1. Current status of cell damage repair and related drug research and development
- Author
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Ge Yan, Shen Yongmei, Liu Shu, Zeng Chenjuan, Liu Bin, Jiang Shunri, and Geng Funeng
- Subjects
tissue injury ,cell death ,repair ,medicine ,Medicine ,Biotechnology ,TP248.13-248.65 - Abstract
The fundamental aspect of tissue injury was the structural changes and functional disorders caused by a great deal of cell death, it might further develop into organ damage in severe cases. At present, the treatment of tissue injury was more focused on improving the micro-environment and promoting cell renewing. Insufficient attention was paid to the repair of cell damage, this oversight could exacerbate disease conditions and create difficulties in achieving healing. Thus, treating tissue injury should be based on repairing cell damage. In order to systematically grasp the research status and drug development of cell damage and repair, this article provided a systematic review of the damaging causes, repair mechanisms, and drug development from the perspectives of DNA damage, RNA damage, protein damage, mitochondrial damage, membrane damage and cell death. It was expected to contribute to promoting the research and development of repair medicines.
- Published
- 2023
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