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Jihui Yue,1,2,* Shuming Zhong,1,* Aimin Luo,3 Shunkai Lai,1 Tingting He,4 Yuchong Luo,2 Ying Wang,5 Yiliang Zhang,1 Shiyi Shen,4 Hui Huang,4 Shenglin Wen,2 Yanbin Jia1 1Department of Psychiatry, First Affiliated Hospital, Jinan University, Guangzhou, Guangdong Province, People’s Republic of China; 2Department of Psychiatry, The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, People’s Republic of China; 3Department of Psychology, Guangdong Sanjiu Brain Hospital, Guangzhou, Guangdong Province, People’s Republic of China; 4School of Management, Jinan University, Guangzhou, Guangdong Province, People’s Republic of China; 5Medical Imaging Center, First Affiliated Hospital, Jinan University, Guangzhou, Guangdong Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yanbin JiaDepartment of Psychiatry, First Affiliated Hospital, Jinan University, Guangzhou, People’s Republic of ChinaTel +86 13392489168Fax +86 020-38688888Email Yanbinjia2006@163.comPurpose: This study aimed to investigate the mechanism of working memory (WM) impairment in drug-naive obsessive-compulsive disorder (OCD) by using neuropsychological tests and proton magnetic resonance spectroscopy (1H-MRS).Patients and Methods: A total of 55 patients with drug-naive OCD and 55 healthy controls (HCs) were recruited for this study. The working memory (WM) was evaluated using the digit span test (DST), visual space memory test (VSMT), and the 2-back task and stroop color word test (SCWT). The bilateral metabolite levels of the prefrontal cortex (PFC) were evaluated by 1H-MRS, then determined the ratios of N-acetyl aspartate (NAA), choline-containing compounds (Cho), and myo-inositol (MI) to creatine (Cr). The independent sample t-test was used to analyse the differences in WM performance and neurometabolite ratios. Multivariate linear regression analysis was performed to screen the influential factors of WM, with an introduction level of 0.05 and a rejection level of 0.10.Results: 1) Patients with OCD performed significantly worse on DST (score), VSMT (score), 2-back task (accuracy rate), SCWT (execution time) when compared with HCs. 2) NAA/Cr and Cho/Cr in the left PFC (lPFC) and MI/Cr ratios in the bilateral PFC of OCD patients were significantly lower when compared to HCs. 3) For OCD patients, the NAA/Cr ratio in the lPFC was negatively correlated with the score of DST (forwards), the Cho/Cr ratio in the lPFC was positively correlated with the accuracy rate of 2-back task, and the MI/Cr ratio in the right PFC (rPFC) was positively correlated with the score of DST (forwards) and the accuracy rate of VSMT. We also found that the compulsive symptoms showed a positive correlation with MI/Cr ratio of the rPFC.Conclusion: Drug-naive OCD patients have demonstrated WM impairments, including phonological loop, visual-spatial sketchpad and central executive system, and the WM impairments might be associated with hypometabolism in the PFC, especially the lPFC.Keywords: obsessive compulsive disorder, prefrontal cortex, working memory, neurometabolites, proton magnetic resonance spectroscopy

Ultraintense optical vortices carrying orbital angular momentum have attracted much attention in strong-field laser physics due to their spiral phase and hollow intensity. This Letter introduces a fully continuous spiral phase plate (FC-SPP) that enables the generation of an ultraintense Laguerre–Gaussian beam. An optimization design method based on the spatial filter technique and chirp-z transform is proposed to match the polishing processing and the tightly focusing performance. To enable its use in high-power laser systems, a large-aperture (200 × 200 mm2) FC-SPP has been fabricated on a fused silica substrate through magnetorheological finishing without the use of mask techniques. The far-field phase pattern and intensity distribution based on vector diffraction calculation were compared with those of ideal spiral phase plate and fabricated FC-SPP, which confirmed the high quality of the output vortex beams and their feasibility for producing high-intensity vortices.

