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273 results on '"Shey, Muki"'

1. SpeChrOmics: A Biomarker Characterization Framework for Medical Hyperspectral Imaging

Author

Oladokun, Ajibola S., Malila, Bessie, Campello, Victor M., Shey, Muki, Mutsvangwa, Tinashe E. M., Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Linguraru, Marius George, editor, Dou, Qi, editor, Feragen, Aasa, editor, Giannarou, Stamatia, editor, Glocker, Ben, editor, Lekadir, Karim, editor, and Schnabel, Julia A., editor

Published
2024
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2. Comparing the immune abnormalities in MIS-C to healthy children and those with inflammatory disease reveals distinct inflammatory cytokine production and a monofunctional T cell response

Author

Butters, Claire, Benede, Ntombi, Moyo-Gwete, Thandeka, Richardson, Simone I., Rohlwink, Ursula, Shey, Muki, Ayres, Frances, Manamela, Nelia P., Makhado, Zanele, Balla, Sashkia R., Madzivhandila, Mashudu, Ngomti, Amkele, Baguma, Richard, Facey-Thomas, Heidi, Spracklen, Timothy F., Day, Jonathan, van der Ross, Hamza, Riou, Catherine, Burgers, Wendy A., Scott, Christiaan, Zühlke, Liesl, Moore, Penny L., Keeton, Roanne S., and Webb, Kate

Published
2024
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3. Editorial: Immunological Memory to Fungal Infections and Vaccine Development

Author

Nicola, André Moraes, Desai, Jigar V, Swidergall, Marc, Shey, Muki, and Dambuza, Ivy M

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Genetics, Immunology, Humans, Immunologic Memory, Lung Diseases, Fungal, Mycoses, Vaccine Development, vaccine, immunological memory, fungi, aspergillosis, paracoccidioidomycosis, histoplasmosis, mycoses, candidiasis, Medical Microbiology, Biochemistry and cell biology
Published
2022

4. Cost-effectiveness of single, high-dose, liposomal amphotericin regimen for HIV-associated cryptococcal meningitis in five countries in sub-Saharan Africa: an economic analysis of the AMBITION-cm trial

Author

Goodall, Jack, Lechiile, Kwana, Mawoko, Norah, Mbangiwa, Tshepiso, Milburn, James, Mmipi, Refilwe, Ponatshego, Ponego, Rulaganyang, Ikanyang, Seatla, Kaelo, Siamisang, Keatlaretse, Tlhako, Nametso, Tsholo, Katlego, April, Samantha, Bekiswa, Abulele, Boloko, Linda, Bookholane, Hloni, Crede, Thomas, Davids, Lee-Ann, Goliath, Rene, Hlungulu, Siphokazi, Hoffman, Regina, Kyepa, Henriette, Masina, Noma, Maughan, Deborah, Mnguni, Trevor, Moosa, Sumaiyya, Morar, Tania, Mpalali, Mkanyiseli, Naude, Jonathan, Oliphant, Ida, Singh, Achita, Sayed, Sumaya, Sebesho, Leago, Shey, Muki, Swanepoel, Loraine, Chasweka, Madalitso, Chimang'anga, Wezi, Chimphambano, Tipatseni, Gondwe, Ebbie, Mzinganjira, Henry, Kadzilimbile, Aubrey, Kateta, Steven, Kossam, Evelyn, Kukacha, Christopher, Lipenga, Bright, Ndaferankhande, John, Ndalama, Maureen, Shah, Reya, Singini, Andreas, Stott, Katherine, Zambasa, Agness, Banda, Towera, Chikaonda, Tarsizio, Chitulo, Gladys, Chiwoko, Lorren, Chome, Nelecy, Gwin, Mary, Kachitosi, Timothy, Kamanga, Beauty, Kazembe, Mussah, Kumwenda, Emily, Kumwenda, Masida, Maya, Chimwemwe, Mhango, Wilberforce, Mphande, Chimwemwe, Msumba, Lusungu, Munthali, Tapiwa, Ngoma, Doris, Nicholas, Simon, Simwinga, Lusayo, Stambuli, Anthony, Tegha, Gerald, Zambezi, Janet, Ahimbisibwe, Cynthia, Akampurira, Andrew, Alice, Anamudde, Cresswell, Fiona, Gakuru, Jane, Kagimu, Enock, Kasibante, John, Kiiza, Daniel, Kisembo, John, Kwizera, Richard, Kugonza, Florence, Laker, Eva, Luggya, Tonny, Lule, Andrew, Musubire, Abdu, Muyise, Rhona, Namujju, Carol Olivie, Ndyetukira, Jane Francis, Nsangi, Laura, Okirworth, Michael, Rhein, Joshua, Rutakingirwa, Morris K, Sadiq, Alisat, Ssebambulidde, Kenneth, Tadeo, Kiiza, Tukundane, Asmus, Atwine, Leo, Buzaare, Peter, Collins, Muganzi, Emily, Ninsima, Inyakuwa, Christine, Kariisa, Samson, Mwesigye, James, Nuwamanya, Simpson, Rodgers, Ankunda, Rukundo, Joan, Rwomushana, Irene, Ssemusu, Mike, Stead, Gavin, Boyd, Kathyrn, Gondo, Secrecy, Kufa, Prosper, Makaha, Edward, Moyo, Colombus, Mtisi, Takudzwa, Mudzinga, Shepherd, Mutata, Constantine, Mwarumba, Taddy, Zinyandu, Tawanda, Alanio, Alexandre, Dromer, Francoise, Lortholary, Olivier, Sturny-Leclere, Aude, Griffin, Philippa, Hafeez, Sophia, Loyse, Angela, van Widenfelt, Erik, Lawrence, David S, Muthoga, Charles, Meya, David B, Tugume, Lillian, Williams, Darlisha, Rajasingham, Radha, Boulware, David R, Mwandumba, Henry C, Moyo, Melanie, Dziwani, Eltas N, Maheswaran, Hendramoorthy, Kanyama, Cecilia, Hosseinipour, Mina C, Chawinga, Chimwemwe, Meintjes, Graeme, Schutz, Charlotte, Comins, Kyla, Bango, Funeka, Muzoora, Conrad, Jjunju, Samuel, Nuwagira, Edwin, Mosepele, Mosepele, Leeme, Tshepo, Ndhlovu, Chiratidzo E, Hlupeni, Admire, Shamu, Shepherd, Boyer-Chammard, Timothée, Molloy, Síle F, Youssouf, Nabila, Chen, Tao, Shiri, Tinevimbo, Jaffar, Shabbar, Harrison, Thomas S, Jarvis, Joseph N, and Niessen, Louis W

Published
2022
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5. Pharmacokinetics of antitubercular drugs in patients hospitalized with HIV-associated tuberculosis: a population modeling analysis

Author

Abdelgawad, Noha, primary, Chirehwa, Maxwell, additional, Schutz, Charlotte, additional, Barr, David, additional, Ward, Amy, additional, Janssen, Saskia, additional, Burton, Rosie, additional, Wilkinson, Robert J., additional, Shey, Muki, additional, Wiesner, Lubbe, additional, McIlleron, Helen, additional, Maartens, Gary, additional, Meintjes, Graeme, additional, and Denti, Paolo, additional

Published
2024
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8. A Functional Toll-Interacting Protein Variant Is Associated with Bacillus Calmette-Guérin–Specific Immune Responses and Tuberculosis

Author

Shah, Javeed A, Musvosvi, Munyaradzi, Shey, Muki, Horne, David J, Wells, Richard D, Peterson, Glenna J, Cox, Jeffery S, Daya, Michelle, Hoal, Eileen G, Lin, Lin, Gottardo, Raphael, Hanekom, Willem A, Scriba, Thomas J, Hatherill, Mark, and Hawn, Thomas R

Subjects
Infectious Diseases, Genetics, Tuberculosis Vaccine, Prevention, Vaccine Related, Rare Diseases, Immunization, Tuberculosis, Aetiology, 2.1 Biological and endogenous factors, Infection, Inflammatory and immune system, Good Health and Well Being, Humans, Immunity, Innate, Intracellular Signaling Peptides and Proteins, Mycobacterium bovis, Polymorphism, Single Nucleotide, Prospective Studies, bacillus Calmette-Guerin, tuberculosis, Toll interacting protein, adaptiye immunity, genetics, Toll-interacting protein, adaptive immunity, bacillus Calmette-Guérin, Medical and Health Sciences, Respiratory System
Abstract

RationaleThe molecular mechanisms that regulate tuberculosis susceptibility and bacillus Calmette-Guérin (BCG)-induced immunity are mostly unknown. However, induction of the adaptive immune response is a critical step in host control of Mycobacterium tuberculosis. Toll-interacting protein (TOLLIP) is a ubiquitin-binding protein that regulates innate immune responses, including Toll-like receptor signaling, which initiate adaptive immunity. TOLLIP variation is associated with susceptibility to tuberculosis, but the mechanism by which it regulates tuberculosis immunity is poorly understood.ObjectivesTo identify functional TOLLIP variants and evaluate the role of TOLLIP variation on innate and adaptive immune responses to mycobacteria and susceptibility to tuberculosis.MethodsWe used human cellular immunology approaches to characterize the role of a functional TOLLIP variant on monocyte mRNA expression and M. tuberculosis-induced monocyte immune functions. We also examined the association of TOLLIP variation with BCG-induced T-cell responses and susceptibility to latent tuberculosis infection.Measurements and main resultsWe identified a functional TOLLIP promoter region single-nucleotide polymorphism, rs5743854, which was associated with decreased TOLLIP mRNA expression in infant monocytes. After M. tuberculosis infection, TOLLIP-deficient monocytes demonstrated increased IL-6, increased nitrite, and decreased bacterial replication. The TOLLIP-deficiency G/G genotype was associated with decreased BCG-specific IL-2+ CD4+ T-cell frequency and proliferation. This genotype was also associated with increased susceptibility to latent tuberculosis infection.ConclusionsTOLLIP deficiency is associated with decreased BCG-specific T-cell responses and increased susceptibility to tuberculosis. We hypothesize that the heightened antibacterial monocyte responses after vaccination of TOLLIP-deficient infants are responsible for decreased BCG-specific T-cell responses. Activating TOLLIP may provide a novel adjuvant strategy for BCG vaccination.

