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275 results on '"Sheu, Jim Jinn-Chyuan"'

6. Identification of RNF213 as a potential suppressor of local invasion in intrahepatic cholangiocarcinoma

Author

Chiablaem, Khajeelak, primary, Jinawath, Artit, additional, Nuanpirom, Jiratchaya, additional, Arora, Jantarika Kumar, additional, Nasaree, Sirawit, additional, Thanomchard, Thanastha, additional, Singhto, Nilubon, additional, Chittavanich, Pamorn, additional, Suktitipat, Bhoom, additional, Charoensawan, Varodom, additional, Chairoungdua, Arthit, additional, Sheu, Jim Jinn-Chyuan, additional, Kiyotani, Kazuma, additional, Svasti, Jisnuson, additional, Nakamura, Yusuke, additional, and Jinawath, Natini, additional

Published
2024
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18. Data from Functional Genomic Analysis Identified Epidermal Growth Factor Receptor Activation as the Most Common Genetic Event in Oral Squamous Cell Carcinoma

Author

Sheu, Jim Jinn-Chyuan, primary, Hua, Chun-Hung, primary, Wan, Lei, primary, Lin, Ying-Ju, primary, Lai, Ming-Tsung, primary, Tseng, Hsien-Chang, primary, Jinawath, Natini, primary, Tsai, Ming-Hsui, primary, Chang, Nai-Wen, primary, Lin, Chin-Fen, primary, Lin, Chyi-Chyang, primary, Hsieh, Lie-Jiau, primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, and Tsai, Fuu-Jen, primary

Published
2023
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20. Supplementary Figures 1-6 from Functional Genomic Analysis Identified Epidermal Growth Factor Receptor Activation as the Most Common Genetic Event in Oral Squamous Cell Carcinoma

Author

Sheu, Jim Jinn-Chyuan, primary, Hua, Chun-Hung, primary, Wan, Lei, primary, Lin, Ying-Ju, primary, Lai, Ming-Tsung, primary, Tseng, Hsien-Chang, primary, Jinawath, Natini, primary, Tsai, Ming-Hsui, primary, Chang, Nai-Wen, primary, Lin, Chin-Fen, primary, Lin, Chyi-Chyang, primary, Hsieh, Lie-Jiau, primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, and Tsai, Fuu-Jen, primary

Published
2023
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21. Supplementary Figure Legends 1-6 from Functional Genomic Analysis Identified Epidermal Growth Factor Receptor Activation as the Most Common Genetic Event in Oral Squamous Cell Carcinoma

Author

Sheu, Jim Jinn-Chyuan, primary, Hua, Chun-Hung, primary, Wan, Lei, primary, Lin, Ying-Ju, primary, Lai, Ming-Tsung, primary, Tseng, Hsien-Chang, primary, Jinawath, Natini, primary, Tsai, Ming-Hsui, primary, Chang, Nai-Wen, primary, Lin, Chin-Fen, primary, Lin, Chyi-Chyang, primary, Hsieh, Lie-Jiau, primary, Wang, Tian-Li, primary, Shih, Ie-Ming, primary, and Tsai, Fuu-Jen, primary

Published
2023
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22. Ethnic-specific genetic susceptibility loci for endometriosis in Taiwanese-Han population: a genome-wide association study

Author

Sheu, Jim Jinn-Chyuan, Lin, Wei-Yong, Liu, Ting-Yuan, Chang, Cherry Yin-Yi, Cheng, Jack, Li, Yau-Hong, Chen, Chih-Mei, Tseng, Chung-Chen, Ding, Wendy Yarou, Chung, Ching, Hwang, Tritium, Chen, Ping-Ho, and Tsai, Fuu-Jen

