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274 results on '"Sheppard, Karen E."'

2. Adaptive translational reprogramming of metabolism limits the response to targeted therapy in BRAFV600 melanoma

Author

Smith, Lorey K., Parmenter, Tiffany, Kleinschmidt, Margarete, Kusnadi, Eric P., Kang, Jian, Martin, Claire A., Lau, Peter, Patel, Riyaben, Lorent, Julie, Papadopoli, David, Trigos, Anna, Ward, Teresa, Rao, Aparna D., Lelliott, Emily J., Sheppard, Karen E., Goode, David, Hicks, Rodney J., Tiganis, Tony, Simpson, Kaylene J., Larsson, Ola, Blythe, Benjamin, Cullinane, Carleen, Wickramasinghe, Vihandha O., Pearson, Richard B., and McArthur, Grant A.

Published
2022
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3. Correction: Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

Author

AbuHammad, Shatha, Cullinane, Carleen, Martin, Claire, Bacolas, Zoe, Ward, Teresa, Chen, Huiqin, Slater, Alison, Ardley, Kerry, Kirby, Laura, Chan, Keefe T., Brajanovski, Natalie, Smith, Lorey K., Rao, Aparna D., Lelliott, Emily J., Kleinschmidt, Margarete, Vergara, Ismael A., Papenfuss, Anthony T., Lau, Peter, Ghosh, Prerana, Haupt, Sue, Haupt, Ygal, Sanij, Elaine, Poortinga, Gretchen, Pearson, Richard B., Falk, Hendrik, Curtis, David J., Stupple, Paul, Devlin, Mark, Street, Ian, Davies, Michael A., McArthur, Grant A., and Sheppard, Karen E.

Published
2020

4. The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

Author

Yan, Shunfei, Xuan, Jiachen, Brajanovski, Natalie, Tancock, Madeleine R. C., Madhamshettiwar, Piyush B., Simpson, Kaylene J., Ellis, Sarah, Kang, Jian, Cullinane, Carleen, Sheppard, Karen E., Hannan, Katherine M., Hannan, Ross D., Sanij, Elaine, Pearson, Richard B., and Chan, Keefe T.

Published
2021
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6. Regulation of PRMT5–MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

Author

AbuHammad, Shatha, Cullinane, Carleen, Martin, Claire, Bacolas, Zoe, Ward, Teresa, Chen, Huiqin, Slater, Alison, Ardley, Kerry, Kirby, Laura, Chan, Keefe T., Brajanovski, Natalie, Smith, Lorey K., Rao, Aparna D., Lelliott, Emily J., Kleinschmidt, Margarete, Vergara, Ismael A., Papenfuss, Anthony T., Lau, Peter, Ghosh, Prerana, Haupt, Sue, Haupt, Ygal, Sanij, Elaine, Poortinga, Gretchen, Pearson, Richard B., Falk, Hendrik, Curtis, David J., Stupple, Paul, Devlin, Mark, Street, Ian, Davies, Michael A., McArthur, Grant A., and Sheppard, Karen E.

Published
2019

7. Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

Author

Parmenter, Tiffany J, Kleinschmidt, Margarete, Kinross, Kathryn M, Bond, Simon T, Li, Jason, Kaadige, Mohan R, Rao, Aparna, Sheppard, Karen E, Hugo, Willy, Pupo, Gulietta M, Pearson, Richard B, McGee, Sean L, Long, Georgina V, Scolyer, Richard A, Rizos, Helen, Lo, Roger S, Cullinane, Carleen, Ayer, Donald E, Ribas, Antoni, Johnstone, Ricky W, Hicks, Rodney J, and McArthur, Grant A

Subjects
Clinical Research, Genetics, Cancer, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Cell Line, Tumor, Drug Resistance, Neoplasm, Glycolysis, HEK293 Cells, Humans, Indoles, MAP Kinase Signaling System, Melanoma, Piperazines, Protein Kinase Inhibitors, Proto-Oncogene Proteins B-raf, Pyridines, Sulfonamides, Transcription Factors, Vemurafenib, Oncology and Carcinogenesis
Abstract