Published
2017

11. Comparing the immune abnormalities in MIS-C to healthy children and those with inflammatory disease reveals distinct inflammatory cytokine production and a monofunctional T cell response

Author

Butters, Claire, primary, Benede, Ntombi, additional, Moyo-Gwete, Thandeka, additional, Richardson, Simone I., additional, Rohlwink, Ursula, additional, Shey, Muki, additional, Ayres, Frances, additional, Manamela, Nelia P., additional, Makhado, Zanele, additional, Balla, Sashkia R., additional, Madzivhandila, Mashudu, additional, Ngomti, Amkele, additional, Baguma, Richard, additional, Facey-Thomas, Heidi, additional, Spracklen, Timothy F., additional, Day, Jonathan, additional, van der Ross Debbie, Hamza, additional, Riou, Catherine, additional, Burgers, Wendy A., additional, Scott, Christiaan, additional, Zuhlke, Liesl, additional, Moore, Penny L., additional, Keeton, Roanne S., additional, and Webb, Kate, additional

Published
2023
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12. Myocardial extracellular volume fraction is positively associated with activated monocyte subsets among cART-treated persons living with HIV in South Africa

Author

Peterson, Tess E., primary, Shey, Muki, additional, Masina, Nomawethu, additional, Wong, Lye-Yeng, additional, Shuldiner, Scott R., additional, Wolfson, Julian, additional, Jermy, Stephen, additional, Saad, Hadil, additional, Lumbamba, Mbalabu A.J., additional, Singh, Achita, additional, Meintjes, Graeme, additional, Ntusi, Ntobeko A.B., additional, Ntsekhe, Mpiko, additional, and Baker, Jason V., additional

Published
2023
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13. The global burden of tuberculosis: results from the Global Burden of Disease Study 2015

Author

Kyu, Hmwe H, Maddison, Emilie R, Henry, Nathaniel J, Mumford, John Everett, Barber, Ryan, Shields, Chloe, Brown, Jonathan C, Nguyen, Grant, Carter, Austin, Wolock, Timothy M, Wang, Haidong, Liu, Patrick Y, Reitsma, Marissa, Ross, Jennifer M, Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbas, Kaja, Abera, Mubarek, Abera, Semaw Ferede, Abera Hareri, Habtamu, Ahmed, Muktar, Alene, Kefyalew Addis, Alvis-Guzman, Nelson, Amo-Adjei, Joshua, Andrews, Jason, Ansari, Hossein, Antonio, Carl Abelardo, Anwari, Palwasha, Asayesh, Hamid, Atey, Tesfay Mehari, Atre, Sachin, Barac, Aleksandra, Beardsley, Justin, Bedi, Neeraj, Bensenor, Isabela, Beyene, Addisu Shunu, Butt, Zahid Ahmad, Cardona, Pere-Joan, Christopher, Devasahayam, Dandona, Lalit, Dandona, Rakhi, Deribe, Kebede, Deribew, Amare, Ehrenkranz, Rebecca, El Sayed Zaki, Maysaa, Endries, Aman, Feyissa, Tesfaye R, Fischer, Florian, Gai, Ruoyan, Garcia-Basteiro, Alberto L, Gebrehiwot, Tsegaye Tewelde, Gesesew, Hailay, Getahun, Belete, Gona, Philimon, Goodridge, Amador, Gugnani, Harish, Haghparast-Bidgoli, Hassan, Hailu, Gessessew Bugssa, Hassen, Hamid Yimam, Hilawe, Esayas, Horita, Nobuyuki, Jacobsen, Kathryn H, Jonas, Jost B, Kasaeian, Amir, Kedir, Muktar Sano, Kemmer, Laura, Khader, Yousef, Khan, Ejaz, Khang, Young-Ho, Khoja, Abdullah T, Kim, Yun Jin, Koul, Parvaiz, Koyanagi, Ai, Krohn, Kristopher J, Kumar, G Anil, Kutz, Michael, Lodha, Rakesh, Magdy And El Razek, Hassan, Majdzadeh, Reza, Manyazewal, Tsegahun, Memish, Ziad, Mendoza, Walter, Mezgebe, Haftay Berhane, Mohammed, Shafiu, Ogbo, Felix Akpojene, Oh, In-Hwan, Oren, Eyal, Osgood-Zimmerman, Aaron, Pereira, David, Plass, Dietrich, Pourmalek, Farshad, Qorbani, Mostafa, Rafay, Anwar, Rahman, Mahfuzar, Rai, Rajesh Kumar, Rao, Puja C, Ray, Sarah E, Reiner, Robert, Reinig, Nickolas, Safiri, Saeid, Salomon, Joshua A, Sandar, Logan, Sartorius, Benn, Shamsizadeh, Morteza, Shey, Muki, Shifti, Desalegn Markos, Shore, Hirbo, Singh, Jasvinder, Sreeramareddy, Chandrashekhar T, Swaminathan, Soumya, Swartz, Scott J, Tadese, Fentaw, Tedla, Bemnet Amare, Tegegne, Balewgizie Sileshi, Tessema, Belay, Topor-Madry, Roman, Ukwaja, Kingsley Nnanna, Uthman, Olalekan A., Vlassov, Vasiliy, Vollset, Stein Emil, Wakayo, Tolassa, Weldegebreal, Solomon, Westerman, Ronny, Workicho, Abdulhalik, Yonemoto, Naohiro, Yoon, Seok-Jun, Yotebieng, Marcel, Naghavi, Mohsen, Hay, Simon I, Vos, Theo, and Murray, Christopher JL

Published
2018
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15. Mycobacterial-specific secretion of cytokines and chemokines in healthcare workers with apparent resistance to infection with Mycobacterium tuberculosis

Author

Shey, Muki Shehu, primary, Balfour, Avuyonke, additional, Masina, Nomawethu, additional, Bekiswa, Abulele, additional, Schutz, Charlotte, additional, Goliath, Rene, additional, Dielle, Rachel, additional, Katoto, Patrick DMC., additional, Wilkinson, Katalin Andrea, additional, Lewinsohn, David, additional, Lewinsohn, Deborah Anne, additional, and Meintjes, Graeme, additional

Published
2023
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16. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016

