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381 results on '"Shen, Zhanlong"'

29. An Asia-specific variant of human IgG1 represses colorectal tumorigenesis by shaping the tumor microenvironment

Author

Yang, Bing, Zhang, Zhen, Chen, Xiangjun, Wang, Xu-Yan, Qin, Shishang, Du, Liaoqi, Yang, Changjiang, Zhu, Liyu, Sun, Wenbo, Zhu, Yongjie, Zheng, Qinwen, Zhao, Shidong, Wang, Quan, Zhao, Long, Lin, Yilin, Huang, Jinghe, Wu, Fan, Lu, Lu, Wang, Fei, Zheng, Wenjie, Zhou, Xiao-Hua, Zhao, Xiaozhen, Wang, Ziye, Xiao-Lin, Sun, Ye, Yingjiang, Wang, Shan, Li, Zhanguo, Qi, Hai, Zhang, Zemin, Kuang, Dong-Ming, Zhang, Lei, Shen, Zhanlong, and Liu, Wanli

Subjects
Oncology, Experimental, Immunotherapy -- Research, Colorectal cancer -- Care and treatment -- Genetic aspects, Genetic variation -- Research, Immunoglobulin G -- Health aspects -- Genetic aspects, Cancer -- Research, Molecular targeted therapy -- Research, Health care industry
Abstract

Emerging studies have focused on ways to treat cancers by modulating T cell activation. However, whether B cell receptor signaling in the tumor microenvironment (TME) can be harnessed for immunotherapy is unclear. Here, we report that an Asia-specific variant of human IgG1 containing a Gly396 to Arg396 substitution (hIgG1-G396R) conferred improved survival of patients with colorectal cancer (CRC). Mice with knockin of the murine functional homolog mIgG2c-G400R recapitulated the alleviated tumorigenesis and progression in murine colon carcinoma models. Immune profiling of the TME revealed broad mobilizations of [IgG1.sup.+] plasma cells, [CD8.sup.+] T cells, [CD103.sup.+] DCs, and active tertiary lymphoid structure formation, suggesting an effective antitumor microenvironment in hIgG1-G396R CRC patients. Mechanistically, this variant potentiated tumorassociated antigen-specific (TAA-specific) plasma cell differentiation and thus antibody production. These elevated TAA-specific IgG2c antibodies in turn efficiently boosted the antibody-dependent tumor cell phagocytosis and TAA presentation to effector [CD8.sup.+] T cells. Notably, adoptive transfer of TAA-specific class-switched memory B cells harboring this variant exhibited therapeutic efficacy in murine tumor models, indicating their clinical potential. All these results prompted a prospective investigation of hIgG1-G396R in patients with CRC as a biomarker for clinical prognosis and demonstrated that manipulating the functionality of [IgG1.sup.+] memory B cells in tumors could improve immunotherapy outcomes., Introduction Effective immune responses are indispensable for optimal cancer treatment; however, tumor cells often evade immune clearance by inhibiting neoantigen presentation and inducing immune silencing in the tumor microenvironment (TME) [...]

Published
2022
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35. Expert consensus on multidisciplinary therapy of colorectal cancer with lung metastases (2019 edition)

Author

Li, Jian, Yuan, Ying, Yang, Fan, Wang, Yi, Zhu, Xu, Wang, Zhenghang, Zheng, Shu, Wan, Desen, He, Jie, Wang, Jianping, Ba, Yi, Bai, Chunmei, Bai, Li, Bai, Wei, Bi, Feng, Cai, Kaican, Cai, Muyan, Cai, Sanjun, Chen, Gong, Chen, Keneng, Chen, Lin, Chen, Pengju, Chi, Pan, Dai, Guanghai, Deng, Yanhong, Ding, Kefeng, Fan, Qingxia, Fang, Weijia, Fang, Xuedong, Feng, Fengyi, Fu, Chuangang, Fu, Qihan, Gu, Yanhong, He, Yulong, Jia, Baoqing, Jiang, Kewei, Lai, Maode, Lan, Ping, Li, Enxiao, Li, Dechuan, Li, Jin, Li, Leping, Li, Ming, Li, Shaolei, Li, Yexiong, Li, Yongheng, Li, Zhongwu, Liang, Xiaobo, Liang, Zhiyong, Lin, Feng, Lin, Guole, Liu, Hongjun, Liu, Jianzhong, Liu, Tianshu, Liu, Yunpeng, Pan, Hongming, Pan, Zhizhong, Pei, Haiping, Qiu, Meng, Qu, Xiujuan, Ren, Li, Shen, Zhanlong, Sheng, Weiqi, Song, Chun, Song, Lijie, Sun, Jianguo, Sun, Lingyu, Sun, Yingshi, Tang, Yuan, Tao, Min, Wang, Chang, Wang, Haijiang, Wang, Jun, Wang, Shubin, Wang, Xicheng, Wang, Xishan, Wang, Ziqiang, Wu, Aiwen, Wu, Nan, Xia, Lijian, Xiao, Yi, Xing, Baocai, Xiong, Bin, Xu, Jianmin, Xu, Jianming, Xu, Nong, Xu, Ruihua, Xu, Zhongfa, Yang, Yue, Yao, Hongwei, Ye, Yingjiang, Yu, Yonghua, Yu, Yueming, Yue, Jinbo, Zhang, Jingdong, Zhang, Jun, Zhang, Suzhan, Zhang, Wei, Zhang, Yanqiao, Zhang, Zhen, Zhang, Zhongtao, Zhao, Lin, Zhao, Ren, Zhou, Fuxiang, Zhou, Jian, Jin, Jing, Gu, Jin, and Shen, Lin