UnlabelledDeregulated glucose metabolism fulfills the energetic and biosynthetic requirements for tumor growth driven by oncogenes. Because inhibition of oncogenic BRAF causes profound reductions in glucose uptake and a strong clinical benefit in BRAF-mutant melanoma, we examined the role of energy metabolism in responses to BRAF inhibition. We observed pronounced and consistent decreases in glycolytic activity in BRAF-mutant melanoma cells. Moreover, we identified a network of BRAF-regulated transcription factors that control glycolysis in melanoma cells. Remarkably, this network of transcription factors, including hypoxia-inducible factor-1α, MYC, and MONDOA (MLXIP), drives glycolysis downstream of BRAF(V600), is critical for responses to BRAF inhibition, and is modulated by BRAF inhibition in clinical melanoma specimens. Furthermore, we show that concurrent inhibition of BRAF and glycolysis induces cell death in BRAF inhibitor (BRAFi)-resistant melanoma cells. Thus, we provide a proof-of-principle for treatment of melanoma with combinations of BRAFis and glycolysis inhibitors.SignificanceBRAF is suppress glycolysis and provide strong clinical benefi t in BRAF V600 melanoma. We show that BRAF inhibition suppresses glycolysis via a network of transcription factors that are critical for complete BRAFi responses. Furthermore, we provide evidence for the clinical potential of therapies that combine BRAFis with glycolysis inhibitors.

Published
2014

10. Supplementary Table S1 from Combined BRAF, MEK, and CDK4/6 Inhibition Depletes Intratumoral Immune-Potentiating Myeloid Populations in Melanoma

Author

Lelliott, Emily J., primary, Mangiola, Stefano, primary, Ramsbottom, Kelly M., primary, Zethoven, Magnus, primary, Lim, Lydia, primary, Lau, Peter K.H., primary, Oliver, Amanda J., primary, Martelotto, Luciano G., primary, Kirby, Laura, primary, Martin, Claire, primary, Patel, Riyaben P., primary, Slater, Alison, primary, Cullinane, Carleen, primary, Papenfuss, Anthony T., primary, Haynes, Nicole M., primary, McArthur, Grant A., primary, Oliaro, Jane, primary, and Sheppard, Karen E., primary

Published
2023
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11. Data from Combined BRAF, MEK, and CDK4/6 Inhibition Depletes Intratumoral Immune-Potentiating Myeloid Populations in Melanoma

Author

Lelliott, Emily J., primary, Mangiola, Stefano, primary, Ramsbottom, Kelly M., primary, Zethoven, Magnus, primary, Lim, Lydia, primary, Lau, Peter K.H., primary, Oliver, Amanda J., primary, Martelotto, Luciano G., primary, Kirby, Laura, primary, Martin, Claire, primary, Patel, Riyaben P., primary, Slater, Alison, primary, Cullinane, Carleen, primary, Papenfuss, Anthony T., primary, Haynes, Nicole M., primary, McArthur, Grant A., primary, Oliaro, Jane, primary, and Sheppard, Karen E., primary

Published
2023
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12. Supplementary Figures from Combined BRAF, MEK, and CDK4/6 Inhibition Depletes Intratumoral Immune-Potentiating Myeloid Populations in Melanoma

Author

Lelliott, Emily J., primary, Mangiola, Stefano, primary, Ramsbottom, Kelly M., primary, Zethoven, Magnus, primary, Lim, Lydia, primary, Lau, Peter K.H., primary, Oliver, Amanda J., primary, Martelotto, Luciano G., primary, Kirby, Laura, primary, Martin, Claire, primary, Patel, Riyaben P., primary, Slater, Alison, primary, Cullinane, Carleen, primary, Papenfuss, Anthony T., primary, Haynes, Nicole M., primary, McArthur, Grant A., primary, Oliaro, Jane, primary, and Sheppard, Karen E., primary

Published
2023
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13. Data from Inhibition of the MNK1/2–eIF4E Axis Augments Palbociclib-Mediated Antitumor Activity in Melanoma and Breast Cancer