Author

Naghavi, Mohsen, Abajobir, Amanuel Alemu, Abbafati, Cristiana, Abbas, Kaja M, Abd-Allah, Foad, Abera, Semaw Ferede, Aboyans, Victor, Adetokunboh, Olatunji, Afshin, Ashkan, Agrawal, Anurag, Ahmadi, Alireza, Ahmed, Muktar Beshir, Aichour, Amani Nidhal, Aichour, Miloud Taki Eddine, Aichour, Ibtihel, Aiyar, Sneha, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alam, Tahiya, Alene, Kefyalew Addis, Al-Eyadhy, Ayman, Ali, Syed Danish, Alizadeh-Navaei, Reza, Alkaabi, Juma M, Alkerwi, Ala'a, Alla, François, Allebeck, Peter, Allen, Christine, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampem, Anber, Nahla, Andersen, Hjalte H, Andrei, Catalina Liliana, Androudi, Sofia, Ansari, Hossein, Antonio, Carl Abelardo T, Anwari, Palwasha, Ärnlöv, Johan, Arora, Megha, Artaman, Al, Aryal, Krishna Kumar, Asayesh, Hamid, Asgedom, Solomon W, Atey, Tesfay Mehari, Avila-Burgos, Leticia, Avokpaho, Euripide Frinel G, Awasthi, Ashish, Babalola, Tesleem Kayode, Bacha, Umar, Balakrishnan, Kalpana, Barac, Aleksandra, Barboza, Miguel A, Barker-Collo, Suzanne L, Barquera, Simon, Barregard, Lars, Barrero, Lope H, Baune, Bernhard T, Bedi, Neeraj, Beghi, Ettore, Béjot, Yannick, Bekele, Bayu Begashaw, Bell, Michelle L, Bennett, James R, Bensenor, Isabela M, Berhane, Adugnaw, Bernabé, Eduardo, Betsu, Balem Demtsu, Beuran, Mircea, Bhatt, Samir, Biadgilign, Sibhatu, Bienhoff, Kelly, Bikbov, Boris, Bisanzio, Donal, Bourne, Rupert R A, Breitborde, Nicholas J K, Bulto, Lemma Negesa Bulto, Bumgarner, Blair R, Butt, Zahid A, Cahuana-Hurtado, Lucero, Cameron, Ewan, Campuzano, Julio Cesar, Car, Josip, Cárdenas, Rosario, Carrero, Juan Jesus, Carter, Austin, Casey, Daniel C, Castañeda-Orjuela, Carlos A, Catalá-López, Ferrán, Charlson, Fiona J, Chibueze, Chioma Ezinne, Chimed-Ochir, Odgerel, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal A, Christopher, Devasahayam Jesudas, Ciobanu, Liliana G, Cirillo, Massimo, Cohen, Aaron J, Colombara, Danny, Cooper, Cyrus, Cowie, Benjamin C, Criqui, Michael H, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I, das Neves, José, Davitoiu, Dragos V, Davletov, Kairat, de Courten, Barbora, Defo, Barthelemy Kuate, Degenhardt, Louisa, Deiparine, Selina, Deribe, Kebede, Deribew, Amare, Dey, Subhojit, Dicker, Daniel, Ding, Eric L, Djalalinia, Shirin, Do, Huyen Phuc, Doku, David Teye, Douwes-Schultz, Dirk, Driscoll, Tim R, Dubey, Manisha, Duncan, Bruce Bartholow, Echko, Michelle, El-Khatib, Ziad Ziad, Ellingsen, Christian Lycke, Enayati, Ahmadali, Ermakov, Sergey Petrovich, Erskine, Holly E, Eskandarieh, Sharareh, Esteghamati, Alireza, Estep, Kara, Farinha, Carla Sofia e Sa, Faro, André, Farzadfar, Farshad, Feigin, Valery L, Fereshtehnejad, Seyed-Mohammad, Fernandes, João C, Ferrari, Alize J, Feyissa, Tesfaye Regassa, Filip, Irina, Finegold, Samuel, Fischer, Florian, Fitzmaurice, Christina, Flaxman, Abraham D, Foigt, Nataliya, Frank, Tahvi, Fraser, Maya, Fullman, Nancy, Fürst, Thomas, Furtado, Joao M, Gakidou, Emmanuela, Garcia-Basteiro, Alberto L, Gebre, Teshome, Gebregergs, Gebremedhin Berhe, Gebrehiwot, Tsegaye Tewelde, Gebremichael, Delelegn Yilma, Geleijnse, Johanna M, Genova-Maleras, Ricard, Gesesew, Hailay Abrha, Gething, Peter W, Gillum, Richard F, Giref, Ababi Zergaw, Giroud, Maurice, Giussani, Giorgia, Godwin, William W, Gold, Audra L, Goldberg, Ellen M, Gona, Philimon N, Gopalani, Sameer Vali, Gouda, Hebe N, Goulart, Alessandra Carvalho, Griswold, Max, Gupta, Rajeev, Gupta, Tanush, Gupta, Vipin, Gupta, Parkash C, Haagsma, Juanita A, Hafezi-Nejad, Nima, Hailu, Alemayehu Desalegne, Hailu, Gessessew Bugssa, Hamadeh, Randah Ribhi, Hambisa, Mitiku Teshome, Hamidi, Samer, Hammami, Mouhanad, Hancock, Jamie, Handal, Alexis J, Hankey, Graeme J, Hao, Yuantao, Harb, Hilda L, Hareri, Habtamu Abera, Hassanvand, Mohammad Sadegh, Havmoeller, Rasmus, Hay, Simon I, He, Fei, Hedayati, Mohammad T, Henry, Nathaniel J, Heredia-Pi, Ileana Beatriz, Herteliu, Claudiu, Hoek, Hans W, Horino, Masako, Horita, Nobuyuki, Hosgood, H Dean, Hostiuc, Sorin, Hotez, Peter J, Hoy, Damian G, Huynh, Chantal, Iburg, Kim Moesgaard, Ikeda, Chad, Ileanu, Bogdan Vasile, Irenso, Asnake Ararsa, Irvine, Caleb Mackay Salpeter, Islam, Sheikh Mohammed Shariful, Jacobsen, Kathryn H, Jahanmehr, Nader, Jakovljevic, Mihajlo B, Javanbakht, Mehdi, Jayaraman, Sudha P, Jeemon, Panniyammakal, Jha, Vivekanand, John, Denny, Johnson, Catherine O, Johnson, Sarah Charlotte, Jonas, Jost B, Jürisson, Mikk, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kamal, Ritul, Karch, André, Karimi, Seyed M, Karimkhani, Chante, Kasaeian, Amir, Kassaw, Nigussie Assefa, Kassebaum, Nicholas J, Katikireddi, Srinivasa Vittal, Kawakami, Norito, Keiyoro, Peter Njenga, Kemmer, Laura, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khan, Ejaz Ahmad, Khang, Young-Ho, Khoja, Abdullah Tawfih Abdullah, Khosravi, Mohammad Hossein, Khosravi, Ardeshir, Khubchandani, Jagdish, Kiadaliri, Aliasghar Ahmad, Kieling, Christian, Kievlan, Daniel, Kim, Yun Jin, Kim, Daniel, Kimokoti, Ruth W, Kinfu, Yohannes, Kissoon, Niranjan, Kivimaki, Mika, Knudsen, Ann Kristin, Kopec, Jacek A, Kosen, Soewarta, Koul, Parvaiz A, Koyanagi, Ai, Kulikoff, Xie Rachel, Kumar, G Anil, Kumar, Pushpendra, Kutz, Michael, Kyu, Hmwe H, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lambert, Tea Lallukka Nkurunziza, Lan, Qing, Lansingh, Van C, Larsson, Anders, Lee, Paul H, Leigh, James, Leung, Janni, Levi, Miriam, Li, Yongmei, Li Kappe, Darya, Liang, Xiaofeng, Liben, Misgan Legesse, Lim, Stephen S, Liu, Patrick Y, Liu, Angela, Liu, Yang, Lodha, Rakesh, Logroscino, Giancarlo, Lorkowski, Stefan, Lotufo, Paulo A, Lozano, Rafael, Lucas, Timothy C D, Ma, Stefan, Macarayan, Erlyn Rachelle King, Maddison, Emilie R, Magdy Abd El Razek, Mohammed, Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malhotra, Rajesh, Malta, Deborah Carvalho, Manguerra, Helena, Manyazewal, Tsegahun, Mapoma, Chabila C, Marczak, Laurie B, Markos, Desalegn, Martinez-Raga, Jose, Martins-Melo, Francisco Rogerlândio, Martopullo, Ira, McAlinden, Colm, McGaughey, Madeline, McGrath, John J, Mehata, Suresh, Meier, Toni, Meles, Kidanu Gebremariam, Memiah, Peter, Memish, Ziad A, Mengesha, Melkamu Merid, Mengistu, Desalegn Tadese, Menota, Bereket Gebremichael, Mensah, George A, Meretoja, Tuomo J, Meretoja, Atte, Millear, Anoushka, Miller, Ted R, Minnig, Shawn, Mirarefin, Mojde, Mirrakhimov, Erkin M, Misganaw, Awoke, Mishra, Shiva Raj, Mohamed, Ibrahim Abdelmageem, Mohammad, Karzan Abdulmuhsin, Mohammadi, Alireza, Mohammed, Shafiu, Mokdad, Ali H, Mola, Glen Liddell D, Mollenkopf, Sarah K, Molokhia, Mariam, Monasta, Lorenzo, Montañez, Julio C, Montico, Marcella, Mooney, Meghan D, Moradi-Lakeh, Maziar, Moraga, Paula, Morawska, Lidia, Morozoff, Chloe, Morrison, Shane D, Mountjoy-Venning, Cliff, Mruts, Kalayu Birhane, Muller, Kate, Murthy, Gudlavalleti Venkata Satyanarayana, Musa, Kamarul Imran, Nachega, Jean B, Naheed, Aliya, Naldi, Luigi, Nangia, Vinay, Nascimento, Bruno Ramos, Nasher, Jamal T, Natarajan, Gopalakrishnan, Negoi, Ionut, Ngunjiri, Josephine Wanjiku, Nguyen, Cuong Tat, Nguyen, Quyen Le, Nguyen, Trang Huyen, Nguyen, Grant, Nguyen, Minh, Nichols, Emma, Ningrum, Dina Nur Anggraini, Nong, Vuong Minh, Noubiap, Jean Jacques N, Ogbo, Felix Akpojene, Oh, In-Hwan, Okoro, Anselm, Olagunju, Andrew Toyin, Olsen, Helen E, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ong, Kanyin, Opio, John Nelson, Oren, Eyal, Ortiz, Alberto, Osman, Majdi, Ota, Erika, PA, Mahesh, Pacella, Rosana E, Pakhale, Smita, Pana, Adrian, Panda, Basant Kumar, Panda-Jonas, Songhomitra, Papachristou, Christina, Park, Eun-Kee, Patten, Scott B, Patton, George C, Paudel, Deepak, Paulson, Katherine, Pereira, David M, Perez-Ruiz, Fernando, Perico, Norberto, Pervaiz, Aslam, Petzold, Max, Phillips, Michael Robert, Pigott, David M, Pinho, Christine, Plass, Dietrich, Pletcher, Martin A, Polinder, Suzanne, Postma, Maarten J, Pourmalek, Farshad, Purcell, Caroline, Qorbani, Mostafa, Quintanilla, Beatriz Paulina Ayala, Radfar, Amir, Rafay, Anwar, Rahimi-Movaghar, Vafa, Rahman, Mohammad Hifz Ur, Rahman, Mahfuzar, Rai, Rajesh Kumar, Ranabhat, Chhabi Lal, Rankin, Zane, Rao, Puja C, Rath, Goura Kishor, Rawaf, Salman, Ray, Sarah E, Rehm, Jürgen, Reiner, Robert C, Reitsma, Marissa B, Remuzzi, Giuseppe, Rezaei, Satar, Rezai, Mohammad Sadegh, Rokni, Mohammad Bagher, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A, Rothenbacher, Dietrich, Ruhago, George Mugambage, SA, Rizwan, Saadat, Soheil, Sachdev, Perminder S, Sadat, Nafis, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahathevan, Ramesh, Salama, Joseph, Salamati, Payman, Salomon, Joshua A, Samy, Abdallah M, Sanabria, Juan Ramon, Sanchez-Niño, Maria Dolores, Santomauro, Damian, Santos, Itamar S, Santric Milicevic, Milena M, Sartorius, Benn, Satpathy, Maheswar, Schmidt, Maria Inês, Schneider, Ione J C, Schulhofer-Wohl, Sam, Schutte, Aletta E, Schwebel, David C, Schwendicke, Falk, Sepanlou, Sadaf G, Servan-Mori, Edson E, Shackelford, Katya Anne, Shahraz, Saeid, Shaikh, Masood Ali, Shamsipour, Mansour, Shamsizadeh, Morteza, Sharma, Jayendra, Sharma, Rajesh, She, Jun, Sheikhbahaei, Sara, Shey, Muki, Shi, Peilin, Shields, Chloe, Shigematsu, Mika, Shiri, Rahman, Shirude, Shreya, Shiue, Ivy, Shoman, Haitham, Shrime, Mark G, Sigfusdottir, Inga Dora, Silpakit, Naris, Silva, João Pedro, Singh, Jasvinder A, Singh, Abhishek, Skiadaresi, Eirini, Sligar, Amber, Smith, David L, Smith, Alison, Smith, Mari, Sobaih, Badr H A, Soneji, Samir, Sorensen, Reed J D, Soriano, Joan B, Sreeramareddy, Chandrashekhar T, Srinivasan, Vinay, Stanaway, Jeffrey D, Stathopoulou, Vasiliki, Steel, Nicholas, Stein, Dan J, Steiner, Caitlyn, Steinke, Sabine, Stokes, Mark Andrew, Strong, Mark, Strub, Bryan, Subart, Michelle, Sufiyan, Muawiyyah Babale, Sunguya, Bruno F, Sur, Patrick J, Swaminathan, Soumya, Sykes, Bryan L, Tabarés-Seisdedos, Rafael, Tadakamadla, Santosh Kumar, Takahashi, Ken, Takala, Jukka S, Talongwa, Roberto Tchio, Tarawneh, Mohammed Rasoul, Tavakkoli, Mohammad, Taveira, Nuno, Tegegne, Teketo Kassaw, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Terkawi, Abdullah Sulieman, Thakur, J S, Thamsuwan, Ornwipa, Thankappan, Kavumpurathu Raman, Thomas, Katie E, Thompson, Alex H, Thomson, Alan J, Thrift, Amanda G, Tobe-Gai, Ruoyan, Topor-Madry, Roman, Torre, Anna, Tortajada, Miguel, Towbin, Jeffrey Allen, Tran, Bach Xuan, Troeger, Christopher, Truelsen, Thomas, Tsoi, Derrick, Tuzcu, Emin Murat, Tyrovolas, Stefanos, Ukwaja, Kingsley N, Undurraga, Eduardo A, Updike, Rachel, Uthman, Olalekan A, Uzochukwu, Benjamin S Chudi, van Boven, Job F M, Vasankari, Tommi, Venketasubramanian, Narayanaswamy, Violante, Francesco S, Vlassov, Vasiliy Victorovich, Vollset, Stein Emil, Vos, Theo, Wakayo, Tolassa, Wallin, Mitchell T, Wang, Yuan-Pang, Weiderpass, Elisabete, Weintraub, Robert G, Weiss, Daniel J, Werdecker, Andrea, Westerman, Ronny, Whetter, Brian, Whiteford, Harvey A, Wijeratne, Tissa, Wiysonge, Charles Shey, Woldeyes, Belete Getahun, Wolfe, Charles D A, Woodbrook, Rachel, Workicho, Abdulhalik, Xavier, Denis, Xiao, Qingyang, Xu, Gelin, Yaghoubi, Mohsen, Yakob, Bereket, Yano, Yuichiro, Yaseri, Mehdi, Yimam, Hassen Hamid, Yonemoto, Naohiro, Yoon, Seok-Jun, Yotebieng, Marcel, Younis, Mustafa Z, Zaidi, Zoubida, Zaki, Maysaa El Sayed, Zegeye, Elias Asfaw, Zenebe, Zerihun Menlkalew, Zerfu, Taddese Alemu, Zhang, Anthony Lin, Zhang, Xueying, Zipkin, Ben, Zodpey, Sanjay, Lopez, Alan D, and Murray, Christopher J L

Published
2017
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17. The SIGLEC14 null allele is associated with Mycobacterium tuberculosis- and BCG-induced clinical and immunologic outcomes

Author

Graustein, Andrew D., Horne, David J., Fong, Jerry J., Schwarz, Flavio, Mefford, Heather C., Peterson, Glenna J., Wells, Richard D., Musvosvi, Munyaradzi, Shey, Muki, Hanekom, Willem A., Hatherill, Mark, Scriba, Thomas J., Thuong, Nguyen Thuy Thuong, Mai, Nguyen Thi Hoang, Caws, Maxine, Bang, Nguyen Duc, Dunstan, Sarah J., Thwaites, Guy E., Varki, Ajit, Angata, Takashi, and Hawn, Thomas R.

