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508 results on '"Shergill, Sukhi"'

1. Connectome dysfunction in patients at clinical high risk for psychosis and modulation by oxytocin

Author

Davies, Cathy, Martins, Daniel, Dipasquale, Ottavia, McCutcheon, Robert A., De Micheli, Andrea, Ramella-Cravaro, Valentina, Provenzani, Umberto, Rutigliano, Grazia, Cappucciati, Marco, Oliver, Dominic, Williams, Steve, Zelaya, Fernando, Allen, Paul, Murguia, Silvia, Taylor, David, Shergill, Sukhi, Morrison, Paul, McGuire, Philip, Paloyelis, Yannis, and Fusar-Poli, Paolo

Published
2024
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9. Monitoring Daily Sleep, Mood, and Affect Using Digital Technologies and Wearables: A Systematic Review.

Author

Hickman, Robert, D'Oliveira, Teresa C., Davies, Ashleigh, and Shergill, Sukhi

Subjects
SLEEP duration, WEARABLE technology, SLEEP quality, SLEEP interruptions, SLEEP, AFFECTIVE disorders, DIGITAL technology
Abstract

Background: Sleep and affective states are closely intertwined. Nevertheless, previous methods to evaluate sleep-affect associations have been limited by poor ecological validity, with a few studies examining temporal or dynamic interactions in naturalistic settings. Objectives: First, to update and integrate evidence from studies investigating the reciprocal relationship between daily sleep and affective phenomena (mood, affect, and emotions) through ambulatory and prospective monitoring. Second, to evaluate differential patterns based on age, affective disorder diagnosis (bipolar, depression, and anxiety), and shift work patterns on day-to-day sleep-emotion dyads. Third, to summarise the use of wearables, actigraphy, and digital tools in assessing longitudinal sleep-affect associations. Method: A comprehensive PRISMA-compliant systematic review was conducted through the EMBASE, Ovid MEDLINE(R), PsycINFO, and Scopus databases. Results: Of the 3024 records screened, 121 studies were included. Bidirectionality of sleep-affect associations was found (in general) across affective disorders (bipolar, depression, and anxiety), shift workers, and healthy participants representing a range of age groups. However, findings were influenced by the sleep indices and affective dimensions operationalised, sampling resolution, time of day effects, and diagnostic status. Conclusions: Sleep disturbances, especially poorer sleep quality and truncated sleep duration, were consistently found to influence positive and negative affective experiences. Sleep was more often a stronger predictor of subsequent daytime affect than vice versa. The strength and magnitude of sleep-affect associations were more robust for subjective (self-reported) sleep parameters compared to objective (actigraphic) sleep parameters. [ABSTRACT FROM AUTHOR]

Published
2024
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10. A systematic review of TMS and neurophysiological biometrics in patients with schizophrenia

Author

di Hou, Meng, Santoro, Viviana, Biondi, Andrea, Shergill, Sukhi S., and Premoli, Isabella

Subjects
Schizophrenia -- Physiological aspects, Health, Psychology and mental health
Abstract

Background: Transcranial magnetic stimulation can be combined with electromyography (TMS-EMG) and electroencephalography (TMS-EEG) to evaluate the excitatory and inhibitory functions of the cerebral cortex in a standardized manner. It has been postulated that schizophrenia is a disorder of functional neural connectivity underpinned by a relative imbalance of excitation and inhibition. The aim of this review was to provide a comprehensive overview of TMS-EMG and TMS-EEG research in schizophrenia, focused on excitation or inhibition, connectivity, motor cortical plasticity and the effect of antipsychotic medications, symptom severity and illness duration on TMS-EMG and TMS-EEG indices. Methods: We searched PsycINFO, Embase and Medline, from database inception to April 2020, for studies that included TMS outcomes in patients with schizophrenia. We used the following combination of search terms: transcranial magnetic stimulation OR tms AND interneurons OR glutamic acid OR gamma aminobutyric acid OR neural inhibition OR pyramidal neurons OR excita * OR inhibit * OR GABA * OR glutam* OR E-I balance OR excitation-inhibition balance AND schizoaffective disorder * OR Schizophrenia OR schizophreni*. Results: TMS-EMG and TMS-EEG measurements revealed deficits in excitation or inhibition, functional connectivity and motor cortical plasticity in patients with schizophrenia. Increased duration of the cortical silent period (a TMS-EMG marker of y-aminobutyric acid B receptor activity) with clozapine was a relatively consistent finding. Limitations: Most of the studies used patients with chronic schizophrenia and medicated patients, employed cross-sectional group comparisons and had small sample sizes. Conclusion: TMS-EMG and TMS-EEG offer an opportunity to develop a novel and improved understanding of the physiologic processes that underlie schizophrenia and to assess the therapeutic effect of antipsychotic medications. In the future, these techniques may also help predict disease progression and further our understanding of the excitatory/inhibitory balance and its implications for mechanisms that underlie treatment-resistant schizophrenia., Introduction Schizophrenia is a neuropsychiatric illness that affects nearly 1% of the population. (1) It is characterized by 3 main clusters of symptoms: positive symptoms (e.g., delusions and hallucinations), negative [...]