Author

Prabhu, Sathyen A., primary, Moussa, Omar, primary, Gonçalves, Christophe, primary, LaPierre, Judith H., primary, Chou, Hsiang, primary, Huang, Fan, primary, Richard, Vincent R., primary, Ferruzo, Pault Y. M., primary, Guettler, Elizabeth M., primary, Soria-Bretones, Isabel, primary, Kirby, Laura, primary, Gagnon, Natascha, primary, Su, Jie, primary, Silvester, Jennifer, primary, Krisna, Sai Sakktee, primary, Rose, April A. N., primary, Sheppard, Karen E., primary, Cescon, David W., primary, Mallette, Frédérick A., primary, Zahedi, Rene P., primary, Borchers, Christoph H., primary, del Rincon, Sonia V., primary, and Miller, Wilson H., primary

Published
2023
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14. Data from Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition

Author

Davis, Sally J., primary, Sheppard, Karen E., primary, Anglesio, Michael S., primary, George, Joshy, primary, Traficante, Nadia, primary, Fereday, Sian, primary, Intermaggio, Maria P., primary, Menon, Usha, primary, Gentry-Maharaj, Aleksandra, primary, Lubinski, Jan, primary, Gronwald, Jacek, primary, Pearce, Celeste Leigh, primary, Pike, Malcolm C., primary, Wu, Anna, primary, Kommoss, Stefan, primary, Pfisterer, Jacobus, primary, du Bois, Andreas, primary, Hilpert, Felix, primary, Ramus, Susan J., primary, Bowtell, David D.L., primary, Huntsman, David G., primary, Pearson, Richard B., primary, Simpson, Kaylene J., primary, Campbell, Ian G., primary, and Gorringe, Kylie L., primary

Published
2023
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15. Supplementary Data 2 from Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

Author

Parmenter, Tiffany J., primary, Kleinschmidt, Margarete, primary, Kinross, Kathryn M., primary, Bond, Simon T., primary, Li, Jason, primary, Kaadige, Mohan R., primary, Rao, Aparna, primary, Sheppard, Karen E., primary, Hugo, Willy, primary, Pupo, Gulietta M., primary, Pearson, Richard B., primary, McGee, Sean L., primary, Long, Georgina V., primary, Scolyer, Richard A., primary, Rizos, Helen, primary, Lo, Roger S., primary, Cullinane, Carleen, primary, Ayer, Donald E., primary, Ribas, Antoni, primary, Johnstone, Ricky W., primary, Hicks, Rodney J., primary, and McArthur, Grant A., primary

Published
2023
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16. Supplementary Table 1 from Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition

Author

Davis, Sally J., primary, Sheppard, Karen E., primary, Anglesio, Michael S., primary, George, Joshy, primary, Traficante, Nadia, primary, Fereday, Sian, primary, Intermaggio, Maria P., primary, Menon, Usha, primary, Gentry-Maharaj, Aleksandra, primary, Lubinski, Jan, primary, Gronwald, Jacek, primary, Pearce, Celeste Leigh, primary, Pike, Malcolm C., primary, Wu, Anna, primary, Kommoss, Stefan, primary, Pfisterer, Jacobus, primary, du Bois, Andreas, primary, Hilpert, Felix, primary, Ramus, Susan J., primary, Bowtell, David D.L., primary, Huntsman, David G., primary, Pearson, Richard B., primary, Simpson, Kaylene J., primary, Campbell, Ian G., primary, and Gorringe, Kylie L., primary

Published
2023
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17. Supplementary Figure S1 from First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study

Author

Khot, Amit, primary, Brajanovski, Natalie, primary, Cameron, Donald P., primary, Hein, Nadine, primary, Maclachlan, Kylee H., primary, Sanij, Elaine, primary, Lim, John, primary, Soong, John, primary, Link, Emma, primary, Blombery, Piers, primary, Thompson, Ella R., primary, Fellowes, Andrew, primary, Sheppard, Karen E., primary, McArthur, Grant A., primary, Pearson, Richard B., primary, Hannan, Ross D., primary, Poortinga, Gretchen, primary, and Harrison, Simon J., primary

Published
2023
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18. Data from CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory

