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5. Economic Assessment of Meteorological Information Services for Capture Fisheries in Taiwan.

Author

Lin, Hen-I, Sheu, Sheng-Jang, Chen, Chu-Wei, Wen, Fang-I, Yang, Chin-Wen, Liou, Je-Liang, Chen, Meng-Wei, Hsu, Jen-Hung, and Chang, Yu-Chieh

Subjects
*CONTINGENT valuation, *METEOROLOGICAL services, *VALUATION, *WILLINGNESS to pay, *FISHERIES
Abstract

This study evaluates the economic benefits of meteorological information services (MISs) provided by the Central Weather Administration (CWA) in Taiwan, specifically for Taiwan's capture fishery industry. Using the contingent valuation method (CVM) and conducting in-person interviews, we collected questionnaires from capture fishery practitioners nationwide to gather their subjective evaluations of the meteorological information services provided by the CWA. Based on these evaluations, we further investigated the respondents' willingness to pay (WTP) for the CWA's meteorological information services. An empirical analysis of the bid function was conducted to identify the key factors influencing the respondents' bidding behavior. The empirical findings indicate that the primary factors affecting bids include subjective perceptions (such as forecast accuracy ratings and the ratings of the impacts on fishing production), working location, fishing vessel tonnage, and fishing methods. The median WTP for Taiwanese capture fishery practitioners is Taiwan dollar (TWD) 2111.12 per person per year. Based on the number of capture fishery practitioners in Taiwan in 2019, the total annual economic value of applying MIS in coastal and offshore fisheries is estimated to be between TWD 376 million and TWD 496 million per year. [ABSTRACT FROM AUTHOR]

Published
2024
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7. The Beneficial Effect of the SGLT2 Inhibitor Dapagliflozin in Alleviating Acute Myocardial Infarction-Induced Cardiomyocyte Injury by Increasing the Sirtuin Family SIRT1/SIRT3 and Cascade Signaling.

Author

Lin, Yi-Hsiung, Tsai, Wei-Chung, Chiu, Chien-Chih, Chi, Nai-Yu, Liu, Yi-Hsueh, Huang, Tien-Chi, Wu, Wei-Tsung, Lin, Tsung-Hsien, Lai, Wen-Ter, Sheu, Sheng-Hsiung, and Hsu, Po-Chao

Subjects
CORONARY artery surgery, MYOCARDIAL infarction, SODIUM-glucose cotransporter 2 inhibitors, GENE expression, RNA sequencing
Abstract

Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have a variety of cardiovascular and renoprotective effects and have been developed as novel agents for the treatment of heart failure. However, the beneficial mechanisms of SGLT2i on cardiac tissue need to be investigated further. In this study, we established a mouse model of acute myocardial infarction (AMI) using coronary artery constriction surgery and investigated the role of dapagliflozin (DAPA) in protecting cardiomyocytes from hypoxic injury induced by AMI. In vitro experiments were done using hypoxic cultured H9c2 ventricular cells to verify this potential mechanism. Expression of the SIRT family and related genes and proteins was verified by qPCR, Western blotting and immunofluorescence staining, and the intrinsic potential mechanism of cardiomyocyte death due to AMI and hypoxia was comprehensively investigated by RNA sequencing. The RNA sequencing results of cardiomyocytes from AMI mice showed that the SIRT family may be mainly involved in the mechanisms of hypoxia-induced cardiomyocyte death. In vitro hypoxia-induced ventricular cells showed the role of dapagliflozin in conferring resistance to hypoxic injury in cardiomyocytes. It showed that SIRT1/3/6 were downregulated in H9c2 cells in a hypoxic environment, and the addition of dapagliflozin significantly increased the gene and protein expression of SIRT1, 3 and 6. We then verified the underlying mechanisms induced by dapagliflozin in hypoxic cardiomyocytes using RNA-seq, and found that dapagliflozin upregulated the hypoxia-induced gene downregulation, which includes ESRRA, EPAS1, AGTRAP, etc., that associated with SIRTs-related and apoptosis-related signaling to prevent H9c2 cell death. This study provides laboratory data for SGLT2i dapagliflozin treatment of AMI and confirms that dapagliflozin can be used to treat hypoxia-induced cellular necrosis in cardiomyocytes, in which SIRT1 and SIRT3 may play an important role. This opens up further opportunities for SGLT2i in the treatment of heart disease. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Prescription Pattern in Angiotensin Receptor Neprilysin Inhibitor is Associated with Heart Failure Events

Author

Wu, Wei-Tsung, Wang, Shih-Han, Wang, Ya-Lin, Lin, Tsung-Hsien, Lai, Wen-Ter, and Sheu, Sheng-Hsiung

