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8 results on '"Shen, Yujiang"'

4. Porcine epidemic diarrhea virus E protein suppresses RIG-I signaling-mediated interferon-β production

Author

Zheng, Liang, primary, Wang, Xianhe, additional, Guo, Dexuan, additional, Cao, Jinglong, additional, Cheng, Lixin, additional, Li, Xingzhi, additional, Zou, Dehua, additional, Zhang, Yating, additional, Xu, Jiaxin, additional, Wu, Xuening, additional, Shen, Yujiang, additional, Wang, Hongyu, additional, Yu, Wen, additional, Li, Liyang, additional, Xiao, Lijie, additional, Song, Baifen, additional, Ma, Jinzhu, additional, Liu, Xinyang, additional, Li, Pengfei, additional, Xu, Shuyan, additional, Xu, Xin, additional, Zhang, Hua, additional, Wu, Zhijun, additional, and Cao, Hongwei, additional

Published
2021
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6. The accessory protein ORF3 of porcine epidemic diarrhea virus inhibits cellular interleukin-6 and interleukin-8 productions by blocking the nuclear factor-κB p65 activation

Author

Wu, Zhijun, primary, Cheng, Lixin, additional, Xu, Jiaxin, additional, Li, Pengfei, additional, Li, Xingzhi, additional, Zou, Dehua, additional, Zhang, Yating, additional, Wang, Xianhe, additional, Wu, Xuening, additional, Shen, Yujiang, additional, Li, Yuchang, additional, Yao, Lili, additional, Guo, Dexuan, additional, Li, Liyang, additional, Xiao, Lijie, additional, Song, Baifen, additional, Ma, Jinzhu, additional, Liu, Xinyang, additional, Xu, Shuyan, additional, Xu, Xin, additional, Zhang, Hua, additional, Zheng, Liang, additional, and Cao, Hongwei, additional

Published
2020
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7. Porcine epidemic diarrhea virus ORF3 protein causes endoplasmic reticulum stress to facilitate autophagy

Author

Zou, Dehua, primary, Xu, Jiaxin, additional, Duan, Xulai, additional, Xu, Xin, additional, Li, Pengfei, additional, Cheng, Lixin, additional, Zheng, Liang, additional, Li, Xingzhi, additional, Zhang, Yating, additional, Wang, Xianhe, additional, Wu, Xuening, additional, Shen, Yujiang, additional, Yao, Xiangyu, additional, Wei, Jiaqi, additional, Yao, Lili, additional, Li, Liyang, additional, Song, Baifen, additional, Ma, Jinzhu, additional, Liu, Xinyang, additional, Wu, Zhijun, additional, Zhang, Hua, additional, and Cao, Hongwei, additional

Published
2019
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8. Lipid raft-associated PI3K/Akt/SREBP1 signaling regulates coxsackievirus A16 (CA16) replication.

Author

Wu, Zhijun, Li, Xingzhi, Guo, Dexuan, Li, Pengfei, Zhang, Yating, Zou, Dehua, Wang, Xianhe, Xu, Jiaxin, Wu, Xuening, Shen, Yujiang, Li, Yuchang, Yao, Lili, Li, Liyang, Xiao, Lijie, Song, Baifen, Ma, Jinzhu, Liu, Xinyang, Xu, Shuyan, Xu, Xin, and Zhang, Hua

Subjects
*STEROL regulatory element-binding proteins, *LIPID rafts, *LIPIDS, *VIRAL replication, *VIRAL proteins
Abstract

• Lipid rafts are required for activation of PI3K/Akt signaling both at early and late stages of CA16 infection. • Lipid raft-associated PI3K/Akt plays critical roles in mediating SREBP1 maturation during late stage of CA16 infection. • This finding of lipid raft-associated PI3K/Akt/SREBP1 will deepen our understanding mechanism of CA16 infection. Coxsackievirus A16 (CA16) is one of predominant Enterovirus that possesses high pathogenicity. Lipid rafts, as cholesterol - and sphingolipid - enriched membrane nanodomains, are involved into many aspects of the virus life cycle. Our previous study found that lipid rafts integrity was essential for CA16 replication, but how lipid rafts regulate CA16 replication through activating downstream signaling remains largely unknown. Thus, in this study, we revealed that lipid rafts were required for activation of PI3K/Akt signaling at early stage of CA16 infection. Treatment with wortmannin significantly reduced the expression of virus protein, indicating PI3K/Akt signaling was beneficial for early stage of virus infection. In addition, lipid rafts integrity was also indispensable for PI3K/Akt activation during the late stage of CA16 infection, which played critical functions in mediating sterol regulatory element-binding proteins 1 (SREBP1) maturation. Whereas, over-expression of SREBP1 exhibited inhibition on virus replication, suggesting that PI3K/Akt signaling and SREBP1 might positively and negatively influence virus replication in two different stages of infection, respectively. Taken together, our study demonstrates an important role of the lipid raft-associated PI3K/Akt/SREBP1 signaling in modulating CA16 replication, which will deepen our understanding mechanism of CA16 infection. [ABSTRACT FROM AUTHOR]

Published
2021
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