Published
2017
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19. Measuring the health-related Sustainable Development Goals in 188 countries: a baseline analysis from the Global Burden of Disease Study 2015

Author

Lim, Stephen S, Allen, Kate, Bhutta, Zulfiqar A, Dandona, Lalit, Forouzanfar, Mohammad H, Fullman, Nancy, Gething, Peter W, Goldberg, Ellen M, Hay, Simon I, Holmberg, Mollie, Kinfu, Yohannes, Kutz, Michael J, Larson, Heidi J, Liang, Xiaofeng, Lopez, Alan D, Lozano, Rafael, McNellan, Claire R, Mokdad, Ali H, Mooney, Meghan D, Naghavi, Mohsen, Olsen, Helen E, Pigott, David M, Salomon, Joshua A, Vos, Theo, Wang, Haidong, Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M, Abd-Allah, Foad, Abdulle, Abdishakur M, Abraham, Biju, Abubakar, Ibrahim, Abu-Raddad, Laith J, Abu-Rmeileh, Niveen M E, Abyu, Gebre Yitayih, Achoki, Tom, Adebiyi, Akindele Olupelumi, Adedeji, Isaac Akinkunmi, Afanvi, Kossivi Agbelenko, Afshin, Ashkan, Agarwal, Arnav, Agrawal, Anurag, Kiadaliri, Aliasghar Ahmad, Ahmadieh, Hamid, Ahmed, Kedir Yimam, Akanda, Ali Shafqat, Akinyemi, Rufus Olusola, Akinyemiju, Tomi F, Akseer, Nadia, Al-Aly, Ziyad, Alam, Khurshid, Alam, Uzma, Alasfoor, Deena, AlBuhairan, Fadia S, Aldhahri, Saleh Fahed, Aldridge, Robert William, Alemu, Zewdie Aderaw, Ali, Raghib, Alkerwi, Ala'a, Alkhateeb, Mohammad AB, Alla, François, Allebeck, Peter, Allen, Christine, Al-Raddadi, Rajaa, Alsharif, Ubai, Altirkawi, Khalid A, Martin, Elena Alvarez, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amberbir, Alemayehu, Amegah, Adeladza Kofi, Amini, Heresh, Ammar, Walid, Amrock, Stephen Marc, Andersen, Hjalte H, Anderson, Benjamin O, Anderson, Gregory M, Antonio, Carl Abelardo T, Anwari, Palwasha, Ärnlöv, Johan, Artaman, Al, Asayesh, Hamid, Asghar, Rana Jawad, Atique, Suleman, Avokpaho, Euripide Frinel G Arthur, Awasthi, Ashish, Quintanilla, Beatriz Paulina Ayala, Azzopardi, Peter, Bacha, Umar, Badawi, Alaa, Balakrishnan, Kalpana, Banerjee, Amitava, Barac, Aleksandra, Barber, Ryan, Barker-Collo, Suzanne L, Bärnighausen, Till, Barrero, Lope H, Barrientos-Gutierrez, Tonatiuh, Basu, Sanjay, Bayou, Tigist Assefa, Bazargan-Hejazi, Shahrzad, Beardsley, Justin, Bedi, Neeraj, Beghi, Ettore, Béjot, Yannick, Bell, Michelle L, Bello, Aminu K, Bennett, Derrick A, Bensenor, Isabela M, Benzian, Habib, Berhane, Adugnaw, Bernabé, Eduardo, Bernal, Oscar Alberto, Betsu, Balem Demtsu, Beyene, Addisu Shunu, Bhala, Neeraj, Bhatt, Samir, Biadgilign, Sibhatu, Bienhoff, Kelly A, Bikbov, Boris, Binagwaho, Agnes, Bisanzio, Donal, Bjertness, Espen, Blore, Jed, Bourne, Rupert R A, Brainin, Michael, Brauer, Michael, Brazinova, Alexandra, Breitborde, Nicholas J K, Broday, David M, Brugha, Traolach S, Buchbinder, Rachelle, Butt, Zahid A, Cahill, Leah E, Campos-Nonato, Ismael Ricardo, Campuzano, Julio Cesar, Carabin, Hélène, Cárdenas, Rosario, Carrero, Juan Jesus, Carter, Austin, Casey, Daniel, Caso, Valeria, Castañeda-Orjuela, Carlos A, Rivas, Jacqueline Castillo, Catalá-López, Ferrán, Cavalleri, Fiorella, Cecílio, Pedro, Chang, Hsing-Yi, Chang, Jung-Chen, Charlson, Fiona J, Che, Xuan, Chen, Alan Zian, Chiang, Peggy Pei-Chia, Chibalabala, Mirriam, Chisumpa, Vesper Hichilombwe, Choi, Jee-Young Jasmine, Chowdhury, Rajiv, Christensen, Hanne, Ciobanu, Liliana G, Cirillo, Massimo, Coates, Matthew M, Coggeshall, Megan, Cohen, Aaron J, Cooke, Graham S, Cooper, Cyrus, Cooper, Leslie Trumbull, Cowie, Benjamin C, Crump, John A, Damtew, Solomon Abrha, Dandona, Rakhi, Dargan, Paul I, Neves, José das, Davis, Adrian C, Davletov, Kairat, de Castro, E Filipa, De Leo, Diego, Degenhardt, Louisa, Del Gobbo, Liana C, Deribe, Kebede, Derrett, Sarah, Des Jarlais, Don C, Deshpande, Aniruddha, deVeber, Gabrielle A, Dey, Subhojit, Dharmaratne, Samath D, Dhillon, Preet K, Ding, Eric L, Dorsey, E Ray, Doyle, Kerrie E, Driscoll, Tim R, Duan, Leilei, Dubey, Manisha, Duncan, Bruce Bartholow, Ebrahimi, Hedyeh, Endries, Aman Yesuf, Ermakov, Sergey Petrovich, Erskine, Holly E, Eshrati, Babak, Esteghamati, Alireza, Fahimi, Saman, Farid, Talha A, Farinha, Carla Sofia e Sa, Faro, André, Farvid, Maryam S, Farzadfar, Farshad, Feigin, Valery L, Felicio, Manuela Mendonca, Fereshtehnejad, Seyed-Mohammad, Fernandes, Jefferson G, Fernandes, Joao C, Ferrari, Alize J, Fischer, Florian, Fitchett, Joseph R A, Fitzmaurice, Christina, Foigt, Nataliya, Foreman, Kyle, Fowkes, F Gerry R, Franca, Elisabeth Barboza, Franklin, Richard C, Fraser, Maya, Friedman, Joseph, Frostad, Joseph, Fürst, Thomas, Gabbe, Belinda, Garcia-Basteiro, Alberto L, Gebre, Teshome, Gebrehiwot, Tsegaye Tewelde, Gebremedhin, Amanuel Tesfay, Gebru, Alemseged Aregay, Gessner, Bradford D, Gillum, Richard F, Ginawi, Ibrahim Abdelmageem Mohamed, Giref, Ababi Zergaw, Giroud, Maurice, Gishu, Melkamu Dedefo, Giussani, Giorgia, Godwin, William, Gona, Philimon, Goodridge, Amador, Gopalani, Sameer Vali, Gotay, Carolyn C, Goto, Atsushi, Gouda, Hebe N, Graetz, Nicholas, Greenwell, Karen Fern, Griswold, Max, Gugnani, Harish, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Gupta, Vipin, Gutiérrez, Reyna A, Gyawali, Bishal, Haagsma, Juanita A, Haakenstad, Annie, Hafezi-Nejad, Nima, Haile, Demewoz, Hailu, Gessessew Bugssa, Halasa, Yara A, Hamadeh, Randah Ribhi, Hamidi, Samer, Hammami, Mouhanad, Hankey, Graeme J, Harb, Hilda L, Haro, Josep Maria, Hassanvand, Mohammad Sadegh, Havmoeller, Rasmus, Heredia-Pi, Ileana Beatriz, Hoek, Hans W, Horino, Masako, Horita, Nobuyuki, Hosgood, H Dean, Hoy, Damian G, Htet, Aung Soe, Hu, Guoqing, Huang, Hsiang, Iburg, Kim Moesgaard, Idrisov, Bulat T, Inoue, Manami, Islami, Farhad, Jacobs, Troy A, Jacobsen, Kathryn H, Jahanmehr, Nader, Jakovljevic, Mihajlo B, James, Peter, Jansen, Henrica A F M, Javanbakht, Mehdi, Jayaraman, Sudha P, Jayatilleke, Achala Upendra, Jee, Sun Ha, Jeemon, Panniyammakal, Jha, Vivekanand, Jiang, Ying, Jibat, Tariku, Jin, Ye, Jonas, Jost B, Kabir, Zubair, Kalkonde, Yogeshwar, Kamal, Ritul, Kan, Haidong, Kandel, Amit, Karch, André, Karema, Corine Kakizi, Karimkhani, Chante, Karunapema, Palitha, Kasaeian, Amir, Kassebaum, Nicholas J, Kaul, Anil, Kawakami, Norito, Kayibanda, Jeanne Françoise, Keiyoro, Peter Njenga, Kemmer, Laura, Kemp, Andrew Haddon, Kengne, Andre Pascal, Keren, Andre, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khan, Abdur Rahman, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khang, Young-Ho, Khoja, Tawfik Ahmed Muthafer, Khosravi, Ardeshir, Khubchandani, Jagdish, Kieling, Christian, Kim, Cho-il, Kim, Daniel, Kim, Sungroul, Kim, Yun Jin, Kimokoti, Ruth W, Kissoon, Niranjan, Kivipelto, Miia, Knibbs, Luke D, Kokubo, Yoshihiro, Kolte, Dhaval, Kosen, Soewarta, Kotsakis, Georgios A, Koul, Parvaiz A, Koyanagi, Ai, Kravchenko, Michael, Krueger, Hans, Defo, Barthelemy Kuate, Kuchenbecker, Ricardo S, Kuipers, Ernst J, Kulikoff, Xie Rachel, Kulkarni, Veena S, Kumar, G Anil, Kwan, Gene F, Kyu, Hmwe H, Lal, Aparna, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lam, Hilton, Lan, Qing, Langan, Sinead M, Larsson, Anders, Laryea, Dennis Odai, Latif, Asma Abdul, Leasher, Janet L, Leigh, James, Leinsalu, Mall, Leung, Janni, Leung, Ricky, Levi, Miriam, Li, Yichong, Li, Yongmei, Lind, Margaret, Linn, Shai, Lipshultz, Steven E, Liu, Patrick Y, Liu, Shiwei, Liu, Yang, Lloyd, Belinda K, Lo, Loon-Tzian, Logroscino, Giancarlo, Lotufo, Paulo A, Lucas, Robyn M, Lunevicius, Raimundas, El Razek, Mohammed Magdy Abd, Magis-Rodriguez, Carlos, Mahdavi, Mahdi, Majdan, Marek, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah Carvalho, Mapoma, Chabila C, Margolis, David Joel, Martin, Randall V, Martinez-Raga, Jose, Masiye, Felix, Mason-Jones, Amanda J, Massano, João, Matzopoulos, Richard, Mayosi, Bongani M, McGrath, John J, McKee, Martin, Meaney, Peter A, Mehari, Alem, Mekonnen, Alemayehu B, Melaku, Yohannes Adama, Memiah, Peter, Memish, Ziad A, Mendoza, Walter, Mensink, Gert B M, Meretoja, Atte, Meretoja, Tuomo J, Mesfin, Yonatan Moges, Mhimbira, Francis Apolinary, Micha, Renata, Miller, Ted R, Mills, Edward J, Mirarefin, Mojde, Misganaw, Awoke, Mitchell, Philip B, Mock, Charles N, Mohammadi, Alireza, Mohammed, Shafiu, Monasta, Lorenzo, de la Cruz Monis, Jonathan, Hernandez, Julio Cesar Montañez, Montico, Marcella, Moradi-Lakeh, Maziar, Morawska, Lidia, Mori, Rintaro, Mueller, Ulrich O, Murdoch, Michele E, Murimira, Brighton, Murray, Joseph, Murthy, Gudlavalleti Venkata Satyanarayana, Murthy, Srinivas, Musa, Kamarul Imran, Nachega, Jean B, Nagel, Gabriele, Naidoo, Kovin S, Naldi, Luigi, Nangia, Vinay, Neal, Bruce, Nejjari, Chakib, Newton, Charles R, Newton, John N, Ngalesoni, Frida Namnyak, Nguhiu, Peter, Nguyen, Grant, Le Nguyen, Quyen, Nisar, Muhammad Imran, Pete, Patrick Martial Nkamedjie, Nolte, Sandra, Nomura, Marika, Norheim, Ole F, Norrving, Bo, Obermeyer, Carla Makhlouf, Ogbo, Felix Akpojene, Oh, In-Hwan, Oladimeji, Olanrewaju, Olivares, Pedro R, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Opio, John Nelson, Oren, Eyal, Ortiz, Alberto, Osborne, Richard H, Ota, Erika, Owolabi, Mayowa O, PA, Mahesh, Park, Eun-Kee, Park, Hye-Youn, Parry, Charles D, Parsaeian, Mahboubeh, Patel, Tejas, Patel, Vikram, Caicedo, Angel J Paternina, Patil, Snehal T, Patten, Scott B, Patton, George C, Paudel, Deepak, Pedro, João Mário, Pereira, David M, Perico, Norberto, Pesudovs, Konrad, Petzold, Max, Phillips, Michael Robert, Piel, Frédéric B, Pillay, Julian David, Pinho, Christine, Pishgar, Farhad, Polinder, Suzanne, Poulton, Richie G, Pourmalek, Farshad, Qorbani, Mostafa, Rabiee, Rynaz H S, Radfar, Amir, Rahimi-Movaghar, Vafa, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahman, Sajjad Ur, Rai, Rajesh Kumar, Rajsic, Sasa, Raju, Murugesan, Ram, Usha, Rana, Saleem M, Ranabhat, Chhabi Lal, Ranganathan, Kavitha, Rao, Puja C, Refaat, Amany H, Reitsma, Marissa B, Remuzzi, Giuseppe, Resnikoff, Serge, Ribeiro, Antonio L, Blancas, Maria Jesus Rios, Roba, Hirbo Shore, Roberts, Bayard, Rodriguez, Alina, Rojas-Rueda, David, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A, Rothenbacher, Dietrich, Roy, Ambuj, Roy, Nobhojit, Sackey, Ben Benasco, Sagar, Rajesh, Saleh, Muhammad Muhammad, Sanabria, Juan R, Santos, João Vasco, Santomauro, Damian F, Santos, Itamar S, Sarmiento-Suarez, Rodrigo, Sartorius, Benn, Satpathy, Maheswar, Savic, Miloje, Sawhney, Monika, Sawyer, Susan M, Schmidhuber, Josef, Schmidt, Maria Inês, Schneider, Ione J C, Schutte, Aletta E, Schwebel, David C, Seedat, Soraya, Sepanlou, Sadaf G, Servan-Mori, Edson E, Shackelford, Katya, Shaheen, Amira, Shaikh, Masood Ali, Levy, Teresa Shamah, Sharma, Rajesh, She, Jun, Sheikhbahaei, Sara, Shen, Jiabin, Sheth, Kevin N, Shey, Muki, Shi, Peilin, Shibuya, Kenji, Shigematsu, Mika, Shin, Min-Jeong, Shiri, Rahman, Shishani, Kawkab, Shiue, Ivy, Sigfusdottir, Inga Dora, Silpakit, Naris, Silva, Diego Augusto Santos, Silverberg, Jonathan I, Simard, Edgar P, Sindi, Shireen, Singh, Abhishek, Singh, Gitanjali M, Singh, Jasvinder A, Singh, Om Prakash, Singh, Prashant Kumar, Skirbekk, Vegard, Sligar, Amber, Soneji, Samir, Søreide, Kjetil, Sorensen, Reed J D, Soriano, Joan B, Soshnikov, Sergey, Sposato, Luciano A, Sreeramareddy, Chandrashekhar T, Stahl, Hans-Christian, Stanaway, Jeffrey D, Stathopoulou, Vasiliki, Steckling, Nadine, Steel, Nicholas, Stein, Dan J, Steiner, Caitlyn, Stöckl, Heidi, Stranges, Saverio, Strong, Mark, Sun, Jiandong, Sunguya, Bruno F, Sur, Patrick, Swaminathan, Soumya, Sykes, Bryan L, Szoeke, Cassandra E I, Tabarés-Seisdedos, Rafael, Tabb, Karen M, Talongwa, Roberto Tchio, Tarawneh, Mohammed Rasoul, Tavakkoli, Mohammad, Taye, Bineyam, Taylor, Hugh R, Tedla, Bemnet Amare, Tefera, Worku, Tegegne, Teketo Kassaw, Tekle, Dejen Yemane, Shifa, Girma Temam, Terkawi, Abdullah Sulieman, Tessema, Gizachew Assefa, Thakur, J S, Thomson, Alan J, Thorne-Lyman, Andrew L, Thrift, Amanda G, Thurston, George D, Tillmann, Taavi, Tobe-Gai, Ruoyan, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Fotis, Tran, Bach Xuan, Truelsen, Thomas, Dimbuene, Zacharie Tsala, Tura, Abera Kenay, Tuzcu, Emin Murat, Tyrovolas, Stefanos, Ukwaja, Kingsley Nnanna, Undurraga, Eduardo A, Uneke, Chigozie Jesse, Uthman, Olalekan A, van Donkelaar, Aaron, Varakin, Yuri Y, Vasankari, Tommi, Vasconcelos, Ana Maria Nogales, Veerman, J Lennert, Venketasubramanian, Narayanaswamy, Verma, Raj Kumar, Violante, Francesco S, Vlassov, Vasiliy Victorovich, Volkow, Patricia, Vollset, Stein Emil, Wagner, Gregory R, Wallin, Mitchell T, Wang, Linhong, Wanga, Valentine, Watkins, David A, Weichenthal, Scott, Weiderpass, Elisabete, Weintraub, Robert G, Weiss, Daniel J, Werdecker, Andrea, Westerman, Ronny, Whiteford, Harvey A, Wilkinson, James D, Wiysonge, Charles Shey, Wolfe, Charles D A, Wolfe, Ingrid, Won, Sungho, Woolf, Anthony D, Workie, Shimelash Bitew, Wubshet, Mamo, Xu, Gelin, Yadav, Ajit Kumar, Yakob, Bereket, Yalew, Ayalnesh Zemene, Yan, Lijing L, Yano, Yuichiro, Yaseri, Mehdi, Ye, Pengpeng, Yip, Paul, Yonemoto, Naohiro, Yoon, Seok-Jun, Younis, Mustafa Z, Yu, Chuanhua, Zaidi, Zoubida, El Sayed Zaki, Maysaa, Zambrana-Torrelio, Carlos, Zapata, Tomas, Zegeye, Elias Asfaw, Zhao, Yi, Zhou, Maigeng, Zodpey, Sanjay, Zonies, David, and Murray, Christopher J L

