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BACKGROUND: Limb-threatening ischemia is one of more important problem of fundamental and practice modern angiology. Despite the development of modern diagnostic and therapeutic approaches good results, Limb-Threatening Ischemia deserves special attention and occupies a special place among medical, biomedical and socio-economic problems. A comprehensive study will make it possible to develop new approaches, the result of which should be a decrease in the total number of diseases, as well as a minimization of complications leading to large-scale tissue losses and amputations. OBJECTIVE: We set out to develop a new non-invasive method for studying microcirculation in patients with limb-threatening ischemia. METHODS: We investigated control group and adults of both sexes (age: 50–75 years) with a confirmed diagnosis of the claudication. Men and women in ratio 1 : 1 in control and target groups. RESULTS: The research results showed that the original microcirculation coefficient calculated according to our algorithm in patients with intermittent claudication was 70% better than in the control group and 120% of patients were worse than in patients with Limb-Threatening Ischemia. CONCLUSION: Our research team created an original so called coefficient of microcirculation. In order to determine it, we studied the blood flow in the pulsations on the left and right side of the posterior tibial arteries of the legs at rest (names of lines SIN F, DEX F) and during post-ischemic hyperemia in the same lines. The study of microcirculation based on the microcirculation coefficient is very informative. The importance of this methodology for studying the total peripheral blood flow and arteriolar response is due to fundamental and clinical developments, as well as financial costs. Considering the technique described in the article can be easily mastered by medical personnel, it is easy to use in the inpatient and outpatient sectors, its use does not require large areas of the medical facility, the equipment is not expensive and the test itself does not cause inconvenience to the patient, then we can recommend including the described method is included in the list of functional diagnostic tests as a direct and quantitative method for determining microcirculation (without special costs on the part of medical institutions, insurance companies and the patient). [ABSTRACT FROM AUTHOR]