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Introduction: At present, there is no convincing evidence-based medical basis for the placement of prophylactic drain after gastrectomy.This meta-analysis aimed to analyze the incidence of complications and the recovery of gastrointestinal function after gastrectomy in the drain group and the no-drain group. Methods: Data were retrieved from electronic databases PubMed, EMBASE, Medline, Cochrane Library, CNKI, Wanfang and VIP databases up to December 2022, including the outcomes of individual treatment after gastrectomy. Complication related index:Incidence of Postoperative Complications, Anastomotic leak，Intra-abdominal bleeding, Wound Infection, Hospital mortality, Pulmonary infection, Intra-abdominal abscess, Abdominal infection, Readmission, Reoperation, Drain related complications etc. Recovery of gastrointestinal function related index: Passage of flatus, Initiation of soft diet, Hospital stay after surgery. The Jadad score and Newcastle-Ottawa scale were used to assess the quality of the included studies. Results: After screening, 20 literatures were finally included, including 4984 patients. Meta-analysis results showed that the passage of flatus（WMD=0.32, 95%CI=0.07~0.58, P=0.01）and initiation of soft diet（WMD=0.45, 95%CI=0.20~0.71, P=0.0005）in the no-drain group were better than those in the drain group. The drain group was not superior to the no-drain group in hospital stay after surgery, postoperative complications, wound infection, pulmonary infection, anastomotic leakage, intra-abdominal abscess, intra-abdominal bleeding, intra-abdominal infection, mortality, reoperation, readmission, and drainage-related complications. Conclusions: Prophylactic placement of the peritoneal drainage tube did not reduce the incidence of early complications but delayed recovery of gastrointestinal function. Abdominal drainage is not required after radical gastrectomy, but is recommended for high-risk patients with anastomotic fistula and intraperitoneal bleeding.

The number of stomach cancer (SC) patients is increasing sharply every year, and gastroscope is a common method to check stomach-related diseases. A bulging lesion in the stomach is encountered during a gastroscopy. Due to the change in eating habits, the enhancement of health awareness, and the wide application of gastroscopy, the detection rate and cure rate of tumors have been significantly improved. This has certain clinical value for the early diagnosis and treatment of early SC. In this paper, based on the background of artificial intelligence, image segmentation technology is used to analyze and process the detection results of SC, so as to judge the effect of drug treatment. A total of 1408 gastric bulge lesions were investigated in 11023 patients during the one-year period 2019-2020. It also analyzed the age, lesion location, size, pathological type, and tumor detection results of 1408 patients. The experiment showed that among the 289 cases of submucosal bulging lesions, the detection rates of the young group, middle-aged group, and elderly group were 14.9% (43/289), 67.5% (195/289), and 17.6% (51/289), respectively. Among them, middle-aged people aged 41–65 have the highest detection rate. The incidence of gastric polyps was similar between different age groups. But with age, the rate of fundic gland polyps increases. The incidence of SC is not related to the age of the patient, but to its pathological type. The incidence of SC in middle-aged and elderly people is significantly higher than that in young people. SC is more common in the cardia, and gastrointestinal stromal tumors are most common with submucosal protrusion.

Shengyong Zhai,1,* Xiaojing Sun,2,* Longfeng Du,1 Kai Chen,1 Shanshan Zhang,2 Yiran Shi,1 Fei Yuan1 1Department of Oncology Surgery, Weifang People’ s Hospital, Weifang Medical College, Weifang City, Shandong Province, 261041, People’s Republic of China; 2School of Management and Information, Shandong Transport Vocational College, Weifang City, Shandong Province, 261041, People’s Republic of China*These authors contributed equally to this workCorrespondence: Fei YuanDepartment of Oncology Surgery, Weifang People’s Hospital, Weifang Medical College, NO.181, Guangwen Street, Kuiwen District, Weifang City, Shandong Province, 261041, People’s Republic of ChinaTel +86 13696360906Fax +86-536-8675792Email zsy-1985122@163.comPurpose: This study is a retrospective analysis of exploring the efficiency of surgical management on patients with synchronous colorectal liver metastasis (SCLM).Patients and Methods: Nine hundred fifty-three consecutive patients with SCLM from Weifang People’s Hospital of Shandong Province between January 2006 and December 2015 were reviewed. The values of different factors were analyzed, such as different surgical indications of liver metastases, simultaneous or staged resection of primary colorectal cancer and liver metastases, and primary tumor resection (PTR) of asymptomatic patients with unresectable liver metastases.Results: Median survival time (47.3 months) and 5-year survival rate (31%) for patients with resected liver metastases were significantly superior to that of with nonoperative treatment (17.2 months, 4%, P< 0.001); enlarging the standard of liver metastases resection can improve the resection rates (31.0% vs 13.6%, P< 0.001); for patients with resectable liver metastases, the in-hospital cost for simultaneous resection group was lower than that in the staged resection group (36,698 vs 45,134 RMB, P< 0.001); for patients of the asymptomatic primary tumor with unresectable liver metastases, PTR was associated with improved median survival (18.0 vs 15.0 months, P=0.006).Conclusion: For patients with SCLM, liver resection is considered the best treatment; expanding indications of liver resection can improve the resection rates. Simultaneous resection of the primary tumor and liver metastases were indicated in patients with resectable SCLM; PTR was recommended for asymptomatic patients with unresectable hepatic metastases.Keywords: surgical treatment, synchronous colorectal liver metastases, survival analysis, primary tumor resection