This study was designed to explore the relationship between anorexia nervosa and depression and to evaluate the role that endocrine hormones play in anorexia nervosa with functional hypothalamic amenorrhea and comorbid depression. In this study, thyroid hormones and sex hormones were compared between 30 first-episode drug-naive female patients with anorexia nervosa with depression (AND), and 20 female patients with anorexia nervosa with no depression (ANND). There were no differences between anorexia nervosa participants with and without depression in thyroid hormones levels. Patients with AND had significantly lower prolactin serum levels; patients with AND had a median [P25, P75] prolactin level of 213.0 uIU/ml [12.1-268.2] vs. 446.6 uIU/ml [119.1-35.5] for patients with ANND. There were no differences in other sex hormones between the two groups. Our data suggested that a lower prolactin serum level is a characteristic of first-episode neuroleptic-naive patients with AND.

Objective: To explore the influence of mental health course on the mental health level of college students. Method: To organize psychiatrists or psychotherapists to give lectures on college students’ mental health by comprehensive teaching methods, and to evaluate the teaching effect by Symptom Check List, Connor Davidson Resilience Scale and Positive and Negative Affect Schedule. Result: 1) The scores of interpersonal sensitivity, diet and sleep factors are significantly lower than those before teaching, with statistical significance difference. 2) The scores of resilience, strength and optimism are significantly higher than those before teaching, with statistical significance difference. 3) The positive emotions grow while the negative emotions are lower after teaching, without statistical significance difference. Conclusion: The mental health course is of positive significance for improving the mental health level of college students, which is worth popularizing.

Magnetorheological polishing technology is a high-deterministic, high-precision optical ultra-precision processing technology, which is widely used in the polishing of large-aperture flat optical elements. The accuracy of magnetorheological removal function is a key factor that determines the accuracy and efficiency of magnetorheological polishing. In the process of making the removal function, it is easy to introduce spurious fringes when an interferometer is used for surface shape test. The spurious fringes will reduce the extraction accuracy of the removal function, and affect the certainty of magnetorheological polishing. In addition, the introduced spurious fringes contain complex mid- and high-frequency structures, which seriously affect the evaluation of the ability to remove function modification. In order to eliminate the spurious fringes, this paper proposes a method of removing the spurious fringes of the removal function based on the characteristic spectrum band-stop filter. First, the ZooMFFT algorithm is used to amplify the frequency spectrum to realize the effective identification of the spectral characteristics of the spurious fringes; secondly, a specific algorithm is used to eliminate only the frequency spectrum of the spurious fringes, completely retaining the frequency spectrum of the removal function itself, and does not change the valid shape of the removal function, making the spurious fringes are removed. And the Quad Flip operation is used in spectral filtering to improve the filtering accuracy. The magnetorheological making spot experiment uses a fused silica plate element with a diameter of 50mm. A static interferometer is used to measure the component wavefront data, and the tested result data contains obvious spurious fringes. Using the method described in this article, the spurious fringes are completely removed, and the morphological and removal efficiency of the removal function remains unchanged. Compared with the traditional frequency domain band-stop filter, the residual surface RMS of the spurious fringes separation is reduced from 5.45nm to 1.98nm; improve the extraction accuracy of the removal function. It can be effectively used to eliminate the spurious fringes of the magnetorheological removal function.

Magnetorheological polishing technology is a new type of ultra-precision processing technology. It has many advantages such as no sub-surface defects, easy realization of numerical precision control, high machining accuracy, and high polishing efficiency; and its small removal function size makes it very suitable for processing optical elements with complex geometric structures. It has been widely used in phase optical processing. In order to realize the processing of phase optical elements with a small space periodic structure, a smaller removal function is required. The traditional magnetorheological fluid circulation system structure is difficult to achieve stable control of the magnetorheological fluid flow under small flow conditions. Therefore, it is difficult to obtain a stable small size removal function. This paper analyzes the characteristics of the peristaltic pump, and aiming at the problem of strong pulse in its output flow; uses a pulsation damper and a variable-diameter back pressure pipeline to eliminate the flow pulse, realizes the stable and smooth output of the peristaltic pump flow. On this basis, this paper proposes a new type of magnetorheological fluid circulation system structure, which realizes the stable control of the flow rate under small flow rate conditions. The magnetorheological fluid flow fluctuation error of the magnetorheological fluid circulation system was from more than 25% reduced to less than 2%, realizing high stability control of magnetorheological fluid flow. Use small size removal function to process Continuous Phase Plates (CPP) with large depth and small periodic structure. The CPP is designed with a PV of 5μm and a minimum space period of 3mm. After processing, the residual error RMS of the CPP from 830nm converges to 24.5nm, realize high-precision processing of phase components with large depth and small structure.