Published
2016
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20. Myocardial Extracellular Volume Fraction is Positively Associated with Activated Monocyte Subsets Among cART-Treated Persons Living with HIV in South Africa

Author

Peterson, Tess Eirene, primary, Shey, Muki, additional, Masina, Nomawethu, additional, Wong, Lye-Yeng, additional, Shuldiner, Scott R., additional, Wolfson, Julian, additional, Jermy, Stephen, additional, Saad, Hadil, additional, Lumbamba, Mbalabu J., additional, Singh, Achita, additional, Meintjes, Graeme, additional, Ntusi, Ntobeko, additional, Ntsekhe, Mpiko, additional, and Baker, Jason V., additional

Published
2023
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22. Cost-effectiveness of single, high-dose, liposomal amphotericin regimen for HIV-associated cryptococcal meningitis in five countries in sub-Saharan Africa: an economic analysis of the AMBITION-cm trial

Author

Lawrence, David S, primary, Muthoga, Charles, additional, Meya, David B, additional, Tugume, Lillian, additional, Williams, Darlisha, additional, Rajasingham, Radha, additional, Boulware, David R, additional, Mwandumba, Henry C, additional, Moyo, Melanie, additional, Dziwani, Eltas N, additional, Maheswaran, Hendramoorthy, additional, Kanyama, Cecilia, additional, Hosseinipour, Mina C, additional, Chawinga, Chimwemwe, additional, Meintjes, Graeme, additional, Schutz, Charlotte, additional, Comins, Kyla, additional, Bango, Funeka, additional, Muzoora, Conrad, additional, Jjunju, Samuel, additional, Nuwagira, Edwin, additional, Mosepele, Mosepele, additional, Leeme, Tshepo, additional, Ndhlovu, Chiratidzo E, additional, Hlupeni, Admire, additional, Shamu, Shepherd, additional, Boyer-Chammard, Timothée, additional, Molloy, Síle F, additional, Youssouf, Nabila, additional, Chen, Tao, additional, Shiri, Tinevimbo, additional, Jaffar, Shabbar, additional, Harrison, Thomas S, additional, Jarvis, Joseph N, additional, Niessen, Louis W, additional, Goodall, Jack, additional, Lechiile, Kwana, additional, Mawoko, Norah, additional, Mbangiwa, Tshepiso, additional, Milburn, James, additional, Mmipi, Refilwe, additional, Ponatshego, Ponego, additional, Rulaganyang, Ikanyang, additional, Seatla, Kaelo, additional, Siamisang, Keatlaretse, additional, Tlhako, Nametso, additional, Tsholo, Katlego, additional, April, Samantha, additional, Bekiswa, Abulele, additional, Boloko, Linda, additional, Bookholane, Hloni, additional, Crede, Thomas, additional, Davids, Lee-Ann, additional, Goliath, Rene, additional, Hlungulu, Siphokazi, additional, Hoffman, Regina, additional, Kyepa, Henriette, additional, Masina, Noma, additional, Maughan, Deborah, additional, Mnguni, Trevor, additional, Moosa, Sumaiyya, additional, Morar, Tania, additional, Mpalali, Mkanyiseli, additional, Naude, Jonathan, additional, Oliphant, Ida, additional, Singh, Achita, additional, Sayed, Sumaya, additional, Sebesho, Leago, additional, Shey, Muki, additional, Swanepoel, Loraine, additional, Chasweka, Madalitso, additional, Chimang'anga, Wezi, additional, Chimphambano, Tipatseni, additional, Gondwe, Ebbie, additional, Mzinganjira, Henry, additional, Kadzilimbile, Aubrey, additional, Kateta, Steven, additional, Kossam, Evelyn, additional, Kukacha, Christopher, additional, Lipenga, Bright, additional, Ndaferankhande, John, additional, Ndalama, Maureen, additional, Shah, Reya, additional, Singini, Andreas, additional, Stott, Katherine, additional, Zambasa, Agness, additional, Banda, Towera, additional, Chikaonda, Tarsizio, additional, Chitulo, Gladys, additional, Chiwoko, Lorren, additional, Chome, Nelecy, additional, Gwin, Mary, additional, Kachitosi, Timothy, additional, Kamanga, Beauty, additional, Kazembe, Mussah, additional, Kumwenda, Emily, additional, Kumwenda, Masida, additional, Maya, Chimwemwe, additional, Mhango, Wilberforce, additional, Mphande, Chimwemwe, additional, Msumba, Lusungu, additional, Munthali, Tapiwa, additional, Ngoma, Doris, additional, Nicholas, Simon, additional, Simwinga, Lusayo, additional, Stambuli, Anthony, additional, Tegha, Gerald, additional, Zambezi, Janet, additional, Ahimbisibwe, Cynthia, additional, Akampurira, Andrew, additional, Alice, Anamudde, additional, Cresswell, Fiona, additional, Gakuru, Jane, additional, Kagimu, Enock, additional, Kasibante, John, additional, Kiiza, Daniel, additional, Kisembo, John, additional, Kwizera, Richard, additional, Kugonza, Florence, additional, Laker, Eva, additional, Luggya, Tonny, additional, Lule, Andrew, additional, Musubire, Abdu, additional, Muyise, Rhona, additional, Namujju, Carol Olivie, additional, Ndyetukira, Jane Francis, additional, Nsangi, Laura, additional, Okirworth, Michael, additional, Rhein, Joshua, additional, Rutakingirwa, Morris K, additional, Sadiq, Alisat, additional, Ssebambulidde, Kenneth, additional, Tadeo, Kiiza, additional, Tukundane, Asmus, additional, Atwine, Leo, additional, Buzaare, Peter, additional, Collins, Muganzi, additional, Emily, Ninsima, additional, Inyakuwa, Christine, additional, Kariisa, Samson, additional, Mwesigye, James, additional, Nuwamanya, Simpson, additional, Rodgers, Ankunda, additional, Rukundo, Joan, additional, Rwomushana, Irene, additional, Ssemusu, Mike, additional, Stead, Gavin, additional, Boyd, Kathyrn, additional, Gondo, Secrecy, additional, Kufa, Prosper, additional, Makaha, Edward, additional, Moyo, Colombus, additional, Mtisi, Takudzwa, additional, Mudzinga, Shepherd, additional, Mutata, Constantine, additional, Mwarumba, Taddy, additional, Zinyandu, Tawanda, additional, Alanio, Alexandre, additional, Dromer, Francoise, additional, Lortholary, Olivier, additional, Sturny-Leclere, Aude, additional, Griffin, Philippa, additional, Hafeez, Sophia, additional, Loyse, Angela, additional, and van Widenfelt, Erik, additional