Activated carbon particle electrodes modified by oxygen or nitrogen groups could be promising electrode candidates for capacitive deionization (CDI) processes. In this work, activated carbon particle electrodes were modified by phosphoric acid, nitric acid, urea, melamine, and zinc chloride to enhance desalination of an aqueous electrolytic solution. The modified activated carbon particles were characterized by scanning electron microscopy, energy dispersive X-ray spectroscopy, Fourier transform infrared spectroscopy, Brunauer–Emmett–Teller measurements and electrochemical scanning. The electrodes with oxygen or nitrogen groups on the surface exhibited a much higher desalination capacity and charge efficiency than those without any surface modification. Particularly, the activated carbon particle electrode modified by phosphoric acid exhibited a desalination capacity of 15.52 mg/g at 1.4 V in 500 mg/L NaCl solution, which was approximately eight times that of the unmodified electrode (2.46 mg/g). The enhancement was attributed to a higher specific capacitance, a lower electrochemical impedance and an increase in oxygen or nitrogen-containing groups on the surface.

In this work, near-infrared light (NIRL)-responsively controlled-release herbicide particles (NCHPs) were fabricated using biochar, attapulgite (ATP), NH4HCO3, ethylcellulose (EC), silicon oil (SO)...

Research about constructing multi-dimensional carbon nanomaterials is of great significance in electrocatalytic and sensing fields in order to integrate structural merits of each individual unit. Also, nanomaterials with enzyme-like activities are prospective candidates for artificial enzyme design and electrochemical application. Herein, we fabricate Co, N co-doped hierarchical hybrid (Co@NCNTs/NC) nanozyme, which integrates of both N-doped carbon nanotubes (NCNTs) and N-doped carbon sheets (NC). The three-dimensional (3D) porous carbon composite is prepared by thermal treatment of metal-organic framework (MOF) which was synthesized by growing of ZIF-67 on ZIF-L at room temperature. The obtained nanomaterial not only possesses an improved oxidase-like activity that can catalyze 3,3′,5,5′-tetramethylbenzidine (TMB) in the absence of hydrogen peroxide (H2O2), but also constructs a signal amplification platform towards dopamine (DA) due to the synergistic catalysis of Co species and N-doped porous carbon architecture. The electrocatalytic performance for DA detection shows a broad linear range from 30 nM to 710 μM and a detection limit of 9 nM. The Co@NCNTs/NC/GCE is employed to practically detect DA in human serum and artificial cerebrospinal fluid (aCSF) samples with satisfactory results. The present work exhibits a great promising in colorimetric and electrochemical sensing fields and presents a new sight for the fabrication of MOF-derived nanozyme.

Freezing methods, progressive freezing and suspension crystallization, were examined for treating Grignard reagent wastewater containing tetrahydrofuran (THF) used as a solvent. The effect of freezing temperature, addition of seed ice crystals, and stirring speed on performance were investigated. The addition of seed ice with appropriate temperature contributed to enhance the purity. The optimal operating conditions of freezing temperature and stirring speed were −6 °C and 300 rpm respectively while the removal efficiency of COD was above 90%. The suspension crystallization is superior to progressive freezing in terms of performance and energy consumption, with an estimation of about 38.26 kW h per ton of wastewater treated. Based on these results, a freezing/concentration concept for THF recovery from Grignard reagent wastewater is proposed.

