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541 results on '"Shen Meixiao"'

13. Effects of orthokeratology and spectacle lenses with highly aspherical lenslets on unilateral myopic anisometropia control.

Author

Zhai, Jing, Fang, Wei, Zhang, Yunjie, Lian, Hengli, Hou, Lijie, Shen, Meixiao, and Lu, Fan

Subjects
EYEGLASSES, ANISOMETROPIA, MYOPIA, REGRESSION analysis, ORTHOKERATOLOGY
Abstract

Purpose: To evaluate the 1‐year effects of orthokeratology (OK) lenses and spectacle lenses with highly aspherical lenslets (HALs) on axial length (AL) elongation in children with unilateral myopic anisometropia. Methods: This ambispective cohort study recruited 81 children aged 8–14 years with unilateral myopic anisometropia. Of these, 42 participants (mean age 11.07 ± 1.54 years; 23 males) were treated with monocular OK lenses (OK group), and 39 (mean age 10.64 ± 1.72 years; 22 males) with binocular HALs (HAL group). Changes in AL and spherical equivalent refraction (SER) from baseline at 3, 6 and 12 months were compared between eyes and groups. Kaplan–Meier estimation and Cox proportional hazard regression were performed to analyse the risk of myopia onset in the initially non‐myopic eyes. Results: Mean axial elongation in the myopic and non‐myopic eyes at the 12‐month follow‐up visit were 0.17 ± 0.20 and 0.41 ± 0.26 mm in the OK group (p < 0.001) and 0.10 ± 0.15 and 0.12 ± 0.12 mm in the HAL group (p = 0.32), respectively. Compared with the OK group, the non‐myopic eyes in the HAL group had less axial elongation, lower cumulative myopia incidence and percentage of participants with rapid myopic shift at the 6‐ and 12 month follow‐up (all p < 0.05). Cox regression analysis showed that a higher initial SER decreased the risk of myopia onset significantly in the initially non‐myopic eyes (B = −2.06; 95% CI, 0.03–0.49; p = 0.003). Conclusions: Monocular OK lenses suppressed axial elongation in the myopic eye and minimised anisometropia; however, the non‐treated contralateral eye may experience faster myopia onset and myopic shift. Binocular HALs can effectively reduce axial elongation in both eyes of children with unilateral myopic anisometropia. [ABSTRACT FROM AUTHOR]

Published
2024
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21. In vivo imaging of retinal hemodynamics with OCT angiography and Doppler OCT

Author

Huang, Shenghai, Shen, Meixiao, Zhu, Dexi, Chen, Qi, Shi, Ce, Chen, Zhongping, and Lu, Fan

Subjects
Biomedical Imaging, Bioengineering, Eye Disease and Disorders of Vision, Neurosciences, Detection, screening and diagnosis, 4.2 Evaluation of markers and technologies, Eye, (100.2960) Image analysis, (100.6890) Three-dimensional image processing, (170.4460) Ophthalmic optics and devices, (170.4500) Optical coherence tomography, Optical Physics, Materials Engineering
Abstract

Retinal hemodynamics is important for early diagnosis and precise monitoring in retinal vascular diseases. We propose a novel method for measuring absolute retinal blood flow in vivo using the combined techniques of optical coherence tomography (OCT) angiography and Doppler OCT. Doppler values can be corrected by Doppler angles extracted from OCT angiography images. A three-dimensional (3D) segmentation algorithm based on dynamic programming was developed to extract the 3D boundaries of optic disc vessels, and Doppler angles were calculated from 3D vessel geometry. The accuracy of blood flow from the Doppler OCT was validated using a flow phantom. The feasibility of the method was tested on a subject in vivo. The pulsatile retinal blood flow and the parameters for retinal hemodynamics were successfully obtained.

Published
2016

29. Trio-based exome sequencing arrests de novo mutations in early-onset high myopia

Author

Jin, Zi-Bing, Wu, Jinyu, Huang, Xiu-Feng, Feng, Chun-Yun, Cai, Xue-Bi, Mao, Jian-Yang, Xiang, Lue, Wu, Kun-Chao, Xiao, Xueshan, Kloss, Bethany A., Li, Zhongshan, Liu, Zhenwei, Huang, Shenghai, Shen, Meixiao, Cheng, Fei-Fei, Cheng, Xue-Wen, Zheng, Zhi-Li, Chen, Xuejiao, Zhuang, Wenjuan, Zhang, Qingjiong, Young, Terri L., Xie, Ting, Lu, Fan, and Qu, Jia

Published
2017

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