Published
2022
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23. Pharmacokinetics of antitubercular drugs in patients hospitalized with HIV-associated tuberculosis: a population modeling analysis

Author

Abdelgawad, Noha, primary, Chirehwa, Maxwell, additional, Schutz, Charlotte, additional, Barr, David, additional, Ward, Amy, additional, Janssen, Saskia, additional, Burton, Rosie, additional, Wilkinson, Robert J., additional, Shey, Muki, additional, Wiesner, Lubbe, additional, McIlleron, Helen, additional, Maartens, Gary, additional, Meintjes, Graeme, additional, and Denti, Paolo, additional

Published
2022
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24. Mycobacterial-specific secretion of cytokines and chemokines in healthcare workers with apparent resistance to infection with Mycobacterium tuberculosis

Author

Shey, Muki Shehu, Balfour, Avuyonke, Masina, Nomawethu, Bekiswa, Abulele, Schutz, Charlotte, Goliath, Rene, Dielle, Rachel, Katoto, Patrick DMC, Wilkinson, Katalin Andrea, Lewinsohn, David, Lewinsohn, Deborah Anne, and Meintjes, Graeme

Subjects
Model organisms, Human Biology & Physiology, FOS: Clinical medicine, Immunology, Immunology and Allergy, Infectious Disease
Abstract

BackgroundCurrently, diagnosis of latent TB infection (LTBI) is based on the secretion of IFN-γ in response to Mycobacterium tuberculosis (Mtb) antigens, the absence of which is regarded as no infection. Some individuals appear to resist Mtb infection despite sustained exposure (resisters). In this study, we aimed to assess cytokines, chemokines and antibodies that may be associated with resistance to Mtb infection. We hypothesized that there may be an alternative immune response to Mtb exposure in the absence of IFN-γ in resisters.MethodsWe enrolled HIV-uninfected healthcare workers who had worked in high TB-exposure environments for 5 years or longer. We screened them for LTBI using the tuberculin skin test and the QuantiFERON-TB Gold Plus assay. We performed multiplex Luminex to measure concentrations of T cell-associated cytokines and chemokines as well as total antibodies in plasma collected from unstimulated fresh whole blood and supernatants from QuantiFERON-TB Gold Plus tubes following incubation of whole blood for 16-24 hours with ESAT6/CFP10 peptides.ResultsSamples from 78 individuals were analyzed: 33 resisters (TSTConclusionResistance to Mtb infection despite sustained exposure is associated with lower Mtb-specific secretion of Th1-associated cytokines and chemokines. However, resisters showed secreted concentrations after Mtb stimulation of total antibodies and cytokines/chemokines associated with innate and Th17 immune responses similar to those with Mtb infection. This suggests an ability to mount non-IFN-γ immune responses to Mtb in apparent resisters.

Published
2023
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25. The global inequity of COVID-19 diagnostics : challenges and opportunities

Author

Narayanasamy, Shanti, Okware, Brenda, Muttamba, Winters, Patel, Kirtika, Duedu, Kwabena Obeng, Ravi, Nirmal, Ellermeier, Nathan, Shey, Muki, Woods, Christopher W, Sabiiti, Wilber, COVID-19 Clinical Research Coalition, Virology, Immunology, and Diagnostics Working Group, University of St Andrews. Infection and Global Health Division, and University of St Andrews. School of Medicine

Subjects
HV, SDG 3 - Good Health and Well-being, Epidemiology, RA0421, RA0421 Public health. Hygiene. Preventive Medicine, MCP, HV Social pathology. Social and public welfare, Public Health, Environmental and Occupational Health, T-DAS, COVID-19
Abstract

Diagnostics for COVID-19 have advanced at an unprecedented pace over the last two years. Testing is a critical pillar of pandemic control, and is required for epidemiological tracking, treatment, and surveillance. Despite high quality SARS-CoV-2 viral diagnostic capability, there are vast global inequities in access. The Virology, Immunology, and Diagnostics Working Group(WG) of the COVID-19 Clinical Research Coalition (CRC) brings together experts in immunology, infectious diseases, and microbiology to advocate for equity-based COVID-19 research, prioritising solutions driven by communities in low-income and lower middle-income countries (LMICs).1 This commentary shares the unique perspective of the WG on the asymmetry in COVID-19 diagnostic access between low-income and high-income settings, the barriers to these disparities, and highlights opportunities to remedy these inequities. Postprint

Published
2022

26. Phenotypic Profile of Mycobacterium tuberculosis-Specific CD4 T-Cell Responses in People With Advanced Human Immunodeficiency Virus Who Develop Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome

Author

Moseki, Raymond M, primary, Barber, Daniel L, additional, Du Bruyn, Elsa, additional, Shey, Muki, additional, Van der Plas, Helen, additional, Wilkinson, Robert J, additional, Meintjes, Graeme, additional, and Riou, Catherine, additional

Published
2022
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29. Cross-cultural adaptation and validation of the 5C scale to identify factors associated with COVID-19 and influenza vaccine hesitancy among healthcare workers in Cape Town, South Africa – a protocol

Author

Alobwede, Samuel Muabe, primary, Katoto, Patrick DMC, additional, Cooper, Sara, additional, Lumngwena, Evelyn N, additional, Kidzeru, Elvis B, additional, Goliath, Rene, additional, Jackson, Amanda, additional, Wiysonge, Charles S, additional, and Shey, Muki S, additional

Published
2022
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32. Xpert Ultra testing of blood in severe HIV-associated tuberculosis to detect and measure Mycobacterium tuberculosis blood stream infection: a diagnostic and disease biomarker cohort study

Author

Boloko, Linda, primary, Schutz, Charlotte, additional, Sibiya, Nomfundo, additional, Balfour, Avuyonke, additional, Ward, Amy, additional, Shey, Muki, additional, Nicol, Mark P, additional, Burton, Rosie, additional, Wilkinson, Robert J, additional, Maartens, Gary, additional, Meintjes, Graeme, additional, and Barr, David A, additional

Published
2022
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34. Clinical, microbiologic, and immunologic determinants of mortality in hospitalized patients with HIV-associated tuberculosis: A prospective cohort study

Author

Schutz, Charlotte, Barr, David, Andrade, Bruno B., Shey, Muki, Ward, Amy, Janssen, Saskia, Burton, Rosie, Wilkinson, Katalin A., Sossen, Bianca, Fukutani, Kiyoshi F., Nicol, Mark, Maartens, Gary, Wilkinson, Robert J., and Meintjes, Graeme

Subjects
HIV patients -- Death of, Mortality -- Risk factors -- South Africa, HIV infections -- Complications and side effects -- Demographic aspects, Tuberculosis -- Demographic aspects -- Causes of, Death, Hospital patients, HIV, Antitubercular agents, Biological response modifiers, Strategic planning (Business), Biological markers, Lactates, Interferon gamma, Interleukins, Macrophages, Blood tests, Immune system, Interferon, Rifampin, Novels, Biological sciences
Abstract

Background In high-burden settings, case fatality rates are reported to be between 11% and 32% in hospitalized patients with HIV-associated tuberculosis, yet the underlying causes of mortality remain poorly characterized. Understanding causes of mortality could inform the development of novel management strategies to improve survival. We aimed to assess clinical and microbiologic determinants of mortality and to characterize the pathophysiological processes underlying death by evaluating host soluble inflammatory mediators and determined the relationship between these mediators and death as well as biomarkers of disseminated tuberculosis. Methods and findings Adult patients with HIV hospitalized with a new diagnosis of HIV-associated tuberculosis were enrolled in Cape Town between 2014 and 2016. Detailed tuberculosis diagnostic testing was performed. Biomarkers of tuberculosis dissemination and host soluble inflammatory mediators at baseline were assessed. Of 682 enrolled participants, 576 with tuberculosis (487/576, 84.5% microbiologically confirmed) were included in analyses. The median age was 37 years (IQR = 31-43), 51.2% were female, and the patients had advanced HIV with a median cluster of differentiation 4 (CD4) count of 58 cells/L (IQR = 21-120) and a median HIV viral load of 5.1 log.sub.10 copies/mL (IQR = 3.3-5.7). Antituberculosis therapy was initiated in 566/576 (98.3%) and 487/576 (84.5%) started therapy within 48 hours of enrolment. Twelve-week mortality was 124/576 (21.5%), with 46/124 (37.1%) deaths occurring within 7 days of enrolment. Clinical and microbiologic determinants of mortality included disseminated tuberculosis (positive urine lipoarabinomannan [LAM], urine Xpert MTB/RIF, or tuberculosis blood culture in 79.6% of deaths versus 60.7% of survivors, p = 0.001), sepsis syndrome (high lactate in 50.8% of deaths versus 28.9% of survivors, p < 0.001), and rifampicin-resistant tuberculosis (16.9% of deaths versus 7.2% of survivors, p = 0.002). Using non-supervised two-way hierarchical cluster and principal components analyses, we describe an immune profile dominated by mediators of the innate immune system and chemotactic signaling (interleukin-1 receptor antagonist [IL-1Ra], IL-6, IL-8, macrophage inflammatory protein-1 beta [MIP-1[beta]]/C-C motif chemokine ligand 4 [CCL4], interferon gamma-induced protein-10 [IP-10]/C-X-C motif chemokine ligand 10 [CXCL10], MIP-1 alpha [MIP-1[alpha]]/CCL3), which segregated participants who died from those who survived. This immune profile was associated with mortality in a Cox proportional hazards model (adjusted hazard ratio [aHR] = 2.2, 95%CI = 1.9-2.7, p < 0.001) and with detection of biomarkers of disseminated tuberculosis. Clinicians attributing causes of death identified tuberculosis as a cause or one of the major causes of death in 89.5% of cases. We did not perform longitudinal sampling and did not have autopsy-confirmed causes of death. Conclusions In this study, we did not identify a major contribution from coinfections to these deaths. Disseminated tuberculosis, sepsis syndrome, and rifampicin resistance were associated with mortality. An immune profile dominated by mediators of the innate immune system and chemotactic signaling was associated with both tuberculosis dissemination and mortality. These findings provide pathophysiologic insights into underlying causes of mortality and could be used to inform the development of novel treatment strategies and to develop methods to risk stratify patients to appropriately target novel interventions. Causal relationships cannot be established from this study., Author(s): Charlotte Schutz 1,2,*, David Barr 3, Bruno B. Andrade 1,4,5,6,7, Muki Shey 1,2, Amy Ward 1,2, Saskia Janssen 8, Rosie Burton 9, Katalin A. Wilkinson 1,2,10, Bianca Sossen 1,2, [...]