Published
2021
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11. Developing a process for assessing the safety of a digital mental health intervention and gaining regulatory approval: an academic’s guide

Author

Taher, Rayan, primary, Hall, Charlotte L, additional, Gomez, Aislinn D, additional, Gupta, Neha, additional, Heaysman, Clare, additional, Jacobsen, Pamela, additional, Kabir, Thomas, additional, Kalnad, Nayan, additional, Keppens, Jeroen, additional, Hsu, Che-Wei, additional, McGuire, Philip, additional, Peters, Emmanuelle, additional, Shergill, Sukhi, additional, Stahl, Daniel, additional, Stock, Ben Wensley, additional, and Yiend, Jenny, additional

Published
2024
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14. User-Centered Development of STOP (Successful Treatment for Paranoia): Material Development and Usability Testing for a Digital Therapeutic for Paranoia

Author

Hsu, Che-Wei, primary, Stahl, Daniel, additional, Mouchlianitis, Elias, additional, Peters, Emmanuelle, additional, Vamvakas, George, additional, Keppens, Jeroen, additional, Watson, Miles, additional, Schmidt, Nora, additional, Jacobsen, Pamela, additional, McGuire, Philip, additional, Shergill, Sukhi, additional, Kabir, Thomas, additional, Hirani, Tia, additional, Yang, Ziyang, additional, and Yiend, Jenny, additional

Published
2023
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22. Neurochemical effects of oxytocin in people at clinical high risk for psychosis

Author

Davies, Cathy, Rutigliano, Grazia, De Micheli, Andrea, Stone, James M, Ramella-Cravaro, Valentina, Provenzani, Umberto, Cappucciati, Marco, Scutt, Eleanor, Paloyelis, Yannis, Oliver, Dominic, Murguia, Silvia, Zelaya, Fernando, Allen, Paul, Shergill, Sukhi, Morrison, Paul, Williams, Steve, Taylor, David, Lythgoe, David J, McGuire, Philip, and Fusar-Poli, Paolo

Published
2019
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27. Oxytocin modulates hippocampal perfusion in people at clinical high risk for psychosis

Author

Davies, Cathy, Paloyelis, Yannis, Rutigliano, Grazia, Cappucciati, Marco, De Micheli, Andrea, Ramella-Cravaro, Valentina, Provenzani, Umberto, Antoniades, Mathilde, Modinos, Gemma, Oliver, Dominic, Stahl, Daniel, Murguia, Silvia, Zelaya, Fernando, Allen, Paul, Shergill, Sukhi, Morrison, Paul, Williams, Steve, Taylor, David, McGuire, Philip, and Fusar-Poli, Paolo

Published
2019
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28. Acute oxytocin effects in inferring others’ beliefs and social emotions in people at clinical high risk for psychosis

Author

Schmidt, André, Davies, Cathy, Paloyelis, Yannis, Meyer, Nicholas, De Micheli, Andrea, Ramella-Cravaro, Valentina, Provenzani, Umberto, Aoki, Yuta, Rutigliano, Grazia, Cappucciati, Marco, Oliver, Dominic, Murguia, Silvia, Zelaya, Fernando, Allen, Paul, Shergill, Sukhi, Morrison, Paul, Williams, Steve, Taylor, David, Borgwardt, Stefan, Yamasue, Hidenori, McGuire, Philip, and Fusar-Poli, Paolo