Abstract

Endometriosis is a common gynecological disorder affecting around 10% of reproductive-age women. Although many hypotheses were proposed, genetic alteration has been considered as one of the key factors promoting pathogenesis. Due to racial/ethnic disparities in the process of hormone regulation and nutrition metabolism, a genome-wide association study (GWAS) with 2794 cases and 27,940 controls was conducted in a Taiwanese-Han population. Our study identified five significant susceptibility loci for endometriosis, and three of them, WNT4(on the 1p36.12), RMND1(6q25.1), and CCDC170(6q25.1), have been previously associated with endometriosis across different populations, including European and Japanese descent cohorts. Other two including C5orf66/C5orf66-AS2(5q31.1) and STN1(10q24.33) are newly identified ones. Functional network analysis of potent risk genes revealed the involvement of cancer susceptibility and neurodevelopmental disorders in endometriosis development. In addition, long non-coding RNAs (lncRNAs) C5orf66 and C5orf66-AS2 can interact with many RNA-binding proteins (RBPs) which can influence RNA metabolic process, mRNA stabilization, and mRNA splicing, leading to dysregulation in tumor-promoting gene expression. Those findings support clinical observations of differences in the presentation of endometriosis in Taiwanese-Han population with higher risks of developing deeply infiltrating/invasive lesions and the associated malignancies.

Published
2024
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26. Genetic variations in UCA1, a lncRNA functioning as a miRNA sponge, determine endometriosis development and the potential associated infertility via regulating lipogenesis

Author

Chang, Cherry Yin-Yi, primary, Yang, Li, additional, Tse, Joe, additional, Lo, Lun-Chien, additional, Tseng, Chung-Chen, additional, Sun, Li, additional, Lai, Ming-Tsung, additional, Chen, Ping-Ho, additional, Hwang, Tritium, additional, Chen, Chih-Mei, additional, Tsai, Fuu-Jen, additional, and Sheu, Jim Jinn-Chyuan, additional

Published
2022
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36. RSF-1 siRNA Enhances Tumor Radiosensitivity in Cervical Cancer via Enhanced DNA Damage, Cell Cycle Redistribution, and Promotion of Apoptosis

Author

Tian, Jing, Kong, Enqi, Wang, Xiangyu, Xie, Zhaoguang, Chang, Cherry Yin-Yi, Sheu, Jim Jinn-Chyuan, Hao, Quan, and Sun, Li

Subjects
cervical cancer, RSF-1, DNA damage, OncoTargets and Therapy, radiotherapy, Original Research
Abstract

Jing Tian,1 Enqi Kong,2 Xiangyu Wang,3 Zhaoguang Xie,4 Cherry Yin-Yi Chang,5 Jim Jinn-Chyuan Sheu,6– 9 Quan Hao,1 Li Sun10,11 1Department of Gynecological Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, People’s Republic of China, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, People’s Republic of China; 2School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250200, People’s Republic of China; 3The Third School of Clinical Medicine, Southern Medical University, Guangzhou 510515, People’s Republic of China; 4Department of Maternity, Jinan Maternal and Child Health Hospital Affiliated to Shandong First Medical University, Jinan, 250001, People’s Republic of China; 5Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung 40447, Taiwan; 6Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan; 7Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; 8School of Chinese Medicine, China Medical University, Taichung 40402, Taiwan; 9Department of Health and Nutrition Biotechnology, Asia University, Taichung 41354, Taiwan; 10Department of Gynecological Oncology, Qingdao Central Hospital, The Second Affiliated Hospital of Medical College of Qingdao University, Qingdao, 266042, People’s Republic of China; 11Department of Gynecological Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, People’s Republic of ChinaCorrespondence: Li SunDepartment of Gynecological Oncology, Qingdao Central Hospital, The Second Affiliated Hospital of Medical College of Qingdao University, Qingdao 266042, People’s Republic of ChinaTel +86-532-84962590Email sunli766@163.comBackground: Remodeling and spacing factor-1 (RSF-1) is an identified tumor biomarker that is overexpressed in a variety of human cancers, but its effect on radiotherapy remains unclear. In this study, we aimed to explore the effect of RSF-1 siRNA on sensitizing cervical cancer cells to radiation and its underlying mechanism.Methods: The mRNA and protein expression of RSF-1 in tissue and cells were measured by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting. Cell counting kit-8 (CCK-8) and colony formation assay were used to examine cell proliferation. Flow cytometry was used to analyzed the cell cycle and cell apoptosis. DNA damage was examined by the comet assay. ATM, ATR, CHK1, CHK2, H2AX, γH2AX and phosphorylated ATM, ATR, CHK1 and CHK2 were detected by Western blotting. γH2AX foci were demonstrated by immunofluorescence staining.Results: RSF-1 was upregulated in cervical cancer tissue and decreased after effective treatment. RSF-1 siRNA in combination with radiation suppressed cell viability, redistributed cell cycles and also induced cell apoptosis in HeLa and SiHa cell lines. Further, knockdown of RSF-1 induced DNA damage by attenuating DNA repair capability, thereby sensitizing cervical cancer cells to radiation.Conclusions: These data demonstrate that RSF-1 siRNA enhanced the sensitivity of radiotherapy, and targeting RSF-1 may be a promising approach for the development of novel radiosensitizing agents for the treatment of cervical cancer.Keywords: RSF-1, cervical cancer, radiotherapy, DNA damage