The electrocatalytic activities of a series of copper alloys, Cu/Ni/Zn (Cu60 Ni15 Zn25 ) and Cu/Zn (Cu62 Zn38 ), toward the reduction of nitrate were investigated, in comparison with that of pure copper. Electrochemical analysis showed that the copper alloy electrode exhibited higher electrochemical reduction rate of nitrate. The extreme difference (R) between the orthogonal experiments revealed that the NO3--N concentration was the main determinant of the removal percentage, followed by the current density and electrolyte concentration, while the impact of the initial pH was minimal. The conditions of the electrolysis experiments with Cu/Ni/Zn and Cu/Zn cathodes were optimized as follows: a current density of 8 mA/cm2 , a NaCl concentration of 2.0 g/L, and an initial pH of 3.0. The nitrate reduction reaction process with copper alloy cathodes was confirmed by electrochemical analysis and electrolysis experiments. Therefore, copper alloyed with Zn and Ni is a feasible option for practical application to the electrocatalytic reduction of nitrate. PRACTITIONER POINTS: Alloy of Cu, Zn, and Ni improved electrochemical nitrate reduction reaction. Electrochemical reduction of nitrate was confirmed in the presence of NaCl. The optimized current density with copper alloy cathodes was 6 mA/cm2 . A feasible strategy was provided for the improving nitrate removal and minimizing by-products.

An ultrasensitive biosensor based on a glassy carbon electrode (GCE) modified with poly(diallyldimethylammonium chloride)-functionalized graphene (PDDA-GN) and DNA assemblies mainly containing double helix and hairpin structures (DNA) has been employed to detect metronidazole. Due to the excellent synergistic electrocatalytical effect between the PDDA-GN and the DNA, the biosensor remarkably enhanced the electrocatalytic activity compared with the bare GCE toward the reduction of metronidazole in phosphate buffer solution (PBS) (pH = 6.0). The electrode materials were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Raman spectroscopy and transmission electron microscopy (TEM). The electrochemical properties of this composite film (PDDA-GN/DNA) were evaluated by means of cyclic voltammetry (CV) and linear sweep voltammetry (LSV). Under the optimized conditions, the fabricated biosensor showed remarkable signal amplification performance and a linear response to metronidazole in the range of 0.05–100 μM and 400–9500 μM, with a limit of detection as low as 24 nM (signal-to-noise ratio of 3). Moreover, the biosensor displayed excellent stability, reproducibility, and selectivity ability. Furthermore, this biosensor was applied to the detection of metronidazole in urine and lake water with satisfactory results.

The determination of pKa of Bronsted–Lowry acids in aprotic solvent is a meaningful work. We observed that a small concentration of acids caused a new cathodic peak during quinone reduction in acetonitrile. The new peak is independent of the quinone concentration, but its height increases with increasing acid concentration and its potential is dependent on the pKa of the acids. Moreover, the substituent of quinones strongly affects the potential difference between the new peak and the original peak. The new peak is produced by a sharp increase in pH on the electrode surface. Therefore, the new peak is independent of the concentration of quinone. We suggest a new mechanism of voltammetric determination of pKa of Bronsted acids in acetonitrile. In addition, the pKa values obtained in this work are consistent with those in literature.

To study the effect of neoadjuvant chemotherapy on nutritional status in patients with locally advanced gastric cancer.Cases inclusion criteria: (1)18-65 years old; (2) Gastric cancer confirmed by gastroscopic biopsy; (3) Preoperative TNM stage III( according to the AJCC stage 2000 standard; (4) Kamosfsky functional status score60 points; (5)Receiving neoadjuvant chemotherapy voluntarily and signing the informed consent form. Case exclusion criteria: (1)Having contraindications of chemotherapy and surgery; (2) Suffering from heart, liver and kidney and other underlying diseases; (3) Concurrent with malignant diseases, wasting disease or other digestive diseases. According to the above criteria, clinical data of 73 patients of stage III( gastric cancer receiving neoadjuvant chemotherapy at Weifang People's Hospital from May 2015 to March 2017 were prospectively collected. The cohort study was adopted. After removing 3 patients who did not complete the chemotherapy, a total of 70 patients who completed the chemotherapy were included in the study. All the patients received SOX chemotherapy without nutritional support during chemotherapy. Changes of body composition and nutritional indicators were analyzed before and after chemotherapy, and according to the tumor regression after chemotherapy, patients were divided into response group (complete or sub-total tumor regression) and non-response group (tumor part, with or without a small amount of retreat) for stratified analysis.Of 70 gastric cancer patients, 40 were male and 30 were female with a age of (53.8±6.4) (28 to 64) years. There were 26 cases (37.1%) of stage III(a, 35 cases (50.0%) of stage III(b and 9 cases (12.9%) of stage III(c. There were 41 cases in response group and 29 cases in non-response group. Three patients (4.3%) were complete remission (CR) and 38 patients (54.3%) were partial remission (PR) in response group, while 23 cases (32.9%) were stable disease (SD) and 6 cases (8.6%) were progressive disease (PD). After neoadjuvant chemotherapy, the extracellular fluid of the whole patients increased from (13.3±1.7) L to (13.5±1.6) L (t=-2.044, P=0.045); the intracellular fluid decreased from (21.4±2.5) L to (21.1±2.4) L (t=2.369, P=0.021); the lymphocyte count decreased from (0.31±0.10)×10Neoadjuvant chemotherapy does not aggravate malnutrition in patients with locally advanced gastric cancer.

