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Abstract Objective This study aims to explore the clinical effect of Tetrandrine (Tet) on progressive massive fibrosis (PMF) of pneumoconiosis. Methods This retrospective study collected 344 pneumoconiosis patients with PMF, and 127 were eligible for the final analysis, including 57 patients in the Tet group and 70 patients in the control group. The progress of imaging and lung function were compared between the two groups. Results After 13 months (median) of treatment, the size of PMF was smaller in the Tet group than that in the control group (1526 vs. 2306, p=0.001), and the size was stable in the Tet group (1568 vs. 1526, p= 0.381), while progressed significantly in the control group (2055 vs. 2306, p=0.000). The small nodule profusion and emphysema were also milder than that in the control group (6.0 vs. 7.5, p=0.046 and 8.0 vs. 12, p=0.016 respectively). Pulmonary ventilation function parameters FVC and FEV1 improved in the Tet group (3222 vs. 3301, p=0.021; 2202 vs. 2259, p=0.025 respectively) and decreased in the control group (3272 vs. 3185, p= 0.00; 2094 vs. 1981, p=0.00 respectively). FEV1/FVC was also significantly higher in the Tet group than that in the control group (68.45vs. 60.74, p=0.001). However, similar result was failed to observed for DLco%, which showed a significant decrease in both groups. Conclusion Tet has shown great potential in the treatment of PMF by slowing the progression of pulmonary fibrosis and the decline of lung function.

Nanofluidic energy absorption system (NEAS) with cascade energy absorption characteristics can absorb energy on different levels simultaneously in one system, which greatly enriches its functions and applications. The pore structure and size distribution of porous media play a crucial role in the design and construction of cascade nanofluidic systems. In this paper, two cascade pore models were constructed using carbon nanotubes with different diameters, one was the model of two tubes with both one end immersed in water (DNEAS), and the other was the model of two tubes end to end, with the end of the big tube immersed in water (SNEAS). The effects of temperature-coupled pore size on the infiltration processes of water molecules into two models were investigated. The fitting correlations between critical pore size difference and temperature were established. The microscopic mechanism of temperature effect was illuminated. With the increase in temperature, systems displaying cascade characteristics transformed into a single-stage system without cascade characteristics. Due to the significant size effect of system temperature, the critical pore difference increased with both system temperature and the pore size. The research results expanded the basic database of cascade nanofluidic systems and provided guidance for the application design of cascade nanofluidic systems.