Published
2020

38. RSF-1 overexpression determines cancer progression and drug resistance in cervical cancer

Author

Wang Xiangyu, Sheu Jim Jinn-Chyuan, Lai Ming-Tsung, Yin-Yi Chang Cherry, Sheng Xiugui, Wei Ling, Gao Yongsheng, Wang Xingwu, Liu Naifu, Xie Wenli, Chen Chih-Mei, Ding Wendy Y., and Sun Li

Subjects
RSF-1 (HBXAP), Cervical cancer, Clinical pathological, characteristics, Anti-RSF-1 therapy, Medicine
Abstract

Background: Remodeling spacing factor 1 (RSF-1/HBXAP) has been linked to a variety of cancer types, however, its roles and the therapeutic potential are not clear in cervical cancer. Methods: RSF-1 expression in cancer tissues was analyzed by immunohistochemical staining followed by statistical analysis with SPSS. Anti-RSF-1 studies were performed by treating cells with specific siRNA or a dominant mutant form (RSF-D4). Results: RSF-1 expression correlates with cancer progression that strongly-positive staining can be found in 67.7% carcinomas and 66.7% CIN lesions, but none in normal tissues. Such overexpression also associated with increased tumor size, poor differentiation, higher nodal metastasis and advanced clinical stages. Kaplan– Meier analysis confirmed that cancer patients with high RSF-1 levels exhibited a significantly shorter survival time than those with low RSF-1 levels. Downregulation of RSF-1 by siRNA silencing or RSF-D4 reduced cell growth and increased drug sensitivity toward paclitaxel treatment in HeLa cells. Conclusions: RSF-1 participates in the tumor progression of cervical cancer and could be considered as an early prognostic marker for cancer development and clinical outcome. Therapies based on anti-RSF-1 activity may be beneficial for patients with RSF-1 overexpression in their tumors.

Published
2018
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42. Ribosome Biogenesis Serves as a Therapeutic Target for Treating Endometriosis and the Associated Complications

Author

Chang, Cherry Yin-Yi, primary, Chiang, An-Jen, additional, Yan, Man-Ju, additional, Lai, Ming-Tsung, additional, Su, Yun-Yi, additional, Huang, Hsin-Yi, additional, Chang, Chan-Yu, additional, Li, Ya-Hui, additional, Li, Pei-Fen, additional, Chen, Chih-Mei, additional, Hwang, Tritium, additional, Hogg, Chloe, additional, Greaves, Erin, additional, and Sheu, Jim Jinn-Chyuan, additional

Published
2022
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43. A More Diverse Cervical Microbiome Associates with Better Clinical Outcomes in Patients with Endometriosis: A Pilot Study