Background Obsessive–compulsive disorder (OCD) is a mental disease with heterogeneous behavioral phenotypes, including repetitive behaviors, anxiety, and impairments in cognitive functions. The brain regions related to the behavioral heterogeneity, however, are unknown. Methods We systematically examined the behavioral phenotypes of three OCD mouse models induced by pharmacological reagents [RU24969, 8-hydroxy-DPAT hydrobromide (8-OH-DPAT), and 1-(3-chlorophenyl) piperazine hydrochloride-99% (MCPP)], and compared the activated brain regions in each model, respectively. Results We found that the mouse models presented distinct OCD-like behavioral traits. RU24969-treated mice exhibited repetitive circling, anxiety, and impairments in recognition memory. 8-OH-DPAT-treated mice exhibited excessive spray-induced grooming as well as impairments in recognition memory. MCPP-treated mice showed only excessive self-grooming. To determine the brain regions related to these distinct behavioral traits, we examined c-fos expression to indicate the neuronal activation in the brain. Our results showed that RU24969-treated mice exhibited increased c-fos expression in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), prelimbic cortex (PrL), infralimbic cortex (IL), nucleus accumbens (NAc), hypothalamus, bed nucleus of the stria terminalis, lateral division, intermediate part (BSTLD), and interstitial nucleus of the posterior limb of the anterior commissure, lateral part (IPACL), whereas in 8-OH-DPAT-treated mice showed increased c-fos expression in the ACC, PrL, IL, OFC, NAc shell, and hypothalamus. By contrast, MCPP did not induce higher c-fos expression in the cortex than control groups. Conclusion Our results indicate that different OCD mouse models exhibited distinct behavioral traits, which may be mediated by the activation of different brain regions.

In the interference test process of a parallel flat optical element, the light beam after multiple reflections on the front and rear surfaces of the element with the wavefront to be measured often cause multi-surface interference, forming spurious fringes on the interferogram, which will introduce large errors to the wavefront measurement. Spurious fringes mainly have a great impact on the parameters such as wavefront gradient root mean square (GRMS) and mid-spatial-frequency power spectral density (PSD). The RMS value of the wavefront containing spurious fringes is generally significantly larger than the true value, which will affect the accurate measurement and evaluation of the wavefront quality of optical components. Existing spurious fringes suppression methods often have the disadvantages of multiple adjustment steps in the test process or high hardware requirements, and it is difficult to match the requirements for rapid and high-efficiency test of high-precision optical flat components. This paper proposes a method for removing spurious fringes in interference test based on characteristic spectrum band-stop filter, which can achieve accurate removal of spurious fringes. First, by using the ZoomFFT algorithm to zoom up the spectrum of the wavefront data points, the effective identification of the spectral characteristics of the spurious fringe is realized; then the band-stop filter in a specific area is used according to the spectral characteristics of the spurious fringes, only the frequency spectrum of the spurious fringes is removed, and the wavefront data of the component to be tested is completely retained without changing its own shape; the Quad-Flip operation and error function filter window are used for spectrum filtering, which effectively reduces Gibb's noise in the frequency domain due to the sudden truncation of the input data edge during FFT transformation. The transmitted wavefront of a fused silica element with a diameter of Φ100mm was tested on the ZYGO static interferometer, and the test results contained a large number of spurious fringes. After processing by this method, the spurious fringes were removed. The mid-spatial-frequency wavefront RMS of the component is reduced from 5.365nm to 3.678nm. The method does not need to add additional hardware and tedious measurement and adjustment operations, the calculation is fast, and the spurious fringes removal is accurate.