Published
2019
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36. Serial measurement of M. tuberculosis in blood from critically-ill patients with HIV-associated tuberculosis

Author

Barr, David A., primary, Schutz, Charlotte, additional, Balfour, Avuyonke, additional, Shey, Muki, additional, Kamariza, Mireille, additional, Bertozzi, Carolyn R., additional, de Wet, Timothy J., additional, Dinkele, Ryan, additional, Ward, Amy, additional, Haigh, Kathryn A., additional, Kanyik, Jean-Paul, additional, Mizrahi, Valerie, additional, Nicol, Mark P., additional, Wilkinson, Robert J., additional, Lalloo, David G., additional, Warner, Digby F., additional, Meintjes, Graeme, additional, and Davies, Gerry, additional

Published
2022
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37. A comparison of the population pharmacokinetics of rifampicin, isoniazid and pyrazinamide between hospitalized and non-hospitalized tuberculosis patients with or without HIV

Author

Abdelgawad, Noha, primary, Chirehwa, Maxwell, additional, Schutz, Charlotte, additional, Barr, David, additional, Ward, Amy, additional, Janssen, Saskia, additional, Burton, Rosie, additional, Wilkinson, Robert J., additional, Shey, Muki, additional, Wiesner, Lubbe, additional, McIlleron, Helen, additional, Maartens, Gary, additional, Meintjes, Graeme, additional, and Denti, Paolo, additional

Published
2022
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39. Phenotypic Profile of Mycobacterium tuberculosis-Specific CD4 T-Cell Responses in People With Advanced Human Immunodeficiency Virus Who Develop Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome.

Author

Moseki, Raymond M, Barber, Daniel L, Bruyn, Elsa Du, Shey, Muki, Plas, Helen Van der, Wilkinson, Robert J, Meintjes, Graeme, and Riou, Catherine

Subjects
IMMUNE reconstitution inflammatory syndrome, HIV, CD4 antigen, T cells, MYCOBACTERIUM, MYCOBACTERIUM avium
Abstract

Background Tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) is a frequent complication of cotreatment for TB and human immunodeficiency virus (HIV)-1. We characterized Mycobacterium tuberculosis (Mtb)-specific CD4 T-cell phenotype and transcription factor profile associated with the development of TB-IRIS. Methods We examined the role of CD4 T-cell transcription factors in a murine model of mycobacterial IRIS. In humans, we used a longitudinal study design to compare the magnitude of antiretroviral therapy, activation, transcription factor profile, and cytotoxic potential of Mtb-specific CD4 T cells between TB-IRIS (n = 25) and appropriate non-IRIS control patients (n = 18) using flow cytometry. Results In the murine model, CD4 T-cell expression of Eomesodermin (Eomes), but not Tbet, was associated with experimentally induced IRIS. In patients, TB-IRIS onset was associated with the expansion of Mtb-specific IFNγ+CD4 T cells (P =.039). Patients with TB-IRIS had higher HLA-DR expression (P =.016), but no differences in the expression of T-bet or Eomes were observed. At TB-IRIS onset, Eomes+Tbet+Mtb-specific IFNγ+CD4+ T cells showed higher expression of granzyme B in patients with TB-IRIS (P =.026). Conclusions Although the murine model of Mycobacterium avium complex-IRIS suggests that Eomes+CD4 T cells underly IRIS, TB-IRIS was not associated with Eomes expression in patients. Mycobacterium tuberculosis -specific IFNγ+CD4 T-cell responses in TB-IRIS patients are differentiated, highly activated, and potentially cytotoxic. [ABSTRACT FROM AUTHOR]

Published
2023
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42. Contribution of APCs to mucosal-associated invariant T cell activation in infectious disease and cancer

Author

Shey, Muki Shehu, Balfour, Avuyonke, Wilkinson, Katalin Andrea, and Meintjes, Graeme

Subjects
Model organisms, Human Biology & Physiology, FOS: Clinical medicine, Immunology, food and beverages, Infectious Disease
Abstract

APCs such as monocytes and dendritic cells are among the first cells to recognize invading pathogens and initiate an immune response. The innate response can either eliminate the pathogen directly, or through presentation of Ags to T cells, which can help to clear the infection. Mucosal-associated invariant T (MAIT) cells are among the unconventional T cells whose activation does not involve the classical co-stimulation during Ag presentation. MAIT cells can be activated either via presentation of unconventional Ags (such as riboflavin metabolites) through the evolutionarily conserved major histocompatibility class I-like molecule, MR1, or directly by cytokines such as IL-12 and IL-18. Given that APCs produce cytokines and can express MR1, these cells can play an important role in both pathways of MAIT cell activation. In this review, we summarize evidence on the role of APCs in MAIT cell activation in infectious disease and cancer. A better understanding of the interactions between APCs and MAIT cells is important in further elucidating the role of MAIT cells in infectious diseases, which may facilitate the design of novel interventions such as vaccines.

Published
2021
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43. Intervening along the spectrum of tuberculosis: meeting report from the World TB Day nanosymposium in the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town

Author

Massachusetts Institute of Technology. Department of Biological Engineering, Ragon Institute of MGH, MIT and Harvard, Hadebe, Sabelo, Chengalroyen, Melissa, Guler, Reto, Nakedi, Kehilwe, Koch, Anastasia, Makatsa, Mohau, Shey, Muki, Parihar, Suraj P, Bryson, Bryan, Marakalala, Mohlopheni J, Ndlovu, Hlumani, Massachusetts Institute of Technology. Department of Biological Engineering, Ragon Institute of MGH, MIT and Harvard, Hadebe, Sabelo, Chengalroyen, Melissa, Guler, Reto, Nakedi, Kehilwe, Koch, Anastasia, Makatsa, Mohau, Shey, Muki, Parihar, Suraj P, Bryson, Bryan, Marakalala, Mohlopheni J, and Ndlovu, Hlumani

Abstract

Tuberculosis (TB), caused by the highly infectious Mycobacterium tuberculosis, remains a leading cause of death worldwide, with an estimated 1.6 million associated deaths reported in 2017. In South Africa, an estimated 322,000 (range 230,000-428,000) people were infected with TB in 2017, and a quarter of them lost their lives due to the disease. Bacille Calmette-Guérin (BCG) remains the only effective vaccine against disseminated TB, but its inability to confer complete protection against pulmonary TB in adolescents and adults calls for an urgent need to develop new and better vaccines. There is also a need to identify markers of disease protection and develop novel drugs. It is within this backdrop that we convened a nanosymposium at the Institute of Infectious Disease and Molecular Medicine at the University of Cape Town to commemorate World TB Day and showcase recent findings generated by early career scientists in the institute. The speakers spoke on four broad topics: identification of novel drug targets, development of host-directed drug therapies, transmission of TB and immunology of TB/HIV co-infections.

Published
2021

44. Functional and Activation Profiles of Mucosal-Associated Invariant T Cells in Patients With Tuberculosis and HIV in a High Endemic Setting

Author

Balfour, Avuyonke, primary, Schutz, Charlotte, additional, Goliath, Rene, additional, Wilkinson, Katalin A., additional, Sayed, Sumaya, additional, Sossen, Bianca, additional, Kanyik, Jean-Paul, additional, Ward, Amy, additional, Ndzhukule, Rhandzu, additional, Gela, Anele, additional, Lewinsohn, David M., additional, Lewinsohn, Deborah A., additional, Meintjes, Graeme, additional, and Shey, Muki, additional

Published
2021
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47. Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017