Author

Lelliott, Emily J., primary, Kong, Isabella Y., primary, Zethoven, Magnus, primary, Ramsbottom, Kelly M., primary, Martelotto, Luciano G., primary, Meyran, Deborah, primary, Zhu, Joe Jiang, primary, Costacurta, Matteo, primary, Kirby, Laura, primary, Sandow, Jarrod J., primary, Lim, Lydia, primary, Dominguez, Pilar M., primary, Todorovski, Izabela, primary, Haynes, Nicole M., primary, Beavis, Paul A., primary, Neeson, Paul J., primary, Hawkins, Edwin D., primary, McArthur, Grant A., primary, Parish, Ian A., primary, Johnstone, Ricky W., primary, Oliaro, Jane, primary, Sheppard, Karen E., primary, Kearney, Conor J., primary, and Vervoort, Stephin J., primary

Published
2023
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19. Supplementary Methods from First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study

Author

Khot, Amit, primary, Brajanovski, Natalie, primary, Cameron, Donald P., primary, Hein, Nadine, primary, Maclachlan, Kylee H., primary, Sanij, Elaine, primary, Lim, John, primary, Soong, John, primary, Link, Emma, primary, Blombery, Piers, primary, Thompson, Ella R., primary, Fellowes, Andrew, primary, Sheppard, Karen E., primary, McArthur, Grant A., primary, Pearson, Richard B., primary, Hannan, Ross D., primary, Poortinga, Gretchen, primary, and Harrison, Simon J., primary

Published
2023
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20. Supplementary Figure 1 from Inhibition of the MNK1/2–eIF4E Axis Augments Palbociclib-Mediated Antitumor Activity in Melanoma and Breast Cancer

Author

Prabhu, Sathyen A., primary, Moussa, Omar, primary, Gonçalves, Christophe, primary, LaPierre, Judith H., primary, Chou, Hsiang, primary, Huang, Fan, primary, Richard, Vincent R., primary, Ferruzo, Pault Y. M., primary, Guettler, Elizabeth M., primary, Soria-Bretones, Isabel, primary, Kirby, Laura, primary, Gagnon, Natascha, primary, Su, Jie, primary, Silvester, Jennifer, primary, Krisna, Sai Sakktee, primary, Rose, April A. N., primary, Sheppard, Karen E., primary, Cescon, David W., primary, Mallette, Frédérick A., primary, Zahedi, Rene P., primary, Borchers, Christoph H., primary, del Rincon, Sonia V., primary, and Miller, Wilson H., primary

Published
2023
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21. Supplementary Table 5 from Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition

Author

Davis, Sally J., primary, Sheppard, Karen E., primary, Anglesio, Michael S., primary, George, Joshy, primary, Traficante, Nadia, primary, Fereday, Sian, primary, Intermaggio, Maria P., primary, Menon, Usha, primary, Gentry-Maharaj, Aleksandra, primary, Lubinski, Jan, primary, Gronwald, Jacek, primary, Pearce, Celeste Leigh, primary, Pike, Malcolm C., primary, Wu, Anna, primary, Kommoss, Stefan, primary, Pfisterer, Jacobus, primary, du Bois, Andreas, primary, Hilpert, Felix, primary, Ramus, Susan J., primary, Bowtell, David D.L., primary, Huntsman, David G., primary, Pearson, Richard B., primary, Simpson, Kaylene J., primary, Campbell, Ian G., primary, and Gorringe, Kylie L., primary

Published
2023
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22. Supplementary Figures and Tables from Enhanced GAB2 Expression Is Associated with Improved Survival in High-Grade Serous Ovarian Cancer and Sensitivity to PI3K Inhibition

Author

Davis, Sally J., primary, Sheppard, Karen E., primary, Anglesio, Michael S., primary, George, Joshy, primary, Traficante, Nadia, primary, Fereday, Sian, primary, Intermaggio, Maria P., primary, Menon, Usha, primary, Gentry-Maharaj, Aleksandra, primary, Lubinski, Jan, primary, Gronwald, Jacek, primary, Pearce, Celeste Leigh, primary, Pike, Malcolm C., primary, Wu, Anna, primary, Kommoss, Stefan, primary, Pfisterer, Jacobus, primary, du Bois, Andreas, primary, Hilpert, Felix, primary, Ramus, Susan J., primary, Bowtell, David D.L., primary, Huntsman, David G., primary, Pearson, Richard B., primary, Simpson, Kaylene J., primary, Campbell, Ian G., primary, and Gorringe, Kylie L., primary