Due to the characteristics of large depth, small period and high steepness, phase optical elements with complex structure need to use a small size removal function in magnetorheological processing, and use very small line spacing and step size values when planning the polishing path，so the dwell time matrix is very large, and the dwell time calculation speed is slow; besides, because of the complicated phase optical profile, it is difficult to achieve high-precision convergence of the dwell time. This paper proposes a fast and high-precision numerical iterative dwell time algorithm for complex structure phase optical elements. this paper proposes the concept of the dwell point matrix, which realizes the methods of the FFT convolution multi-core parallel algorithm to calculate the dwell time in the entire iterative calculation process. Also, to achieve high-precision convergence of the dwell time calculation, this paper proposes a calculation rule based on machine dynamic performance matching, when calculating the dwell time, the speed, acceleration, and speed smoothness of the machine were matched with the performance of the magnetorheological machine, which improves the stability of the machine. A large-diameter Continuous Phase Plate (CPP) is processed on a magnetorheological machine. The shape of the CPP contains a random structure of various periods. The initial RMS = 228.07nm, the CPP data matrix size is 2424 × 2424, and the line spacing is 0.6mm, the dwell time is calculated using the algorithm described in this article, the entire calculation process takes only 4.2 seconds, the calculation speed is about 3 times faster than the traditional iterative methods, the CPP residual error RMS converges to 10.2nm; After the CPP processing is completed, the CPP actual residual error RMS is reduced from the original 228.07nm to 15.6nm, and its convergence rate is 93.1%, which shows that the algorithm has high calculation efficiency and convergence accuracy.

BACKGROUND: Obsessive-compulsive disorder (OCD) is a severe, chronic, disabling neuropsychiatric disorder, the pathophysiology of which has yet to be fully understood. In this study, we aimed to detect the levels of miRNA-132 and miRNA-134 in the plasma of patients with OCD and to analyze the factors influencing OCD. METHODS: The levels of miRNA-132 and miRNA-134 in peripheral blood of 30 patients with OCD and 32 normal controls were detected by quantitative reverse transcription polymerase chain reaction (RT-qPCR). Patients were assessed using clinical scales, including the Hamilton Anxiety Rating Scale (HAMA), Hamilton Depression Rating Scale (HAMD), and Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). RESULTS: The plasma levels of miRNA-132 and miRNA 134 in the OCD group were significantly higher than those in the control group (P

The effect of chronic insomnia carries along a physical and psychological state of dysfunctionality felt by the individual. The purpose of the study was to investigate the effects of hypnotherapeutic intervention applied in the case of patients who present insomnia accompanied by rumination. We performed the study of 42 patients who underwent the Symptom Checklist-90 (SCL-90) for the psychiatric evaluation and the Pittsburgh Sleep Quality Index (PSQI) for sleep quality at baseline, 1 month after the program and follow-up (2 months) after finalizing the program. Our findings revealed that hypnotherapeutic intervention that involves relaxation and positive self-suggestion leads to positive results among the patient who experience insomnia accompanied by rumination.

Focal spot with moving speed is a new concept proposed in recent years, which has many applications in physics of intense field. The current method is to control the moving speed of focal spot by chirped pulse technique and chromatic aberration focusing, which suffers from the change of frequency components with the movement of focal spot. In this paper, we propose a method to realize the colorless movement of focal spot at arbitrary speed by using two kinds of mirrors. One is an aspherical mirror with long focal depth and the other is a stepped mirror. For a specific moving speed, we derive the relationship between the surface of aspherical mirror and the wavefront of laser by the geometrical optics. The stepped mirror is used to form stepped wavefront to separate the relationship between the shape of wavefront and the direction of laser. Time-dependent simulations are carried out to verify the real focusing property after considering diffraction effects, and focal spots with moving speed of 0.5c, 2c and −c are obtained.

Here, we report a female patient developing neuroleptic malignant syndrome following the use of a combination of clozapine and haloperidol. Subsequently, the patient presented withdrawal effects after an abrupt discontinuation of clozapine. Psychiatrists not aware of possible clozapine-withdrawal effects may misdiagnose as a part of the primary mental illness or as the initial symptoms worsening, if unrecognized.

