366 results on '"Sheridan H"'
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2. A comparison of grassland vegetation from three agri-environment conservation measures
- Author
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Ó hUallacháin D., Finn J.A., Keogh B., Fritch R., and Sheridan H.
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agri-environment scheme ,grassland botanical diversity ,grassland conservation ,high nature value farmland ,semi-natural grassland ,Agriculture (General) ,S1-972 ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Semi-natural grassland habitats have declined significantly throughout Europe. To halt the decline, grassland conservation measures have been included in most European agri-environment schemes. This is the first study to compare the botanical composition of grassland habitats managed under the Irish Agri-Environment Options Scheme (AEOS). Sixty fields on drystock pastoral farms in receipt of agri-environment payments for grassland conservation were surveyed, with 20 fields being enrolled in each of the following AEOS options: Traditional Hay Meadow (THM), Species-Rich Grassland (SRG) and Natura 2000 species-rich grassland (Natura). The vegetation quality of sites enrolled in the Natura measure was higher than the quality of those enrolled in the THM and SRG measures. Natura sites had the greatest species richness, with a mean >40 species per site, which included approximately 17 species indicative of high botanical quality. Traditional Hay Meadows sites had the lowest species richness (mean: 29 species per site) and were dominated by species associated with improved grassland. Some THM sites had good levels of botanical richness and were similar in composition to Natura sites, with some Natura sites having lower vegetation quality, more similar to that of THM sites. Species-Rich Grassland had botanical richness that was intermediate between THM and Natura sites. A thorough assessment of the effectiveness of these measures was confounded by a lack of quantitative objectives for the target community composition to be attained. We discuss limitations and potential opportunities regarding the design, targeting, implementation and cost-effectiveness of these agri-environment measures.
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- 2016
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3. Prevalence and distribution of paratuberculosis (johne's disease) in cattle herds in ireland
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Good M, Clegg T, Sheridan H, Yearsely D, O'Brien T, Egan J, and Mullowney P
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herd ELISA-prevalence ,Ireland ,Johne's disease ,Mycobacterium avium subspecies paratuberculosis ,Paratuberculosis ,Veterinary medicine ,SF600-1100 - Abstract
Abstract A simple random survey was conducted in Ireland during 2005 to estimate the ELISA-prevalence of paratuberculosis, commonly called Johne's disease (JD), in the cattle population. Serum samples were collected from all 20,322 females/breeding bulls over 12 months-of-age in 639 herds. All samples were tested using a commercially available absorbed ELISA. The overall prevalence of infected herds, based on the presence of at least one ELISA-positive animal, was 21.4% (95% CI 18.4%-24.9%). Herd prevalence levels amongst dairy herds (mean 31.5%; 95% CI: 24.6%, 39.3%) was higher than among beef herds (mean 17.9%; 95% CI: 14.6%-21.8%). However, the animal level prevalence was similar. The true prevalence among all animals tested, was calculated to be 2.86% (95%CI: 2.76, 2.97) and for animals >= 2 yrs, it was 3.30% (95%CI: 3.17, 3.43). For animals in beef herds, true prevalence was 3.09% (95%CI: 2.93, 3.24), and for those in dairy herds, 2.74% (95%CI: 2.59, 2.90). The majority of herds had only one ELISA-positive infected animal. Only 6.4% (95% CI 4.7%-8.7%) of all herds had more than one ELISA-positive infected animal; 13.3% (CI 8.7%-19.7%) of dairy herds ranging from two to eight ELISA-positive infected animals; and, 3.9% beef herds (CI 2.4%-6.2%) ranging from two to five ELISA-positive infected animals. The true prevalence of herds infected and shedding Mycobacterium avium subspecies paratuberculosis is estimated to be 9.5% for all herd types; 20.6% for dairy herds; and 7.6% for beef herds. If ELISA positive animals
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- 2009
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4. Developing fibre optic Raman spectroscopy probes for cancer diagnosis
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Sheridan, H., Stone, Nick, and Phillips, Dave
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Raman ,Spectroscopy ,Probes ,Lymphoma ,Needle Probe - Abstract
Cancer affects 1 in 2 people during their lifetime. Early diagnosis is critical for ensuring good prognostic outcomes for patients, enabling earlier intervention and informing patient care. The current 'gold standard' of cancer diagnosis is histopathological analysis; visual assessment of morphological features within samples. This process is labour intensive, time consuming, and prone to inter- and intra- observer disagreements. Raman spectroscopy is a highly specific, real-time, chemical analysis tool with the ability to discriminate between cancerous and healthy tissue, and thus represents a potentially powerful diagnostic tool. Fibre optic Raman probes provide the flexibility and size required in order to facilitate in vivo diagnostics. This study develops upon previous work investigating the use of Raman spectroscopy needle probes for the analysis of lymph node tissue. Raman needle probes can incorporate the chemical specificity of Raman spectroscopy into the existing diagnostic pathway, however issues with etaloning and silica background contributions were identified as areas for increasing performance. This work addresses both of these issues through the optimisation of the experimental setup, as well as the creation and testing of different fibre optic probe designs. Analysis of the effect of different cameras on obtained etaloning signals determined that the use of a camera with an AR coating optimised for the spectral region of interest resulted in a significant reduction in etaloning signals. It was identified that the use of 200 μm fibres leads to improvements in sampling volume, signal quality and silica contributions. The use of higher sampling volume in particular may prove beneficial when measuring lymph node samples, which are known to be highly heterogeneous and therefore prone to under sampling issues during diagnosis. The use of this fibre and the high performance camera within a final probe design obtained a higher diagnostic performance with measurements of ten lymph node samples than was achievable with the previous generation of probe design, indicating the strength of the optimisation of the design. The use of the final design also reduced the incidence of burning of the samples and overall levels of fluorescence and etaloning. Further testing of Shifted Excitation Raman Difference Spectroscopy (SERDS) indicated that of 7 tested excitation wavelengths between 830.0 nm and 833.9 nm, a combination of 830.0 and 832.4 represents the best available performance in terms of both removal of silica and etaloning signals. This shift was then tested on two lymph node samples for the first analysis of lymph node tissue measured with a Raman needle probe using the SERDS technique, and demonstrated a powerful reduction in etaloning signals in particular. This development of the probe design and optimisation of experimental setup lead to measurements that indicate the strength of Raman spectroscopy needle probes as a potential tool for the in vivo assessment of lymph nodes.
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- 2023
5. Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3′ UTR of FAIM2
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Littleton, Sheridan H., Trang, Khanh B., Volpe, Christina M., Cook, Kieona, DeBruyne, Nicole, Maguire, Jean Ann, Weidekamp, Mary Ann, Hodge, Kenyaita M., Boehm, Keith, Lu, Sumei, Chesi, Alessandra, Bradfield, Jonathan P., Pippin, James A., Anderson, Stewart A., Wells, Andrew D., Pahl, Matthew C., and Grant, Struan F.A.