Published
2023
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23. Data from Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

Author

Parmenter, Tiffany J., primary, Kleinschmidt, Margarete, primary, Kinross, Kathryn M., primary, Bond, Simon T., primary, Li, Jason, primary, Kaadige, Mohan R., primary, Rao, Aparna, primary, Sheppard, Karen E., primary, Hugo, Willy, primary, Pupo, Gulietta M., primary, Pearson, Richard B., primary, McGee, Sean L., primary, Long, Georgina V., primary, Scolyer, Richard A., primary, Rizos, Helen, primary, Lo, Roger S., primary, Cullinane, Carleen, primary, Ayer, Donald E., primary, Ribas, Antoni, primary, Johnstone, Ricky W., primary, Hicks, Rodney J., primary, and McArthur, Grant A., primary

Published
2023
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24. Supplementary Data from Inhibition of the MNK1/2–eIF4E Axis Augments Palbociclib-Mediated Antitumor Activity in Melanoma and Breast Cancer

Author

Prabhu, Sathyen A., primary, Moussa, Omar, primary, Gonçalves, Christophe, primary, LaPierre, Judith H., primary, Chou, Hsiang, primary, Huang, Fan, primary, Richard, Vincent R., primary, Ferruzo, Pault Y. M., primary, Guettler, Elizabeth M., primary, Soria-Bretones, Isabel, primary, Kirby, Laura, primary, Gagnon, Natascha, primary, Su, Jie, primary, Silvester, Jennifer, primary, Krisna, Sai Sakktee, primary, Rose, April A. N., primary, Sheppard, Karen E., primary, Cescon, David W., primary, Mallette, Frédérick A., primary, Zahedi, Rene P., primary, Borchers, Christoph H., primary, del Rincon, Sonia V., primary, and Miller, Wilson H., primary

Published
2023
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25. TableS1.xlsx from CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory

Author

Lelliott, Emily J., primary, Kong, Isabella Y., primary, Zethoven, Magnus, primary, Ramsbottom, Kelly M., primary, Martelotto, Luciano G., primary, Meyran, Deborah, primary, Zhu, Joe Jiang, primary, Costacurta, Matteo, primary, Kirby, Laura, primary, Sandow, Jarrod J., primary, Lim, Lydia, primary, Dominguez, Pilar M., primary, Todorovski, Izabela, primary, Haynes, Nicole M., primary, Beavis, Paul A., primary, Neeson, Paul J., primary, Hawkins, Edwin D., primary, McArthur, Grant A., primary, Parish, Ian A., primary, Johnstone, Ricky W., primary, Oliaro, Jane, primary, Sheppard, Karen E., primary, Kearney, Conor J., primary, and Vervoort, Stephin J., primary

Published
2023
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26. Supplementary Figure 2 from Inhibition of the MNK1/2–eIF4E Axis Augments Palbociclib-Mediated Antitumor Activity in Melanoma and Breast Cancer

Author

Prabhu, Sathyen A., primary, Moussa, Omar, primary, Gonçalves, Christophe, primary, LaPierre, Judith H., primary, Chou, Hsiang, primary, Huang, Fan, primary, Richard, Vincent R., primary, Ferruzo, Pault Y. M., primary, Guettler, Elizabeth M., primary, Soria-Bretones, Isabel, primary, Kirby, Laura, primary, Gagnon, Natascha, primary, Su, Jie, primary, Silvester, Jennifer, primary, Krisna, Sai Sakktee, primary, Rose, April A. N., primary, Sheppard, Karen E., primary, Cescon, David W., primary, Mallette, Frédérick A., primary, Zahedi, Rene P., primary, Borchers, Christoph H., primary, del Rincon, Sonia V., primary, and Miller, Wilson H., primary

Published
2023
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27. Supplementary Data 1 from Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