Objective This study was designed to investigate the correlation between serum uric acid (UA) levels and the clinical characteristics of depression. Design and methods The serum UA levels were measured in 124 patients with depression, 660 patients with different types of other mental disorders (OMD) and 42 healthy subjects. Clinical characteristics of depression and OMD were also investigated. Results Depressive patients (271.97 ± 77.50 μmol/L) had significantly lower UA levels than those with delirium, dementia, amnesia and other cognitive disorders (339.95 ± 141.74 μmol/L, P = 0.004), substances related disorders (359.61 ± 125.02 μmol/L, P = 0.022), schizophrenia (341.03 ± 106.84 μmol/L, P = 0.000), schizoaffective disorder (336.78 ± 155.49 μmol/L, P = 0.024), bipolar disorder (323.04 ± 108.70 μmol/L, P = 0.008) and the healthy control group (315.76 ± 87.50 μmol/L, P = 0.012). We also found that the UA levels of depressive patients normalised after a five week treatment with antidepressants. Conclusion Our data suggested that a lowered UA level is another characteristic of depression.

To explore the magnetic resonance spectroscopy characteristics of lenticular nucleus in Bipolar II disorder and its relation with cognitive function.Thirty Bipolar II disorder patients in hospital from 2012 September to 2013 April and twenty healthy controls were evaluated with Multi-Voxel 1H-MRS scans on lenticular nucleus to assess the NAA, Cho, Cr and MI. All subjects were assessed for attention using the Stroop Test and executive function by Wisconsin card sorting test.NAA, Cho, Cr in right lenticular nucleus and Cr in left lenticular nucleus were lower than healthy controls (P0.05). The patients showed significant cognitive impairment in all aspects of Stroop Test and Wisconsin card sorting test (P0.05). NAA in right lenticular nucleus was positively correlated with correct number of Stroop-CW.Neural dysfunction in right lenticular nucleus of Bipolar II disorder may influence attention function. Cellular energy metabolism rate was reduced in bilateral lenticular nucleus.

This paper studies the robust adaptive fuzzy control design problem for a class of uncertain multiple-input and multiple-output (MIMO) nonlinear systems in the presence of actuator amplitude and rate saturation. In the control scheme, fuzzy logic systems are used to approximate unknown nonlinear systems. To compensate the effect of input saturations, an auxiliary system is constructed and the actuator saturations then can be augmented into the controller. The modified tracking error is introduced and used in fuzzy parameter update laws. Furthermore, in order to deal with fuzzy approximation errors for unknown nonlinear systems and external disturbances, a robust compensation control is designed. It is proved that the closed-loop system obtainsH∞tracking performance through Lyapunov analysis. Steady and transient modified tracking errors are analyzed and the bound of modified tracking errors can be adjusted by tuning certain design parameters. The proposed control scheme is applicable to uncertain nonlinear systems not only with actuator amplitude saturation, but also with actuator amplitude and rate saturation. Detailed simulation results of a rigid body satellite attitude control system in the presence of parametric uncertainties, external disturbances, and control input constraints have been presented to illustrate the effectiveness of the proposed control scheme.

Previous research characterizes obsessive compulsive disorder (OCD) as a complex neurobehavioral disorder that may have multiple etiologies ( den Braber et al., 2008 ). This study analyzed neurocognitive function and change in regional cerebral blood flow (rCBF) to characterize OCD. Neurocognitive function and rCBF were examined in medically naive patients with OCD and contrasted with controls. Results of this study indicated that the neurocognitive functions impaired in OCD are memory, attention, and executive function, which are primarily associated with the frontal and occipital lobes. Dysfunction in the basal ganglia and occipital lobes were associated with OCD and may be an etiological factor in the disorder.

Spheric lens designed by nonlinear phase fitting method is proposed to duplicate the performance of logarithmic axicon, which can obtain a beam with long-focal-depth, small focal spot and side lobe. Moreover, the spheric lens is easier and less expensive for manufacture than logarithmic or aspherical elements. Based on this method, a simple lens is designed for the plasma diagnostic system in inertial confinement fusion. It is verified through Fresnel diffraction integral and an initial experiment that the performance of the lens can satisfy the requirements of the plasma measurements.