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- 2024
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6. Immunomodulatory therapy in children with paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS, MIS-C; RECOVERY): a randomised, controlled, open-label, platform trial
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Faust, Saul N, Haynes, Richard, Jones, Christine E, Staplin, Natalie, Whittaker, Elizabeth, Jaki, Thomas, Juszczak, Ed, Spata, Enti, Wan, Mandy, Bamford, Alasdair, Dimitri, Paul, Finn, Adam, Furness, John, Ramanan, Athimalaipet V, Gale, Christopher, Cathie, Katrina, Drysdale, Simon, Bernatoniene, Jolanta, Murray, Clare, Roehr, Charles C, Fleming, Paul, Riordan, Andrew, Bandi, Srini, Jyothish, Deepthi, Evans, Jennifer, Emonts, Marieke, Kelly, Dominic, Pathan, Nazima, Davies, Patrick, Hague, Rosie, Pollock, Louisa, Semple, Malcolm G, Peto, Leon, Baillie, J Kenneth, Buch, Maya, Jeffery, Katie, Knight, Marian, Lim, Wei Shen, Montgomery, Alan, Mukherjee, Aparna, Mumford, Andrew, Rowan, Kathryn, Thwaites, Guy, Mafham, Marion, Emberson, Jonathan, Landray, Martin J, Horby, Peter W, Chappell, Lucy, Day, Jeremy, Dung, DV, Quang, NN, Binh, Prof, Burhan, E, Alisjahbana, B, Koirala, J, Basnet, S, Kestelyn, E, Basnyat, B, Gyanwali, P, Hamers, RL, Sandercock, P, Darbyshire, J, DeMets, D, Fowler, R, Lalloo, D, Munavvar, M, Roberts, I, Warris, A, Wittes, J, Craddock-Bamford, A, Barton, J, Basoglu, A, Brown, R, Brudlo, W, Denis, E, Fletcher, L, Howard, S, Musini, S, Taylor, K, Cui, G, Goodenough, B, King, A, Lay, M, Murray, D, Stevens, W, Wallendszus, K, Welsh, R, Crichton, C, Davies, J, Goldacre, R, Harper, C, Knight, F, Nunn, M, Salih, H, Welch, J, Campbell, M, Pessoa-Amorim, G, Zayed, M, Wiles, J, Bagley, G, Cameron, S, Chamberlain, S, Farrell, B, Freeman, H, Kennedy, A, Whitehouse, A, Wilkinson, S, Wood, C, Reith, C, Davies, K, Halls, H, Holland, L, Truell, R, Wilson, K, Lingwood, Emma, Howie, L, Lunn, M, Rodgers, Penelope, Amuasi, J, Baird, K, Bao, T, Bittaye, M, Bonney, J, D'Alessandro, U, Dhimal, M, Huyen, T, Jagne, A, Karkey, A, Maiga, O, Matey, E, Nadjm, B, Nel, J, Pant, S, Puspatriani, K, Rahardjani, M, Raijal, S, Rees, H, Rimainar, A, Roberts, C, Rocca, A, Shrestha, S, Usuf, E, Vidaillic, C, Wulandari, F, Alexander, A, Amezaga, M, Armah, C, Asghar, A, Aubrey, P, Barker-Williams, K, Barnard, A, Bartholomew, J, Beaumont-Jewell, D, Beddows, S, Beety, J, Birch, C, Boyle, P, Brend, M, Brookes, M, Callens, C, Campbell, D, Campbell, H, Cate, H, Chambers, E, Chapman, K, Coe, A, Collins, J, Crawshaw, S, Das, S, De Soyza, A, Denton, E, Dicks, P, Dolman, M, Donaldson, K, Dowden, L, Dowling, S, Drake, C, Duckles-Leech, H, Duffy, H, Gerdes, L, Gibbons, K, Gill, L, Gilmour, K, Goodwin, J, Graham, J, Green, C, Hall, C, Hall, A, Hampshire, K, Hanson, J, Harman, T, Harper, H, Harrison, S, Hicks, J, Hodgson, H, Hough, M, Jackson, S, Johnson, G, Kirk, J, Lemoine, N, Levett, C, Lock, S, Lockett, T, Logan, M, Lomme, K, Luo, J, McMillan, N, Membrey, H, Mguni, N, Minton, J, Monaghan, H, Murphy, S, Muzengi, N, Naz, M, Nickson, I, Odam, M, Ohia, U, Okell, E, Oliver, A, Pearson, K, Pine, K, Pleass, R, Porter, D, Porter, L, Potter, A, Poustie, V, Pratt, S, Price, A, Priest, A, Rodgers, A, Rook, C, Ryan, P, Sam, S, Sharratt, P, Sheffield, J, Shenton, J, Shirley, K, Skinner, T, Slade, H, Sutu, M, Taylor, J, Thomas, E, Tinkler, H, Unsworth, A, Usher, R, van't Hoff, W, Walker, S, Walters, J, Walton, E, Warmington, J, Wayman, E, Williams, P, Williamson, J, Williamson, D, Yelnoorkar, F, Knight, M, Hodson, K, Pavord, S, Williamson, C, Bowman, L, Chen, F, Clarke, R, Goonasekara, M, Herrington, W, Judge, P, Ng, S, Preiss, D, Sammons, E, Zhu, D, Arkley, C, Bowker, P, Bruce, J, Byrne-Watts, V, Chapman, G, Coleman, G, Denwood, T, Gray, J, Harrison, D, Mather, N, Pinches, H, Rees, A, Rees, S, Turner, G, Abani, O, Abbas, A, Abbas, F, Abbas, J, Abbas, K, Abbas, M, Abbasi, S, Abbass, H, Abbott, A, Abdallah, N, Abdelaziz, A, Abdelfattah, M, Abdelqader, B, Abdul, A, Abdul, B, Abdul, S, Abdul Rasheed, A, Abdulakeem, A, Abdul-Kadir, R, Abdullah, A, Abdulmumeen, A, Abdul-Raheem, R, Abdulshukkoor, N, Abdusamad, K, Abed El Khaleq, Y, Abedalla, M, Abeer Ul Amna, A, Abel, L, Abernethy, K, Abeywickrema, M, Abhinaya, C, Aboaba, A, Aboagye-Odei, A, Aboelela, H, Abo-Leyah, H, Abouelela, K, Abou-Haggar, A, Abouibrahim, M, Abousamra, A, Abouzaid, M, Abraham, M, Abraham, T, Abraheem, A, Abrams, J, Abrams, R, Abu, H, Abu-Arafeh, A, Abubacker, S, Abung, A, Abusamra, Y, Aceampong, Y, Achara, A, Acharya, D, Acheampong, S, Acheampong, P, Acheson, J, Achieng, S, Acosta, A, Acquah, R, Acton, C, Adabie-Ankrah, J, Adair, P, Adam, F, Adam, M, Adamali, H, Adamczyk, M, Adams, C, Adams, D, Adams, K, Adams, L, Adams, N, Adams, R, Adams, T, Adamu-Ikeme, L, Adati, K, Adcock, K, Addo, A, Adeagbo, O, Adebiyi, A, Adedeji, O, Adegeye, Y, Adegoke, K, Adell, V, Adenwalla, S, Adeoye, F, Adesemoye, O, Adewunmi, E, Adeyanju, A, Adeyemi, J, Adeyemo, T, Adhikary, R, Aditya, A, Adkins, G, Adnan, A, Aeron-Thomas, J, Affleck, D, Afnan, C, Afridi, M, Aftab, Z, Agarwal, M, Agbeko, R, Agbo, C, Aggarwal, S, Aghababaie, A, Aguilar Jimenez, L, Ahamed Sadiq, S, Ahammed Nazeer, M, Ahmed, A, Ahmed, B, Ahmed, F, Ahmed, H, Ahmed, I, Ahmed, K, Ahmed, L, Ahmad, M, Ahmed, N, Ahmed, O, Ahmed, R, Ahmad, S, Ahmed, S H, Ahmed Ali, R, Ahmed Mohamud, B, Ahmer, S, Ahonia, A, Aiken, C, Ail, D, Ainsworth, M, Aissa, M, Aitken, L, Ajay, B, Ajibode, A, Ajmi, A, Akhtar, N, Akili, S, Akinbiyi, B, Akindolie, O, Akinfenwa, Y, Akinkugbe, O, Akinpelu, I, Akram, M, Aktinade, O, Akudi, U, Al Aaraj, A, Al Balushi, A, Al Dakhola, M, Al Swaifi, A, Al-Abadi, E, Alabi, A, Aladangady, N, Alafifi, M, Alam, A, Alam, S, Al-Asadi, A, Alatzoglou, K, Albert, P, Albon, L, Alcala, A, Alcorn, G, Alcorn, S, Aldana, A, Alderdice, D, Aldesouki, A, Aldouri, R, Aldridge, J, Aldridge, N, Alegria, A, Alexander, C, Alexander, J, Alexander, P, Al-Fori, J, Alghazawi, L, Alhabsha, O, Al-Hakim, B, Alhameed, R, Al-Hayali, M, Al-Hity, S, Ali, A, Ali, F, Ali, J, Ali, M, Ali, N, Ali, O, Ali, R, Ali, S, Aliberti, E, Alin, J, Alina, A, Alipustain, A, Aliyuda, F, Alizaedeh, K, Al-Jibury, M, Al-Juboori, S, Al-Khalil, M, Alkhudhayri, A, Alkhusheh, M, Allan, F, Allan, N, Allanson, A, Allcock, R, Allen, E, Allen, J, Allen, K, Allen, L, Allen, P, Allen, R, Allen, S, Allen, T, Alli, A, Allison, K, Allman, B, Allsup, D, Allsop, H, Allsop, L, Almahroos, A, Al-Moasseb, H, Al-Obaidi, M, Alomari, L, Al-Rabahi, A, Al-Ramadhani, B, Al-Saadi, Z, Al-Sammarraie, R, Alshaer, I, Al-Shahi