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Your search keyword '"Shende, Manisha R."' showing total 14 results
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14 results on '"Shende, Manisha R."'

3. Transoral endoscopic repair of Zenker diverticulum by a thoracic surgical service

Author

Levy, Ryan M., primary, Luketich, James D., additional, Brynien, Daniel, additional, Mpamaugo, Chinenyenwa, additional, Shende, Manisha R., additional, Gooding, William E., additional, Pennathur, Arjun, additional, Sanchez, Manuel Villa, additional, Ferson, Peter F., additional, Awais, Omar, additional, Schuchert, Matthew J., additional, and Sarkaria, Inderpal S., additional

Published
2022
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7. Post-esophagectomy cancer recurrence: Impact of postoperative infection in propensity-matched cohorts

Author

Tam, Vernissia, Luketich, James D., Winger, Daniel G., Sarkaria, Inderpal, Levy, Ryan M., Christie, Neil A., Awais, Omar, Shende, Manisha R., and Nason, Katie S.

Subjects
Male, Time Factors, Esophageal Neoplasms, Incidence, Adenocarcinoma, Middle Aged, Pennsylvania, Article, Esophagectomy, Survival Rate, Treatment Outcome, Humans, Minimally Invasive Surgical Procedures, Surgical Wound Infection, Female, Neoplasm Recurrence, Local, Propensity Score, Aged, Follow-Up Studies, Neoplasm Staging, Retrospective Studies
Abstract

Postoperative infection increases cancer recurrence and worsens survival in colorectal cancer, but the relationship for esophagogastric adenocarcinoma after esophagectomy is not well defined. We aimed to determine whether recurrence and survival after minimally invasive esophagectomy for esophagogastric adenocarcinoma were influenced by postoperative infection using propensity-matched analysis.We abstracted data for 810 patients (1997-2010) and defined exposure as at least 1 in-hospital or 30-day infectious complication (n = 206 [25%]). Using 29 pretreatment/intraoperative variables, patients were propensity-score matched (caliper = 0.05). Time to cancer recurrence and survival (Kaplan-Meier curves and the Breslow test), and associated factors (Cox regression with shared frailty) were assessed.After propensity matching (n = 167 pairs), median bias across propensity-score variables was reduced from 12.9% (p0.001) to 4.4% (p = 1.000). Postoperative infection was not associated with rate (n = 60 versus 63; McNemar p = 0.736) or time to recurrence in those in whom disease recurred (median, 10.7 versus 11.1 months; Wilcoxon signed-rank p = 0.455) but was associated with shorter overall survival (n = 124 versus 102 deaths; median, 26 versus 41 months; Breslow p = 0.002). After adjusting for age, body mass index, neoadjuvant therapy, sex, comorbidity score, positive resection margins, pathologic stage, R0 resection, and recurrence, postoperative infection was associated with a 44% greater hazard for death (hazard ratio, 1.44; 95% confidence interval, 1.10-1.89).In patients with esophagogastric adenocarcinoma, infections after esophagectomy were not associated with an increased rate or earlier time to recurrence when baseline characteristics associated with infection risk were balanced using propensity-score matching. Despite this, overall survival was shorter in patients with infectious complications. After adjusting for other important survival predictors, infections after esophagectomy continued to be independently associated with worse survival.

Published
2016

9. Castleman Disease Presenting with Pseudotumour Cerebri and Myasthenia Gravis: A Case Report and Literature Review.

Author

Fein, Alexander S., Trejo Bittar, Humberto E., Shende, Manisha R., Scalzetti, Ernest M., and Ko, Melissa W.

Subjects
MYASTHENIA gravis, CASTLEMAN'S disease, INTRACRANIAL hypertension, COMORBIDITY, POEMS syndrome
Abstract

Castleman disease (CD) is a rare lymphoproliferative disorder that may present with various autoimmune, inflammatory, or neurologic syndromes. This is a case of a 21-year-old woman who presented with signs and symptoms of pseudotumour cerebri (PTC) who subsequently developed myasthenia gravis (MG), and was incidentally found to have a large mass in the posterior mediastinum. Upon resection, the mass was classified as unicentric CD involved with follicular dendritic cell sarcoma. Following treatment with IVIG in the setting of progressive weakness and dyspnea, she has had complete symptom resolution while maintained on a low dose of pyridostigmine for the last two years. There are 13 cases of MG and five cases of optic disc edema described as PTC associated with CD in the literature, but to our knowledge, this is the sole case reported of the intersection of all three conditions in one patient. Increased serum levels of interleukin-6 and vascular endothelial growth factor may provide clues as to the association of CD with these neurologic syndromes. [ABSTRACT FROM AUTHOR]

Published
2019
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12. Determinants Of Chronic Post Thoracotomy Pain

Author

Hopkins, Kathleen G., primary, Hoffman, Leslie A., additional, Zullo, Thomas G., additional, Shende, Manisha R., additional, Luketich, James D., additional, Christie, Neil A., additional, Pennathur, Arjun, additional, Weksler, Benny, additional, and Ferson, Peter F., additional

Published
2012
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