Published
2020
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32. Connectome dysfunction in patients at clinical high risk for psychosis and modulation by oxytocin

Author

Davies, Cathy, primary, Martins, Daniel, additional, Dipasquale, Ottavia, additional, McCutcheon, Robert, additional, De Micheli, Andrea, additional, Ramella-Cravaro, Valentina, additional, Provenzani, Umberto, additional, Rutigliano, Grazia, additional, Cappucciati, Marco, additional, Oliver, Dominic, additional, Williams, Steve, additional, Zelaya, Fernando, additional, Allen, Paul, additional, Murguia, Silvia, additional, Taylor, David, additional, Shergill, Sukhi, additional, Morrison, Paul, additional, McGuire, Philip, additional, Paloyelis, Yannis, additional, and Fusar-Poli, Paolo, additional

Published
2023
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39. Effects of psychosis-associated genetic markers on brain volumetry: a systematic review of replicated findings and an independent validation

Author

Vouga Ribeiro, Nuno, Tavares, Vânia, Bramon, Elvira, Toulopoulou, Timothea, Valli, Isabel, Shergill, Sukhi, Murray, Robin, Prata, Diana, Toulopoulou, Timothea, and Repositório da Universidade de Lisboa

Subjects
Psychiatry and Mental health, Brain structure, GWAS, Imaging genetics, Applied Psychology, Candidate genes, MRI
Abstract

© The Author(s), 2022. Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited., Background: Given psychotic illnesses' high heritability and associations with brain structure, numerous neuroimaging-genetics findings have been reported in the last two decades. However, few findings have been replicated. In the present independent sample we aimed to replicate any psychosis-implicated SNPs (single nucleotide polymorphisms), which had previously shown at least two main effects on brain volume. Methods: A systematic review for SNPs showing a replicated effect on brain volume yielded 25 studies implicating seven SNPs in five genes. Their effect was then tested in 113 subjects with either schizophrenia, bipolar disorder, 'at risk mental state' or healthy state, for whole-brain and region-of-interest (ROI) associations with grey and white matter volume changes, using voxel-based morphometry. Results: We found FWER-corrected (Family-wise error rate) (i.e. statistically significant) associations of: (1) CACNA1C-rs769087-A with larger bilateral hippocampus and thalamus white matter, across the whole brain; and (2) CACNA1C-rs769087-A with larger superior frontal gyrus, as ROI. Higher replication concordance with existing literature was found, in decreasing order, for: (1) CACNA1C-rs769087-A, with larger dorsolateral-prefrontal/superior frontal gyrus and hippocampi (both with anatomical and directional concordance); (2) ZNF804A-rs11681373-A, with smaller angular gyrus grey matter and rectus gyri white matter (both with anatomical and directional concordance); and (3) BDNF-rs6265-T with superior frontal and middle cingulate gyri volume change (with anatomical and allelic concordance). Conclusions: Most literature findings were not herein replicated. Nevertheless, high degree/likelihood of replication was found for two genome-wide association studies- and one candidate-implicated SNPs, supporting their involvement in psychosis and brain structure., VT was supported by a Fundação para a Ciência e Tecnologia (FCT) PhD fellowship (PD/BD/114460/2016) and hired on the FCT DSAIPA/DS/0065/2018 grant. DP was supported, during this work, by the European Commission Seventh Framework Programme Marie Curie Career Integration Grant FP7-PEOPLE-2013-CIG-631952, the 2016 Bial Foundation Psychophysiology Grant – Ref. 292/16, and the FCT IF/00787/2014, LISBOA-01-0145-FEDER-030907, DSAIPA/DS/0065/2018 and UIDB/00645/2020 grants, and the Instituto de Medicina Molecular (iMM) Lisboa Director's Fund Breakthrough Idea Grant 2016.

Published
2022

43. Correspondence

Author

Casetta, Cecilia, primary, Gaughran, Fiona, additional, MacCabe, James, additional, Oloyede, Ebenezer, additional, Shergill, Sukhi, additional, and Taylor, David, additional

Published
2022
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