Salman, R, Al-Shamkhani, W, Alsheikh, F, Al-Sheklly, B, Altaf, S, Alty, A, Alvarez, M, Alvarez Corral, M, Alveyn, E, Alzetani, M, Amamou, S, Amar, N, Ambalavanan, S, Ambrogetti, R, Ambrose, C, Ameen, A, Ames, K, Amin, A, Amin, K, Amin, S, Amin, T, Amit, B, Amjad, A, Amjad, N, Amosun, V, Amsal, M, Amsha, K, Amutio Martin, N, Amy, P, Anada, A, Anand, A, Anandappa, S, Anantapatnaikuni, S, Anderson, E, Anderson, J, Anderson, L, Anderson, M, Anderson, N, Anderson, R, Anderson, S, Anderson, W, Andreou, P, Andrews, A, Andrews, J, Aneke, K, Ang, A, Ang, W, Angel, T, Angela, A, Angelini, P, Anguvaa, L, Anichtchik, O, Anim-Somuah, M, Aniruddhan, K, Annett, J, Anning, L, Anstey, P, Anstey, R, Anthony, A, Anthony-Pillai, A, Antill, P, Antonnia, Z, Anu, V, Anwar, M, Apetri, E, Apostolopoulos, A, Appleby, S, Appleyard, D, Aquino, M, Araba, B, Aransiola, S, Araujo, M, Archer, A, Archer, D, Archer, S, Arcoria, D, Ardley, C, Arias, A, Aribike, O, Arimoto, R, Armata, I, Armistead, J, Armitage, A, Armstrong, C, Armstrong, M, Armstrong, S, Armstrong, W, Armtrong, P, Arndt, H, Arnison-Newgass, C, Arnold, D, Arnold, R, Arnott, A, Arora, D, Arora, R, Arora, K, Arora, P, Arter, A, Arumaithurai, A, Arya, A, Arya, R, Asandei, D, Asghar, M, Ashab, M, Ashbrook-Raby, C, Ashby, H, Ashcroft, J, Ashcroft, S, Asher, G, Ashfak, Z, Ashfaq, A, Ashish, A, Ashley, D, Ashman-Flavell, S, Ashok, S, Ashour, A, Ashraf, S, Ashraf, M, Ashraq, M, Ashton, D, Ashton, S, Ashworth, A, Ashworth, F, Ashworth, R, Aslam, A, Aslam, I, Aslam, S, Aslett, L, Asogan, H, Asrar, A, Assaf, O, Astin-Chamberlain, R, Athorne, D, Atkins, B, Atkins, C, Atkins, S, Atkinson, J, Atkinson, V, Atomode, A, Atraskiewicz, B, Attia, A, Attubato, E, Attwood, M, Auer, Z, Aujayeb, A, Aung, A, Aung, H, Aung, K, Aung, N, Aung, Y, Aung, Z, Austin, E, Austin, K, Auwal, A, Avari, M, Avery, M, Aveyard, N, Avis, J, Aviss, G, Avram, C, Avram, P, Awadelkareem, A, Awadzi, G, Awaly, M, Awan, A, Awoseyila, A, Aya, A, Ayaz, E, Ayers, A, Azam, J, Azeem, A, Azharuddin, M, Aziz, A, Aziz, G, Aziz, I, Aziz, N, Azkoul, A, Azman Shah, A, Azzopardi, G, Azzoug, H, Babatunde, F, Babi, M, Babiker, B, Babington, G, Babirecki, M, Babores, M, Babs-Osibodu, A, Bacciarelli, S, Bachar, R, Bachour, M, Bacon, G, Bacon, J, Badal, B, Bader, M, Badhan, G, Badhrinarayanan, S, Bae, J, Baggaley, A, Baggott, A, Bagmane, D, Bagshaw, L, Bahadori, K, Bailey, A, Bailey, J, Bailey, K, Bailey, L, Bailey, M, Bailey, P, Bailey, S, Baillie, H, Baillie, J, Bain, J, Bains, V, Baird, D, Baird, E, Baird, S, Baird, T, Baird, Y, Bajandouh, A, Baker, D, Baker, E, Baker, J, Baker, K, Baker, M, Baker, R, Baker, T, Baker, V, Bakere, H, Bakerly, N, Baker-Moffatt, M, Bakhai, A, Bakhtiar, N, Bakoulas, P, Bakthavatsalam, D, Balachandran, N, Balan, A, Balasingam, P, Balaskas, T, Balasubramania, M, Balatoni, N, Balcombe, A, Baldwin, A, Baldwin, C, Baldwin, D, Baldwin, F, Baldwin-Jones, R, Bale, N, Balfour, J, Ball, R, Ball, M, Ballard, K, Balluz, I, Balmforth, C, Balogh, E, Baltmr, A, Baluwala, A, Bambridge, G, Bamford, P, Bamford, A, Bamgboye, A, Bancroft, H, Bancroft, E, Banda, J, Bandaru, K, Bandla, N, Bandyopadhyam, S, Banerjee, A, Banerjee, R, Bani-Saad, O, Banks, H, Banks, L, Banks, P, Bann, C, Bannister, H, Bannister, O, Banton, L, Baptist, M, Baqai, T, Baral, A, Baramova, D, Barbe, R, Barbon, E, Barbosa, M, Barbour, J, Barclay, A, Barclay, C, Bardsley, G, Bareford, S, Bari, S, Barker, A, Barker, D, Barker, E, Barker, H, Barker, J, Barker, L, Barker, O, Barkha, S, Barla, J, Barlow, G, Barlow, R, Barlow, V, Barnacle, J, Barnes, D, Barnes, N, Barnes, R, Barnes, T, Barnetson, C, Barnett, A, Barnett-Vanes, A, Barnsley, W, Barr, A, Barr, C, Barr, D, Barr, J, Barratt, N, Barratt, S, Barrera, M, Barrett, A, Barrett, F, Barrett, J, Barrett, S, Barrow, E, Bartlett, C, Bartlett, G, Bartlett, J, Bartlett, L, Bartley, S, Bartolmeu-Pires, S, Barton, A, Barton, G, Barton, L, Barton, R, Baruah, R, Baryschpolec, S, Bashir, H, Bashyal, A, Basker, B, Basran, A, Bassett, G, Bassett, J, Bassford, C, Bassoy, B, Bastion, V, Basumatary, A, Basvi, P, Bataduwaarachchi, V, Bate, T, Bateman, H, Bateman, K, Bateman, V, Bates, E, Bates, H, Bates, M, Bates, S, Batham, S, Batista, A, Batla, A, Batra, D, Batty, A, Batty, H, Batty, T, Baum, M, Baumbe, R, Bautista, C, Bawa, T, Bawa, F, Bawani, F, Bax, S, Baxter, M, Baxter, N, Baxter, Z, Bayes, H, Bayo, L-A, Bazari, F, Bazaz, R, Bazli, A, Beacham, L, Beadles, W, Beadon, K, Beak, P, Beale, A, Beard, K, Beardsal, K, Bearpark, J, Beasley, A, Beattie, S, Beaumont, K, Beaver, T, Beavis, S, Beazley, C, Beck, S, Beckett, V, Beckitt, R, Beckley, S, Beddall, H, Beeby, D, Beeby, S, Beech, G, Beecroft, M, Beer, S, Beer, N, Bega, G, Begg, A, Begg, S, Beghini, S, Begum, A, Begum, S, Behan, T, Behrouzi, R, Beishon, J, Beith, C, Belcher, J, Belfield, H, Belfield, K, Belgaumkar, A, Bell, D, Bell, G, Bell, J, Bell, L, Bell, N, Bell, P, Bell, S, Bellamu, J, Bellamy, M, Bellamy, T, Bellini, A, Bellis, A, Bellis, F, Bendall, L, Benesh, N, Benetti, N, Benham, L, Benison-Horner, G, Benkenstein, S, Benn, T, Bennett, A, Bennett, C, Bennett, D, Bennett, G, Bennett, K, Bennett, L, Bennett, M, Bennett, S, Bennion, K, Benoy, G, Benson, V, Bentley, A, Bentley, J, Benton, I, Beranova, E, Beresford, M, Bergin, C, Bergstrom, M, Berriman, T, Berry, Z, Best, K, Best, F, Bester, A, Beuvink, Y, Bevan, E, Bevins, S, Bewick, T, Bexley, A, Beyatli, S, Beynon, F, Bhadi, A, Bhagani, S, Bhakta, S, Bhalla, R, Bhandal, K, Bhandari, A, Bhandari, S, Bhanich Supapol, J, Bhanot, A, Bhanot, R, Bhasin, S, Bhat, A, Bhat, P, Bhatnagar, R, Bhatt, K, Bhayani, J, Bhojwani, D, Bhuie, P, Bhuiyan, S, Bibby, A, Bibi, F, Bibi, N, Bibi, S, Bicanic, T, Bidgood, S, Bigg, J, Biggs, S, Biju, A, Bikov, A, Billingham, S, Billings, J, Binns, A, BinRofaie, M, Bintcliffe, O, Birch, J, Birchall, K, Bird, S, Birt, M, Bishop, C, Bishop, K, Bishop, L, Bisnauthsing, K, Biswas, N, Biuk, S, Blachford, K, Black, E, Black, H, Black, K, Black, M, Black, P, Black, S, Blackgrove, H, Blackledge, B, Blackler, J, Blackley, S, Blackman, H, Blackstock, C, Blair, C, Blakemore, F, Blamey, H, Bland, A, Blane, S, Blankley, S, Blaxill, P, Blaylock, K, Blazeby, J, Blencowe, N, Bloom, B, Bloomfield, J, Bloss, A, Blowers, A, Blows, S, Bloxham, H, Blundell, L, Blunsum, A, Blunt, M, Blunt, T, Blyth, I, Blyth, K, Blythe, A, Blythe, K, Boampoaa, M, Board, S, Bobie, B, Bobruk, K, Bodalia, P, Bodasing, N, Boden, M, Bodenham, T, Boehmer, G, Boffito, M, Bohanan, K, Bohmov, K, Bohnacker, N, Bokhandi, S, Bokhar, M, Bokhari, S, Bokobza, I, Boles, A, Bolger, C, Bond, C, Bond, H, Bond, S, Bond, T, Bone, A, Boniface, G, Bonney, L, Booker, L, Boot, S, Boothroyd, M, Borbone, J, Borman, N, Bosence, S, Bostock, K, Botting, N, Bottrill, F, Bouattia, H, Bough, L, Boughton, H, Boult, Z, Boumrah, T, Bourke, M, Bourke, S, Bourne, M, Bousfield, R, Boustred, L, Bowes, A, Bowker, T, Bowler, H, Bowman, S, Bowmer, R, Bowring, A, Bowyer, H, Boyd, A, Boyd, J, Boyd, L, Boyer, N, Boyle, N, Boyle, R, Boyles, L, Brace, L, Bracken, A, Bradder, J, Bradley, C, Bradley, P, Bradley-Potts, J, Bradshaw, L, Bradshaw, Z, Brady, C, Brady, R, Brady, S, Braga