Search

Your search keyword '"Sherman T"' showing total 466 results
Start Over Author "Sherman T"
466 results on '"Sherman T"'

1. Design of AIEgens for near-infrared IIb imaging through structural modulation at molecular and morphological levels

Author

Yuanyuan Li, Zhaochong Cai, Shunjie Liu, Haoke Zhang, Sherman T. H. Wong, Jacky W. Y. Lam, Ryan T. K. Kwok, Jun Qian, and Ben Zhong Tang

Subjects
Science
Abstract

Light has limited penetration depth in vivo which has led to increasing interest in NIR-II fluorophores. Here, the authors report on the design and testing of an organic aggregation induced emission fluorophore with high quantum yield and demonstrate imaging of vasculature and intestines in live mice.

Published
2020
Full Text
View/download PDF

2. Fluorogenic substrates for high-throughput measurements of endothelial lipase activity

Author

Lyndon J. Mitnaul, Jenny Tian, Charlotte Burton, My-Hanh Lam, Yuping Zhu, Steve H. Olson, Jonathan E. Schneeweis, Paul Zuck, Shilpa Pandit, Matt Anderson, Milana M. Maletic, Sherman T. Waddell, Samuel D. Wright, Carl P. Sparrow, and Erik G. Lund

Subjects
bodipy-labeled, synthetic high density lipoprotein, micelles, Biochemistry, QD415-436
Abstract

Endothelial lipase (EL) has been shown to be a critical determinant for high density lipoprotein cholesterol levels in vivo; therefore, assays that measure EL activity have become important for the discovery of small molecule inhibitors that specifically target EL. Here, we describe fluorescent Bodipy-labeled substrates that can be used in homogeneous, ultra-high-throughput kinetic assays that measure EL phospholipase or triglyceride lipase activities. Triton X-100 detergent micelles and synthetic HDL particles containing Bodipy-labeled phospholipid or Bodipy-labeled triglyceride substrates were shown to be catalytic substrates for EL, LPL, and HL. More importantly, only synthetic HDL particles containing Bodipy-labeled triglyceride were ideal substrates for EL, LPL, and HL in the presence of high concentrations of human or mouse serum. These data suggest that substrate presentation is a critical factor when determining EL activity in the presence of serum.

Published
2007
Full Text
View/download PDF

3. Constraints on the Physical Properties of GW190814 through Simulations based on DECam Follow-up Observations by the Dark Energy Survey

Author

Morgan, R., Soares-Santos, M., Annis, J., Herner, K., Garcia, A., Palmese, A., Drlica-Wagner, A., Kessler, R., Garcia-Bellido, J., Sherman, T. G. Bachmann N., Allam, S., Bechtol, K., Bom, C. R., Brout, D., Butler, R. E., Butner, M., Cartier, R., Chen, H., Conselice, C., Cook, E., Davis, T. M., Doctor, Z., Farr, B., Figueiredo, A. L., Finley, D. A., Foley, R. J., Galarza, J. Y., Gill, M. S. S., Gruendl, R. A., Holz, D. E., Kuropatkin, N., Lidman, C., Lin, H., Malik, U., Mann, A. W., Marriner, J., Marshall, J. L., Martinez-Vazquez, C. E., Meza, N., Neilsen, E., Nicolaou, C., E., F. Olivares, Paz-Chinchon, F., Points, S., Quirola, J., Rodriguez, O., Sako, M., Scolnic, D., Smith, M., Sobreira, F., Tucker, D. L., Vivas, A. K., Wiesner, M., Wood, M. L., Yanny, B., Zenteno, A., Abbott, T. M. C., Aguena, M., Avila, S., Bertin, E., Bhargava, S., Brooks, D., Burke, D. L., Rosell, A. Carnero, Kind, M. Carrasco, Carretero, J., da Costa, L. N., Costanzi, M., De Vicente, J., Desai, S., Diehl, H. T., Doel, P., Eifler, T. F., Everett, S., Flaugher, B., Frieman, J., Gaztanaga, E., Gerdes, D. W., Gruen, D., Gschwend, J., Gutierrez, G., Hartley, W. G., Hinton, S. R., Hollowood, D. L., Honscheid, K., James, D. J., Kuehn, K., Lahav, O., Lima, M., Maia, M. A. G., March, M., Miquel, R., Ogando, R. L. C., Plazas, A. A., Roodman, A., Sanchez, E., Scarpine, V., Schubnell, M., Serrano, S., Sevilla-Noarbe, I., Suchyta, E., and Tarle, G.

Subjects
Astrophysics - High Energy Astrophysical Phenomena, Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

On 14 August 2019, the LIGO and Virgo Collaborations detected gravitational waves from a black hole and a 2.6 solar mass compact object, possibly the first neutron star -- black hole (NSBH) merger. In search of an optical counterpart, the Dark Energy Survey (DES) obtained deep imaging of the entire 90 percent confidence level localization area with Blanco/DECam 0, 1, 2, 3, 6, and 16 nights after the merger. Objects with varying brightness were detected by the DES Pipeline and we systematically reduced the candidate counterparts through catalog matching, light curve properties, host-galaxy photometric redshifts, SOAR spectroscopic follow-up observations, and machine-learning-based photometric classification. All candidates were rejected as counterparts to the merger. To quantify the sensitivity of our search, we applied our selection criteria to full light curve simulations of supernovae and kilonovae as they would appear in the DECam observations. Since the source class of the merger was uncertain, we utilized an agnostic, three-component kilonova model based on tidally-disrupted NS ejecta properties to quantify our detection efficiency of a counterpart if the merger included a NS. We find that if a kilonova occurred during this merger, configurations where the ejected matter is greater than 0.07 solar masses, has lanthanide abundance less than $10^{-8.56}$, and has a velocity between $0.18c$ and $0.21c$ are disfavored at the $2\sigma$ level. Furthermore, we estimate that our background reduction methods are capable of associating gravitational wave signals with a detected electromagnetic counterpart at the $4\sigma$ level in $95\%$ of future follow-up observations., Comment: Published in ApJ

Published
2020
Full Text
View/download PDF

5. Characterizing Reactive Transport Behavior in a Three-Dimensional Discrete Fracture Network

Author

Sherman, T, Sole-Mari, G, Hyman, J, Sweeney, MR, Vassallo, D, and Bolster, D

Subjects
Applied Mathematics, Chemical Engineering, Civil Engineering, Environmental Engineering
Abstract

While several studies have linked network and in-fracture scale properties to conservative transport behavior in subsurface fractured media, studies on reactive transport cases remain relatively underdeveloped. In this study, we explore the behavior of an irreversible kinetic reaction during the interaction of two solute plumes, one consisting of species A and the other species B. When the plumes converge, these species react kinetically to form a new species C via A+ B→ kC. This reactive system is studied using a three-dimensional discrete fracture network (DFN) model coupled with reactive Lagrangian particle tracking. We find that the interplay of network topology and chemical properties of the reactive solutes controls reactive transport processes. The network topology drives species A and B together, and the chemical properties dictate whether and how quickly a reaction occurs. Results demonstrate that reactions are most likely to occur in high-velocity fractures that make up the network backbone. The interplay between species’ chemical properties and transport is characterized by a non-dimensional Damköhler (Da) number. We show that the spatial distribution of reactions is sensitive to Da, which subsequently influences late-time tailing behavior in outlet breakthrough time distributions. The results of this study provide initial insights into how an irreversible reaction occurs during transport in a fracture network, using a methodology that can be applied to study reactive transport in a wide range of fractured media environments and contexts.

Published
2021

7. Characterizing Reactive Transport Behavior in a Three-Dimensional Discrete Fracture Network

Author

Sherman, T, Sherman, T, Sole-Mari, G, Hyman, J, Sweeney, MR, Vassallo, D, Bolster, D, Sherman, T, Sherman, T, Sole-Mari, G, Hyman, J, Sweeney, MR, Vassallo, D, and Bolster, D

Abstract

While several studies have linked network and in-fracture scale properties to conservative transport behavior in subsurface fractured media, studies on reactive transport cases remain relatively underdeveloped. In this study, we explore the behavior of an irreversible kinetic reaction during the interaction of two solute plumes, one consisting of species A and the other species B. When the plumes converge, these species react kinetically to form a new species C via A+ B→ kC. This reactive system is studied using a three-dimensional discrete fracture network (DFN) model coupled with reactive Lagrangian particle tracking. We find that the interplay of network topology and chemical properties of the reactive solutes controls reactive transport processes. The network topology drives species A and B together, and the chemical properties dictate whether and how quickly a reaction occurs. Results demonstrate that reactions are most likely to occur in high-velocity fractures that make up the network backbone. The interplay between species’ chemical properties and transport is characterized by a non-dimensional Damköhler (Da) number. We show that the spatial distribution of reactions is sensitive to Da, which subsequently influences late-time tailing behavior in outlet breakthrough time distributions. The results of this study provide initial insights into how an irreversible reaction occurs during transport in a fracture network, using a methodology that can be applied to study reactive transport in a wide range of fractured media environments and contexts.

Published
2023

10. Perceptions and Actions of Distance Educators on Academic Procrastination.

Author

Wilkinson, T. W. and Sherman, T. M.

Abstract

Describes study of distance educators that investigated academic procrastination in telecommunications-based distance education programs in higher education. Perceptions of the causes of academic procrastination are examined, data collection techniques on academic procrastination is discussed, strategies to reduce procrastination are described, and additional research is suggested. (11 references) (LRW)

Published
1990

19. Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV-1 Protease Inhibitors

Author

Carolyn Bahnck-Teets, Xu Min, Lehua Chang, Tracy L. Diamond, M. Katharine Holloway, John F. Fay, David Jonathan Bennett, John A. Mccauley, Jurgen Schulz, Marie Loughran, Peter D. Williams, Alejandro Crespo, Andrew Stamford, Hua-Poo Su, Michael D. Miller, Kartik M. Keertikar, Christopher J. Bungard, Catherine M. Wiscount, Bin Zhong, Jeanine E. Ballard, Sherman T. Waddell, Steven S. Carroll, Tao Ji, Jesse J. Manikowski, Bin Hu, Xin-jie Chu, Gregori J. Morriello, William J. Morris, and Michael P. Dwyer

Subjects
chemistry.chemical_classification, Bicyclic molecule, biology, 010405 organic chemistry, Stereochemistry, Protease binding, Organic Chemistry, 010402 general chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, Sulfonamide, Enzyme binding, Aspartate binding, Piperazine, chemistry.chemical_compound, chemistry, HIV-1 protease, Drug Discovery, biology.protein, Protease inhibitor (pharmacology)
Abstract

Using the HIV-1 protease binding mode of MK-8718 and PL-100 as inspiration, a novel aspartate binding bicyclic piperazine sulfonamide core was designed and synthesized. The resulting HIV-1 protease inhibitor containing this core showed an 60-fold increase in enzyme binding affinity and a 10-fold increase in antiviral activity relative to MK-8718.

Published
2017
Full Text
View/download PDF

20. Preparative enzymatic synthesis and characterization of the cytoplasmic intermediates of murein biosynthesis

Author

Reddy, Sreelatha G., Waddell, Sherman T., Kuo, David W., Wong, Kenny K., and Pompliano, David L.

Subjects
Peptidoglycans -- Research, Biosynthesis -- Research, Pharmaceutical research -- Case studies, Chemistry
Abstract

A study on cell wall or murein biosynthesis and antibiotic preparations reports a unified protocol for the quick synthesis and purification of 10-100 mg quantities of murein substrates. A detailed characterization for each of the intermediates is provided including H and C nuclear magnetic resonance assignments, elemental analysis and mass spectral data. Many of the intermediates have not been chemically characterized in previous studies.

Published
1999

21. Design of AIEgens for Near-Infrared IIb Imaging Through Structural Modulation at Molecular and Morphological Levels

Author

Li, Yuanyuan CHEM, Cai, Zhaochong, Liu, Shunjie, Zhang, Haoke, Wong, Sherman T. H., Lam, Wing Yip, Kwok, Tsz Kin, Qian, Jun, Tang, Benzhong, Li, Yuanyuan CHEM, Cai, Zhaochong, Liu, Shunjie, Zhang, Haoke, Wong, Sherman T. H., Lam, Wing Yip, Kwok, Tsz Kin, Qian, Jun, and Tang, Benzhong

Abstract

Fluorescence imaging in near-infrared IIb (NIR-IIb, 1500–1700 nm) spectrum holds a great promise for tissue imaging. While few inorganic NIR-IIb fluorescent probes have been reported, their organic counterparts are still rarely developed, possibly due to the shortage of efficient materials with long emission wavelength. Herein, we propose a molecular design philosophy to explore pure organic NIR-IIb fluorophores by manipulation of the effects of twisted intramolecular charge transfer and aggregation-induced emission at the molecular and morphological levels. An organic fluorescent dye emitting up to 1600 nm with a quantum yield of 11.5% in the NIR-II region is developed. NIR-IIb fluorescence imaging of blood vessels and deeply-located intestinal tract of live mice based on organic dyes is achieved with high clarity and enhanced signal-to-background ratio. We hope this study will inspire further development on the evolution of pure organic NIR-IIb dyes for bio-imaging. © 2020, The Author(s).

