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Your search keyword '"Sherwin, Eoin"' showing total 20 results
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20 results on '"Sherwin, Eoin"'

1. The live biotherapeutic Blautia stercoris MRx0006 attenuates social deficits, repetitive behaviour, and anxiety-like behaviour in a mouse model relevant to autism

Author

Sen, Paromita, Sherwin, Eoin, Sandhu, Kiran, Bastiaanssen, Thomaz F.S., Moloney, Gerard M., Golubeva, Anna, Fitzgerald, Patrick, Paula Ventura Da Silva, Ana, Chruścicka-Smaga, Barbara, Olavarría-Ramírez, Loreto, Druelle, Clementine, Campos, David, Jayaprakash, Pooja, Rea, Kieran, Jeffery, Ian B., Savignac, Helene, Chetal, Sasha, Mulder, Imke, Schellekens, Harriet, Dinan, Timothy G., and Cryan, John F.

Published
2022
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9. Contributors

Author

Barch, Deanna M., primary, Beckmann, Christian F., additional, Booij, Linda, additional, Cicchetti, Dante, additional, Coffey, Eleanor T., additional, Doucet, Marika V., additional, Frodl, Thomas, additional, Harkin, Andrew, additional, Hegerl, Ulrich, additional, Hensch, Tilman, additional, Hirota, Tomoya, additional, Levesque, Melissa L., additional, Manning, Kevin J., additional, McNicholas, Fiona, additional, Milavić, Gordana, additional, Mohammad, Hasan, additional, Mueller, Bernhard, additional, Mulders, Peter C., additional, Müller, Norbert, additional, O'Keane, Veronica, additional, O'Toole, Eileen, additional, Pagliaccio, David, additional, Sander, Christian, additional, Sherwin, Eoin, additional, Skokauskas, Norbert, additional, Steffens, David C., additional, Szyf, Moshe, additional, Tendolkar, Indira, additional, van Eijndhoven, Philip F., additional, Varidaki, Artemis, additional, and Young, Christina B., additional

Published
2016
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12. The Microbiota-Gut-Brain Axis

Author

Cryan, John F., primary, O'Riordan, Kenneth J., additional, Cowan, Caitlin S. M., additional, Sandhu, Kiran V., additional, Bastiaanssen, Thomaz F. S., additional, Boehme, Marcus, additional, Codagnone, Martin G., additional, Cussotto, Sofia, additional, Fulling, Christine, additional, Golubeva, Anna V., additional, Guzzetta, Katherine E., additional, Jaggar, Minal, additional, Long-Smith, Caitriona M., additional, Lyte, Joshua M., additional, Martin, Jason A., additional, Molinero-Perez, Alicia, additional, Moloney, Gerard, additional, Morelli, Emanuela, additional, Morillas, Enrique, additional, O'Connor, Rory, additional, Cruz-Pereira, Joana S., additional, Peterson, Veronica L., additional, Rea, Kieran, additional, Ritz, Nathaniel L., additional, Sherwin, Eoin, additional, Spichak, Simon, additional, Teichman, Emily M., additional, van de Wouw, Marcel, additional, Ventura-Silva, Ana Paula, additional, Wallace-Fitzsimons, Shauna E., additional, Hyland, Niall, additional, Clarke, Gerard, additional, and Dinan, Timothy G., additional

Published
2019
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14. Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism

Author

Science Foundation Ireland, Irish Government, European Commission, Mead Johnson Nutrition, Golubeva, Anna V., Joyce, Susan A., Moloney, Gerard, Burokas, Aurelijus, Sherwin, Eoin, Arboleya, Silvia, Flynn, Ian, Khochanskiy, Dmitry, Moya-Pérez, Angela, Peterson, Veronica, Rea, Kieran, Murphy, Kiera, Makarova, Olga, Buravkov, Sergey, Hyland, Niall P., Stanton, Catherine, Clarke, Gerard, Gahan, Cormac G. M., Dinan, Timothy G., Cryan, John F., Science Foundation Ireland, Irish Government, European Commission, Mead Johnson Nutrition, Golubeva, Anna V., Joyce, Susan A., Moloney, Gerard, Burokas, Aurelijus, Sherwin, Eoin, Arboleya, Silvia, Flynn, Ian, Khochanskiy, Dmitry, Moya-Pérez, Angela, Peterson, Veronica, Rea, Kieran, Murphy, Kiera, Makarova, Olga, Buravkov, Sergey, Hyland, Niall P., Stanton, Catherine, Clarke, Gerard, Gahan, Cormac G. M., Dinan, Timothy G., and Cryan, John F.

Abstract

Autism spectrum disorder (ASD) is one of the most prevalent neurodevelopmental conditions worldwide. There is growing awareness that ASD is highly comorbid with gastrointestinal distress and altered intestinal microbiome, and that host-microbiome interactions may contribute to the disease symptoms. However, the paucity of knowledge on gut-brain axis signaling in autism constitutes an obstacle to the development of precision microbiota-based therapeutics in ASD. To this end, we explored the interactions between intestinal microbiota, gut physiology and social behavior in a BTBR T+ Itpr3tf/J mouse model of ASD. Here we show that a reduction in the relative abundance of very particular bacterial taxa in the BTBR gut – namely, bile-metabolizing Bifidobacterium and Blautia species, - is associated with deficient bile acid and tryptophan metabolism in the intestine, marked gastrointestinal dysfunction, as well as impaired social interactions in BTBR mice. Together these data support the concept of targeted manipulation of the gut microbiota for reversing gastrointestinal and behavioral symptomatology in ASD, and offer specific plausible targets in this endeavor.

Published
2017

15. Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism

Author

Golubeva, Anna V., primary, Joyce, Susan A., additional, Moloney, Gerard, additional, Burokas, Aurelijus, additional, Sherwin, Eoin, additional, Arboleya, Silvia, additional, Flynn, Ian, additional, Khochanskiy, Dmitry, additional, Moya-Pérez, Angela, additional, Peterson, Veronica, additional, Rea, Kieran, additional, Murphy, Kiera, additional, Makarova, Olga, additional, Buravkov, Sergey, additional, Hyland, Niall P., additional, Stanton, Catherine, additional, Clarke, Gerard, additional, Gahan, Cormac G.M., additional, Dinan, Timothy G., additional, and Cryan, John F., additional

Published
2017
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19. Recent developments in understanding the role of the gut microbiota in brain health and disease.

Author

Sherwin, Eoin, Dinan, Timothy G., and Cryan, John F.

Subjects
*GUT microbiome, *NEURODEGENERATION, *MENTAL depression, *PARKINSON'S disease, *ALZHEIMER'S disease
Abstract

Abstract: There is a growing appreciation of the role of the gut microbiota in all aspects of health and disease, including brain health. Indeed, roles for the bacterial commensals in various psychiatric and neurological conditions, such as depression, autism, stroke, Parkinson's disease, and Alzheimer's disease, are emerging. Microbiota dysregulation has been documented in all of these conditions or in animal models thereof. Moreover, depletion or modulation of the gut microbiota can affect the severity of the central pathology or behavioral deficits observed in a variety of brain disorders. However, the mechanisms underlying such effects are only slowly being unraveled. Additionally, recent preclinical and clinical evidence suggest that targeting the microbiota through prebiotic, probiotic, or dietary interventions may be an effective “psychobiotic” strategy for treating symptoms in mood, neurodevelopmental disorders, and neurodegenerative diseases. [ABSTRACT FROM AUTHOR]

Published
2018
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