In this paper, considering J2 perturbation, we derive the analytical solution of a satellite orbit disturbed by atmospheric drag. The model of atmosphere density considering J2 perturbation and atmosphere drag is first developed. Then the Gaussian equations of satellite motion are simplified, the atmospheric drag is expanded to triangular functions of orbit angular elements and the disturbances are separated into three parts: short-periodic terms, long-periodic terms and secular effects. The integrations are carried out to get the analytical solution and some important conclusions are obtained. The numerical simulation is carried out to make the work clearer and prove it.

The test of wavefront of large aperture continuous phase plate(CPP) is difficult to obtain by whole aperture once because of CPP’s characteristic such as large phase depth and large phase gradient,so sub-aperture stitching technique is often used to test the CPP’s wavefront in whole aperture.We analysed some problems in the traditional sub-aperture stitching test and put forward a new stitching model mathematically in order to improve the precision in CPP’s sub-aperture stitching test.We have found that this new model is available by a serial experiments.

This study was designed to explore the relationship between pituitary microadenoma and psychosis and to evaluate the role that prolactin plays in pituitary microadenoma and comorbid psychosis. In this study, the prolactin serum levels were compared between 74 first-episode drug-naive patients with a pituitary microadenoma with psychosis (PMP), and 58 patients with a pituitary microadenoma with no psychosis (PMNP). Patients with PMP had significantly higher prolactin serum levels; male patients with PMP had a mean [S.D.] prolactin level of 705.4 uIU/ml [226.1] vs. 433.1 uIU/ml [58.4] for male patients with PMNP, while female patients with PMP had a mean prolactin level of 1890.1 uIU/ml [1138.7] vs. 978.6 uIU/ml [657.9] for female patients with PMNP. The size of microadenoma in the patients with PMP was larger than those in the patients with PMNP, regardless of sex. Our data suggested that a higher prolactin serum level is a characteristic of first-episode neuroleptic-naive patients with PMP.

Valproate (VPA) is a medication that is widely used in the treatment of neurological and psychiatric disorders, such as epilepsy and bipolar disorder. Valproate-induced hyperammonemic encephalopathy (VHE) is a rare central nervous system adverse effect of this medication that is characterized by impaired consciousness, which can range from drowsiness to coma; increased seizure frequency; acute cognitive symptoms; and gastrointestinal symptoms. In this manuscript, we report a single case and also review previous cases of VHE (n = 20) in Chinese patients to identify risk factors for VHE. Increasing clinicians’ awareness of VHE during concomitant VPA therapy is of utmost importance. Serum ammonia level is a useful and important diagnostic test. The discontinuation of VPA is currently the mainstay of treatment for VHE.

Few studies have shown that topiramate may induce psychiatric symptoms and metabolic disorders, respectively. Here, we reported a 13-year-old female who presented with topiramate-induced hallucinations and comorbid renal tubular acidosis. She had a history of psychiatric illness and had been taking the medication for 3 months without prior side effects. After the discontinuation of topiramate, she was treated with supplementary potassium and sodium bicarbonate. Subsequently, her psychiatric symptoms and biochemical findings improved. Recognition of drug-induced psychotic symptoms and renal tubular acidosis is important during concomitant topiramate therapy in psychiatric clinic.

The design and manufacure of Continuous Phase Plate(CPP) with a large aperture is very significant and useful to the Inertial Confinement Fusion(ICF) and some physical experiment related due to its several advantages such as high energy availability ratio and easily controllable focal spot's profile. Various processing errors will be inevitably introduced for the limitation of the fabrication technique and hence produce aberrated laser wavefront, which is very influential for the process of beam's propagation and focusing. In this paper we numerically simulate and compare the optical filed distributions of phase-aberrated super-Gaussian beam passing through both designed and manufactured CPP with a large aperture and deep phase. The simulation results prove the CPP's beam smoothing performance and high tolerance of the super-Gaussian beam's far-field focal plane intensity distributions,which has been added by the random phase screen, furthermore, the modulation influence of intermediate frequency phase error to the near-field light intensity distribution has also been simulated and proved, from which we can improve the fabrication technique and optimize the design method.