Author

Parmenter, Tiffany J., primary, Kleinschmidt, Margarete, primary, Kinross, Kathryn M., primary, Bond, Simon T., primary, Li, Jason, primary, Kaadige, Mohan R., primary, Rao, Aparna, primary, Sheppard, Karen E., primary, Hugo, Willy, primary, Pupo, Gulietta M., primary, Pearson, Richard B., primary, McGee, Sean L., primary, Long, Georgina V., primary, Scolyer, Richard A., primary, Rizos, Helen, primary, Lo, Roger S., primary, Cullinane, Carleen, primary, Ayer, Donald E., primary, Ribas, Antoni, primary, Johnstone, Ricky W., primary, Hicks, Rodney J., primary, and McArthur, Grant A., primary

Published
2023
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28. Supplementary Methods from Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

Author

Parmenter, Tiffany J., primary, Kleinschmidt, Margarete, primary, Kinross, Kathryn M., primary, Bond, Simon T., primary, Li, Jason, primary, Kaadige, Mohan R., primary, Rao, Aparna, primary, Sheppard, Karen E., primary, Hugo, Willy, primary, Pupo, Gulietta M., primary, Pearson, Richard B., primary, McGee, Sean L., primary, Long, Georgina V., primary, Scolyer, Richard A., primary, Rizos, Helen, primary, Lo, Roger S., primary, Cullinane, Carleen, primary, Ayer, Donald E., primary, Ribas, Antoni, primary, Johnstone, Ricky W., primary, Hicks, Rodney J., primary, and McArthur, Grant A., primary

Published
2023
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29. Data from First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study

Author

Khot, Amit, primary, Brajanovski, Natalie, primary, Cameron, Donald P., primary, Hein, Nadine, primary, Maclachlan, Kylee H., primary, Sanij, Elaine, primary, Lim, John, primary, Soong, John, primary, Link, Emma, primary, Blombery, Piers, primary, Thompson, Ella R., primary, Fellowes, Andrew, primary, Sheppard, Karen E., primary, McArthur, Grant A., primary, Pearson, Richard B., primary, Hannan, Ross D., primary, Poortinga, Gretchen, primary, and Harrison, Simon J., primary

Published
2023
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30. Supplementary Figures and Tables from Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

Author

Parmenter, Tiffany J., primary, Kleinschmidt, Margarete, primary, Kinross, Kathryn M., primary, Bond, Simon T., primary, Li, Jason, primary, Kaadige, Mohan R., primary, Rao, Aparna, primary, Sheppard, Karen E., primary, Hugo, Willy, primary, Pupo, Gulietta M., primary, Pearson, Richard B., primary, McGee, Sean L., primary, Long, Georgina V., primary, Scolyer, Richard A., primary, Rizos, Helen, primary, Lo, Roger S., primary, Cullinane, Carleen, primary, Ayer, Donald E., primary, Ribas, Antoni, primary, Johnstone, Ricky W., primary, Hicks, Rodney J., primary, and McArthur, Grant A., primary

Published
2023
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31. Supplementary Methods and Tables from Inhibition of the MNK1/2–eIF4E Axis Augments Palbociclib-Mediated Antitumor Activity in Melanoma and Breast Cancer

Author

Prabhu, Sathyen A., primary, Moussa, Omar, primary, Gonçalves, Christophe, primary, LaPierre, Judith H., primary, Chou, Hsiang, primary, Huang, Fan, primary, Richard, Vincent R., primary, Ferruzo, Pault Y. M., primary, Guettler, Elizabeth M., primary, Soria-Bretones, Isabel, primary, Kirby, Laura, primary, Gagnon, Natascha, primary, Su, Jie, primary, Silvester, Jennifer, primary, Krisna, Sai Sakktee, primary, Rose, April A. N., primary, Sheppard, Karen E., primary, Cescon, David W., primary, Mallette, Frédérick A., primary, Zahedi, Rene P., primary, Borchers, Christoph H., primary, del Rincon, Sonia V., primary, and Miller, Wilson H., primary

Published
2023
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32. Supplementary Figure 3 from Inhibition of the MNK1/2–eIF4E Axis Augments Palbociclib-Mediated Antitumor Activity in Melanoma and Breast Cancer

