system (CNS). The etiology of MS is not clear, and it should involve both genetic and extrinsic factors. The extrinsic factors responsible for predisposition to MS remain elusive. Recent studies on MS and its animal model, experimental autoimmune encephalomyelitis (EAE), have found that gastrointestinal microbiota may play an important role in the pathogenesis of MS/EAE. Thus, gut microbiome adjustment may be a future direction of treatment in MS. In this review, we discuss the characteristics of the gut microbiota, the connection between the brain and the gut, and the changes in gut microbiota in MS/EAE, and we explore the possibility of applying microbiota therapies in patients with MS.

Published
2018
Full Text
View/download PDF

29. Rescue Strategy for Hemorrhagic Complication During Mechanical Thrombectomy and the Clinical Outcome

Author

Wang, Chao, Shi, Mingchao, Li, Chao, Wang, Shouchun, and Yang, Yi

Abstract

Purpose: Hemorrhagic complications occasionally occur during mechanical thrombectomy and may lead to catastrophic outcomes. Therefore, remedial strategies require careful investigation. Herein, we aimed to evaluate a cohort of patients who experienced hemorrhage during endovascular procedures, the rescue methods used, and outcomes observed.Method: This prospective study included patients who had hemorrhagic complications observed on digital subtraction angiography (DSA) during mechanical thrombectomy, between October 2017 and October 2022, at a high-volume stroke center. Functional outcomes were assessed using the modified Rankin scale (mRS) score at a 90-day follow-up. The primary outcomes were favorable outcomes (mRS score: 0–2 points) and mortality rates. The secondary outcomes were rescue therapy success rates, according to extravasation observed on the final DSA, recanalization status, and causes of hemorrhage.Results: From October 2017 to October 2022, 1537 patients with stroke received emergency endovascular therapy, and 1147 patients completed a 90-day follow-up. Hemorrhage was observed in 33 (2.1%) patients in the process of endovascular interventions. Eighteen (54.5%) cases of hemorrhage were caused by microwire or microcatheter perforation. Mechanical stretching of the vessel during stent retriever withdrawal resulted in 8 (24.2%) cases of hemorrhage. Nine (27.3%) instances of hemorrhage stopped after the reversal of heparin administration and introduction of blood pressure control measures. Further endovascular rescue treatment was performed in 11 patients. Intracranial inflation of the balloon for tamponade stopped 10 hemorrhages, and 1 patient underwent additional coil embolization. Fifteen (45.5%) patients died within 90 days after the procedure. Three (9.1%) patients recovered functional independence (mRS score: 0–2 points) within 90 days.Conclusion: Hemorrhage during mechanical thrombectomy is a rare but severe complication of acute ischemic stroke with high mortality and disability rates. Intracranial inflation of a balloon for tamponade can effectively stop extravasation.Clinical Impact This paper described haemorrhagic events characterised by contrast extravasation in the procedure of mechanical thrombectomy due to various causes. Although this complication is rare, patients showed a high mortality and disability rate. There are limited reports available. We found self-limiting haemorrhage had a rather benign prognosis and balloon tamponade could effectively stop the extravasation and might reduce the death rate within 90d. The methods we adopted could be applied in the clinical practice and help neuro-interventionist cope with this complication more promptly and effectively

Published
2024
Full Text
View/download PDF

34. Clapping-surpressed focal spikes in EEG may be unique for the patients with rett syndrome : a case report.

Author

Yudan Lv, Chang Liu, Mingchao Shi, Li Cui, Lv, Yudan, Liu, Chang, Shi, Mingchao, and Cui, Li

Subjects
RETT syndrome, BRUXISM, HEAD banging, GAIT disorders, ELECTROENCEPHALOGRAPHY
Abstract

Background: Rett syndrome is a severe neurodevelopmental disorder that primarily affects females. Typical features include a loss of purposeful hand skills, development of hand stereotypies, loss of spoken language, gait abnormalities, and acquired microcephaly. However, Rett syndrome hasn't been recognized by clinical doctors at the early stage. So we need to find some special characters.Case Presentation: We reported a Chinese case of Rett syndrome, exhibiting continuous centrotemporal spikes in EEG with paroxysmal suppression by hand stereotypies (hand clapping). The child, female, 4 years old, presented with a significant regression in her spoken language skills, hand stereotypies (hand clapping and hand wringing), a wider based gait with difficulties in balance, repeated abnormal behaviors (bruxism and head banging). With her clinical-history, Rett syndrome was suspected and genetic testing with mutation in MECP2 confirmed the diagnosis. Her EEG showed slow acticity in background and revealed a specific feature that continuous centrotemporal spikes can be suppressed by the repeated hand clapping. And when the hand stopped, the spikes reoccured again.Conclusions: This unique EEG signature has rarely been reported, which will expand the spectrum of EEG abnormalities in Rett syndrome. [ABSTRACT FROM AUTHOR]

Published
2016
Full Text
View/download PDF

37. The G41D mutation in the superoxide dismutase 1 gene is associated with slow motor neuron progression and mild cognitive impairment in a Chinese family with amyotrophic lateral sclerosis.

Author

Qi Niu, Yongxiang Yi, Xueping Sun, Tiannv Li, Bingfeng Zhang, Hong Chen, Xingxia Wang, Qingchen Xu, Mingchao Shi, Qingwen Jin, Niu, Qi, Yi, Yongxiang, Sun, Xueping, Li, Tiannv, Zhang, Bingfeng, Chen, Hong, Wang, Xingxia, Xu, Qingchen, Shi, Mingchao, and Jin, Qingwen

Subjects
GENETICS of amyotrophic lateral sclerosis, GENETIC mutation, SUPEROXIDE dismutase, MOTOR neuron diseases, COGNITION disorders, MAGNETIC resonance imaging of the brain
Abstract

The article discusses the case of a Chinese family with amyotrophic lateral sclerosis (ALS) associated with G41D mutation in the superoxide dismutase 1 (SOD1) gene. Topics discussed include the slow progression of the loss of motor neuron function, the occurrence of mild cognitive impairment during the later stage of ALS, and magnetic resonance imaging (MRI) which revealed significant changes in the temporal and frontal regions of the brain.

Published
2016
Full Text
View/download PDF

38. The G41D mutation in the superoxide dismutase 1 gene is associated with slow motor neuron progression and mild cognitive impairment in a Chinese family with amyotrophic lateral sclerosis.

Author

Niu Q, Yi Y, Sun X, Li T, Zhang B, Chen H, Wang X, Xu Q, Shi M, and Jin Q

Subjects
Female, Humans, Middle Aged, Pedigree, Amyotrophic Lateral Sclerosis genetics, Asian People genetics, Cognitive Dysfunction etiology, Mutation genetics, Superoxide Dismutase-1 genetics
Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results