Published
2020

22. Constraints on the Physical Properties of S190814bv through Simulations based on DECam Follow-up Observations by the Dark Energy Survey

Author

Morgan, R., Soares-Santos, M., Annis, J., Herner, K., Garcia, A., Palmese, A., Drlica-Wagner, A., Kessler, R., Garcia-Bellido, J., Sherman, T. G. Bachmann N., Allam, S., Bechtol, K., Bom, C. R., Brout, D., Butler, R. E., Butner, M., Cartier, R., Chen, H., Conselice, C., Cook, E., Davis, T. M., Doctor, Z., Farr, B., Figueiredo, A. L., Finley, D. A., Foley, R. J., Galarza, J. Y., Gill, M. S. S., Gruendl, R. A., Holz, D. E., Kuropatkin, N., Lidman, C., Lin, H., Malik, U., Mann, A. W., Marriner, J., Marshall, J. L., Martinez-Vazquez, C. E., Meza, N., Neilsen, E., Nicolaou, C., E., F. Olivares, Paz-Chinchon, F., Points, S., Quirola, J., Rodriguez, O., Sako, M., Scolnic, D., Smith, M., Sobreira, F., Tucker, D. L., Vivas, A. K., Wiesner, M., Wood, M. L., Yanny, B., Zenteno, A., Abbott, T. M. C., Aguena, M., Avila, S., Bertin, E., Bhargava, S., Brooks, D., Burke, D. L., Rosell, A. Carnero, Kind, M. Carrasco, Carretero, J., da Costa, L. N., Costanzi, M., De Vicente, J., Desai, S., Diehl, H. T., Doel, P., Eifler, T. F., Everett, S., Flaugher, B., Frieman, J., Gaztanaga, E., Gerdes, D. W., Gruen, D., Gschwend, J., Gutierrez, G., Hartley, W. G., Hinton, S. R., Hollowood, D. L., Honscheid, K., James, D. J., Kuehn, K., Lahav, O., Lima, M., Maia, M. A. G., March, M., Miquel, R., Ogando, R. L. C., Plazas, A. A., Roodman, A., Sanchez, E., Scarpine, V., Schubnell, M., Serrano, S., Sevilla-Noarbe, I., Suchyta, E., Tarle, G., Morgan, R., Soares-Santos, M., Annis, J., Herner, K., Garcia, A., Palmese, A., Drlica-Wagner, A., Kessler, R., Garcia-Bellido, J., Sherman, T. G. Bachmann N., Allam, S., Bechtol, K., Bom, C. R., Brout, D., Butler, R. E., Butner, M., Cartier, R., Chen, H., Conselice, C., Cook, E., Davis, T. M., Doctor, Z., Farr, B., Figueiredo, A. L., Finley, D. A., Foley, R. J., Galarza, J. Y., Gill, M. S. S., Gruendl, R. A., Holz, D. E., Kuropatkin, N., Lidman, C., Lin, H., Malik, U., Mann, A. W., Marriner, J., Marshall, J. L., Martinez-Vazquez, C. E., Meza, N., Neilsen, E., Nicolaou, C., E., F. Olivares, Paz-Chinchon, F., Points, S., Quirola, J., Rodriguez, O., Sako, M., Scolnic, D., Smith, M., Sobreira, F., Tucker, D. L., Vivas, A. K., Wiesner, M., Wood, M. L., Yanny, B., Zenteno, A., Abbott, T. M. C., Aguena, M., Avila, S., Bertin, E., Bhargava, S., Brooks, D., Burke, D. L., Rosell, A. Carnero, Kind, M. Carrasco, Carretero, J., da Costa, L. N., Costanzi, M., De Vicente, J., Desai, S., Diehl, H. T., Doel, P., Eifler, T. F., Everett, S., Flaugher, B., Frieman, J., Gaztanaga, E., Gerdes, D. W., Gruen, D., Gschwend, J., Gutierrez, G., Hartley, W. G., Hinton, S. R., Hollowood, D. L., Honscheid, K., James, D. J., Kuehn, K., Lahav, O., Lima, M., Maia, M. A. G., March, M., Miquel, R., Ogando, R. L. C., Plazas, A. A., Roodman, A., Sanchez, E., Scarpine, V., Schubnell, M., Serrano, S., Sevilla-Noarbe, I., Suchyta, E., and Tarle, G.

Abstract

On 14 August 2019, the LIGO and Virgo Collaborations alerted the astronomical community of a high significance detection of gravitational waves and classified the source as a neutron star - black hole (NSBH) merger, the first event of its kind. In search of an optical counterpart, the Dark Energy Survey (DES) Gravitational Wave Search and Discovery Team performed the most thorough and accurate analysis to date, targeting the entire 90 percent confidence level localization area with Blanco/DECam 0, 1, 2, 3, 6, and 16 nights after the merger was detected. Objects with varying brightness were detected by the DES Search and Discovery Pipeline and we systematically reduced the list of candidate counterparts through catalog matching, light curve properties, host-galaxy photometric redshifts, SOAR spectroscopic follow-up observations, and machine-learning-based photometric classification. All candidates were rejected as counterparts to the merger. To quantify the sensitivity of our search, we applied our selection criteria to simulations of supernovae and kilonovae as they would appear in the DECam observations. Since there are no explicit light curve models for NSBH mergers, we characterize our sensitivity with binary NS models that are expected to have similar optical signatures as NSBH mergers. We find that if a kilonova occurred during this merger, configurations where the ejected matter is greater than 0.07 solar masses, has lanthanide abundance less than $10^{-8.56}$, and has a velocity between $0.18c$ and $0.21c$ are disfavored at the $2\sigma$ level. Furthermore, we estimate that our background reduction methods are capable of associating gravitational wave signals with a detected electromagnetic counterpart at the $4\sigma$ level in $95\%$ of future follow-up observations., Comment: Submitted to ApJ

Published
2020
Full Text
View/download PDF

23. Comparative study of pattern recognition methods for predicting glaucoma diagnosis

Author

Chen, YW, Tanaka, S, Howlett, R, Jain, L, Williams, L, Waqar, S, Sherman, T, Masala, G, Chen, YW, Tanaka, S, Howlett, R, Jain, L, Williams, L, Waqar, S, Sherman, T, and Masala, G

Abstract

© The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd 2020. Glaucoma is the second leading cause of blindness globally; it is characterised by degeneration of the optic nerve with particular patterns of corresponding defects in the visual field. Aiding doctors in early diagnosis and detection of progression is crucial, as glaucoma is asymptomatic in nature. Furthermore there are good therapeutic results in early cases before irreversible visual loss occurs. Thus it is of great importance to find automated methods to discriminate glaucomatous diseases giving insight to doctors. In order to develop a Computer-Aided Diagnosis system (CAD), we realised an extensive competitive study of pattern recognition methods should be undertaken. A range of methods has been evaluated including the use of Deep Neural Networks (DNN), Support Vector Machines (SVM), Decision Trees (DT), and K-Nearest Neighbours (KNN) for diagnosing glaucoma. Using a range of classification techniques, this paper aims to diagnose glaucomatous diseases. Results have been produced with data comprising of Visual Field and OCT Disc readings from anonymous patients with and without glaucoma. Multiple systems are proposed that can predict diagnosis for ocular hypertension, primary open-angle glaucoma, normal tension glaucoma, and healthy patients with a reasonable confidence. Best performance has been obtained from voting classier comprised of SVM and KNN at 0.87 (AUC) and DNN at 0.87 (AUC) which possibly could be used as an automatic diagnosis aid in order to streamline the diagnosis of glaucoma for complex cases or flagging of urgent cases.

Published
2020

24. Design of AIEgens for Near-Infrared IIb Imaging Through Structural Modulation at Molecular and Morphological Levels

Author

Li, Yuanyuan, Cai, Zhaochong, Liu, Shunjie, Zhang, Haoke, Wong, Sherman T. H., Lam, Wing Yip, Kwok, Tsz Kin, Qian, Jun, Tang, Benzhong, Li, Yuanyuan, Cai, Zhaochong, Liu, Shunjie, Zhang, Haoke, Wong, Sherman T. H., Lam, Wing Yip, Kwok, Tsz Kin, Qian, Jun, and Tang, Benzhong

Abstract

Fluorescence imaging in near-infrared IIb (NIR-IIb, 1500–1700 nm) spectrum holds a great promise for tissue imaging. While few inorganic NIR-IIb fluorescent probes have been reported, their organic counterparts are still rarely developed, possibly due to the shortage of efficient materials with long emission wavelength. Herein, we propose a molecular design philosophy to explore pure organic NIR-IIb fluorophores by manipulation of the effects of twisted intramolecular charge transfer and aggregation-induced emission at the molecular and morphological levels. An organic fluorescent dye emitting up to 1600 nm with a quantum yield of 11.5% in the NIR-II region is developed. NIR-IIb fluorescence imaging of blood vessels and deeply-located intestinal tract of live mice based on organic dyes is achieved with high clarity and enhanced signal-to-background ratio. We hope this study will inspire further development on the evolution of pure organic NIR-IIb dyes for bio-imaging. © 2020, The Author(s).

Published
2020

26. Laparoscopy in management of appendicitis in high, middle and low income countries: A multicenter, prospective, cohort study