Author

Lozano, Rafael, Fullman, Nancy, Abate, Degu, Abay, Solomon M, Abbafati, Cristiana, Abbasi, Nooshin, Abbastabar, Hedayat, Abd-Allah, Foad, Abdela, Jemal, Abdelalim, Ahmed, Abdel-Rahman, Omar, Abdi, Alireza, Abdollahpour, Ibrahim, Abdulkader, Rizwan Suliankatchi, Abebe, Nebiyu Dereje, Abebe, Zegeye, Abejie, Ayenew Negesse, Abera, Semaw F, Abil, Olifan Zewdie, Aboyans, Victor, Abraha, Haftom Niguse, Abrham, Aklilu Roba, Abu-Raddad, Laith Jamal, Abu-Rmeileh, Niveen Me, Abyu, Gebre Y, Accrombessi, Manfred Mario Kokou, Acharya, Dilaram, Acharya, Pawan, Adamu, Abdu A, Adebayo, Oladimeji M, Adedeji, Isaac Akinkunmi, Adedoyin, Rufus Adesoji, Adekanmbi, Victor, Adetokunboh, Olatunji O, Adhena, Beyene Meressa, Adhikari, Tara Ballav, Adib, Mina G, Adou, Arsène Kouablan, Adsuar, Jose C, Afarideh, Mohsen, Afshari, Mahdi, Afshin, Ashkan, Agarwal, Gina, Aghayan, Sargis Aghasi, Agius, Dominic, Agrawal, Anurag, Agrawal, Sutapa, Ahmadi, Alireza, Ahmadi, Mehdi, Ahmadieh, Hamid, Ahmed, Muktar Beshir, Ahmed, Sayem, Akalu, Temesgen Yihunie, Akanda, Ali S, Akbari, Mohammad Esmaeil, Akibu, Mohammed, Akinyemi, Rufus Olusola, Akinyemiju, Tomi, Akseer, Nadia, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alam, Tahiya, Albujeer, Ammar, Alebel, Animut, Alene, Kefyalew Addis, Al-Eyadhy, Ayman, Alhabib, Samia, Ali, Raghib, Alijanzadeh, Mehran, Alizadeh-Navaei, Reza, Aljunid, Syed Mohamed, Alkerwi, Ala'a, Alla, François, Allebeck, Peter, Allen, Christine A, Almasi, Ali, Al-Maskari, Fatma, Al-Mekhlafi, Hesham M, Alonso, Jordi, Al-Raddadi, Rajaa M, Alsharif, Ubai, Altirkawi, Khalid, Alvis-Guzman, Nelson, Amare, Azmeraw T, Amenu, Kebede, Amini, Erfan, Ammar, Walid, Anber, Nahla Hamed, Anderson, Jason A, Andrei, Catalina Liliana, Androudi, Sofia, Animut, Megbaru Debalkie, Anjomshoa, Mina, Ansari, Hossein, Ansariadi, Ansariadi, Ansha, Mustafa Geleto, Antonio, Carl Abelardo T, Anwari, Palwasha, Appiah, Lambert Tetteh, Aremu, Olatunde, Areri, Habtamu Abera, Ärnlöv, Johan, Arora, Monika, Aryal, Krishna K, Asayesh, Hamid, Asfaw, Ephrem Tsegay, Asgedom, Solomon Weldegebreal, Asghar, Rana Jawad, Assadi, Reza, Ataro, Zerihun, Atique, Suleman, Atre, Sachin R, Atteraya, Madhu Sudhan, Ausloos, Marcel, Avila-Burgos, Leticia, Avokpaho, Euripide F G A, Awasthi, Ashish, Ayala Quintanilla, Beatriz Paulina, Ayele, Henok Tadesse, Ayele, Yohanes, Ayer, Rakesh, Azarpazhooh, Mahmoud Reza, Azzopardi, Peter S, Azzopardi-Muscat, Natasha, Babalola, Tesleem Kayode, Babazadeh, Arefeh, Badali, Hamid, Badawi, Alaa, Balakrishnan, Kalpana, Bali, Ayele Geleto, Banach, Maciej, Banerjee, Amitava, Banoub, Joseph Adel Mattar, Banstola, Amrit, Barac, Aleksandra, Barboza, Miguel A, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barrero, Lope H, Barthelemy, Celine M, Bassat, Quique, Basu, Arindam, Basu, Sanjay, Battista, Robert J, Baune, Bernhard T, Baynes, Habtamu Wondifraw, Bazargan-Hejazi, Shahrzad, Bedi, Neeraj, Beghi, Ettore, Behzadifar, Masoud, Behzadifar, Meysam, Béjot, Yannick, Bekele, Bayu Begashaw, Belachew, Abate Bekele, Belay, Aregawi Gebreyesus, Belay, Saba Abraham, Belay, Yihalem Abebe, Bell, Michelle L, Bello, Aminu K, Bennett, Derrick A, Bensenor, Isabela M, Benzian, Habib, Berhane, Adugnaw, Berhe, Abadi Kidanemariam, Berman, Adam E, Bernabe, Eduardo, Bernstein, Robert S, Bertolacci, Gregory J, Beuran, Mircea, Beyranvand, Tina, Bhala, Neeraj, Bhalla, Ashish, Bhansali, Anil, Bhattarai, Suraj, Bhaumik, Soumyadeep, Bhutta, Zulfiqar A, Biadgo, Belete, Biehl, Molly H, Bijani, Ali, Bikbov, Boris, Bililign, Nigus, Bin Sayeed, Muhammad Shahdaat, Birlik, Sait Mentes, Birungi, Charles, Bisanzio, Donal, Biswas, Tuhin, Bitew, Helen, Bizuneh, Hailemichael, Bjertness, Espen, Bobasa, Eshetu Mulisa, Boufous, Soufiane, Bourne, Rupert, Bozorgmehr, Kayvan, Bragazzi, Nicola Luigi, Brainin, Michael, Brant, Luisa C, Brauer, Michael, Brazinova, Alexandra, Breitborde, Nicholas J K, Briant, Paul Svitil, Britton, Gabrielle, Brugha, Traolach, Bukhman, Gene, Busse, Reinhard, Butt, Zahid A, Cahuana-Hurtado, Lucero, Callender, Charlton SKH, Campos-Nonato, Ismael R, Campuzano Rincon, Julio Cesar, Cano, Jorge, Car, Josip, Car, Mate, Cárdenas, Rosario, Carrero, Juan J, Carter, Austin, Carvalho, Félix, Castañeda-Orjuela, Carlos A, Castillo Rivas, Jacqueline, Castro, Franz, Causey, Kate, Çavlin, Alanur, Cercy, Kelly M, Cerin, Ester, Chaiah, Yazan, Chalek, Julian, Chang, Hsing-Yi, Chang, Jung-Chen, Chattopadhyay, Aparajita, Chattu, Vijay Kumar, Chaturvedi, Pankaj, Chiang, Peggy Pei-Chia, Chin, Ken Lee, Chisumpa, Vesper Hichilombwe, Chitheer, Abdulaal, Choi, Jee-Young J, Chowdhury, Rajiv, Christensen, Hanne, Christopher, Devasahayam J, Chung, Sheng-Chia, Cicuttini, Flavia M, Ciobanu, Liliana G, Cirillo, Massimo, Claro, Rafael M, Claßen, Thomas Khaled Dwayne, Cohen, Aaron J, Collado-Mateo, Daniel, Cooper, Cyrus, Cooper, Leslie Trumbull, Cornaby, Leslie, Cortinovis, Monica, Costa, Megan, Cousin, Ewerton, Cromwell, Elizabeth A, Crowe, Christopher Stephen, Cunningham, Matthew, Daba, 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Subjects
GENDER-DIFFERENCES, SUICIDE, Medicine (all), Burden of Disease Study 2017, SDG, CONSUMPTION, 11 Medical And Health Sciences, GBD, Sustainable Development Goals, PREVENTION, ALCOHOL-USE, CARDIOVASCULAR-DISEASE, SMOKING PREVALENCE, General & Internal Medicine, factors risk, Medicine and Health Sciences, Human medicine, CESSATION, PERSPECTIVE, TRANSITION
Abstract

Background Efforts to establish the 2015 baseline and monitor early implementation of the UN Sustainable Development Goals (SDGs) highlight both great potential for and threats to improving health by 2030. To fully deliver on the SDG aim of "leaving no one behind", it is increasingly important to examine the health-related SDGs beyond national-level estimates. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017), we measured progress on 41 of 52 health -related SDG indicators and estimated the health-related SDG index for 195 countries and territories for the period 1990-2017, projected indicators to 2030, and analysed global attainment. Methods We measured progress on 41 health-related S DG indicators from 1990 to 2017, an increase of four indicators since GBD 2016 (new indicators were health worker density, sexual violence by non-intimate partners, population census status, and prevalence of physical and sexual violence [reported separately]). We also improved the measurement of several previously reported indicators. We constructed national-level estimates and, for a subset of health-related SDGs, examined indicator-level differences by sex and Socio-demographic Index (SDI) quintile. We also did subnational assessments of performance for selected countries. To construct the health related SDG index, we transformed the value for each indicator on a scale of 0-100, with 0 as the 2.5th percentile and 100 as the 97.5th percentile of 1000 draws calculated from 1990 to 2030, and took the geometric mean of the scaled indicators by target. To generate projections through 2030, we used a forecasting framework that drew estimates from the broader GBD study and used weighted averages of indicator-specific and country-specific annualised rates of change from 1990 to 2017 to inform future estimates. We assessed attainment of indicators with defined targets in two ways: first, using mean values projected for 2030, and then using the probability of attainment in 2030 calculated from 1000 draws. We also did a global attainment analysis of the feasibility of attaining SDG targets on the basis of past trends. Using 2015 global averages of indicators with defined SDG targets, we calculated the global annualised rates of change required from 2015 to 2030 to meet these targets, and then identified in what percentiles the required global annualised rates of change fell in the distribution of country-level rates of change from 1990 to 2015. We took the mean of these global percentile values across indicators and applied the past rate of change at this mean global percentile to all health-related SDG indicators, irrespective of target definition, to estimate the equivalent 2030 global average value and percentage change from 2015 to 2030 for each indicator. Findings The global median health-related SDG index in 2017 was 59.4 (IQR 35.4-67.3), ranging from a low of 11.6 (95% uncertainty interval 9.6-14.0) to a high of 84.9 (83.1-86.7). SDG index values in countries assessed at the subnational level varied substantially particularly in China and India, although scores in Japan and the UK were more homogeneous. Indicators also varied by SDI quintile and sex, with males having worse outcomes than females for non-communicable disease (NCD) mortality, alcohol use, and smoking, among others. Most countries were projected to have a higher health-related SDG index in 2030 than in 2017, while country-level probabilities of attainment by 2030 varied widely by indicator. Under-5 mortality, neonatal mortality, maternal mortality ratio, and malaria indicators had the most countries with at least 95% probability of target attainment. Other indicators, including NCD mortality and suicide mortality, had no countries projected to meet corresponding SDG targets on the basis of projected mean values for 2030 but showed some probability of attaimnent by 2030. For some indicators, including child malnutrition, several infectious diseases, and most violence measures, the annualised rates of change required to meet SDG targets far exceeded the pace of progress achieved by any country in the recent past. We found that applying the mean global annualised rate of change to indicators without defined targets would equate to about 19% and 22% reductions in global smoking and alcohol consumption, respectively; a 47% decline in adolescent birth rates; and a more than 85% increase in health worker density per 1000 population by 2030. Interpretation The GBD study offers a unique, robust platform for monitoring the health -related SDGs across demographic and geographic dimensions. Our findings underscore the importance of increased collection and analysis of disaggregated data and highlight where more deliberate design or targeting of interventions could accelerate progress in attaining the SDGs. Current projections show that many health -related SDG indicators, NCDs, NCD-related risks, and violence -related indicators will require a concerted shift away from what might have driven past gains curative interventions in the case of NCDs towards multisectoral, prevention -oriented policy action and investments to achieve SDG aims. Notably, several targets, if they are to be met by 2030, demand a pace of progress that no country has achieved in the recent past. The future is fundamentally uncertain, and no model can fully predict what breakthroughs or events might alter the course of the S DGs. What is clear is that our actions or inaction today will ultimately dictate how close the world, collectively, can get to leaving no one behind by 2030. Copyright (C) 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.

Published
2018

48. Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans

Author

Rangaka, Molebogeng X., Diwakar, Lavanya, Seldon, Ronnett, van Cutsem, Gilles, Meintjes, Graeme A., Morroni, Chelsea, Mouton, Priscilla, Shey, Muki S., Maartens, Gary, Wilkinson, Katalin A., and Wilkinson, Robert J.

Subjects
Tuberculosis -- Diagnosis, T cells -- Analysis, HIV patients -- Research, African Americans -- Health aspects, African Americans -- Research, Health, Health care industry
Published
2007

49. Xpert-Ultra to Detect and Quantify HIV-Associated Mycobacterium tuberculosis Blood Stream Infection: A Cohort Study

Author

Boloko, Linda, primary, Schutz, Charlotte, additional, Sibiya, Nomfundo, additional, Balfour, Avuyonke, additional, Ward, Amy, additional, Shey, Muki, additional, Nicol, Mark P., additional, Burton, Rosie, additional, Wilkinson, Robert J., additional, Maartens, Gary, additional, Meintjes, Graeme, additional, and Barr, David A., additional

Published
2021
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50. Postnatal Expansion, Maturation, and Functionality of MR1T Cells in Humans

Author

Swarbrick, Gwendolyn M., primary, Gela, Anele, additional, Cansler, Meghan E., additional, Null, Megan D., additional, Duncan, Rowan B., additional, Nemes, Elisa, additional, Shey, Muki, additional, Nsereko, Mary, additional, Mayanja-Kizza, Harriet, additional, Kiguli, Sarah, additional, Koh, Jeffrey, additional, Hanekom, Willem A., additional, Hatherill, Mark, additional, Lancioni, Christina, additional, Lewinsohn, David M., additional, Scriba, Thomas J., additional, and Lewinsohn, Deborah A., additional

Published
2020
Full Text
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