Author

Chang, Cherry Yin-Yi, primary, Chiang, An-Jen, additional, Lai, Ming-Tsung, additional, Yan, Man-Ju, additional, Tseng, Chung-Chen, additional, Lo, Lun-Chien, additional, Wan, Lei, additional, Li, Chia-Jung, additional, Tsui, Kuan-Hao, additional, Chen, Chih-Mei, additional, Hwang, Tritium, additional, Tsai, Fuu-Jen, additional, and Sheu, Jim Jinn-Chyuan, additional

Published
2022
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48. Genetic impacts on thermostability of onco-lncRNA HOTAIR during the development and progression of endometriosis

Author

Chang, Cherry Yin-Yi, primary, Tseng, Chung-Chen, additional, Lai, Ming-Tsung, additional, Chiang, An-Jen, additional, Lo, Lun-Chien, additional, Chen, Chih-Mei, additional, Yen, Man-Ju, additional, Sun, Li, additional, Yang, Li, additional, Hwang, Tritium, additional, Tsai, Fuu-Jen, additional, and Sheu, Jim Jinn-Chyuan, additional

Published
2021
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49. RSF-1 siRNA Enhances Tumor Radiosensitivity in Cervical Cancer via Enhanced DNA Damage, Cell Cycle Redistribution, and Promotion of Apoptosis

Author

Tian,Jing, Kong,Enqi, Wang,Xiangyu, Xie,Zhaoguang, Chang,Cherry Yin-Yi, Sheu,Jim Jinn-Chyuan, Hao,Quan, Sun,Li, Tian,Jing, Kong,Enqi, Wang,Xiangyu, Xie,Zhaoguang, Chang,Cherry Yin-Yi, Sheu,Jim Jinn-Chyuan, Hao,Quan, and Sun,Li

Abstract

Jing Tian,1 Enqi Kong,2 Xiangyu Wang,3 Zhaoguang Xie,4 Cherry Yin-Yi Chang,5 Jim Jinn-Chyuan Sheu,6– 9 Quan Hao,1 Li Sun10,11 1Department of Gynecological Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, People’s Republic of China, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin 300060, People’s Republic of China; 2School of Medicine and Life Sciences, University of Jinan-Shandong Academy of Medical Sciences, Jinan 250200, People’s Republic of China; 3The Third School of Clinical Medicine, Southern Medical University, Guangzhou 510515, People’s Republic of China; 4Department of Maternity, Jinan Maternal and Child Health Hospital Affiliated to Shandong First Medical University, Jinan, 250001, People’s Republic of China; 5Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung 40447, Taiwan; 6Institute of Biomedical Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan; 7Department of Biotechnology, College of Life Science, Kaohsiung Medical University, Kaohsiung 80708, Taiwan; 8School of Chinese Medicine, China Medical University, Taichung 40402, Taiwan; 9Department of Health and Nutrition Biotechnology, Asia University, Taichung 41354, Taiwan; 10Department of Gynecological Oncology, Qingdao Central Hospital, The Second Affiliated Hospital of Medical College of Qingdao University, Qingdao, 266042, People’s Republic of China; 11Department of Gynecological Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, People’s Republic of ChinaCorrespondence: Li SunDepartment of Gynecological Oncology, Qingdao Central Hospital, The Second Affiliated Hospital of Medical College of Qingdao University, Qingdao 266042, People&r

Published
2020

50. A More Diverse Cervical Microbiome Associates with Better Clinical Outcomes in Patients with Endometriosis

Author

Sheu, Jim Jinn-Chyuan, primary, Chang, Cherry Yin-Yi, additional, Chiang, An-Jen, additional, Lai, Ming-Tsung, additional, Yen, Man-Ju, additional, Tseng, Chung-Chen, additional, Lo, Lun-Chien, additional, Wan, Lei, additional, Li, Chia-Jung, additional, Tsui, Kuan-Hao, additional, Chen, Chih-Mei, additional, Hwang, Tritium, additional, and Tsai, Fuu-Jen, additional

Published
2021
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