Author

Drake, TM, Camilleri-Brennan, J, Tabiri, S, Fergusson, SJ, Spence, R, Fitzgerald, JEF, Bhangu, A, Harrison, EM, Ademuyiwa, AO, Fergusson, S, Glasbey, JC, Khatri, C, Mohan, M, Nepogodiev, D, Soreide, K, Gobin, N, Freitas, AV, Hall, N, Kim, S-H, Negida, A, Jaffry, Z, Chapman, SJ, Arnaud, AP, Recinos, G, Manipal, CE, Amandito, R, Shawki, M, Hanrahan, M, Pata, F, Zilinskas, J, Roslani, AC, Goh, CC, Irwin, G, Shu, S, Luque, L, Shiwani, H, Altamimi, A, Alsaggaf, MU, Rayne, S, Jeyakumar, J, Cengiz, Y, Raptis, DA, Fermani, C, Balmaceda, R, Marta Modolo, M, Macdermid, E, Chenn, R, Yong, CO, Edye, M, Jarmin, M, D'amours, SK, Iyer, D, Youssef, D, Phillips, N, Brown, J, George, R, Koh, C, Warren, O, Hanley, I, Dickfos, M, Nawara, C, Oefner, D, Primavesi, F, Mitul, AR, Mahmud, K, Hussain, M, Hakim, H, Kumar, T, Oosterkamp, A, Assouto, PA, Lawani, I, Souaibou, YI, Tun, AK, Chong, CL, Devadasar, GH, Qadir, MRM, Aung, KP, Yeo, LS, Palomino Castillo, VD, Munhoz, MM, Moreira, G, Barros De Castro Segundo, LC, Khouri Ferreira, SA, Careta, MC, Kim, SB, De Sousa, AV, Lazzarini Cury, AD, Soares Miguel, GP, Carreiro De Freitas, AV, Silvestre, BP, Pinto Vianna, JG, Felipe, CO, Valente Laufer, LA, Altoe, F, Da Silva, LA, Pimenta, ML, Giuriato, TF, Bezerra Morais, PA, Luiz, JS, Araujo, R, Menegussi, J, Leal, M, Barroso de Lima, CV, Tatagiba, LS, Leal, A, Dos Santos, DV, Fraga, GP, Simoes, RL, Stock, S, Nigo, S, Kabba, J, Ngwa, TE, King, S, Zani, A, Azzie, G, Firdouse, M, Kushwaha, S, Agarwal, A, Bailey, K, Cameron, B, Livingston, M, Horobjowsky, A, Deckelbaum, DL, Razek, T, Marinkovic, B, Grasset, E, D'aguzan, N, Jimenez, J, Macchiavello, R, Zhang, Z, Guo, W, Oh, J, Zheng, F, Montes, I, Sierra, S, Mendez, M, Isabel Villegas, M, Mendoza Arango, MC, Mendoza, I, Naranjo Aristizabal, FA, Montoya Botero, JA, Quintero Riaza, VM, Restrepo, J, Morales, C, Cruz, H, Munera, A, Karlo, R, Domini, E, Mihanovic, J, Radic, M, Zamarin, K, Pezelj, N, Hache-Marliere, M, Batista Lemaire, S, Rivas, R, Khyrallh, A, Hassan, A, Shimy, G, Fahmy, MAB, Nabawi, A, Elfil, M, Ghoneem, M, Gohar, ME-SAM, Asal, M, Abdelkader, M, Gomah, M, Rashwan, H, Karkeet, M, Gomaa, A, Hasan, A, Elgebaly, A, Saleh, O, Fattah, AA, Gouda, A, Elshafay, AE, Gharib, A, Menshawy, A, Hanafy, M, Al-Mallah, A, Abdulgawad, M, Baheeg, M, Alhendy, M, AbdelFattah, I, Kenibar, A, Osman, O, Gemeah, M, Mohammed, A, Adel, A, Sayed, A, Abozaid, M, Kotb, AHE-B, Ata, AAA, Nasr, M, Alkammash, A, Saeed, M, Abd El Hamid, N, Attia, AM, Abd El Galeel, A, Elbanby, E, El-Dien, KS, Hantour, U, Alahmady, O, Mansour, B, Elkorashy, AM, Taha, EMS, Lasheen, KT, Elkolaly, SS, Abdel-Wahab, NYE, Abozyed, MAF, Saeed, AM, El Sayed, GS, Youssif, JH, Ahmed, SM, El-Shahat, NS, Khedr, AE-RH, Elsebaaye, AO, Elzayat, M, Abdelraheim, M, Elzayat, I, Warda, M, El Deen, KN, Elnemr, AE, Salah, O, Abbas, M, Rashad, M, Elzayyat, I, Hemeda, D, Tawfik, G, Salama, M, Khaled, H, Seisa, M, Elshaer, K, Hussein, A, Elkhadrawi, M, Afifi, AM, Ebrahim, OS, Metwally, MM, Elmelegy, R, Elsawahly, DME, Safa, H, Nofal, E, Elbermawy, M, Ghazy, AA, Samih, H, Abdelgelil, A, Abdelghany, S, El Kholy, A, Aboraya, M, Elkady, F, Salma, M, Samy, S, Fakher, R, Aboarab, A, Samir, A, Sakr, A, Haroun, A, Al-Aarag, AA-R, Elkholy, A, Elshanwany, S, Ghanem, E, Tammam, A, Hammad, AM, El Shoura, Y, El Ashal, G, Khairy, H, Antar, S, Mehrez, S, Abdelshafy, M, Hamad, MGM, Hosh, M, Abdallah, E, Magdy, B, Alzayat, T, Gamaly, E, Elfeki, H, Abouzahra, A, Elsheikh, S, Elgendy, FI, Abd El-Salam, F, Seifelnasr, O, Ammar, M, Eysa, A, Sadek, A, Toeema, AG, Nasr, A, Abuseif, M, Zidan, H, Barakat, SAE, Elsayed, N, Abd Elrasoul, Y, Elkelany, A, Ammar, MS, Mustafa, M-A, Hegazy, Y, Etman, M, Saad, S, Alrahawy, M, Raslan, A, Morsi, M, Rslan, A, Sabry, A, Elwakil, H, Shaker, H, Abd-Elrasoul, Y, El-Kashef, H, Shaalan, M, Tarek, A, Elwan, A, Nayel, AR, Seif, M, Emadeldin, D, Ghonaim, MA, Almallah, A, Fouad, A, Sayma, EA, Elbatahgy, A, El-Ma'doul, AS, Mosad, A, Tolba, H, Elsorogy, DEAA, Mostafa, HA, Omar, AA, Abd El Hameed, OS, Lasheen, A, Abd El Salam, Y, Morsi, A, Ismail, M, El-badawy, HA, Amer, MA, El-Hamouly, AS, Attallah, NA, Mosalum, O, Afandy, A, Mokhtar, A, Abouelnasr, A, Ayad, S, Shaker, R, Sakr, R, Amreia, M, Elsobky, S, Mustafa, M, El Magd, AA, Marey, A, Hafez, AT, Zalabia, MF, Mohamed, MM, Fadel, A, Ahmed, EA, Ali, A, Alwafai, MG, Dwydar, A, Kharsa, S, Mamdouh, E, El-Sheemy, H, AlYoussef, I, Aly, AK, Aldalaq, A, Alnawam, E, Alkhabbaz, D, Saad, M, Hussein, S, Elazayem, AA, Meshref, A, Elashmawy, M, Mousa, M, Nashaat, A, Ghanem, S, Elsayed, ZM, Elwaey, A, Elkadsh, I, Darweesh, M, Mohameden, A, Hafez, M, Badr, A, Badwy, A, Abd El Slam, M, Elazoul, M, Al-Nahrawi, S, Eldamaty, L, Nada, F, Ameen, M, Hagar, A, Elsehimy, M, Dawoud, H, El Mesery, S, El Gendy, A, Abdelkareem, A, Marey, AS, Allam, M, Shehata, S, Abozeid, K, Elshobary, M, Fahiem, A, Sarsik, S, Hashish, A, Zidan, M, Hashish, M, Aql, S, Elhendawy, AOA, Husseini, M, Kasem, E, Gheith, A, Elfouly, Y, Soliman, AR, Ibrahim, Y, Elfouly, N, Fawzy, A, Rashid, M, Elsherbiny, AS, Sieda, B, Badwi, NM, Mohammed, MMH, Mohamed, O, Habeeb, MA, Worku, M, Starr, N, Desta, S, Wondimu, S, Abebe, NS, Thomas, E, Asele, FA, Dabessa, D, Zerihun, AB, Mentula, P, Leppaniemi, A, Sallinen, V, Scalabre, A, Frade, F, Irtan, S, Graffeille, V, Gaignard, E, Alimi, Q, Graffieille, V, Abbo, O, Mouttalib, S, Bouali, O, Hervieux, E, Aigrain, Y, Botto, N, Faure, A, Fievet, L, Panait, N, Eyssartier, E, Schmitt, F, Podevin, G, Parent, V, Martin, A, Muller, C, Bonnard, A, Peycelon, M, Abantanga, F, Boakye-Yiadom, K, Bukari, M, Owusu, F, Awuku-Asabre, J, Bray, LD, Lytras, D, Psarianos, K, Bamicha, A, Kefalidi, E, Gemenetzis, G, Dervenis, C, Gouvas, N, Agalianos, C, Kontos, M, Kouraklis, G, Karousos, D, Germanos, S, Marinos, C, Anthoulakis, C, Nikoloudis, N, Mitroudis, N, Estupinian, S, Forno, W, Arevalo Azmitia, JR, Ramarez Cabrera, CC, Guevara, R, Aguilera, M, Mendez, N, Azmitia Mendizabal, CA, Ramazzini, P, Contreras Urquizu, M, Tale, F, Soley, R, Barrios, E, Marroquin Rodriguez, DE, Perez Velasquez, CI, Contreras Merida, SM, Regalado, F, Lopez, M, Siguantay, M, Lam, FY, Szeto, KJ-Y, Szeto, CCL, Li, WS, Li, KKK, Leung, MF, Mak, T, Ng, S, Prasad, SS, Kirishnan, A, Gyanchandani, N, Kumar, BS, Rangarajan, M, Bhat, S, Sreedharan, A, Kinnera, SV, Reddy, Y, Venugopal, C, Kumar, S, Mittal, A, Nadkarni, S, Lakshmi, HN, Malik, P, Limaye, N, Pai, S, Jain, P, Khajanchi, M, Satoskar, S, Satoskar, R, Bin Mahamood, A, Sutanto, EPR, Soeselo, DA, Tedjaatmadja, C, Rahmawati, FN, Mayasari, M, Al-Hasani, RKMJ, Al-Hameedi, HII, Ibraheem, HI, Al-Azraqi, IAA, Sabeeh, L, Kamil, R, Telfah, MM, Rasendran, A, Sheehan, J, Kerley, R, Normile, C, Gilbert, RW, Song, J, Dablouk, M, Mauro, L, Dablouk, MO, Kielty, P, Marks, E, Gosling, S, Mccarthy, M, Mirghani, D, Naqvi, SA, Wong, CS, Chung, S, D'cruz, R, Cahill, R, Gosling, SG, Fahy, C, Cadogan, DD, Powell, A, Gilbert, R, Clifford, C, Driscoll, A, Paul, S, Lee, C, Bowe, R, Hutch, W, Mohan, H, O'neill, M, Mealy, K, Danelli, P, Bondurri, A, Maffioli, A, Pasini, M, Pata, G, Roncali, S, Silvani, P, Carlucci, M, Faccincani, R, Bonavina, L, Macchitella, Y, Ceriani, C, Tugnoli, G, Di Saverio, S, Khattab, K, Paludi, MA, Pata, D, Cloro, LM, Allegri, A, Ansaloni, L, Coccolini, F, Veronese, E, Bortolasi, L, Hasheminia, A, Nastri, G, Dal Canto, M, Cucumazzo, S, Benevento, A, Tessera, G, Grandinetti, PP, Maniscalco, A, Lamanna, GL, Turati, L, Sgroi, G, Rausa, E, Villa, R, Monteleone, M, Merlini, D, Grassi, V, Cirocchi, R, Cacurri, A, Waleed, H, Diab, A, Elzowawi, F, Jokubauskas, M, Varkalys, K, Venskutonis, D, Pranevicius, R, Ambrozeviciute, V, Juciute, S, Skardziukaite, A, Bradulskis, S, Urbanavicius, L, Austraite, A, Riauka, R, Dambrauskas, Z, Karumnas, P, Urniezius, Z, Zilinskiene, R, Rudzenskaite, A, Usaityte, A, Montrimaite, M, Kaselis, N, Strazdas, A, Jokubonis, K, Maceviciute, K, Beisa, V, Poskus, T, Strupas, K, Laugzemys, E, Kolosov, A, Jotautas, V, Rakita, I, Mikalauskas, S, Kazanavicius, D, Rackauskas, R, Rakauskas, R, Preckailaite, E, Coomber, R, Johnson, K, Nowers, J, Periasammy, D, Salleh, A, Das, A, Tze, RGE, Kumar, MN, Abdullah, NAN, Kosai, NR, Taher, M, Rajan, R, Chong, HY, Agius, M, Borg, E, Bezzina, M, Bugeja, R, Vella-Baldacchino, M, Spina, A, Psaila, J, Francois-Coridon, H, Tolg, C, Colombani, J-F, Diaz-Zorrilla, C, Ramos-De La Medina, A, Corro-Diaz Gonzalez, S, Jacobe, M, Mapasse, D, Snyder, E, Oumer, R, Osman, M, Mohammad, A, Anyanwu, L-J, Sheshe, A, Adesina, A, Faturoti, O, Taiwo, O, Ibrahim, MH, Nasir, AA, Suleiman, SI, Adeniyi, A, Adesanya, O, Adebanjo, A, Osuoji, R, Atobatele, K, Ogunyemi, A, Williams, O, Oludara, M, Oshodi, O, Ademuyiwa, A, Lawal, AO, Alakaloko, F, Elebute, O, Osinowo, A, Bode, C, Adesuyi, A, Tade, A, Adekoya, A, Nwokoro, C, Ayandipo, OO, Lawal, TA, Ajao, AE, Ali, SS, Odeyemi, B, Olori, S, Popoola, A, Adeyeye, A, Adeniran, J, Lossius, WJ, Havemann, I, Thorsen, K, Narvestad, JK, Wold, TB, Nymo, L, Elsiddig, M, Dar, M, Bhopal, KF, Iftikhar, Z, Furqan, MM, Nighat, B, Jawaid, M, Khalique, A, Zil-E-Ali, A, Rashid, A, Dharamshi, HA, Naqvi, T, Faraz, A, Anwar, AW, Yaseen, TM, Shamsi, GS, Shamsi, G, Yaseen, T, Anwer, W, Paredes Decoud, H, Aguilera, O, Zelada Alvarez, II, Marcelo Delgado, J, Machain Vega, GM, Segovia Lohse, HA, Messa Aguilar, WL, Cabala Chiong, JA, Manchego Bautista, AC, Huaman, E, Zegarra, S, Camacho, R, Vergara Celis, JM, Romani Pozo, DA, Hamasaki, J, Temoche, E, Herrera-Matta, J, Garcia Torres, CP, Alvarez Barreda, LM, Barrionuevo Ojeda, RR, Garaycochea, O, Castro Mollo, M, Linares Delgado, MSDFT, Fujii, F, Aranzabal Durand, SY, Arroyo Basto, CA, Urbina Rojas, NM, Shu Yip, SB, Contreras Vergara, AL, Rosas Moran, AE, Borda Luque, G, Rodriguez Castro, M, Alvarado Jaramillo, R, Manrique Sila, G, Elizabeth Lopez, C, Zapata Ponze De Leon, M, Machaca, M, Coasaca Huaraya, R, Arenas, A, Lopez, C, Herrera Puma, CM, Pino, W, Hinojosa, C, Limache, S, Manrrique Sila, G, Mercado Rodriguez, L-A, Melo, R, Costa-Maia, J, Muralha, N, Sauvat, F, Dan, I, Hogea, M, Eduard, P, Bratu, R-M, Beuran, M, Diaconescu, I-B, Martian, B-V, Iordache, F-M, Vartic, M, Vida, LC, Muntean, LI, Mironescu, AS, Nsengimana, VJP, Niragire, A, Ingabire, JDLCA, Niyirera, E, Zanini, N, Jovine, E, Landolfo, G, Alomar, IN, Alnuqaydan, SA, Altwigry, AM, Othman, M, Osman, N, Alqahtani, E, Alzahrani, M, Alyami, R, Aljohani, E, Alhabli, I, Mikwar, Z, Almuallem, S, Nawawi, A, Bakhaidar, M, Maghrabi, AA, Alsaggaf, M, Aljiffry, M, Altaf, A, Khoja, A, Habeebullah, A, Akeel, N, Ghandora, N, Almoflihi, A, Huwait, A, Al-shammari, A, Al-Mousa, M, Alghamdi, M, Adham, W, Albeladi, B, Alfarsi, MA, Mahdi, A, Al Awwad, S, Nouh, T, Hassanain, M, Aldhafeeri, S, Sadig, N, Algohary, O, Aledrisy, M, Gudal, A, Alrifaie, A, AlRowais, M, Althwainy, A, Shabkah, A, Alamoudi, U, Alrajraji, M, Alghamdi, B, Aljohani, S, Daqeeq, A, Al-Faifi, JJ, Jennings, V, Ngayu, N, Moore, R, Kong, V, Kretzmann, H, Connor, K, Nel, D, Sampson, C, Panieri, E, Sishuba, N, Tun, M, Mphatsoe, AM, Carreira, J-A, Teasdale, E, Wagener, M, Botes, S, Du Plessis, D, Fernandez-Bueno, F, Aguilar-Jimenez, J, Andres Garcia-Marin, J, Solar Garcia, L, Garcia Florez, LJ, Arias Pacheco, RD, Pagnozzi, J, Jara Quezada, JH, Luis Rodicio, J, Minguez, G, Rodriguez-Uria, R, Ugalde, P, Lopez-Arevalo, C, Barneo, L, Gonzales Stuva, JP, Ortega-Vazquez, I, Rodriguez, L, Herrera, N, Arachchi, PP, Senanayake, WSMKJ, Arachchige, LAJJ, Sivaganesh, S, Samaraweera, DI, Thanusan, V, Musa, AEK, Balila, RMH, Mohamed, MAEH, Ali, H, Elabdin, HZ, Mahdi, S, Ahmed, H, Idris, SAI, Elsayed, M, Mahmoud, M, Boijsen, M, Lundgren, P-O, Gustafsson, U, Kiasat, A, Wogensen, F, Jurdell, E, Thorell, A, Thorarinsdottir, H, Utter, M, Sundstrom, SM, Wredberg, C, Kjellin, A, Nyberg, J, Frisk, B, Sund, M, Andersson, L, Gunnarsson, U, Ahlqvist, S, Bjorklund, I, Royson, H, Weber, P, Pahlsson, H-I, Borin, E, Hjertberg, M, Schmid, R, Schivo, D, Despotidis, V, Breitenstein, S, Staerkle, RF, Schadde, E, Deichsel, F, Gerosa, A, Nocito, A, Mijuskovic, B, Zuber, M, Eisner, L, Kruspi, S, Reinisch, KB, Schoewe, C, Novak, A, Palma, AF, Teufelberger, G, Kimaro, M, King, R, Balkan, AZA, Gumar, M, Yavuz, MA, Karabacak, U, Lap, G, Ozkan, BB, Karakahya, M, Adams, R, Morton, R, Henderson, L, Gratton, R, Clement, KD, Chang, KY-C, Mcnish, D, Mcintosh, R, Milligan, W, Skelly, B, Anderson-Knight, H, Lawther, R, Onimowo, J, Shatkar, V, Tharmalingam, S, Woin, E, Fautz, T, Ziff, O, Dindyal, S, Arman, S, Talukder, S, Gadhvi, V, Chew, LS, Heath, J, Blencowe, N, Hallam, S, Gash, K, Mannu, GS, Zachariades, D-C, Snaith, AC, Hettiarachchi, TS, Nesaratnam, A, Wheeler, J, McCullagh, D, Clements, JM, Khan, A, Koumpa, F, Neophytou, C, Roth, J, Soon, WC, Deputy, M, Ahmed, A, Ashton, A, Vincent, J, Almy, J, Khan, T, Allen, JLY, Mcintyre, CJ, Marshall, DC, Sykes, M, Behar, N, Jordan, H, Rajjoub, Y, Sherman, T, White, T, Watts, A, Ardley, R, Arulampalam, T, Shah, A, Brown, D, Blower, E, Sutton, P, Gasteratos, K, Vimalachandran, D, Magee, C, Mcguigan, A, Mcaleer, S, Morgan, C, Braungart, S, Lafferty, K, Labib, P, Tanase, A, Mangan, C, Reza, L, Woodward, H, Gouldthorpe, C, Turner, M, Wild, JRL, Malik, TAM, Proctor, VK, Hewage, K, Davies, J, Dubois, A, Sarwary, S, Zardab, A, Grant, A, Mcintyre, R, Mogan, YP, Ho, W, Chong, BFHK, Tewari, S, Humm, G, Farinella, E, Hall, NJ, Wright, NJ, Major, CP, Xerri, T, Amin, J, Farhad, M, Camilleri-Brennan, JF, Robertson, AGN, Swann, J, Richards, J, Jabbar, A, De Bono, P, Attard, M, Burns, H, Macdonald, E, Baldacchino, M, Skehan, J, Hall, TF, Gimzewska, M, Mclachlan, G, Shah, J, Giles, J, Chiu, S, Weber, B, Chiu, SMY, Highcock, S, Hassan, M, Beasley, W, Vlachogiorgos, A, Dias, S, Maharaj, G, Mcdonald, R, Macdonald, A, Witherspoon, P, Baird, A, Sarmah, P, Green, N, Youssef, H, Cross, K, Rees, CM, Van Duren, B, Upchurch, E, Khan, K, Abudeeb, H, Hammad, A, Karandikar, S, Bowley, D, Karim, A, Chachulski, W, Richardson, L, Dawnay, G, Thompson, B, Mistry, A, Ghetia, M, Roy, S, Al-Obaedi, O, Das, K, Prabhudesai, A, Cocker, DM, Tan, JJ, Tyler, R, Di Franco, F, Ayyar, S, Vivekanantham, S, Gokani, S, Gillespie, M, Gudlaugsdottir, K, Pezas, T, Currow, C, Kim, MY-H, Birring, A, Edwards, J, Das, S, Jha, M, Atkinson, K, Luck, J, Fozard, T, Puttick, M, Salama, Y, Shah, R, Ibrahem, AA, Ebdewi, H, Gravante, G, El-Rabaa, S, Nnajiuba, H, Allott, R, Bhargava, A, Chan, Z, Hassan, Z, Makinde, M, Hemingway, D, Dean, R, Boddy, A, Aber, A, Patel, V, Parakh, J, Parthiban, S, Ubhi, HK, Hosein, S-P, Ward, S, Malik, K, Jennings, L, Newton, T, Alkhouri, M, Kang, MK, Houlden, C, Barry, J, Raza, I, Farquharson, A, Bhattacharya, S, Chang, K, Wilson, MSJ, Neo, YN, Ibrahim, I, Chan, E, Peck, FS, Lim, PJ, North, AS, Blundell, R, Williamson, A, Fouad, D, Minocha, A, Mccarthy, K, Court, E, Chambers, A, Yee, J, Tham, JC, Beaton, C, Walsh, U, Lockey, J, Bokhari, S, Howells, L, Griffiths, M, Yallop, L, Singh, S, Nasher, O, Jackson, P, Shariffuddin, AM, Ho, WC, Pabla, G, Ramzi, S, Zeidan, S, Doughty, J, Sinha, S, Davenport, R, Lewis, J, Duffy, L, Mcaleer, E, Williams, E, Som, R, Javed, O, Boal, M, Harrison, N, Tafazal, H, Brogden, T, Griffiths, E, Obute, RD, Glover, TE, Clark, DJ, Boshnaq, M, Akhtar, M, Capleton, P, Doughan, S, Rabie, M, Mohamed, I, Samuel, D, Dickson, L, Kennedy, M, Dempster, E, Brown, E, Maple, N, Monaghan, E, Wolf, B, Garland, A, Mcphee, A, Anderson, D, Anderson, R, Hassan, S, Smith, D, Lund, J, Boereboom, C, Murphy, J, Tierney, G, Tou, S, Zimmermann, EF, Smart, NJ, Warwick, AM, Stasinou, T, Daniels, I, Findlay-Cooper, K, Mitrasinovic, S, Ray, S, Varcada, M, D'Souza, R, Omara, S, Spurr, M, Parkinson, L, Hanks, A, Ma, J, Abington, E, Ramcharn, M, Williams, G, Winstanley, J, Kennedy, ED, Yeung, ENW, Jones, C, O'neill, S, Lim, SJ, Liew, I, Nair, H, Fairfield, C, Koh, S, Wilson, A, Anandkumar, D, Kirupagaran, A, Jones, TF, Torrance, HDT, Fowler, AJ, Chandrakumar, C, Patel, P, Ashraf, SF, Lakhani, SM, Mclean, AL, Basson, S, Batt, J, Bowman, C, Stoddart, M, Benons, N, Mason, C, Harrison, R, Quayle, J, Barker, T, Summerour, V, Harper, E, Smith, C, Hampton, M, Pitt, SK, Ward, AE, O'Connor, T, Heywood, EG, Chowdhury, A, Hossaini, S, Watson, NFS, Mckechnie, D, Farah, A, Chun, A, Koh, H, Lim, G, Sunderland, G, Gould, L, Munipalle, PC, Rooney, H, Browning, DRL, Pereira, B, Nemeth, K, Decker, E, Giuliani, S, Shalaby, A, Shaikh, S, Tan, CY, Palkhi, EYA, Szczap, A, Chidambaram, S, Chen, CY, Kulasabanathan, K, Chhabra, S, Kostov, E, Harbord, P, Barnacle, J, Palliyil, MM, Zikry, M, Porter, J, Raslan, C, Hafiz, S, Soltani, N, Baillie, K, Singh, P, Sheth, S, Patel, K, Khalili, M, Choi, J, Benger, M, Marples, L, Macfarlane, A, Thurairaja, R, Boyce, T, Whewell, H, Jones, E, Th'ng, F, Robertson, N, Mirza, A, Saeed, H, Galloway, S, Elena, G, Afzal, M, Zakir, M, Sodde, P, Hand, C, Sriram, A, Clark, T, Holton, P, Livesey, A, Sinha, Y, Iqbal, FM, Bharj, IS, Rotundo, A, Jenvey, C, Slade, R, Golding, D, Haines, S, Abdullah, AAN, Tilston, TW, Loughran, D, Donoghue, D, Giacci, L, Sherif, MA, Harrison, P, Tang, A, Kotecha, D, Elshaer, M, Urbonas, T, Riaz, A, Chapman, A, Acharya, P, Shalhoub, J, Grossart, C, McMorran, D, Mlotshwa, M, Hawkins, W, Loizides, S, Krishna, K, Orchard, M, Ho, CW, Thomson, P, Khan, S, Taylor, F, Shukla, J, Howie, EE, Macdonald, L, Komolafe, O, Mcintyre, N, Cragg, J, Parker, J, Stewart, D, Lintin, L, Tracy, J, Farooq, T, Molina, G, Kaafarani, H, Beyene, R, Sava, J, Scott, M, Swaroop, M, Kennedy, R, Azodo, IA, Heffernan, D, Chun, T, Stephen, A, Sion, M, Weinstein, MS, Punja, V, Bugaev, N, Goodstein, M, Razmdjou, S, Etchill, E, Puyana, JC, Kesinger, M, Napolitano, L, To, K, Hemmila, M, Todd, O, Jenner, E, Hoogakker, E, Chen, JHC, Ismail, L, Roi, D, Escobar, EG, Clinicum, II kirurgian klinikka, Department of Surgery, Pertti Panula / Principal Investigator, HUS Abdominal Center, and OMÜ