Sardo, P, Braganza, D, Braithwaite, M, Brammer, S, Branch, M, Brankin-Frisby, T, Brannigan, J, Brattan, S, Bray, F, Bray, N, Brazil, M, Brear, L, Brear, T, Brearey, S, Bremner, L, Bresges, X, Bressington, C, Bretland, G, Brewer, C, Bridgett, M, Bridgwood, G, Brigham, S, Bright, J, Brightling, C, Brigstock, T, Brimfield, L, Brinksman, P, Brinkworth, E, Brittain-Long, R, Britten, V, Britton, H, Broad, L, Broadhead, S, Broadhurst, R, Broadley, A, Broadway, M, Brockelsby, C, Brocken, M, Brockley, T, Brodsky, M, Brogan, F, Brohan, L, Brokke, F, Brolly, J, Bromley, D, Brooke-Ball, H, Brooker, V, 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Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A
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7. Metabolic links among milk, genes and gut
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8. Empagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
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von Oven, L, Vooght, C, Vu Thai, KT, Vutipongsatorn, K, Vuylsteke, A, Vyras, E, Wach, R, Wadams, B, Wadd, S, Waddington, N, Wade, P, Wadsley, J, Wadsworth, K, Wafa, SEI, Wagstaff, D, Wagstaff, L, Wahab, D, Wahbi, Z, Waheed Adigun, A, Waidyanatha, S, Waite, A, Wake, R, Wakefield, A, Wakeford, W, Wakinshaw, F, Waldeck, E, Walden, A, Walding, L, Waldron, A, Waldron, J, Wales, E, Wali, B, Walker, D, Walker, G, Walker, H, Walker, I, Walker, K, Walker, L, Walker, O, Walker, R, Walker, S, Wallace, G, Wallbutton, R, Wallen, J, Wallendszus, K, Waller, A, Waller, R, Wallis, G, Wallis, L, Wallis, M, Walmsley, E, Walsh, D, Walsh, E, Walsh, L, Walstow, D, Walter, D, Walters, A, Walters, H, Walters, J, Walton, E, Walton, L, Walton, M, Walton, O, Walton, S, Wan, M, Wanda, J, Wands, M, Wane, R, Wang, F, Wang, N, Wang, R, Wang, S, Warbrick, D, Warburton, S, Ward, C, Ward, D, Ward, E, Ward, H, Ward, J, Ward, L, Ward, N, Ward, R, Ward, T, Warden, SA, Wardere, G, Wardle, S, Wardy, H, Waring, G, Waring, S, Warmington, J, Warner, B, Warner, C, Warnock, L, Warran, S, Warren, J, Warren, L, Warren, R, Warren, Y, Warrender, D, Warren-Miell, H, Warris, A, Warwick, G, Wassall, H, Wasserman, S, Wasson, E, Watchorn, HJ, Waterfall, H, Waters, A, Waters, D, Waterstone, M, Watkin, A, Watkins, C, Watkins, E, Watkins, K, Watkins, L, Watson, A, Watson, AJR, Watson, E, Watson, F, Watson, JGR, Watson, L, Watson, P, Watson, R, Watson, K, Watters, M, Watterson, D, Wattimena, K, Watts, D, Watts, J, Watts, M, Waugh, V, Wayman, E, Wayman, M, Wazir, A, Weatherhead, M, Weatherly, N, Webb, C, Webb, H, Webb, K, Webb, S, Websdale, C, Webster, D, Webster, I, Webster, J, Webster, T, Wedlin, J, Wee, L, Weerakoon, R, Weerasinghe, T, Weeratunga, J, Weetman, M, Wei, S, Weichert, I, Welch, E, Welch, H, Welch, J, Welch, L, Welch, S, Welham, B, Weller, S, Wellings, L, Wells, B, Wellstead, S, Welsh, B, Welsh, R, Welters, I, Welton, R, Wenn, V, Wentworth, L, Wesonga, J, Wesseldine, K, West, J, West, M, West, R, West, S, Western, L, Westhead, R, Weston, H, Westwood, A, Westwood, K, Westwood, S, Wetherill, B, Wheaver, S, Wheeler, H, Whelan, B, Whelband, M, Whileman, A, Whitcher, A, White, A, White, B, White, C, White, D, White, J, White, K, White, M, White, N, White, S, White, T, Whitehead, C, Whitehorn, K, Whitehouse, A, Whitehouse, C, Whitehouse, T, Whiteley, J, Whiteley, L, Whiteley, S, Whitham, R, Whitlingum, G, Whitmore, D, Whittaker, E, Whittam, L, Whittington, A, Whittle, H, Whittle, R, Wiafe, E, Wiblin, L, Wickens, O, Widdrington, J, Wieboldt, J, Wieringa, H, Wiesender, C, Wiffen, L, Wight, A, Wignall, A, Wignall, C, Wilce, A, Wilcock, D, Wilcock, E, Wilcox, L, Wild, B, Wild, L, Wild, S, Wilde, M, Wilding, L, Wilding, P, Wildsmith, T, Wileman, J, Wiles, J, Wiles, K, Wilhelmsen, E, Wiliams, T, Wilkie, J, Wilkin, D, Wilkins, H, Wilkins, J, Wilkins, S, Wilkinson, I, Wilkinson, L, Wilkinson, N, Wilkinson, S, Wilkinson, T, Willetts, S, Williams, A, Williams, C, Williams, CV, Williams, D, Williams, E, Williams, G, Williams, H, Williams, J, Williams, K, Williams, M, Williams, P, Williams, R, Williams, S, Williams, T, Williamson, A, Williamson, C, Williamson, D, Williamson, J, Williamson, JD, Williamson, R, Williamson, H, Willis, E, Willis, H, Willis, J, Wills, L, Willsher, L, Willshire, C, Willson, F, Willson, J, Wilson, A, Wilson, B, Wilson, D, Wilson, I, Wilson, J, Wilson, K, Wilson, K-A, Wilson, L, Wilson, M, Wilson, S, Wilson, T, Win, KLY, Win, M, Win, T, Win, TT, Win, WYW, Winckworth, L, Winder, L, Winder, P, Winearl, S, Winmill, H, Winn, S, Winpenny, C, Winslow, H, Winter, H, Winter, J, Winter-Goodwin, B, Winterton, J, Winwood, H, Wischhusen, J, Wisdom, S, Wise, M, Wiselka, M, Wiseman, R, Wiseman, S, Wishart, S, WIshlade, T, Witele, E, Withers, N, Wittes, J, Wixted, D, Wodehouse, T, Wolf, W, Wolff, N, Wolffsohn, K, Wolf-Roberts, R, Wolodimeroff, E, Wolstencroft, A, Wong, A, Wong, C, Wong, C-H, Wong, C-M, Wong, E, Wong, JSY, Wong, KY, Wong, MY, Wong, N, Wong, S, Wong, T, Wongkyezeng, AA, Wood, A, Wood, C, Wood, D, Wood, F, Wood, G, Wood, H, Wood, J, Wood, L, Wood, M, Wood, S, Wood, T, Woodall, K, Woodfield, R, Woodford, C, Woodford, E, Woodford, J, Woodhead, L, Woodhead, T, Woodland, P, Woodman, M, Woodmansey, S, Woods, C, Woods, J, Woods, K, Woods, S, Woodward, Z, Woolcock, M, Wooldridge, G, Woolf, R, Woollard, C, Woollen, L, Woolley, E, Woolley, J, Woosey, D, Wootton, D, Wootton, J, Worley, D, Worton, S, Wraight, J, Wray, M, Wren, K, Wren, L, Wrey