In this paper, a new focusing method adopting an axicon for the demand of the plasma measurements in inertial confinement fusion (ICF) drivers is presented. In order to improve the performance of this element, annular-aperture and Super-Guassian apodization are introduced to remove the on-axis oscillations. Meanwhile, the lateral width is optimized through choosing appropriate radius ratio of the inner ring to outer ring of the element. Furthermore, the feasibility is conformed by numerical evaluation of Fresnel diffraction integral .The results obtained are accordant with our designed intention. At last, as an example and for specific application, we designed an axicon, which has almost unchanged axial intensity, a focal depth more than 3mm, beam size smaller than 100μm and the maximal relative intensity of side lobe less than 2%. The performance of this element satisfies the requirements of plasma measurements in ICF drivers.

In the final optics assembly of ICF driver, Diffractive Optical Elements (DOEs) are applied to achieve some important functions. Due to the advantage of easy integration, DOEs that achieve different functions can be combined into one element, and thus the system structure and performance of ICF driver can be optimized. In this paper, we present a new means to fabricate color separation grating (CSG) and beam sampling grating (BSG) on two surfaces of one fused-silica substrate with two-surface exposure method. The mask for CSG can be fabricated with common optical method since the period of CSG is large; whereas the mask for BSG cannot be made with normal micro-fabrication system whose resolution cannot meet the requirement of fabrication precision of slowly changed BSG fringes (from 2μm to 4μm). Therefore, we use e-beam direct writing method to fabricate mask for BSG. The alignment of CSG and BSG is designed in accordance with the requirement of actual system. Thus the functions of harmonic wave separation and beam sampling are realized through one silica plate. The satisfying experimental results are illustrated.

Color Separating Grating (CSG) is one of the important Diffractive Optical Elements (DOE) used in the final optical system of high power laser system. Its periodic step-phase structure can separate the third harmonic frequency from base- and second-harmonic waves in the far field. But the structure abbreviations of CSG, caused by the fabrication process, generate great modulations to the laser beam, which may lead to severe optical damages to CSG itself and the system. In this paper, a comprehensive error model is built, in which each structural parameter of CSG is expressed as a variable, and the structural parameter error induced by fabrication process is expressed as minute disturb of relative variable. With this error model, the near field diffraction pattern of CSG is calculated based on Fresnel diffractive theory. Through simulation and analysis, we obtain the amplitude modulation of different harmonic waves in near field, and also the relationship between the amplitude modulation and the fabrication error. The results show that beam modulations are mainly caused by the stair depth error and the slope error. This study provides a convenient way to estimate the possibility of optical damages induced by CSG.

Objective To analyze the correlation between the pharmacotherapy response and the characteristics of the pre-treatment regional cerebral blood flow (rCBF) in patients with obsessive-compulsive disorder (OCD). Methods Single-photon emission-computed tomography (SPECT) was used to determine the pre-treatment rCBF in 30 OCD patients and 30 normal controls. Based on their clinical remission response, the subjects were divided into two groups: selective serotonin reuptake inhibitors (SSRIs) and SSRIs plus quetiapine. The subjects with clinical remission response were identified after treatment for a period of 24 weeks, and the rCBF imaging data were processed using statistical parametric mapping (SPM) software with two-sample Z-tests. Results Nineteen OCD patients who achieved clinical remission were included in the study. Increased rCBF in forebrain regions, including the frontal lobe, cingulate gyrus, hypothalamus, and basal ganglia, was found in 11 responders to SSRIs compared to normal control patients. The eight SSRI plus quetiapine responders exhibited a decrease in rCBF within posterior brain regions, including the parietal lobe, cerebellar vermis, and occipital lobe, and an increase in rCBF in the frontal lobe, thalamus, basal ganglia, and cerebellum tonsil compared to normal control patients. Conclusions The characteristics of increased rCBF in forebrain regions and decreased rCBF in posterior brain regions before treatment of OCD patients was a potentially predictor of treatment response to guide treatment options.