Subjects
Male, SURGERY, Disease, 030230 surgery, DISEASE, 0302 clinical medicine, Risk Factors, Appendicitis, Appendectomy, Global surgery, Laparoscopic, Operative standards, Postoperative care, Postoperative complications, Surgical site infection, 80 and over, Medicine, Prospective Studies, appendectomy, appendicitis, global surgery, laparoscopic, operative standards, postoperative care, postoperative complications, surgical site infection, Prospective cohort study, Laparoscopy, Child, Aged, 80 and over, medicine.diagnostic_test, Middle Aged, 3. Good health, Treatment Outcome, 030220 oncology & carcinogenesis, Female, HEALTH, BURDEN, Life Sciences & Biomedicine, Adult, medicine.medical_specialty, Adolescent, Developing country, APPENDECTOMY, GlobalSurg Collaborative, Article, 03 medical and health sciences, Young Adult, Internal medicine, Surgery, Humans, Emergency appendectomy, Surgical emergency, Propensity Score, Developing Countries, Aged, Science & Technology, SURGICAL CARE, business.industry, Developed Countries, Kirurgi, 1103 Clinical Sciences, medicine.disease, 3126 Surgery, anesthesiology, intensive care, radiology, Emergencies, Follow-Up Studies, Postoperative Complications, business
Abstract