Brown, C, Wright, C, Wright, D, Wright, F, Wright, H, Wright, I, Wright, L, Wright, R, Wright, S, Wright, T, Wroe, C, Wroe, H, Wu, H, Wu, P, Wubetu, J, Wulandari, F, Wulandari, R, Wurie, S, Wyatt, C, Wyn-Griffiths, F, Wynter, I, Xavier, B, Xhikola, A, Xia, BE, Xia, Z, Yacoba, E, Yadav, S, Yakubi, M, Yan, M, Yanagisawa, Y, Yang, F, Yang, Y, Yanney, M, Yap, WL, Yaqoob, N, Yasmin, S, Yates, B, Yates, D, Yates, E, Yates, H, Yates, T, Yates, M, Ye, J, Yearwood Martin, C, Yein, K, Yelnoorkar, F, Yen, LM, Yeoh, A, Yeung, CY, Yew, P, Yewatkar, D, Ylquimiche Melly, L, Ynter, I, Yong, H, Yorke, J, Youens, J, Younes Ibrahim, A, Young, E, Young, G, Young, L, Yousafzar, A, Youssouf, S, Yousuf, A, Yovita, H, Yu, C, Yuan, JSJ, Yufaniaputri, N, Yung, B, Yusef, D, Yusef, S, Yusuf, I, Zafar, A-S, Zagalo, S, Zaher, S, Zahoor, A, Zainab, M, Zak, T, Zaki, K, Zakir, N, Zalewska, K, Zamalloa, A, Zaman, M, Zaman, S, Zamikula, J, Zammit, L, Zammit-Mangion, M, Zawadzka, M, Zayed, M, Zebracki, E, Zehnder, D, Zeidan, L, Zeinali, D, Zhang, J, Zhao, X, Zheng, D, Zhu, D, Zia, M, Zibdeh, O, Zill-E-Huma, R, Zin, ET, Zincone, E, Zindoga, G, Zinkin, E, Zinyemba, V, Zipitis, C, Zitter, L, Zmierczak, A, Zubikarai, G, Zubir, A, Zuhra, N, Zulaikha, R, Zulfikar, S, Zullo, C, and Zuriaga-Alvaro, A
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- 2023
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9. Benefit of inhalation aromatherapy as a complementary treatment for stress and anxiety in a clinical setting – A systematic review
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Hedigan, F., Sheridan, H., and Sasse, A.
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- 2023
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10. Field margin botanical diversity, composition and quality on intensively managed farming systems
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Larkin, J., hUallacháin, D. Ó, Finn, J.A., and Sheridan, H.
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- 2022
11. BOTANICAL REJUVENATION OF FIELD MARGINS AND BENEFITS FOR INVERTEBRATE FAUNA ON A DRYSTOCK FARM IN COUNTY LONGFORD
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Sheridan, H., Finn, J.A., and O'Donovan, G.
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- 2022
12. Quality control of herbal drugs and preparations: The methods of analysis, their relevance and applications
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Muyumba, N.W., Mutombo, S.C., Sheridan, H, Nachtergael, A., and Duez, P.
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- 2021
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13. 11. Grazing multispecies swards alters enteric methane emissions by ewes and lambs
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Connolly, R., primary, Sheridan, H., additional, McGovern, F., additional, McCarron, P., additional, Egan, G., additional, Lott, S., additional, and Boland, T., additional
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- 2024
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14. 10. Enhancing the sustainability of ruminant livestock systems through multispecies swards
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Sheridan, H., primary
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- 2024
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15. Yield of binary- and multi-species swards relative to single-species swards in intensive silage systems
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Moloney, T., Sheridan, H., Grant, J., O’Riordan, E.G., and O’Kiely, P.
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- 2020
16. Herbage nutritive value of binary- and multi-species swards relative to single-species swards in intensive silage systems
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Moloney, T., Sheridan, H., Grant, J., O’Riordan, E.G., and O’Kiely, P.
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- 2020
17. Conservation efficiency and nutritive value of silages made from grass-red clover and multi-species swards compared with grass monocultures
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Moloney, T., Sheridan, H., Grant, J., O’Riordan, E.G., and O’Kiely, P.
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- 2020
18. Identifying Barriers to HIV and Substance Use Service Engagement for Young Adults Involved in the Criminal Legal System
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Sweet, Sheridan H and Sweet, Sheridan H
- Abstract
Background: The prevalence of HIV and substance use (SU) disorder is significantly higher among individuals involved in the criminal legal system than in the US generally (HIV: 1.2% vs 0.013%) (SUD: 65% vs 16.1%). Young adults (YA) are disproportionately represented in rates of incarceration, HIV, and SU disorder. Despite the high need, there are few successful interventions that link criminal legal involved (CLI) individuals to SU and HIV services, and even fewer tailored to the needs of YA. Studies have shown that YA have lower engagement and retention rates in reentry programming, but causal factors have not been identified. The purpose of this study is to identify barriers to engaging CLI-YA in HIV and SU services. Methods: Key informant interviews were conducted with systems partners (n=8) from the criminal legal (n=3) and public health sectors (n=5). Systems partners were asked about: 1) experiences linking CLI-YA to HIV and SU services; 2) perspectives on a navigator intervention for use with CLI-YA; 3) perspectives on how a navigator intervention could be adapted in the context of the study setting. Interviews were analyzed via Inductive Thematic Analysis. Analyses were facilitated via Dedoose. Results: Four themes impacting HIV and SU service engagement for CLI-YA were identified: 1) the health and social services landscape; 2) life chaos; 3) relationships and social support; 4) readiness to change and engage in services. Structural factors were associated with the health and social service landscape (e.g., accessibility of services) and life chaos (e.g., competing needs), social factors with relationships and social support (e.g., provider relationships), and individual factors with readiness to change and engage in services (e.g. risk perception). Conclusions: Improving rates of HIV and SU service engagement for CLI-YA would require an approach that addresses structural, social, and individual level factors. Instituting a collaborative jail discharge proc
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- 2024
19. Perturbation of the insomnia WDR90 genome-wide association studies locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q.