Published
2019
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37. Histone deacetylase-mediated tumor microenvironment characteristics and synergistic immunotherapy in gastric cancer

Author

Lin, Yilin, primary, Jing, Xiangxiang, additional, Chen, Zhihua, additional, Pan, Xiaoxian, additional, Xu, Duo, additional, Yu, Xiang, additional, Zhong, Fengyun, additional, Zhao, Long, additional, Yang, Changjiang, additional, Wang, Bo, additional, Wang, Shan, additional, Ye, Yingjiang, additional, and Shen, Zhanlong, additional

Published
2023
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39. Front Cover

Author

Cui, Yancheng, primary, Zhong, Qinghua, additional, Sun, Dawei, additional, Chen, Yan, additional, Jiang, Zhe, additional, Yang, Xiaodong, additional, Shen, Zhanlong, additional, Sun, Yunhua, additional, Yin, Mujun, additional, Liang, Bin, additional, Zhu, Xin, additional, Guo, Xuefeng, additional, and Ye, Yingjiang, additional

Published
2022
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42. Young adults with colon cancer: clinical features and surgical outcomes.

Author

Wang, Chao, Gan, Lin, Gao, Zhidong, Shen, Zhanlong, Jiang, Kewei, and Ye, Yingjiang

Subjects
COLON cancer, YOUNG adults, CANCER patients, OVERALL survival, PROGRESSION-free survival, COLECTOMY, ONCOLOGIC surgery
Abstract

Background: The clinicopathological features, surgical outcomes, and long-term survival of patients with young-onset colon cancer (≤ 40 years old) remain controversial. Methods: The clinicopathologic and follow-up data of patients aged < 40 years with colon cancer between January 2014 and January 2022 were reviewed. The primary objectives were clinical features and surgical outcomes. Long-term survival was investigated as a secondary objective. Results: Seventy patients were included in the study, and no significant rising trend (Z=0, P=1) of these patients was observed over the 8-year study period. Stage IV disease was accompanied by more ulcerative or infiltrating type (84.2% vs. 52.9%, P=0.017) and lymphovascular or perineural invasion (64.7% vs. 25.5%, P=0.003) than stage I–III disease. After a median follow-up time of 41 months (range 8–99 months), the 1-, 3-, and 5-year estimated overall survival (OS) rates were 92.6%, 79.5%, and 76.4%, respectively. The 1-, 3-, and 5-year progression-free survival (PFS) rates were 79.6%, 71.7%, and 71.7%, respectively. Multivariate Cox regression showed that M+ stage (hazard ratio [HR], 3.942; 95% confidence interval [CI], 1.176–13.220, P=0.026) was the only independent risk factor affecting OS. Meanwhile, tumor deposits (HR, 4.807; 95% CI, 1.942–15.488, P=0.009), poor differentiation (HR, 2.925; 95% CI, 1.012–8.454, P=0.047), and M+ stage (HR, 3.540; 95% CI, 1.118–11.202, P=0.032) independently affected PFS. Conclusions: The differences in the clinical features, surgical outcomes, and long-term survival between young adults and elderly colon cancer patients need further investigation. [ABSTRACT FROM AUTHOR]

Published
2023
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43. A widely expressed free immunoglobulin κ chain with a unique Vκ4-1/Jκ3 pattern promotes colon cancer invasion and metastasis by activating the integrin β1/FAK pathway

Author

Wang, Qianqian, primary, Jiang, Dongyang, additional, Ye, Qing, additional, Zhou, Wenjing, additional, Ma, Junfan, additional, Wang, Chong, additional, Geng, Zihan, additional, Chu, Ming, additional, Zheng, Jie, additional, Chen, Hongchengcheng, additional, Huang, Jing, additional, Dai, Hui, additional, Zhang, Youhui, additional, Shen, Zhanlong, additional, Fu, Ning, additional, and Qiu, Xiaoyan, additional

Published
2022
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46. Evaluation of histopathological response to neoadjuvant therapy in rectal cancer using slide‐free, stain‐free multimodal multiphoton microscopy

Author

Cui, Yancheng, primary, Zhong, Qinghua, additional, Sun, Dawei, additional, Chen, Yan, additional, Jiang, Zhe, additional, Yang, Xiaodong, additional, Shen, Zhanlong, additional, Sun, Yunhua, additional, Yin, Mujun, additional, Liang, Bin, additional, Zhu, Xin, additional, Guo, Xuefeng, additional, and Ye, Yingjiang, additional

Published
2022
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48. Abstract 5873: Distinct prevalence and spectrum of germline cancer susceptibility gene mutations between early-onset and late-onset colorectal caner

Author

Gao, Zhidong, primary, Zhou, Jing, additional, Xin, Ying, additional, Liang, Bin, additional, Shen, Kai, additional, Guo, Peng, additional, Jiang, Kewei, additional, Yin, Mujun, additional, Yang, Xiaodong, additional, Shen, Zhanlong, additional, Zhang, Hui, additional, Huang, Depei, additional, and Ye, Yingjiang, additional

Published
2022
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