Mak, Tony W. C./0000-0002-4516-3124; Peycelon, Matthieu/0000-0003-3617-4849; Ng, Simon S. M./0000-0002-5389-9297; Negida, Ahmed/0000-0001-5363-6369; Di Saverio, Salomone/0000-0001-5685-5022; Poskus, Tomas/0000-0002-6931-6041; Mihanovic, Jakov/0000-0001-6450-2956; Lund, Jonathan/0000-0001-5195-2181; Alshara, Ahmed/0000-0002-8127-3873; Maffioli, Anna/0000-0001-7116-4019; Smart, Neil/0000-0002-3043-8324; Roslani, April Camilla/0000-0003-2458-965X; Elfeki, Hossam/0000-0003-0704-4068; Samaraweera, Dulan/0000-0001-8334-8157; Mironescu, Aurel/0000-0003-1827-6948; Gemeah, Mostafa/0000-0002-9145-9348; Antar, Sarah/0000-0001-6091-2835; Labib, Peter LZ/0000-0003-2362-9218; Nouh, Thamer/0000-0002-7118-7453; Soreide, Kjetil/0000-0001-7594-4354; Rabie, Mohamed A/0000-0001-7799-2931; Ansaloni, Luca/0000-0001-6427-0307; Pata, Francesco/0000-0003-2634-1199; Barneo, Luis/0000-0001-9410-4262; Fahmy, Mohamed/0000-0002-3570-1742; Coccolini, Federico/0000-0001-6364-4186; Mikalauskas, Saulius/0000-0002-5191-1491; ALI, EMAD ALI AHMED/0000-0003-4384-0934; Cirocchi, Roberto/0000-0002-2457-0636; Nepogodiev, Dmitri/0000-0002-2171-2862; Mitul, Ashrarur Rahman/0000-0002-7100-7723; Zalabia, Mohamed Fadel/0000-0003-2372-2914; Fahmy, Mohamed A Baky/0000-0002-3570-1742; Glasbey, James/0000-0001-7688-5018; Shaikh, Shafaque/0000-0002-4536-9595; Furqan, Muhammad Mohsin/0000-0003-0719-5069; Boddy, Alexander P/0000-0001-7243-0155; Vimalachandran, Dale/0000-0001-5817-8969; Iordache, Florin/0000-0001-7108-7279; Merlini, David A/0000-0002-7981-7149; Beuran, Mircea/0000-0002-0889-1675; Jaffry, Zahra/0000-0003-4101-2246; Hassan, Mariam/0000-0001-6160-9723; Mohan, Midhun/0000-0002-1865-8623; Germanos, Stylianos/0000-0002-1640-1226; afifi, ahmed/0000-0002-4294-8217; Alhendy, Mohammed/0000-0003-3434-1156; Ozkan, Bahar Busra/0000-0002-0939-8049; Todd, Oliver/0000-0001-7212-8095; Ali, Ased/0000-0001-9576-9047; Torrance, Hew David/0000-0002-3854-1748; Morsi, Mahmoud/0000-0002-6621-0751; Lawal, Taiwo Akeem/0000-0002-8632-5783; Bondurri, Andrea/0000-0002-6521-5876; Chapman, Stephen/0000-0003-2413-5690; morsi, mahmoud/0000-0001-6825-7361; Arman, Sam/0000-0001-9620-5171; Lopez, Crislee/0000-0002-8775-3675; van Duren, Bernard/0000-0003-1877-8227; Hanrahan, Michael/0000-0002-2358-5975; , paolo/0000-0001-9844-3149; Lim, Shujing Jane/0000-0003-4970-7405; Turati, Luca/0000-0002-6958-6682; Shehata, Sherif/0000-0002-9733-006X; LAWANI, Ismail/0000-0001-5022-6313; FAURE, alice/0000-0002-3327-6391; Attia, Attia/0000-0003-2602-7263; Tham, Ji Chung/0000-0003-1796-9347; Segovia Lohse, Helmut Alfredo/0000-0003-3255-5345; Sgroi, Giovanni/0000-0003-4956-124X; Mohammed, Mohammed Mustafa Hassan/0000-0003-3013-1792; Warren, Oliver/0000-0001-8948-7473; SHAWKI, Marwan/0000-0001-6053-5523; Abbo, Olivier/0000-0002-4202-4284; Fitzgerald, James/0000-0002-4453-5117; Thorell, Anders/0000-0001-7238-1728; Daniels, Ian/0000-0002-9114-0812; Khatri, Chetan/0000-0002-3961-1314; Hassanain, Mazen/0000-0002-2441-5142; Wright, Naomi/0000-0003-4105-8009; Elgebaly, Ahmed/0000-0002-8324-0960; Tanase, Andrei/0000-0001-9465-8302; IMOROU SOUAIBOU, Yacoubou/0000-0002-1908-6698; Scalabre, Aurelien/0000-0001-7361-1900; Pata, Giacomo/0000-0001-7867-9349; McGuigan, Andrew/0000-0002-5097-5063; Marshall, Dominic/0000-0002-3498-2511; Stoddart, Michael/0000-0001-7346-324X; Amandito, Radhian/0000-0002-1211-7973; Hammad, Ali/0000-0003-1894-3480; ZANI, AUGUSTO/0000-0003-2283-9846 WOS: 000438285100004 PubMed: 29623470 Background Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. Methods This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. Results 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). Conclusion A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. Trial registration: NCT02179112. DFID-MRC-Wellcome Trust Joint Global Health Trial Development Grant [MR/N022114/1]; Wellcome Trust Biomedical Vacation ScholarshipsWellcome Trust; National Institute of Health Research (NIHR) Global Health Research Unit GrantNational Institute for Health Research (NIHR) [NIHR 17-0799] Funded by a DFID-MRC-Wellcome Trust Joint Global Health Trial Development Grant (MR/N022114/1), a Wellcome Trust Biomedical Vacation Scholarships (2015), and a National Institute of Health Research (NIHR) Global Health Research Unit Grant (NIHR 17-0799). The views expressed are those of the authors and not necessarily those of the National Health Service, the NIHR, or the UK Department of Health and Social Care.

Published
2018
Full Text
View/download PDF

28. Constitutional Isomerization Enables Bright NIR-II AIEgen for Brain-Inflammation Imaging

Author

Liu, Shunjie CHEM, Chen, Chao, Li, Yuanyuan, Zhang, Haoke, Liu, Junkai, Wang, Ran, Wong, Sherman T. H., Lam, Jacky W.Y., Ding, Dan, Tang, Benzhong, Liu, Shunjie CHEM, Chen, Chao, Li, Yuanyuan, Zhang, Haoke, Liu, Junkai, Wang, Ran, Wong, Sherman T. H., Lam, Jacky W.Y., Ding, Dan, and Tang, Benzhong

Abstract

The shortage of high quantum yield (QY) organic fluorophores in the second near-infrared window (NIR-II) has become a bottleneck in bioimaging field. Now, a simple strategy is proposed to address this: constitutional isomerization on the basis of the molecular design philosophy of aggregation-induced emission. With the combination of backbone distortion and rotor twisting, the resultant NIR-II fluorophore 2TT-oC6B displays an emission peak at 1030 nm and a QY of 11% in nanoparticles, one of the highest reported so far. Control molecules confirm that the distorted backbone and twisted rotors play equally important roles in determining the fluorescence properties of the NIR-II fluorophores. To allow for the targeting ability to reach deeply located diseases, neutrophils (NEs) are used to penetrate the brain tissues and accumulate in the inflammation site. Herein, it is shown that NEs carrying 2TT-oC6B nanoparticles can penetrate the blood-brain-barrier and visualize the deeply located inflammation through an intact scalp and skull. Notably, the bright 2TT-oC6B contributes to a significantly enhanced signal-to-background ratio of 30.6 in the brain inflammation site. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Published
2019

29. Constitutional Isomerization Enables Bright NIR-II AIEgen for Brain-Inflammation Imaging

Author

Liu, Shunjie, Chen, Chao, Li, Yuanyuan, Zhang, Haoke, Liu, Junkai, Wang, Ran, Wong, Sherman T. H., Lam, Jacky W.Y., Ding, Dan, Tang, Benzhong, Liu, Shunjie, Chen, Chao, Li, Yuanyuan, Zhang, Haoke, Liu, Junkai, Wang, Ran, Wong, Sherman T. H., Lam, Jacky W.Y., Ding, Dan, and Tang, Benzhong

Abstract

The shortage of high quantum yield (QY) organic fluorophores in the second near-infrared window (NIR-II) has become a bottleneck in bioimaging field. Now, a simple strategy is proposed to address this: constitutional isomerization on the basis of the molecular design philosophy of aggregation-induced emission. With the combination of backbone distortion and rotor twisting, the resultant NIR-II fluorophore 2TT-oC6B displays an emission peak at 1030 nm and a QY of 11% in nanoparticles, one of the highest reported so far. Control molecules confirm that the distorted backbone and twisted rotors play equally important roles in determining the fluorescence properties of the NIR-II fluorophores. To allow for the targeting ability to reach deeply located diseases, neutrophils (NEs) are used to penetrate the brain tissues and accumulate in the inflammation site. Herein, it is shown that NEs carrying 2TT-oC6B nanoparticles can penetrate the blood-brain-barrier and visualize the deeply located inflammation through an intact scalp and skull. Notably, the bright 2TT-oC6B contributes to a significantly enhanced signal-to-background ratio of 30.6 in the brain inflammation site. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Published
2019

30. Selective Formation of Functionalized α-Quaternary Malononitriles toward 5,5-Disubstituted Pyrrolopyrimidinones

Author

Edward C. Sherer, Robert K. Orr, Jamie M. McCabe Dunn, Yong Zhang, Aaron X. Sun, Yu-hong Lam, John E. Stelmach, Sherman T. Waddell, Melisa Shiroda, Subharekha Raghavan, and Alan Whitehead

Subjects
Steric effects, 010405 organic chemistry, Chemistry, Stereochemistry, Organic Chemistry, 010402 general chemistry, Ring (chemistry), Highly selective, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences, Nucleophile, Electrophile, Physical and Theoretical Chemistry, Selectivity
Abstract

A modular, selective approach to complex α-tertiary substituted malononitriles is reported. The method takes advantage of β-ester-substituted α,α-dinitrile alkenes as highly reactive, chemoselective electrophiles for 1,4-additions with organometallic nucleophiles to produce functionally and sterically dense all-carbon quaternary centers. In the presence of a chiral ester auxiliary bearing an aromatic ring, the 1,4-addition occurs with good to excellent selectivity due to favorable cation−π interactions. The highly functionalized malononitriles represent versatile building blocks and can be applied toward efficient, highly selective syntheses of 5,5-disubstituted pyrrolopyrimidinones.

Published
2017

31. LORETA Neurofeedback in the Precuneus

Author

Tiffany L. Shaw, Jacob J. Levy, Rex Cannon, Sherman T. Phillips, Dominic J. Diloreto, and Debora R. Baldwin

Subjects
Adult, Male, medicine.medical_specialty, Relative power, Precuneus, Neuroimaging, Audiology, Developmental psychology, Young Adult, Parietal Lobe, medicine, Humans, Left precuneus, Brain Diseases, Brain Mapping, Mechanism (biology), Brain, Electroencephalography, General Medicine, Middle Aged, Neurofeedback, Executive functions, Heterogeneous population, medicine.anatomical_structure, Neurology, Conditioning, Operant, Female, Neurology (clinical), Psychology, Psychopathology
Abstract

Low-resolution brain electomagnetic tomography (LORETA) neurofeedback provides a mechanism to influence the electrical activity of the brain in intracranial space. The aim of this study was to determine the effects of LORETA neurofeedback (LNFB) in the precuneus as a mechanism for improving self-regulation in controls and a heterogeneous diagnostic group (DX). Thirteen participants completed between 10 and 20 sessions of LNFB training in a 3-voxel cluster in the left precuneus. The participants included 5 nonclinical university students, and 8 adults with heterogeneous psychiatric diagnoses. We assessed the effects of LNFB with neurophysiological measures as well as pre- and post-Personality Assessment Inventory (PAI) subscales and selected subtests from the Delis-Kaplan Executive Function System (DKEFS). There was a significant total relative power increase at the precuneus for baseline contrasts for the control group. The DX group did not reach significant levels. All participants showed improvements in executive functions and tended to report significantly less psychopathology. The basic neural mechanisms of self-regulation are poorly understood. The data obtained in this study demonstrate that LNFB in a heterogeneous population enhances executive functions while concordantly decreasing endorsement of psychological symptoms. The alpha frequency in the brain may represent integrative functioning relative to operant efficiency and self-regulatory mechanisms.

Published
2014
Full Text
View/download PDF

32. Constitutional Isomerization Enables Bright NIR‐II AIEgen for Brain‐Inflammation Imaging

Author

Yuanyuan Li, Chao Chen, Ben Zhong Tang, Dan Ding, Junkai Liu, Haoke Zhang, Shunjie Liu, Jacky W. Y. Lam, Sherman T. H. Wong, and Ran Wang

Subjects
Biomaterials, Fluorescence-lifetime imaging microscopy, Nuclear magnetic resonance, Materials science, Inflammation imaging, Electrochemistry, Aggregation-induced emission, Condensed Matter Physics, Isomerization, Electronic, Optical and Magnetic Materials
Published
2019
Full Text
View/download PDF

33. The relative efficiency of slave agriculture: a comment

Author

Hofler, Richard A. and Folland, Sherman T.