Author

Prabhu, Sathyen A., primary, Moussa, Omar, primary, Gonçalves, Christophe, primary, LaPierre, Judith H., primary, Chou, Hsiang, primary, Huang, Fan, primary, Richard, Vincent R., primary, Ferruzo, Pault Y. M., primary, Guettler, Elizabeth M., primary, Soria-Bretones, Isabel, primary, Kirby, Laura, primary, Gagnon, Natascha, primary, Su, Jie, primary, Silvester, Jennifer, primary, Krisna, Sai Sakktee, primary, Rose, April A. N., primary, Sheppard, Karen E., primary, Cescon, David W., primary, Mallette, Frédérick A., primary, Zahedi, Rene P., primary, Borchers, Christoph H., primary, del Rincon, Sonia V., primary, and Miller, Wilson H., primary

Published
2023
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33. Supplementary Figures from CDK4/6 Inhibition Promotes Antitumor Immunity through the Induction of T-cell Memory

Author

Lelliott, Emily J., primary, Kong, Isabella Y., primary, Zethoven, Magnus, primary, Ramsbottom, Kelly M., primary, Martelotto, Luciano G., primary, Meyran, Deborah, primary, Zhu, Joe Jiang, primary, Costacurta, Matteo, primary, Kirby, Laura, primary, Sandow, Jarrod J., primary, Lim, Lydia, primary, Dominguez, Pilar M., primary, Todorovski, Izabela, primary, Haynes, Nicole M., primary, Beavis, Paul A., primary, Neeson, Paul J., primary, Hawkins, Edwin D., primary, McArthur, Grant A., primary, Parish, Ian A., primary, Johnstone, Ricky W., primary, Oliaro, Jane, primary, Sheppard, Karen E., primary, Kearney, Conor J., primary, and Vervoort, Stephin J., primary

Published
2023
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34. Supplementary Tables S1-S7 from First-in-Human RNA Polymerase I Transcription Inhibitor CX-5461 in Patients with Advanced Hematologic Cancers: Results of a Phase I Dose-Escalation Study

Author

Khot, Amit, primary, Brajanovski, Natalie, primary, Cameron, Donald P., primary, Hein, Nadine, primary, Maclachlan, Kylee H., primary, Sanij, Elaine, primary, Lim, John, primary, Soong, John, primary, Link, Emma, primary, Blombery, Piers, primary, Thompson, Ella R., primary, Fellowes, Andrew, primary, Sheppard, Karen E., primary, McArthur, Grant A., primary, Pearson, Richard B., primary, Hannan, Ross D., primary, Poortinga, Gretchen, primary, and Harrison, Simon J., primary

Published
2023
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35. CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

Author

Sanij, Elaine, Hannan, Katherine M., Xuan, Jiachen, Yan, Shunfei, Ahern, Jessica E., Trigos, Anna S., Brajanovski, Natalie, Son, Jinbae, Chan, Keefe T., Kondrashova, Olga, Lieschke, Elizabeth, Wakefield, Matthew J., Frank, Daniel, Ellis, Sarah, Cullinane, Carleen, Kang, Jian, Poortinga, Gretchen, Nag, Purba, Deans, Andrew J., Khanna, Kum Kum, Mileshkin, Linda, McArthur, Grant A., Soong, John, Berns, Els M. J. J., Hannan, Ross D., Scott, Clare L., Sheppard, Karen E., and Pearson, Richard B.

Published
2020
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44. Data from LRP1B Deletion in High-Grade Serous Ovarian Cancers Is Associated with Acquired Chemotherapy Resistance to Liposomal Doxorubicin

Author

Cowin, Prue A., primary, George, Joshy, primary, Fereday, Sian, primary, Loehrer, Elizabeth, primary, Van Loo, Peter, primary, Cullinane, Carleen, primary, Etemadmoghadam, Dariush, primary, Ftouni, Sarah, primary, Galletta, Laura, primary, Anglesio, Michael S., primary, Hendley, Joy, primary, Bowes, Leanne, primary, Sheppard, Karen E., primary, Christie, Elizabeth L., primary, Pearson, Richard B., primary, Harnett, Paul R., primary, Heinzelmann-Schwarz, Viola, primary, Friedlander, Michael, primary, McNally, Orla, primary, Quinn, Michael, primary, Campbell, Peter, primary, deFazio, Anna, primary, and Bowtell, David D.L., primary