Subjects
Original Article
Abstract

BACKGROUND: Angiotensin receptor neprilysin inhibition (ARNI) is superior to enalapril in reducing the risk of cardiovascular death and heart failure hospitalization (HFH). However, whether prescription pattern is associated with heart failure outcome is unknown. METHODS: This is a retrospective study of 153 patients who received ARNI in a tertiary medical center in Taiwan. We analyzed the impact of dose up-titration and prescription timing including during initial admission, within 3 months after initial HFH discharge, and at outpatient clinics without prior HFH. The primary endpoint was the composite of cardiovascular death and HFH. RESULTS: After a mean follow-up period of 287 ± 197 days, the primary endpoint occurred in 43 (28.1%) subjects. Patients without and with a primary endpoint significantly differed in terms of history of valvular heart disease (VHD, p = 0.006), ventricular tachyarrhythmia (VT, p = 0.043), percutaneous coronary intervention (p = 0.007), coronary artery bypass grafting (p = 0.002), chronic kidney disease (p = 0.002), age (p = 0.002), diastolic blood pressure (p = 0.025), and prescription timing (p = 0.002). Kaplan-Meier analysis showed ARNI up-titration and prescription timing had a significant association with primary endpoint-free survival (Breslow test; p = 0.032, and log-rank test; p = 0.001, respectively). Cox regression analysis showed that independent predictors for the primary endpoint were ARNI up-titration [hazard ratio (HR): 0.41, p = 0.024], non-hospital ARNI versus hospital ARNI (HR: 0.41, p = 0.009), VHD (HR: 2.71, p = 0.013), VT (HR: 3.09, p = 0.02), and age (HR: 1.03, p = 0.033). CONCLUSIONS: The prescription pattern of ARNI could be associated with heart failure events.

Published
2023

33. Usefulness of Upstroke Time per Cardiac Cycle for Cardiovascular and All-Cause Mortality Prediction in Patients with Normal Ankle-Brachial Index

Author

Su, Ho-Ming, primary, Lee, Wen-Hsien, additional, Tsai, Wei-Chung, additional, Lin, Tzu-Chieh, additional, Lu, Ye-Hsu, additional, Lee, Chee-Siong, additional, Lin, Tsung-Hsien, additional, Voon, Wen-Chol, additional, Lai, Wen-Ter, additional, Sheu, Sheng-Hsiung, additional, and Hsu, Po-Chao, additional

Published
2022
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34. Association of circadian genes with diurnal blood pressure changes and non-dipper essential hypertension: a genetic association with young-onset hypertension

Author

Leu, Hsin-Bang, Chung, Chia-Min, Lin, Shing-Jong, Chiang, Kuang-Mao, Yang, Hsin-Chou, Ho, Hung-Yun, Ting, Chih-Tai, Lin, Tsung-Hsien, Sheu, Sheng-Hsiung, Tsai, Wei-Chuan, Chen, Jyh-Hong, Yin, Wei-Hsian, Chiu, Ting-Yu, Chen, Chin-Iuan, Fann, Cathy SJ, Chen, Yuan-Tsong, Pan, Wen-Harn, and Chen, Jaw-Wen

Published
2015
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41. CHA(2)DS(2)-VASc Score and Risk of New-Onset Peripheral Arterial Occlusive Disease in Patients without Atrial Fibrillation

Author

Lin, Tzu-Chieh, Su, Ho-Ming, Lee, Wen-Hsien, Chiu, Cheng-An, Chi, Nai-Yu, Tsai, Wei-Chung, Lin, Tsung-Hsien, Voon, Wen-Chol, Lai, Wen-Ter, Sheu, Sheng-Hsiung, and Hsu, Po-Chao

Subjects
parasitic diseases, Original Article
Abstract

BACKGROUND: CHA(2)DS(2)-VASc score is a useful score to evaluate the risk of stroke in patients with atrial fibrillation (AF), and it has been shown to outperform CHADS(2) score. Our recent cross-sectional study showed that CHA(2)DS(2)-VASc score was associated with an ankle-brachial index < 0.9. The aim of the current study was to evaluate whether CHA(2)DS(2)-VASc score is a useful predictor of new-onset peripheral artery occlusive disease (PAOD) and whether it can outperform CHADS(2) and R(2)CHADS(2) scores. METHODS: We used the National Health Insurance Research Database to survey 723750 patients from January 1, 2000 to December 31, 2001. CHADS(2), R(2)CHADS(2), and CHA(2)DS(2)-VASc scores were calculated for every patient. Finally, 280176 (score 0), 307209 (score 1), 61093 (score 2), 35594 (score 3), 18956 (score 4), 11032 (score 5), 6006 (score 6), 2696 (score 7), 843 (score 8), and 145 (score 9) patients were studied and followed to evaluate new-onset PAOD. We further divided the study patients into six groups: group 1 (score 0), group 2 (score 1-2), group 3 (score 3-4), group 4 (score 5-6), group 5 (score 7-8), and group 6 (score 9). RESULTS: Overall, 24775 (3.4%) patients experienced new-onset PAOD during 9.8 years of follow-up. The occurrence rate of PAOD increased from 1.3% (group 1) to 23.4% (group 6). Subgroup analysis by gender also showed an association between CHA(2)DS(2)-VASc score and the occurrence rate of PAOD. After multivariate analysis, groups 2-6 were significantly associated with new-onset PAOD. CHA(2)DS(2)-VASc score also outperformed CHADS(2) and R(2)CHADS(2) scores for predicting new-onset PAOD. CONCLUSIONS: CHA(2)DS(2)-VASc score was a more powerful predictor of new-onset PAOD than CHADS(2) and R(2)CHADS(2) scores in patients without AF.

Published
2021

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