Subjects
Slave labor -- Analysis, Slaveholders -- Economic policy, Plantations -- Statistics, Slavery -- Economic aspects, Business, Business, general, Economics
Published
1991

39. 11β-HSD1 inhibition reduces atherosclerosis in mice by altering proinflammatory gene expression in the vasculature

Author

Gloria C. Koo, Martin S. Springer, Lorraine Malkowitz, Douglas W. Kawka, Kang Cheng, Qi Luo, Serguei Stepaniants, Kenneth K. Wu, Irwin I. Singer, Jeffrey Yuan, Andrew S. Plump, Cheryl B. Le Grand, Jun Zhu, Milana Maletic, Samuel D. Wright, James M. Balkovec, Gloria J.-F. Ding, Sherman T. Waddell, Xia Yang, Rolf Thieringer, Kashmira Shah, Pek Yee Lum, Mingjuan Jane Luo, I-Ming Wang, and Anne Hermanowski-Vosatka

Subjects
Vasculitis, Physiology, Genes, MHC Class II, 11β hsd1, Dehydrogenase, Laser Capture Microdissection, Biology, Proinflammatory cytokine, Mice, Apolipoproteins E, 11-beta-Hydroxysteroid Dehydrogenase Type 1, Gene expression, Genetics, medicine, Animals, Enzyme Inhibitors, Glucocorticoids, Mice, Knockout, Gene Expression Profiling, Atherosclerosis, Microarray Analysis, medicine.disease, Lipids, Gene expression profiling, Cholesterol, Gene Expression Regulation, Immunology, Etiology, Metabolic syndrome, hormones, hormone substitutes, and hormone antagonists
Abstract

11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is implicated in the etiology of metabolic syndrome. We previously showed that pharmacological inhibition of 11β-HSD1 ameliorated multiple facets of metabolic syndrome and attenuated atherosclerosis in ApoE−/− mice. However, the molecular mechanism underlying the atheroprotective effect was not clear. In this study, we tested whether and how 11β-HSD1 inhibition affects vascular inflammation, a major culprit for atherosclerosis and its associated complications. ApoE−/− mice were treated with an 11β-HSD1 inhibitor for various periods of time. Plasma lipids and aortic cholesterol accumulation were quantified. Several microarray studies were carried out to examine the effect of 11β-HSD1 inhibition on gene expression in atherosclerotic tissues. Our data suggest 11β-HSD1 inhibition can directly modulate atherosclerotic plaques and attenuate atherosclerosis independently of lipid lowering effects. We identified immune response genes as the category of mRNA most significantly suppressed by 11β-HSD1 inhibition. This anti-inflammatory effect was further confirmed in plaque macrophages and smooth muscle cells procured by laser capture microdissection. These findings in the vascular wall were corroborated by reduction in circulating MCP1 levels after 11β-HSD1 inhibition. Taken together, our data suggest 11β-HSD1 inhibition regulates proinflammatory gene expression in atherosclerotic tissues of ApoE−/− mice, and this effect may contribute to the attenuation of atherosclerosis in these animals.

Published
2013
Full Text
View/download PDF

40. LETTERS

Author

Nelson, H. Peabody, Sherman, T. W., Sims, Earl, and Graybill, H. B.

Published
1940
Full Text
View/download PDF

41. Broadening the Spectrum of β-Lactam Antibiotics through Inhibition of Signal Peptidase Type I

Author

John W. Phillips, Xin Gu, Mihai Petcu, Molly M. Lin, Ronald E. Painter, Michel Gallant, Lynn Miesel, Kathryn Skorey, Kenneth E. Wilson, David Claveau, Liliana L. Benton-Perdomo, Kathleen Deschamps, Christopher M. Tan, Katherine Young, Andrew Galgoci, John Tam, Christian Lebeau-Jacob, Alexandre Caron, Young-Whan Park, Suzy Lee, Simon Wong, Patrick Beaulieu, Craig A. Parish, Aimie M. Ogawa, Josiane Lafleur, Alex G. Therien, Nancy J. Kevin, Sherman T. Waddell, Robert G. K. Donald, Penny Sue Leavitt, Mary Ann Powles, Joann Huber, and Anna A. Michels

Subjects
Methicillin-Resistant Staphylococcus aureus, Imipenem, Lipoglycopeptide, medicine.drug_class, Antibiotics, Microbial Sensitivity Tests, Biology, beta-Lactams, medicine.disease_cause, beta-Lactam Resistance, beta-Lactamases, Microbiology, Lipopeptides, Mice, chemistry.chemical_compound, Bacterial Proteins, Depsipeptides, polycyclic compounds, medicine, Animals, Humans, Experimental Therapeutics, Pharmacology (medical), Glycosides, Pharmacology, Depsipeptide, Mice, Inbred BALB C, Signal peptidase, Biphenyl Compounds, Serine Endopeptidases, Glycopeptides, Membrane Proteins, Biological Transport, Drug Synergism, Staphylococcal Infections, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, Methicillin-resistant Staphylococcus aureus, Anti-Bacterial Agents, Biphenyl compound, Infectious Diseases, chemistry, Staphylococcus aureus, Multigene Family, Drug Therapy, Combination, Female, Oligopeptides, medicine.drug
Abstract

The resistance of methicillin-resistant Staphylococcus aureus (MRSA) to all β-lactam classes limits treatment options for serious infections involving this organism. Our goal is to discover new agents that restore the activity of β-lactams against MRSA, an approach that has led to the discovery of two classes of natural product antibiotics, a cyclic depsipeptide (krisynomycin) and a lipoglycopeptide (actinocarbasin), which potentiate the activity of imipenem against MRSA strain COL. We report here that these imipenem synergists are inhibitors of the bacterial type I signal peptidase SpsB, a serine protease that is required for the secretion of proteins that are exported through the Sec and Tat systems. A synthetic derivative of actinocarbasin, M131, synergized with imipenem both in vitro and in vivo with potent efficacy. The in vitro activity of M131 extends to clinical isolates of MRSA but not to a methicillin-sensitive strain. Synergy is restricted to β-lactam antibiotics and is not observed with other antibiotic classes. We propose that the SpsB inhibitors synergize with β-lactams by preventing the signal peptidase-mediated secretion of proteins required for β-lactam resistance. Combinations of SpsB inhibitors and β-lactams may expand the utility of these widely prescribed antibiotics to treat MRSA infections, analogous to β-lactamase inhibitors which restored the utility of this antibiotic class for the treatment of resistant Gram-negative infections.