Published
2023
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45. Supplementary Figures 1-10 from LRP1B Deletion in High-Grade Serous Ovarian Cancers Is Associated with Acquired Chemotherapy Resistance to Liposomal Doxorubicin

Author

Cowin, Prue A., primary, George, Joshy, primary, Fereday, Sian, primary, Loehrer, Elizabeth, primary, Van Loo, Peter, primary, Cullinane, Carleen, primary, Etemadmoghadam, Dariush, primary, Ftouni, Sarah, primary, Galletta, Laura, primary, Anglesio, Michael S., primary, Hendley, Joy, primary, Bowes, Leanne, primary, Sheppard, Karen E., primary, Christie, Elizabeth L., primary, Pearson, Richard B., primary, Harnett, Paul R., primary, Heinzelmann-Schwarz, Viola, primary, Friedlander, Michael, primary, McNally, Orla, primary, Quinn, Michael, primary, Campbell, Peter, primary, deFazio, Anna, primary, and Bowtell, David D.L., primary

Published
2023
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46. Supplementary Methods from LRP1B Deletion in High-Grade Serous Ovarian Cancers Is Associated with Acquired Chemotherapy Resistance to Liposomal Doxorubicin

Author

Cowin, Prue A., primary, George, Joshy, primary, Fereday, Sian, primary, Loehrer, Elizabeth, primary, Van Loo, Peter, primary, Cullinane, Carleen, primary, Etemadmoghadam, Dariush, primary, Ftouni, Sarah, primary, Galletta, Laura, primary, Anglesio, Michael S., primary, Hendley, Joy, primary, Bowes, Leanne, primary, Sheppard, Karen E., primary, Christie, Elizabeth L., primary, Pearson, Richard B., primary, Harnett, Paul R., primary, Heinzelmann-Schwarz, Viola, primary, Friedlander, Michael, primary, McNally, Orla, primary, Quinn, Michael, primary, Campbell, Peter, primary, deFazio, Anna, primary, and Bowtell, David D.L., primary

Published
2023
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47. Supplementary Tables 1-6 from LRP1B Deletion in High-Grade Serous Ovarian Cancers Is Associated with Acquired Chemotherapy Resistance to Liposomal Doxorubicin

Author

Cowin, Prue A., primary, George, Joshy, primary, Fereday, Sian, primary, Loehrer, Elizabeth, primary, Van Loo, Peter, primary, Cullinane, Carleen, primary, Etemadmoghadam, Dariush, primary, Ftouni, Sarah, primary, Galletta, Laura, primary, Anglesio, Michael S., primary, Hendley, Joy, primary, Bowes, Leanne, primary, Sheppard, Karen E., primary, Christie, Elizabeth L., primary, Pearson, Richard B., primary, Harnett, Paul R., primary, Heinzelmann-Schwarz, Viola, primary, Friedlander, Michael, primary, McNally, Orla, primary, Quinn, Michael, primary, Campbell, Peter, primary, deFazio, Anna, primary, and Bowtell, David D.L., primary

Published
2023
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49. Inhibition of the MNK1/2–eIF4E Axis Augments Palbociclib-Mediated Antitumor Activity in Melanoma and Breast Cancer

Author

Prabhu, Sathyen A., primary, Moussa, Omar, additional, Gonçalves, Christophe, additional, LaPierre, Judith H., additional, Chou, Hsiang, additional, Huang, Fan, additional, Richard, Vincent R., additional, Ferruzo, Pault Y. M., additional, Guettler, Elizabeth M., additional, Soria-Bretones, Isabel, additional, Kirby, Laura, additional, Gagnon, Natascha, additional, Su, Jie, additional, Silvester, Jennifer, additional, Krisna, Sai Sakktee, additional, Rose, April A. N., additional, Sheppard, Karen E., additional, Cescon, David W., additional, Mallette, Frédérick A., additional, Zahedi, Rene P., additional, Borchers, Christoph H., additional, del Rincon, Sonia V., additional, and Miller, Wilson H., additional

Published
2022
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