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Sonti, Shilpa, Littleton, Sheridan H, Pahl, Matthew C, Zimmerman, Amber J, Chesi, Alessandra, Palermo, Justin, Lasconi, Chiara, Brown, Elizabeth B, Pippin, James A, Wells, Andrew D, Doldur-Balli, Fusun, Pack, Allan I, Gehrman, Phillip R, Keene, Alex C, and Grant, Struan F A
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- 2024
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20. Analysis of international, European and Scot's law governing marine litter and integration of policy within regional marine plans
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Sheridan, H., Johnson, K., and Capper, A.
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- 2020
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21. Including clover and herb species in grazing forages – effects on milk production, milk processability and milk fatty acid profile of late lactation dairy cows supplemented with grass silage and concentrate
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McCarthy, K.M., primary, Walsh, N., additional, Serra, E., additional, Fahey, A.G., additional, Lynch, M.B., additional, Pierce, K.M., additional, Boland, T.M., additional, Sheridan, H., additional, Markiewicz-Keszycka, M., additional, and Mulligan, F.J., additional
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- 2024
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22. P103 Natural compounds in Ulcerative Colitis and Irritable Bowel Syndrome: Insights from immune-metabolic profiles
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McShane, C, primary, O'Connell, F, additional, Pigott, M, additional, Obaidi, I, additional, Sheridan, H, additional, Kevans, D, additional, and O'Sullivan, J, additional
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- 2024
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23. Genetic Determinants of Childhood Obesity
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Littleton, Sheridan H., Berkowitz, Robert I., and Grant, Struan F. A.
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- 2020
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24. Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
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Pahl, Matthew C., Doege, Claudia A., Hodge, Kenyaita M., Littleton, Sheridan H., Leonard, Michelle E., Lu, Sumei, Rausch, Rick, Pippin, James A., De Rosa, Maria Caterina, Basak, Alisha, Bradfield, Jonathan P., Hammond, Reza K., Boehm, Keith, Berkowitz, Robert I., Lasconi, Chiara, Su, Chun, Chesi, Alessandra, Johnson, Matthew E., Wells, Andrew D., Voight, Benjamin F., Leibel, Rudolph L., Cousminer, Diana L., and Grant, Struan F. A.
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- 2021
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25. 3D genomic features across >50 diverse cell types reveal insights into the genomic architecture of childhood obesity
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Trang, Khanh B, primary, Pahl, Matthew C, additional, Pippin, James A, additional, Su, Chun, additional, Littleton, Sheridan H, additional, Sharma, Prabhat, additional, Kulkarni, Nikhil N, additional, Ghanem, Louis R, additional, Terry, Natalie A, additional, O'Brien, Joan M, additional, Wagley, Yadav, additional, Hankenson, Kurt D, additional, Jermusyk, Ashley, additional, Hoskins, Jason W, additional, Amundadottir, Laufey T, additional, Xu, Mai, additional, Brown, Kevin M, additional, Anderson, Stewart A, additional, Yang, Wenli, additional, Titchenell, Paul M, additional, Seale, Patrick, additional, Cook, Laura, additional, Levings, Megan K, additional, Zemel, Babette S, additional, Chesi, Alessandra, additional, Wells, Andrew D, additional, and Grant, Struan FA, additional
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- 2023
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26. Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3′ UTR ofFAIM2
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Littleton, Sheridan H, primary, Trang, Khanh B, additional, Volpe, Christina M, additional, Cook, Kieona, additional, DeBruyne, Nicole, additional, Maguire, Jean Ann, additional, Weidekamp, Mary Ann, additional, Boehm, Keith, additional, Chesi, Alessandra, additional, Pippin, James A, additional, Anderson, Stewart A, additional, Wells, Andrew D, additional, Pahl, Matthew C, additional, and Grant, Struan FA, additional
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- 2023
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27. Perturbation of the insomnia WDR90 GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q
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SONTI, SHILPA, primary, Littleton, Sheridan H, additional, Pahl, Matthew C, additional, Zimmerman, Amber J, additional, Chesi, Alessandra, additional, Palermo, Justin, additional, Lasconi, Chiara, additional, Brown, Elizabeth B, additional, Pippin, James A, additional, Wells, Andrew D, additional, Balli, Fusun Doldur, additional, Pack, Allan I, additional, Gehrman, Philip R, additional, Keen, Alex C, additional, and Grant, Struan FA, additional
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- 2023
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28. The effect of a zero-grazed perennial ryegrass, perennial ryegrass and white clover, or multispecies forage on the dry matter intake, milk production and nitrogen utilization of dairy cows in mid-late lactation
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McCarthy, K.M., primary, Walsh, N., additional, van Wylick, C., additional, McDonald, M., additional, Fahey, A.G., additional, Lynch, M.B., additional, Pierce, K.M., additional, Boland, T.M., additional, Sheridan, H., additional, Markiewicz-Keszycka, M., additional, and Mulligan, F.J., additional
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- 2023
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29. Farmland habitat diversity in Ireland
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Sheridan, H., Keogh, B., Anderson, A., Carnus, T., McMahon, B.J., Green, S., and Purvis, G.
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- 2017
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30. The effect of sward type on average daily gain, meat fatty acid and vitamin E profile of co-grazed heifers and lambs
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Beaucarne, G., primary, Kearns, M., additional, Cama-Moncunill, R., additional, Grace, C., additional, Kennedy, J., additional, Monahan, F.J., additional, Sheridan, H., additional, and Boland, T., additional
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- 2023
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31. Rumen fermentation and forage degradability in dairy cows offered perennial ryegrass, perennial ryegrass and white clover, or a multispecies forage
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McCarthy, K.M., primary, Lynch, M.B., additional, Pierce, K.M., additional, Fahey, A.G., additional, Gath, V.P., additional, McDonald, M., additional, Boland, T.M., additional, Sheridan, H., additional, Markiewicz-Keszycka, M., additional, and Mulligan, F.J., additional
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- 2023
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32. Legumes as a Biological Tool to Address the Sustainability of Ruminant Production Systems
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Sheridan, H., primary, Lynch, M. B., additional, and Hameed, A., additional
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- 2023
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33. Unlocking Natureʼs Pharmacy: An Electrophysiological Assessment of The Impact of Cannabis-Derived Terpenes on Acute Seizure Activity In Vitro
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Sheridan, H, primary, Cunningham, M O, additional, Walsh, A, additional, Macaulay, H, additional, and Dunbar, A, additional
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- 2022
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34. Carissa spinarum L.: a study using ethnomedicine-guided systems pharmacology in identifying a mechanism of action of a medicinal plant
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Smyth, C, primary, Liu, J, additional, Yuan, S, additional, Obaidi, I, additional, and Sheridan, H, additional
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- 2022
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35. Unlocking Natureʼs Pharmacy: Composition and bioactivity of essential oil of bog-myrtle (Myrica gale) grown on Irish boglands