Published
2012
Full Text
View/download PDF

42. Mortality of emergency abdominal surgery in high-, middle- and low-income countries

Author

J E, F Fitzgerald, Khatri, C, C Glasbey, J, Mohan, M, Lilford, R, M Harrison, E, Holmer, H, Hall, N, S-H, Kim, Negida, A, Jaffry, Z, J Chapman, S, Shu, S, Shiwani, H, Jeyakumar, J, Fermani, C, Balmaceda, R, M Marta Modolo, Macdermid, E, Gobin, N, Chenn, R, C Ou Yong, Edye, M, Jarmin, M, K D'amours, S, Iyer, D, Youssef, D, Phillips, N, Brown, J, George, R, Koh, C, Warren, O, Hanley, I, Dickfos, M, Nawara, C, Öfner, D, Primavesi, F, R Mitul, A, Mahmud, K, Hussain, M, Hakim, H, Kumar, T, Oosterkamp, A, A Assouto, P, Lawani, I, Y Imorou Souaibou, A Kyaw Tun, C Leung Chong, H Devadasar, G, M Rashid Minhas Qadir, K Phyo Aung, L Shi Yeo, D Palomino Castillo, V, M Moron Munhoz, Moreira, G, C Barros De Castro Segundo, L, S Anderson Khouri Ferreira, M Cassa Careta, S Binna Kim, A Venâncio De Sousa, A Daltri Lazzarini Cury, G Peixoto Soares Miguel, A Vega Carreiro De Freitas, B Pereira Silvestre, J Guasti Pinto Vianna, C Oliveira Felipe, L Alberto Valente Laufer, Altoe, F, L Ayres Da Silva, L Pimenta, M, T Fernandes Giuriato, P Alves Bezerra Morais, J Souza Luiz, Araujo, R, Menegussi, J, Leal, M, C Vinícius Barroso de Lima, L Sarmento Tatagiba, Leal, A, D Vinicius Dos Santos, G Pereira Fraga, R Lages Simoes, Stock, S, Nigo, S, Kabba, J, T Ebogo Ngwa, King, S, Zani, A, Azzie, G, Firdouse, M, Kushwaha, S, Agarwal, A, Bailey, K, Cameron, B, Livingston, M, Horobjowsky, A, L Deckelbaum, D, T Razek, B Marinkovic, Grasset, E, D'Aguzan, N, Jimenez, J, Macchiavello, R, Zhang, Z, Guo, W, J, Oh, Zheng, F, Montes, I, Sierra, S, Mendez, M, I Villegas, M, C Mendoza Arango, M, Mendoza, I, A Naranjo Aristizã Bal, F, A Montoya Botero, J, M Quintero Riaza, V, Restrepo, J, Morales, C, Cruz, H, Munera, A, Karlo, R, Domini, E, Mihanovic, J, Radic, M, Zamarin, K, Pezelj, N, Hache-Marliere, M, S Batista Lemaire, Rivas, R, Khyrallh, A, Hassan, A, Shimy, G, A Baky Fahmy, M, Nabawi, A, S Ali Muhammad Gohar, M, Elfil, M, Ghoneem, M, Asal, M, Abdelkader, M, Gomah, M, Rashwan, H, Karkeet, M, Gomaa, A, Hasan, A, Elgebaly, A, Azzam, O, Abdelfattah, A, Gouda, A, Elshafay, A, Gharib, A, Menshawy, A, Hanafy, M, Al-Mallah, A, Abdulgawad, M, Baheeg, M, Alhendy, M, A Fattah, I, Kenibar, A, Osman, O, Gemeah, M, Mohammed, A, Adel, A, Sayed, A, Abozaid, M, A Hafez El-Badri Kotb, A Ahmed Ata, A, Nasr, M, Alkammash, A, Saeed, M, N Abd El Hamid, M Attia, A, A Abd El Galeel, Elbanby, E, K Salah El-Dien, Hantour, U, Alahmady, O, Mansour, B, M Elkorashy, A, M Saeed Taha, E, T Lasheen, K, S Said Elkolaly, N Yosri Elsayed Abdel-Wahab, A Fathi Abozyed, M, M Saeed, A, G Samir El Sayed, H Youssif, J, S Magdy Ahmed, N Soubhy El-Shahat, A Hegazy Khedr, A Osama Elsebaaye, Elzayat, M, Abdelraheim, M, Elzayat, I, Warda, M, K Naser El Deen, A Essam Elnemr, Salah, O, Abbas, M, Rashad, M, Elzayyat, I, Hemeda, D, Tawfik, G, Salama, M, Khaled, H, Seisa, M, Elshaer, K, Hussein, A, Elkhadrawi, M, M Afifi, A, O Saadeldeen Ebrahim, M Metwally, M, Elmelegy, R, M Elbendary Elsawahly, D, Safa, H, Nofal, E, Elbermawy, M, M Abo Raya, A Abdelmotaleb Ghazy, Samih, H, Abdelgelil, A, Abdelghany, S, A El Kholy, Elkady, F, Salma, M, Samy, S, Fakher, R, Aboarab, A, Samir, A, Sakr, A, Haroun, A, A Abdel-Rahman Al-Aarag, Elkholy, A, Elshanwany, S, Ghanem, E, Tammam, A, M Hammad, A, Y El Shoura, G El Ashal, Khairy, H, Antar, S, Mehrez, S, Abdelshafy, M, M Gamal Mohamad Hamad, M Farid Hosh, Abdallah, E, Magdy, B, Alzayat, T, Gamaly, E, Elfeki, H, Abouzahra, A, Elsheikh, S, Elgendy, F, F Abd El-Salam, Seifelnasr, O, Ammar, M, Eysa, A, Sadek, A, A Gamal Toeema, Shady, K, Nasr, A, Abuseif, M, Zidan, H, S Abd Elmageed Barakat, Elsayed, N, Y Abd Elrasoul, Elkelany, A, M Sabry Ammar, Mustafa, M, Hegazy, Y, Etman, M, Saad, S, Alrahawy, M, Raslan, A, Morsi, M, Rslan, A, Sabry, A, Elwakil, H, Shaker, H, Abd-Elrasoul, Y, El-Kashef, H, Shaalan, M, Tarek, A, Elwan, A, A Ragab Nayel, Seif, M, Emadeldin, D, M Ali Ghonaim, Almallah, A, Fouad, A, E Adel Sayma, Elbatahgy, A, A Solaiman El-Ma'doul, Mosad, A, Tolba, H, A Amin Elsorogy, D, H Ali Mostafa, A Atef Omar, O Sherief Abd El Hameed, Lasheen, A, Y Abd El Salam, Morsi, A, Ismail, M, H Ahmed El-Badawy, Amer, M, A Sabry El-Hamouly, N Ahmed Attallah, Mosalum, O, Afandy, A, Mokhtar, A, Abouelnasr, A, Ayad, S, Shaker, R, Sakr, R, Amreia, M, Elsobky, S, A Abo El Magd, Marey, A, A Tarek Hafez, Zalabia, M, M Moamen Mohamed, Fadel, A, E Ali Ahmed, Ali, A, M Ghassan Alwafai, Dwydar, A, Kharsa, S, Mamdouh, E, El-Sheemy, H, Youssef, I, A Khairy Aly, Aldalaq, A, Alnawam, E, Alkhabbaz, D, Saad, M, Hussein, S, A Abo Elazayem, Ramadan, A, Elashmawy, M, Mousa, M, Nashaat, A, Ghanem, S, Oof, Z, Elwaey, A, Elkadsh, I, Darweesh, M, Mohameden, A, Hafez, M, Badr, A, Badwy, A, M Abd El Slam, Elazoul, M, Al-Nahrawi, S, Eldamaty, L, Nada, F, Ameen, M, Hagar, A, Elsehimy, M, Aboraya, M, Dawoud, H, S El Mesery, A El Gendy, Abdelkareem, A, A Safwan Marey, Allam, M, Shehata, S, Abozeid, K, Elshobary, M, Fahiem, A, Sarsik, S, Hashish, A, Zidan, M, Hashish, M, Sanad, A, Mesalam, M, Aql, S, A Osman Abdelaziz Elhendawy, Husseini, M, Kasem, E, Gheith, A, Elfouly, Y, A Ragab Soliman, Ibrahim, Y, Elfouly, N, Fawzy, A, Rashid, M, A Salah Elsherbiny, Sieda, B, Badwi, N, M Hassan Mohammed, M, Mohamed, O, M Abdulkhalek Habeeb, Worku, M, Starr, N, Desta, S, Wondimu, S, S Abebe, N, Thomas, E, A Asele, F, Dabessa, D, N Seyoum Abebe, B Zerihun, A, Mentula, P, Leppäniemi, A, Sallinen, V, Scalabre, A, Frade, F, Irtan, S, Graffeille, V, Gaignard, E, Alimi, Q, Graffieille, V, Abbo, O, Mouttalib, S, Bouali, O, Hervieux, E, Aigrain, Y, Botto, N, Faure, A, Fievet, L, Panait, N, Eyssartier, E, Schmitt, F, Podevin, G, Parent, V, Martin, A, P Arnaud, A, Muller, C, Bonnard, A, Peycelon, M, Abantanga, F, Boakye-Yiadom, K, Bukari, M, Owusu, F, Awuku-Asabre, J, Tabiri, S, D Bray, L, Lytras, D, Psarianos, K, Bamicha, A, Kefalidi, E, Gemenetzis, G, Dervenis, C, Gouvas, N, Agalianos, C, Kontos, M, Kouraklis, G, Karousos, D, Germanos, S, Marinos, C, Anthoulakis, C, Nikoloudis, N, S Mitroudis, N, Recinos, G, Estupinian, S, Forno, W, R Arévalo Azmitia, J, C Ramã Rez Cabrera, C, Guevara, R, Aguilera, M, Mendez, N, A Azmitia Mendizabal, C, Ramazzini, P, M Contreras Urquizu, Tale, F, Soley, R, Barrios, E, E Marroquín Rodríguez, D, I Pérez Velásquez, C, M Contreras Mérida, S, Regalado, F, Lopez, M, Siguantay, M, Y Lam, F, K J-Y Szeto, C C, L Szeto, S Li, W, K K, K Li, F Leung, M, Mak, T, S, Ng, S Prasad, S, Kirishnan, A, Gyanchandani, N, Bhat, S, Sreedharan, A, V Kinnera, S, S Kumar, B, Rangarajan, M, Reddy, Y, Venugopal, C, Kumar, S, Mittal, A, Nadkarni, S, N Lakshmi, H, Malik, P, Limaye, N, Pai, S, Jain, P, Khajanchi, M, Satoskar, S, Satoskar, R, Abid Bin Mahamood, P Refianti Sutanto, E, A Soeselo, D, Tedjaatmadja, C, N Rahmawati, F, Amandito, R, Mayasari, M, R K, M Jawad Al-Hasani, I Ibraheem Al-Hameedi, H, A Aziz Al-Azraqi, I, Sabeeh, L, Kamil, R, Shawki, M, M Mezeil Telfah, Rasendran, A, Sheehan, J, Kerley, R, Normile, C, W Gilbert, R, Song, J, Dablouk, M, Mauro, L, O Dablouk, M, Hanrahan, M, Kielty, P, Marks, E, Gosling, S, Mccarthy, M, Mirghani, D, S Altaf Naqvi, S Wong, C, Chung, S, D'Cruz, R, Cahill, R, G Gosling, S, Fahy, C, D Duarte Cadogan, Powell, A, Gilbert, R, Clifford, C, Driscoll, A, Stassen, P, Lee, C, Bowe, R, Hutch, W, Mohan, H, O'Neill, M, Mealy, K, Danelli, P, Bondurri, A, Maffioli, A, Pasini, M, Pata, G, Roncali, S, Silvani, P, Carlucci, M, Faccincani, R, Bonavina, L, Macchitella, Y, Ceriani, C, Tugnoli, G, S Di Saverio, Khattab, K, M Angel Paludi, Pata, D, L Maria Cloro, Allegri, A, Ansaloni, L, Coccolini, F, Veronese, E, Bortolasi, L, Hasheminia, A, Nastri, G, M Dal Canto, Cucumazzo, S, Pata, F, Benevento, A, Tessera, G, P Paolo Grandinetti, Maniscalco, A, G Luca Lamanna, Turati, L, Sgroi, G, Rausa, E, Villa, R, Monteleone, M, Merlini, D, Grassi, V, Cirocchi, R, Cacurri, A, Waleed, H, Diab, A, Elzowawi, F, Jokubauskas, M, Varkalys, K, Venskutonis, D, Pranevicius, R, Ambrozeviciute, V, Juciute, S, Skardžiukaitė, A, Bradulskis, S, Urbanavicius, L, Austraite, A, Riauka, R, Zilinskas, J, Dambrauskas, Z, Karumnas, P, Urniezius, Z, Zilinskiene, R, Rudzenskaite, A, Usaityte, A, Montrimaite, M, Kaselis, N, Strazdas, A, Jokubonis, K, Maceviciute, K, Laugzemys, E, Kolosov, A, Jotautas, V, Rakita, I, Mikalauskas, S, Kazanavicius, D, Rackauskas, R, Strupas, K, Poskus, T, Beisa, V, Rakauskas, R, Preckailaite, E, Coomber, R, Johnson, K, Nowers, J, Periasammy, D, Salleh, A, Das, A, R Goh Ern Tze, M Nirumal Kumar, A Nik Abdullah, N, R Kosai, N, Taher, M, Rajan, R, Y Chong, H, C Roslani, A, C Goh, C, Agius, M, Borg, E, Bezzina, M, Bugeja, R, Vella-Baldacchino, M, Spina, A, Psaila, J, Francois-Coridon, H, Tolg, C, J-F, Colombani, Diaz-Zorrilla, C, A Ramos-De La Medina, S Corro-Diaz Gonzalez, Jacobe, M, Mapasse, D, Snyder, E, Oumer, R, Osman, M, Mohammad, A, L-J, Anyanwu, Sheshe, A, Adesina, A, Faturoti, O, Taiwo, O, M Habib Ibrahim, A Nasir, A, S Itopa Suleiman, Adeniyi, A, Adesanya, O, Adebanjo, A, Osuoji, R, Atobatele, K, Ogunyemi, A, Wiliams, O, Oludara, M, Oshodi, O, Ademuyiwa, A, A Oluwagbemiga Lawal, Alakaloko, F, Elebute, O, Osinowo, A, Bode, C, Adesuyi, A, Tade, A, Adekoya, A, Nwokoro, C, O Ayandipo, O, T Akeem Lawal, E Ajao, A, S Sani Ali, Odeyemi, B, Olori, S, Popoola, A, Adeyeye, A, Adeniran, J, J Lossius, W, Havemann, I, Thorsen, K, K Narvestad, J, Søreide, K, B Wold, T, Nymo, L, Elsiddig, M, Dar, M, F Bhopal, K, Iftikhar, Z, M Furqan, M, Nighat, B, Jawaid, M, Khalique, A, Zil-E-Ali, A, Rashid, A, H Abbas Dharamshi, Naqvi, T, Faraz, A, W Anwar, A, T Muhammad Yaseen, S Shamsi, G, Yaseen, T, Anwer, W, H Paredes Decoud, Aguilera, O, I Zelada Alvarez, I, J Marcelo Delgado, M Machain Vega, G, A Segovia Lohse, H, L Messa Aguilar, W, A Cabala Chiong, J, C Manchego Bautista, A, Huaman, E, Zegarra, S, Camacho, R, M Vergara Celis, J, A Romani Pozo, D, Hamasaki, J, Temoche, E, Herrera-Matta, J, P García Torres, C, M Alvarez Barreda, L, R Barrionuevo Ojeda, Garaycochea, O, M Castro Mollo, M Linares Delgado, Fujii, F, A Durand, S, A Arroyo Basto, C, M Urbina Rojas, N, B Shu Yip, S, L Contreras Vergara, A, A Echevarria Rosas Moran, G Borda Luque, M Rodriguez Castro, R Alvarado Jaramillo, G Manrique Sila, E Lopez, C, M Zapata Ponze De Leon, Machaca, M, R Coasaca Huaraya, Arenas, A, López, C, C Milagros Herrera Puma, Pino, W, Hinojosa, C, Limache, S, G Manrrique Sila, L-A Mercado Rodriguez, Melo, R, Costa-Maia, J, Muralha, N, Sauvat, F, Dan, I, Hogea, M, Eduard, P, R-M, Bratu, Beuran, M, I-B, Diaconescu, B-V, Martian, F-M, Iordache, Vartic, M, C Vida, L, I Muntean, L, S Mironescu, A, V J, P Nsengimana, Niragire, A, J D L, C Allen Ingabire, Niyirera, E, Zanini, N, Jovine, E, Landolfo, G, N Alomar, I, A Alnuqaydan, S, M Altwigry, A, Othman, M, Osman, N, Alqahtani, E, Alzahrani, M, Alyami, R, Aljohani, E, Alhabli, I, Mikwar, Z, Almuallem, S, Nawawi, A, Bakhaidar, M, A Maghrabi, A, Alsaggaf, M, Aljiffry, M, Altaf, A, Khoja, A, Habeebullah, A, Akeel, N, Ghandora, N, Almoflihi, A, Huwait, A, Al-Shammari, A, Al-Mousa, M, Alghamdi, M, Adham, W, Albeladi, B, A Alfarsi, M, Mahdi, A, S Al Awwad, Altamimi, A, Nouh, T, Hassanain, M, Aldhafeeri, S, Sadig, N, Algohary, O, Aledrisy, M, Gudal, A, Alrifaie, A, Alrowais, M, Althwainy, A, Shabkah, A, Alamoudi, U, Alrajraji, M, Alghamdi, B, Aljohani, S, Daqeeq, A, J Al-Faifi, J, Jennings, V, Ngayu, N, Moore, R, Kong, V, Kretzmann, H, Connor, K, Nel, D, Sampson, C, Spence, R, Panieri, E, Rayne, S, Sishuba, N, Tun, M, M Mphatsoe, A, A Carreira, J, Teasdale, E, Wagener, M, Botes, S, D Du Plessis, Fernandez-Bueno, F, Aguilar-Jimenez, J, A Garcia-Marin, J, S García, L, J García Florez, L, R Darío Arias Pacheco, Pagnozzi, J, H Jara Quezada, J, L Rodicio, J, Minguez, G, Rodríguez-Uría, R, Ugalde, P, Lopez-Arevalo, C, Barneo, L, P Gonzales Stuva, J, Ortega-Vazquez, I, Rodriguez, L, Herrera, N, P Pitigala Arachchi, W S, M Kithsiri Janakantha Senanayake, L A, J Jayasooriya Arachchige, Sivaganesh, S, I Samaraweera, D, Thanusan, V, A E, K Musa, R M, H Balila, M A E, H Mohamed, Ali, H, H Zain Elabdin, Mahdi, S, Ahmed, H, S Abdoun Ishag Idris, Elsayed, M, Mahmoud, M, Boijsen, M, P-O, Lundgren, Gustafsson, U, Kiasat, A, Wogensen, F, Jurdell, E, Thorell, A, Thorarinsdottir, H, Utter, M, M Sundstrom, S, Wredberg, C, Kjellin, A, Nyberg, J, Frisk, B, Sund, M, Andersson, L, Gunnarsson, U, Cengiz, Y, Ahlqvist, S, Björklund, I, Royson, H, Weber, P, H-I, Pahlsson, Borin, E, Hjertberg, M, Schmid, R, Schivo, D, Despotidis, V, Breitenstein, S, F Staerkle, R, Schadde, E, Deichsel, F, Gerosa, A, Nocito, A, A Raptis, D, Mijuskovic, B, Zuber, M, Eisner, L, Kruspi, S, B Reinisch, K, Schoewe, C, Novak, A, F Palma, A, Teufelberger, G, Kimaro, M, King, R, A Zeynel, A Balkan, Gumar, M, M Ali Yavuz, Karabacak, U, Lap, G, B Ozkan, B, Karakahya, M, Adams, R, Morton, R, Henderson, L, Gratton, R, D Clement, K, K Yu-Ching Chang, Mcnish, D, Mcintosh, R, Milligan, W, Skelly, B, Anderson-Knight, H, Lawther, R, Onimowo, J, Shatkar, V, Tharmalingam, S, Woin, E, Fautz, T, Ziff, O, Dindyal, S, Talukder, S, Arman, S, Gadhvi, V, S Chew, L, Heath, J, Blencowe, N, Hallam, S, Gash, K, G Singh Mannu, D-C, Zachariades, C Snaith, A, S Hettiarachchi, T, Nesaratnam, A, Wheeler, J, Mccullagh, D, M Clements, J, Khan, A, Koumpa, F, Neophytou, C, Roth, J, C Soon, W, Deputy, M, Ahmed, A, Ashton, A, Vincent, J, Almy, J, Khan, T, J L, Y Allen, J Mcintyre, C, C Marshall, D, Sykes, M, Behar, N, Jordan, H, Rajjoub, Y, Sherman, T, White, T, Watts, A, Ardley, R, Arulampalam, T, Shah, A, Brown, D, Blower, E, Sutton, P, Gasteratos, K, Vimalachandran, D, Magee, C, Irwin, G, Mcguigan, A, Mcaleer, S, Morgan, C, Braungart, S, Lafferty, K, Labib, P, Tanase, A, Mangan, C, Reza, L, Woodward, H, Gouldthorpe, C, Turner, M, J R, L Wild, T A, M Malik, K Proctor, V, Hewage, K, Davies, J, Dubois, A, Sarwary, S, Zardab, A, Grant, A, Mcintyre, R, P Mogan, Y, W, Ho, F Hon Khi Chong, B, Tewari, S, Humm, G, Farinella, E, J Hall, N, J Wright, N, P Major, C, Xerri, T, P De Bono, Amin, J, Farhad, M, F Camilleri-Brennan, J, A G, N Robertson, Swann, J, Richards, J, Jabbar, A, Attard, M, Burns, H, Macdonald, E, Baldacchino, M, Skehan, J, Camilleri-Brennan, J, T Falconer Hall, Gimzewska, M, Mclachlan, G, Shah, J, Giles, J, Chiu, S, Weber, B, S Man Yeng Chiu, Highcock, S, Hassan, M, Beasley, W, Vlachogiorgos, A, Dias, S, Maharaj, G, Mcdonald, R, Macdonald, A, Witherspoon, P, Baird, A, Sarmah, P, Green, N, Youssef, H, Cross, K, M Rees, C, B Van Duren, Upchurch, E, Khan, K, Abudeeb, H, Hammad, A, Karandikar, S, Bowley, D, Karim, A, Chachulski, W, Richardson, L, Dawnay, G, Thompson, B, Mistry, A, Bhangu, A, Ghetia, M, Roy, S, Al-Obaedi, O, Das, K, Prabhudesai, A, M Cocker, D, J Tan, J, Tyler, R, F Di Franco, Ayyar, S, Vivekanantham, S, Gokani, S, Gillespie, M, Gudlaugsdottir, K, Pezas, T, Currow, C, M Young-Han Kim, Birring, A, Edwards, J, Das, S, Jha, M, Atkinson, K, Luck, J, Fozard, T, Puttick, M, Salama, Y, Shah, R, A Ibrahem, A, Ebdewi, H, Gravante, G, El-Rabaa, S, Nnajiuba, H, Allott, R, Bhargava, A, Chan, Z, Hassan, Z, Makinde, M, Hemingway, D, Dean, R, Boddy, A, Aber, A, Patel, V, Parakh, J, Parthiban, S, K Ubhi, H, S-P, Hosein, Ward, S, Malik, K, Jennings, L, Newton, T, Alkhouri, M, K Kang, M, Houlden, C, Barry, J, Raza, I, Farquharson, A, Bhattacharya, S, Chang, K, M S, J Wilson, N Neo, Y, Ibrahim, I, Chan, E, S Peck, F, J Lim, P, S North, A, Blundell, R, Williamson, A, Fouad, D, Minocha, A, Mccarthy, K, Court, E, Chambers, A, Yee, J, C Tham, J, Beaton, C, Walsh, U, Lockey, J, Bokhari, S, Howells, L, Griffiths, M, Yallop, L, Singh, S, Nasher, O, Jackson, P, M Shariffuddin, A, C Ho, W, Pabla, G, Ramzi, S, Zeidan, S, Doughty, J, Sinha, S, Davenport, R, Lewis, J, Duffy, L, Mcaleer, E, Williams, E, Som, R, Javed, O, Boal, M, Harrison, N, Tafazal, H, Brogden, T, Griffiths, E, D Obute, R, E Glover, T, J Clark, D, Boshnaq, M, Akhtar, M, Capleton, P, Doughan, S, Rabie, M, Mohamed, I, Samuel, D, Dickson, L, Kennedy, M, Dempster, E, Brown, E, Maple, N, Monaghan, E, Wolf, B, Garland, A, Mcphee, A, Anderson, D, Anderson, R, Hassan, S, Smith, D, Lund, J, Boereboom, C, Murphy, J, Tierney, G, Tou, S, F Zimmermann, E, J Smart, N, M Warwick, A, Stasinou, T, Daniels, I, Findlay-Cooper, K, Mitrasinovic, S, Ray, S, Varcada, M, R D, S Omara, Spurr, M, Parkinson, L, Hanks, A, J, Ma, Abington, E, Ramcharn, M, Williams, G, Winstanley, J, D Kennedy, E, E N, W Yeung, Fergusson, S, Jones, C, O'Neill, S, J Lim, S, Liew, I, Nair, H, Fairfield, C, Koh, S, Wilson, A, Anandkumar, D, Kirupagaran, A, F Jones, T, D Torrance, H, J Fowler, A, Chandrakumar, C, Patel, P, F Ashraf, S, M Lakhani, S, L Mclean, A, Basson, S, Batt, J, Bowman, C, Stoddart, M, Benons, N, Mason, C, Harrison, R, Quayle, J, Barker, T, Summerour, V, Harper, E, Smith, C, Hampton, M, K Pitt, S, E Ward, A, O'Connor, T, G Heywood, E, M Drake, T, Chowdhury, A, Hossaini, S, F Watson, N, Mckechnie, D, Farah, A, Chun, A, Koh, H, Lim, G, Sunderland, G, Gould, L, C Munipalle, P, Rooney, H, D R, L Browning, Pereira, B, Nemeth, K, Decker, E, Giuliani, S, Shalaby, A, Shaikh, S, Y Tan, C, E Y, A Palkhi, Kostov, E, Harbord, P, Barnacle, J, Szczap, A, Chidambaram, S, Y Chen, C, Kulasabanathan, K, Chhabra, S, M Palliyil, M, Zikry, M, Porter, J, Raslan, C, Hafiz, S, Soltani, N, Baillie, K, Marples, L, Macfarlane, A, Thurairaja, R, Singh, P, Sheth, S, Patel, K, Khalili, M, Choi, J, Benger, M, Boyce, T, Whewell, H, Jones, E, Th'Ng, F, Robertson, N, Mirza, A, Saeed, H, Galloway, S, Elena, G, Afzal, M, Zakir, M, Sodde, P, Hand, C, Sriram, A, Clark, T, Holton, P, Livesey, A, Sinha, Y, M Iqbal, F, S Bharj, I, Rotundo, A, Jenvey, C, Slade, R, Golding, D, Haines, S, A Ne'ma Abdullah, A, W Tilston, T, Loughran, D, Donoghue, D, Giacci, L, M Ashur Sherif, Harrison, P, Tang, A, Kotecha, D, Elshaer, M, Urbonas, T, Riaz, A, Chapman, A, Acharya, P, Shalhoub, J, Grossart, C, Mcmorran, D, Mlotshwa, M, Hawkins, W, Loizides, S, Krishna, K, Orchard, M, W Ho, C, Thomson, P, Khan, S, Taylor, F, Shukla, J, E Howie, E, Macdonald, L, Komolafe, O, Mcintyre, N, Cragg, J, Parker, J, Stewart, D, L, L, Tracy, J, Farooq, T, Molina, G, Kaafarani, H, Luque, L, Beyene, R, Sava, J, Scott, M, Swaroop, M, Kennedy, R, A Azodo, I, Heffernan, D, Chun, T, Stephen, A, Sion, M, S Weinstein, M, Punja, V, Bugaev, N, Goodstein, M, Razmdjou, S, Etchill, E, C Puyana, J, Kesinger, M, Napolitano, L, K, To, Hemmila, M, Todd, O, Jenner, E, Hoogakker, E, Roi, D, H Chieh Chen, J, Ismail, L, and G Escobar, E