In this communication, we demonstrate the development of nickel oxide nanosheets array on carbon cloth (nio na/cc) as an integrated three-dimensional oxygen-evolving electrode. the electrode exhibits high catalytic activity with an onset overpotential of 295 mv and a tafel slope of 116 mv/dec. it needs an overpotential of 422 mv to drive current density of 10 ma/cm(2) and maintains its catalytic activity for at least 10 h. copyright (c) 2015, hydrogen energy publications, llc. published by elsevier ltd. all rights reserved.

The introduction of electron-withdrawing group into porphyrin molecule as cytochrome P450 model can tune the energy level and have an effect on the electronic structure. In this work, linking with the strong electron-withdrawing fluorine atoms, a starburst dendritic molecule, 5,10,15,20-tetrakis(pentafluorophenyl)−21H,23H-porphyrin iron (III) chloride (FeTFPP), containing a saddle-shaped porphyrin as the central core and four pentafluorophenyl rings as the peripheral functional groups was successfully synthesized. Subsequently, the macrocyclic conjugate polymer film of FeTFPP was achieved via a low-cost electrochemical method and exploited as an efficient mimetic enzyme. Furthermore, a biomimetic sensor was constructed by the poly(FeTFPP) film and graphene (rGO) sheet (rGO-poly(FeTFPP)) for selective and sensitive detection of dopamine (DA). Here, the FeTFPP polymer performs three functions: electrochemical recognition (owing to the hydrogen bonding between the strongly electronegative fluorine atoms and DA), biomimetic microenvironment (owing to interaction between porphyrin core and DA), electrocatalysis (owing to remarkable catalytic ability of iron (III) ion). Under optimum conditions, the response to DA was linear in the concentration range between 0.05 to 300 μM, and the detection limit was 0.023 μM. In addition, we applied the rGO-poly(FeTFPP) film to detect DA in real samples and the results implied its feasibility for practical application. As a result, it is believed that the rGO-poly(FeTFPP) film is one of the promising biomimetic catalysts for electrocatalysis and relevant fields.

An amperometric glucose biosensor based on the direct electron transfer (DET) of glucose oxidase (GOx) was developed and the enhanced catalytic current in presence of substrate was used to quantify glucose. GOx was adsorbed onto nanostructured ZnO modified indium tin oxide (ITO) electrodes. The goal of this work was to study the effects of morphology of nanostructured ZnO on DET of GOx and the sensor's analytical properties. Nanostructured ZnO materials including nanorods (NRs) and nanoplates (NPs) were electrochemical deposited onto ITO and were characterized using scanning electron microscopy and X-ray diffraction. Through adjusting the precursor of Zn ions, electrolytes and controlling deposition charge (Q in Coulomb. C), different nanostructured ZnO with different size, shape and deposition density were obtained. GOx was adsorbed onto nanostructured ZnO via layer-by-layer assembling to form GOx and polylectrolyte multilayer films. Compared to bare ITO or ITO deposited with nanostructured ZnO with other morphologies, GOx immobilized onto ZnO NRs arrays (Q = 0.1 C) gave higher current signals, exhibited reversible DET (k(s,) 2.16 s(-1)), wide linear range (from 0.1 to 9 mM) with the limit of detection of 1.94 mu M and low apparent Michaelis-Menten constant (K(Mapp,) 3.12 mM). (C) 2010 Elsevier B.V. All rights reserved.