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Pigott, M, primary, Nagar, S, additional, Woulfe, I, additional, Scalabrino, G, additional, and Sheridan, H, additional
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- 2022
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36. Unlocking Natureʼs Pharmacy: Effects of processing on chemical composition and biological activity of Echinacea purpurea
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Tolan, K, primary, OʼConnell, P, additional, Obadi, I, additional, Carty, M, additional, Gorman, A, additional, OʼConnor, S, additional, OʼHara, H, additional, Healy, A M, additional, and Sheridan, H, additional
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- 2022
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37. Short Lecture “Unique Molecules from a Bioactive Irish Bog Lichen, Cladonia portentosa”
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Nagar, S, primary, Obadi, I, additional, Carty, M, additional, Kukuła-Koch, W, additional, and Sheridan, H, additional
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- 2022
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38. Unlocking natureʼs Pharmacy from Bogland Species: Root and aerial extracts of Tormentil exhibit antimicrobial and antibiofilm effects against Acinetobacter baumannii
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Gately, C, primary, Gadar, K, additional, Obaidi, I, additional, McCarthy, R, additional, and Sheridan, H, additional
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- 2022
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39. Natural products in drug discovery: advances and opportunities
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Atanasov, A. G., Zotchev, S. B., Dirsch, V. M., Orhan, I. E., Banach, M., Rollinger, J. M., Barreca, D., Weckwerth, W., Bauer, R., Bayer, E. A., Majeed, M., Bishayee, A., Bochkov, V., Bonn, G. K., Braidy, N., Bucar, F., Cifuentes, A., D'Onofrio, G., Bodkin, M., Diederich, M., Dinkova-Kostova, A. T., Efferth, T., El Bairi, K., Arkells, N., Fan, T. -P., Fiebich, B. L., Freissmuth, M., Georgiev, M. I., Gibbons, S., Godfrey, K. M., Gruber, C. W., Heer, J., Huber, L. A., Ibanez, E., Kijjoa, A., Kiss, A. K., Lu, A., Macias, F. A., Miller, M. J. S., Mocan, A., Muller, R., Nicoletti, F., Perry, G., Pittala, V., Rastrelli, L., Ristow, M., Russo, G. L., Silva, A. S., Schuster, D., Sheridan, H., Skalicka-Wozniak, K., Skaltsounis, L., Sobarzo-Sanchez, E., Bredt, D. S., Stuppner, H., Sureda, A., Tzvetkov, N. T., Vacca, R. A., Aggarwal, B. B., Battino, M., Giampieri, F., Wink, M., Wolfender, J. -L., Xiao, J., Yeung, A. W. K., Lizard, G., Popp, M. A., Heinrich, M., Berindan-Neagoe, I., Stadler, M., Daglia, M., Verpoorte, R., Supuran, C. T., Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), Atanasov, A. G., Zotchev, S. B., Dirsch, V. M., Orhan, I. E., Banach, M., Rollinger, J. M., Barreca, D., Weckwerth, W., Bauer, R., Bayer, E. A., Majeed, M., Bishayee, A., Bochkov, V., Bonn, G. K., Braidy, N., Bucar, F., Cifuentes, A., D'Onofrio, G., Bodkin, M., Diederich, M., Dinkova-Kostova, A. T., Efferth, T., El Bairi, K., Arkells, N., Fan, T. -P., Fiebich, B. L., Freissmuth, M., Georgiev, M. I., Gibbons, S., Godfrey, K. M., Gruber, C. W., Heer, J., Huber, L. A., Ibanez, E., Kijjoa, A., Kiss, A. K., Lu, A., Macias, F. A., Miller, M. J. S., Mocan, A., Muller, R., Nicoletti, F., Perry, G., Pittala, V., Rastrelli, L., Ristow, M., Russo, G. L., Silva, A. S., Schuster, D., Sheridan, H., Skalicka-Wozniak, K., Skaltsounis, L., Sobarzo-Sanchez, E., Bredt, D. S., Stuppner, H., Sureda, A., Tzvetkov, N. T., Vacca, R. A., Aggarwal, B. B., Battino, M., Giampieri, F., Wink, M., Wolfender, J. -L., Xiao, J., Yeung, A. W. K., Lizard, G., Popp, M. A., Heinrich, M., Berindan-Neagoe, I., Stadler, M., Daglia, M., Verpoorte, R., and Supuran, C. T.
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0301 basic medicine ,Engineering ,Drug Industry ,Review Article ,Communicable Diseases ,Natural (archaeology) ,03 medical and health sciences ,0302 clinical medicine ,Transferases ,Neoplasms ,Drug Discovery ,Humans ,Pharmaceutical industry ,Pharmacology ,Biological Products ,Natural products ,Genome ,business.industry ,Drug discovery ,General Medicine ,Chemical biology ,030104 developmental biology ,Risk analysis (engineering) ,030220 oncology & carcinogenesis ,Genome mining ,business - Abstract
The International Natural Product Sciences Taskforce: et al., Natural products and their structural analogues have historically made a major contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless, natural products also present challenges for drug discovery, such as technical barriers to screening, isolation, characterization and optimization, which contributed to a decline in their pursuit by the pharmaceutical industry from the 1990s onwards. In recent years, several technological and scientific developments — including improved analytical tools, genome mining and engineering strategies, and microbial culturing advances — are addressing such challenges and opening up new opportunities. Consequently, interest in natural products as drug leads is being revitalized, particularly for tackling antimicrobial resistance. Here, we summarize recent technological developments that are enabling natural product-based drug discovery, highlight selected applications and discuss key opportunities., A.C. and E.I. thank the Ministerio de Ciencia, Innovación y Universidades, Spain (Project AGL2017-89417-R) for support. F.A.M. acknowledges the support by Ministerio de Economia y Competitividad, Spain (project AGL2017-88083-R).
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- 2021
40. Cis-regulatory architecture of human ESC-derived hypothalamic neuron differentiation aids in variant-to-gene mapping of relevant complex traits
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Jonathan P. Bradfield, Benjamin F. Voight, Chun Su, Kenyaita M. Hodge, Claudia A. Doege, Rick Rausch, Robert I. Berkowitz, Struan F.A. Grant, Diana L. Cousminer, Sumei Lu, Michelle E. Leonard, Matthew E. Johnson, Alisha Basak, Maria Caterina De Rosa, Matthew C. Pahl, James A. Pippin, Sheridan H. Littleton, Rudolph L. Leibel, Keith Boehm, Andrew D. Wells, Reza K. Hammond, Chiara Lasconi, and Alessandra Chesi
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Epigenomics ,Multifactorial Inheritance ,Science ,Human Embryonic Stem Cells ,Hypothalamus ,General Physics and Astronomy ,Genome-wide association study ,Computational biology ,Biology ,Article ,General Biochemistry, Genetics and Molecular Biology ,Cell Line ,Gene mapping ,Humans ,Gene Regulatory Networks ,RNA-Seq ,Regulatory Elements, Transcriptional ,Transcription factor ,Gene ,Neurons ,Regulation of gene expression ,Multidisciplinary ,Effector ,Chromosome Mapping ,Gene Expression Regulation, Developmental ,Cell Differentiation ,General Chemistry ,Gene regulation ,Chromatin ,Neuron differentiation ,General Economics, Econometrics and Finance ,Function (biology) ,Genome-Wide Association Study - Abstract
The hypothalamus regulates metabolic homeostasis by influencing behavior and endocrine systems. Given its role governing key traits, such as body weight and reproductive timing, understanding the genetic regulation of hypothalamic development and function could yield insights into disease pathogenesis. However, given its inaccessibility, studying human hypothalamic gene regulation has proven challenging. To address this gap, we generate a high-resolution chromatin architecture atlas of an established embryonic stem cell derived hypothalamic-like neuron model across three stages of in vitro differentiation. We profile accessible chromatin and identify physical contacts between gene promoters and putative cis-regulatory elements to characterize global regulatory landscape changes during hypothalamic differentiation. Next, we integrate these data with GWAS loci for various complex traits, identifying multiple candidate effector genes. Our results reveal common target genes for these traits, potentially affecting core developmental pathways. Our atlas will enable future efforts to determine hypothalamic mechanisms influencing disease susceptibility., Understanding the genetic regulation of hypothalamic function could yield insights into disease pathogenesis, but its inaccessibility has made this challenging. Here the authors present a high-resolution chromatin atlas of a hypothalamic-like neuron model across three stages of differentiation.