Subjects
Adult, Male, Gastrointestinal Diseases, mortality, global surgery, abdominal, emergency, LMIC, surgery, Developed Countries, Checklist, Cohort Studies, Health Care, Abdomen, Humans, Female, Patient Safety, Emergencies, Quality Assurance, Developing Countries, Digestive System Surgical Procedures, Quality Assurance, Health Care
Published
2016

43. Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV-1 Protease Inhibitors

Author

Bungard, Christopher J., primary, Williams, Peter D., additional, Schulz, Jurgen, additional, Wiscount, Catherine M., additional, Holloway, M. Katharine, additional, Loughran, H. Marie, additional, Manikowski, Jesse J., additional, Su, Hua-Poo, additional, Bennett, David J., additional, Chang, Lehua, additional, Chu, Xin-Jie, additional, Crespo, Alejandro, additional, Dwyer, Michael P., additional, Keertikar, Kartik, additional, Morriello, Gregori J., additional, Stamford, Andrew W., additional, Waddell, Sherman T., additional, Zhong, Bin, additional, Hu, Bin, additional, Ji, Tao, additional, Diamond, Tracy L., additional, Bahnck-Teets, Carolyn, additional, Carroll, Steven S., additional, Fay, John F., additional, Min, Xu, additional, Morris, William, additional, Ballard, Jeanine E., additional, Miller, Michael D., additional, and McCauley, John A., additional

Published
2017
Full Text
View/download PDF

45. Fluorogenic substrates for high-throughput measurements of endothelial lipase activity

Author

Matt S. Anderson, Yuping Zhu, Carl P. Sparrow, Erik G. Lund, Jenny Tian, My-Hanh Lam, Lyndon J. Mitnaul, Samuel D. Wright, Paul Zuck, Sherman T. Waddell, Milana Maletic, Jonathan Schneeweis, Shilpa Pandit, Steve H. Olson, and Charlotte Burton

Subjects
Endothelial lipase, micelles, Phospholipid, QD415-436, Phospholipase, Biochemistry, Fluorescence, Mice, chemistry.chemical_compound, Endocrinology, Animals, Humans, Fluorescent Dyes, Triglyceride lipase, Lipoprotein lipase, Molecular Structure, Triglyceride, Cholesterol, Substrate (chemistry), Lipase, Cell Biology, bodipy-labeled, chemistry, lipids (amino acids, peptides, and proteins), synthetic high density lipoprotein
Abstract

Endothelial lipase (EL) has been shown to be a critical determinant for high density lipoprotein cholesterol levels in vivo; therefore, assays that measure EL activity have become important for the discovery of small molecule inhibitors that specifically target EL. Here, we describe fluorescent Bodipy-labeled substrates that can be used in homogeneous, ultra-high-throughput kinetic assays that measure EL phospholipase or triglyceride lipase activities. Triton X-100 detergent micelles and synthetic HDL particles containing Bodipy-labeled phospholipid or Bodipy-labeled triglyceride substrates were shown to be catalytic substrates for EL, LPL, and HL. More importantly, only synthetic HDL particles containing Bodipy-labeled triglyceride were ideal substrates for EL, LPL, and HL in the presence of high concentrations of human or mouse serum. These data suggest that substrate presentation is a critical factor when determining EL activity in the presence of serum.

Published
2007

49. Preparative Enzymatic Synthesis and Characterization of the Cytoplasmic Intermediates of Murein Biosynthesis

Author

Kenny K. Wong, Sreelatha G. Reddy, David L. Pompliano, Sherman T. Waddell, and David W. Kuo

Subjects
chemistry.chemical_classification, Stereochemistry, General Chemistry, biochemical phenomena, metabolism, and nutrition, Enzymatic synthesis, Biochemistry, Catalysis, Murein biosynthesis, carbohydrates (lipids), Colloid and Surface Chemistry, Enzyme, chemistry, Cytoplasm, Yield (chemistry), bacteria
Abstract

The first six cytoplasmic intermediates of murein biosynthesis (2−7) have been prepared in high yield (>60%) and at preparative scale (10−100 mg) using purified enzymes of the murein biosynthetic p...

Published
1999
Full Text
View/download PDF

50. Inhibitors of the bacterial cell wall biosynthesis enzyme Mur D

Author

Laura D. Gegnas, Renee M. Chabin, Sreelatha G. Reddy, Kenny K. Wong, and Sherman T. Waddell

Subjects
Clinical Biochemistry, Pharmaceutical Science, medicine.disease_cause, Biochemistry, Bacterial cell structure, Cell wall, chemistry.chemical_compound, Organophosphorus Compounds, Biosynthesis, Cell Wall, Drug Discovery, Escherichia coli, medicine, Peptide Synthases, Molecular Biology, Antibacterial agent, chemistry.chemical_classification, Molecular Structure, biology, Organic Chemistry, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Peptidoglycan
Abstract

A series of transition-state analog inhibitors of the D-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.

Published
1998
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results