Graphene oxide (GO) obtained from chemical oxidation of flake graphite was derivatized with sulfonic groups to form sulfonic-functionalized GO (GO-SO(3)(-)) through four sulfonation routes: through amide formation between the carboxylic group of GO and amine of sulfanilic acid (AA-GO-SO(3)(-)), aryl diazonium reaction of sulfanilic acid (AD-GO-SO(3)(-)), amide formation between the carboxylic group of GO and amine of cysteamine and oxidation by H(2)O(2) (CA-GO-SO(3)(-)), and alkyl diazonium reaction of cysteamine and oxidation by H(2)O(2) (CD-GO-SO(3)(-)). Results of Fourier transform infrared spectroscopy and X-ray photoelectrospectrocopy showed that -SO(3)(-) groups were attached onto GO. Thermo gravimetric analysis showed that derivatization with sulfonic groups improved thermo stability of GO. X-ray diffraction results indicated that GO-SO(3)(-) had more ordered π-π stacking structure than the original GO. GO-SO(3)(-) and cationic polyelectrote, poly (diallyldimethylammoniumchloride) (PDDA) were adsorbed at indium tin oxide (ITO) glass surface through layer-by-layer assembling to form (GO-SO(3)(-)/PDDA)(n)/ITO multilayers. After tris-(2,2'-bipyridyl) ruthenium (II) dichloride (Ru(bpy)(3)(2+)) was incorporated into the multilayers, the obtained Ru(bpy)(3)(2+)/(GO-SO(3)(-)/PDDA)(n)/ITO electrodes can be used as electrochemiluminescence sensors for detection of organic amine with high sensitivity (limit of detection of 1 nM) and stability.

Photoluminescent multilayers were fabricated by layer-by-layer deposition between europium-substituted heteropolytungstate K(13)[Eu(SiW(11)O(39))(2)].28H(2)O (denoted ESW) and a cationic polymer of quaternized poly(4-vinylpyridine) partially complexed with osmium bis(2,2'-bipyridine) (denoted as QPVP-Os) on glassy carbon and quartz substrates. The resulting photoluminescent organic-inorganic hybrid multilayers were characterized by electrochemical impedance spectroscopy, UV-Vis absorption spectrometry, cyclic voltammetry and photoluminescence spectra. Electrochemical impedance spectroscopy, UV-Vis absorption spectrometry and cyclic voltammetry results demonstrated that the multilayers were regular growth each layer adsorption. The photoluminescent properties of the films at room temperature were investigated to show the characteristic Eu(3+) emission pattern of (5)D(0)-->(7)F(j).

We describe the controlled fabrication of ultrathin multilayer films consisting of tri-vanadium- substituted heteropolytungstate anions (denoted as P2W15V3) and a cationic polymer of quaternized poly (4-vinylpyridine) partially complexed with osmium bis(2,2'-bipyridine) (denoted as QPVP-Os) on the 4-aminobenzoic acid (4-ABA) modified glassy carbon electrode (GCE) surface based on layer-by-layer assembly. Cyclic voltammetry and UV-vis absorption spectrometry have been used to easily monitor the thickness and uniformity of thus-formed multilayer films. The V-centered redox reaction of P2W15V3 in the multilayer films can effectively catalyze the reduction of BrO3- and NO2-. The resulting P2W15V3/QPVP-Os multilayer film modified electrode behaves as a much promising electrochemical sensor because of the low overpotential for the catalytic reduction of BrO3- and NO2-, and the catalytic oxidation of ascorbic acid.

Ultrathin multilayer films have been prepared by means of alternate adsorption of iron(III)-substituted heteropolytungstate anions and a cationic redox polymer on the 4-aminobenzoic acid modified glassy carbon electrode surface based on electrostatic layer-by-layer assembly. Cyclic voltammetry, electrochemical impedance spectroscopy and UV-Vis absorption spectrometry have been used to easily monitor the uniformity of thus-formed multilayer films. Especially, the electrochemical impedance spectroscopy is successfully used to monitor the multilayer deposition processes and is a very useful technique in the characterization of multilayer films because it provides valuable information about the interfacial impedance features. All these results reveal regular film growth with each layer adsorption. The resulting multilayer films can effectively catalyze the reduction of H 2 O 2 , NO 2 − and BrO 3 − .

The facile and ecofriendly method for the synthesis of a suitable colloidal nanocrystal ink plays an important role in the field of solar cells. Here, we describe our recent efforts toward this direction by a simple one-pot colloidal method to engineer CuInSe2 (CISe) nanocrystals with cubic zincblende (ZB) structure. The suitable band gap value and obvious photoresponse of the as-synthesized CISe nanocrystals indicate their potential application in the field of thin film solar cells. In addition, a possible crystal growth mechanism has been suggested for the formation of ZB CISe.