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- 2022
41. Strategies to identify causal common genetic variants and corresponding effector genes for paediatric obesity
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Sheridan H. Littleton and Struan F. A. Grant
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Pediatric Obesity ,Nutrition and Dietetics ,Health Policy ,Pediatrics, Perinatology and Child Health ,Public Health, Environmental and Occupational Health ,Humans ,Chromosome Mapping ,Alpha-Ketoglutarate-Dependent Dioxygenase FTO ,Genetic Predisposition to Disease ,Child ,Polymorphism, Single Nucleotide ,Genome-Wide Association Study - Abstract
Childhood obesity rates are on the rise, but there are currently no effective therapies available to slow or halt their progression. Although environmental and lifestyle factors have been implicated in its pathogenesis, childhood obesity is considered a complex disorder with a clear genetic component. Intense genome-wide association study (GWAS) efforts through large-scale collaborations have enabled the discovery of genetic loci robustly associated with childhood obesity beyond the classic FTO locus. That said, GWAS itself does not pinpoint the actual underlying causal effector genes, but rather just yields association signals in the genome.This review aims to outline what has been elucidated thus far on the genetic aetiology of commong childhood obesity and to describe strategies to identify and validate both causal common genetic variants and their corresponding effector genes.Relevant cell types for molecular studies can be identified by gene set enrichment analysis and considering known biology of obesity-related physiological processes. Putatively causal single nucleotide polymorphisms (SNPs) can be identified by several methods including statistical fine mapping and 'assay for transposase accessible chromatin sequencing' (ATAC-seq). Variant to gene mapping can then nominate effector genes likely regulated by cis-regulatory elements harbouring putatively causal SNPs. A SNP's cis-regulatory activity can be functionally validated by several in vitro methods including luciferase assay and CRISPR approaches. These CRISPR approaches can also be used to investigate how dysregulatn of effector genes may confer obesity risk.Uncovering the causative genes related to GWAS signals and elucidating their functional contributions to paediatric obesity with these strategies will deepen our understanding of this disease and serve better treatment outcomes.
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- 2022
42. 298-OR: Variant-to-Gene Mapping at the Childhood Obesity Locus on chr12q13 and Subsequent Luciferase Assay Analyses Implicate rs71329as a Causal Variant within the 3’ UTR of FAIM2
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SHERIDAN H. LITTLETON, JONATHAN BRADFIELD, JAMES A. PIPPIN, CHUN SU, ALESSANDRA CHESI, ANDREW D. WELLS, ROBERT I. BERKOWITZ, MATTHEW C. PAHL, and STRUAN F. GRANT
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Endocrinology, Diabetes and Metabolism ,Internal Medicine - Abstract
A key limitation of genome-wide association studies (GWAS) is that they do not specify either the underlying causal variant (s) or the effector gene (s) at a given locus. The widely reproduced obesity FAIM2 locus, named arbitrarily after the nearest gene, is relatively understudied given it is more strongly associated in children than in adults. Our previously reported trans-ancestral GWAS meta-analysis of childhood obesity enabled fine-mapping of the FAIM2 locus; in the ‘credible set’ of 6 SNPs, rs71329 had the highest probability of being causal. This non-coding variant resides in the 3’ untranslated region (UTR) of FAIM2. Given that obesity-related GWAS signals have been reported to be enriched in genes relevant to neuronal function, we generated ATAC-seq and high-resolution promoter-focused Capture C data in both primary astrocytes and ESC-derived hypothalamic neurons to carry out variant-to-gene mapping at this locus. We observed that rs71329 occupied a region of open chromatin, therefore a putatively functional element, and made physical contact with the FAIM2 promoter. These findings were also supported by both GTEx testes eQTL data and a transcriptome-wide association study in brain tissue. We sought to determine in vitro if the rs71329alleles influence enhancer activity in primary astrocytes. Using technical replicates repeated 8 times, the non-risk allele region increased luciferase reporter expression relative to the FAIM2 promoter alone by a fold change of 1.87, while the risk allele decreased expression by a fold change of 0.68 (non-risk allele+FAIM2 promoter vs. risk allele+FAIM2 promoter P Disclosure S.H.Littleton: None. J.Bradfield: None. J.A.Pippin: None. C.Su: None. A.Chesi: None. A.D.Wells: Stock/Shareholder; Johnson & Johnson. R.I.Berkowitz: Research Support; Eisai Inc., Novo Nordisk. M.C.Pahl: None. S.F.Grant: None. Funding National Institutes of Health (HD056465)
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- 2022
43. Strategies to identify causal common genetic variants and corresponding effector genes for paediatric obesity
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Littleton, Sheridan H., primary and Grant, Struan F. A., additional
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- 2022
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44. 298-OR: Variant-to-Gene Mapping at the Childhood Obesity Locus on chr12q13 and Subsequent Luciferase Assay Analyses Implicate rs71329as a Causal Variant within the 3’ UTR of FAIM2
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LITTLETON, SHERIDAN H., primary, BRADFIELD, JONATHAN, additional, PIPPIN, JAMES A., additional, SU, CHUN, additional, CHESI, ALESSANDRA, additional, WELLS, ANDREW D., additional, BERKOWITZ, ROBERT I., additional, PAHL, MATTHEW C., additional, and GRANT, STRUAN F., additional
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- 2022
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45. Transgenic Leontopodium (Edelweiss)
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Hook, I. L. I., Sheridan, H., and Bajaj, Y. P. S., editor
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- 2001
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46. Genetic Determinants of Childhood Obesity
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Robert I. Berkowitz, Sheridan H. Littleton, and Struan F.A. Grant
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0301 basic medicine ,Multifactorial Inheritance ,Pediatric Obesity ,Genome-wide association study ,Biology ,Bioinformatics ,FTO gene ,Article ,Childhood obesity ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Genetics ,medicine ,Genetic predisposition ,Humans ,Genetic Predisposition to Disease ,Child ,Genetic association ,Pharmacology ,Genetic Variation ,General Medicine ,medicine.disease ,Obesity ,Human genetics ,030104 developmental biology ,030220 oncology & carcinogenesis ,Molecular Medicine ,Genome-Wide Association Study ,Alström syndrome - Abstract
Obesity represents a major health burden to both developed and developing countries. Furthermore, the incidence of obesity is increasing in children. Obesity contributes substantially to mortality in the United States by increasing the risk for type 2 diabetes, cardiovascular-related diseases and other comorbidities. Despite environmental changes over the past decades, including increases in high-calorie foods and sedentary lifestyles, there is very clear evidence of a genetic predisposition to obesity risk. Childhood obesity cases can be categorized in one of two ways: syndromic or non-syndromic. Syndromic obesity includes disorders such as Prader-Willi syndrome, Bardet-Biedl syndrome and Alström syndrome. Non-syndromic cases of obesity can be further separated into rarer instances of monogenic obesity and much more common forms of polygenic obesity. The advent of genome-wide association studies (GWAS) and next generation sequencing has driven significant advances in our understanding of the genetic contribution to childhood obesity. Many rare and common genetic variants have been shown to contribute to the heritability in obesity, although the molecular mechanisms underlying most of these variants remain unclear. An important caveat of GWAS efforts is that they do not strictly represent gene target discoveries, rather simply the uncovering of robust genetic signals. One clear example of this is with progress in understanding the key obesity signal harbored within an intronic region of the FTO gene. It has been shown that the non-coding region in which the variant actually resides in fact influences the expression of genes distal to FTO instead, specifically IRX3 and IRX5. Such discoveries suggest that associated non-coding variants can be embedded within or next to one gene, but commonly influence the expression of other, more distal effector genes. Advances in genetics and genomics are therefore contributing to a deeper understanding of childhood obesity, allowing for development of clinical tools and therapeutic agents.
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- 2020
47. BOTANICAL REJUVENATION OF FIELD MARGINS AND BENEFITS FOR INVERTEBRATE FAUNA ON A DRYSTOCK FARM IN COUNTY LONGFORD
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Sheridan, H., Finn, J.A., and O'Donovan, G.
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- 2009
48. Unlocking Nature's Pharmacy – Assessing the Quality of Irish Echinacea plant materials
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O’Connell, P., additional, Kelly, J., additional, Turner, J., additional, Pigott, M.T., additional, and Sheridan, H., additional
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- 2021
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49. Unlocking Nature’s Pharmacy – from plant to product: An academic odyssey
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Sheridan, H, additional and Frankish, N., additional
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- 2021
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50. Carissa spinarum L. (Apocynaceae): a case study in ethnomedical research
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Smyth, C, additional and Sheridan, H, additional
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- 2021
- Full Text
- View/download PDF
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