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171 results on '"Shen, Yongmei"'

7. Current status of cell damage repair and related drug research and development

Author

Ge Yan, Shen Yongmei, Liu Shu, Zeng Chenjuan, Liu Bin, Jiang Shunri, and Geng Funeng

Subjects
tissue injury, cell death, repair, medicine, Medicine, Biotechnology, TP248.13-248.65
Abstract

The fundamental aspect of tissue injury was the structural changes and functional disorders caused by a great deal of cell death, it might further develop into organ damage in severe cases. At present, the treatment of tissue injury was more focused on improving the micro-environment and promoting cell renewing. Insufficient attention was paid to the repair of cell damage, this oversight could exacerbate disease conditions and create difficulties in achieving healing. Thus, treating tissue injury should be based on repairing cell damage. In order to systematically grasp the research status and drug development of cell damage and repair, this article provided a systematic review of the damaging causes, repair mechanisms, and drug development from the perspectives of DNA damage, RNA damage, protein damage, mitochondrial damage, membrane damage and cell death. It was expected to contribute to promoting the research and development of repair medicines.

Published
2023
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21. Prenatal Genetic Analysis of Kidney Abnormalities

Author

Shen, Yongmei, primary, Li, Yaqi, additional, Zhao, Xiaomin, additional, Li, Wen, additional, Zhang, Lei, additional, Yao, Liying, additional, Cao, Jiasong, additional, Li, Shanshan, additional, Wei, Zhuo, additional, and Chang, Ying, additional

Published
2023
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22. Unraveling the causal genes and transcriptomic determinants of human telomere length

Author

Cao, Jiasong, primary, Shen, Yongmei, additional, Fan, Xutong, additional, Yang, Hongxi, additional, Dong, Xiaobao, additional, Zhang, Shijie, additional, Yi, Xianfu, additional, Shuai, Ling, additional, Shi, Lei, additional, Liu, Zhe, additional, Yang, Jie, additional, Hao, Jihui, additional, Chen, Kexin, additional, Huang, Dandan, additional, Wang, Feng, additional, and Li, Mulin Jun, additional

Published
2023
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28. Supplemental Material - Novel deoxyribonucleic acid methylation perturbations in workers exposed to vinyl chloride novel deoxyribonucleic acid methylation changes exposed to vinyl chloridein workers

Author

Zhao, Xiaotian, Hao, Yan, Wang, Qian, Shen, Yongmei, Cheng, Ying, Li, Ben, Gao, Yi, Wang, Tong, and Qiu, Yulan

Subjects
animal structures, FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental Material for Novel deoxyribonucleic acid methylation perturbations in workers exposed to vinyl chloride novel deoxyribonucleic acid methylation changes exposed to vinyl chloridein workers by Xiaotian Zhao, Yan Hao, Qian Wang, Yongmei Shen, Ying Cheng, Ben Li, Yi Gao, Tong Wang, Yulan Qiu in Toxicology and Industrial Health

Published
2022
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30. Expression of Key Steroidogenic Enzymes in Human Placenta and Associated Adverse Pregnancy Outcomes

Author

Cao, Jiasong, Wang, Yixin, Wang, Shuqi, Shen, Yongmei, Li, Wen, Wei, Zhuo, Li, Shanshan, Lin, Qimei, and Chang, Ying

Abstract

Steroid hormones, including progestagens, estrogens, androgens, corticosteroids, and their precursor cholesterol, perform essential functions in the successful establishment and maintenance of pregnancy and normal fetal development. As the core endocrine organ at the prenatal stage, the human placenta is involved in the biosynthesis, metabolism, and delivery of steroid hormones. Steroidogenic pathways are tightly regulated by placenta-intrinsic cytochrome P450 and hydroxysteroid dehydrogenase. However, the relationship between placental steroidogenic enzyme expression and adverse pregnancy outcomes is controversial. In this review, we summarize the possible upstream regulatory mechanisms of placental steroidogenic enzymes in physiologic and pathophysiologic states. We also describe the human placental barrier model and examine the potential of single-cell sequencing for evaluating the primary functions and cellular origin of steroidogenic enzymes. Finally, we examine the existing evidence for the association between placental steroidogenic enzyme dysregulation and adverse pregnancy outcomes.

Published
2023
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31. Serum estradiol to testosterone ratio as a novel predictor of severe preeclampsia in the first trimester.

Author

Shen, Yongmei, Cao, Jiasong, Yao, Liying, Li, Shanshan, Zhao, Xiaomin, Li, Wen, Wei, Zhuo, Zhang, Lei, Wang, Jianxi, and Chang, Ying

Abstract

Preeclampsia (PE) is the most common medical complication during pregnancy and the second leading cause of maternal death worldwide. However, a better predictive model of PE remains to be explored. A total of 15 severe preeclampsia (sPE) and 75 healthy control patients were included in this study. Patient data was obtained from September 2019 to September 2021. Nuchal translucency (NT) and crown‐rump length (CRL) of the fetus were acquired by ultrasound. Maternal blood samples were collected at 11+0 to 13+6 weeks of gestation. Chemiluminescent immunoassays were used to detect serum testosterone (T) and estradiol (E2) levels. Time‐resolved fluorescence analysis was used to examine the levels of serum pregnancy‐associated plasma protein A (PAPPA) and β‐human chorionic gonadotrophin (β‐HCG) protein. The sPE group exhibited increased T levels, and decreased E2 levels and E2/T ratios from 11 to 14 weeks of gestation, compared with the control group. E2 and the E2/T ratio showed positive linear correlation with CRL in pregnant women. Body‐mass‐index (BMI), T, and E2 were determined to be the main factors that affected the occurrence of sPE at the 12‐week gestation period time point. The receiver operating characteristic (ROC) curve revealed that the AUC of the E2/T ratio was.717. The imbalanced T and E2 levels in the patients had a specific intrinsic relevance with sPE, which suggests them as novel predictors of the sPE. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Gastroprotective effects of Kangfuxin against water-immersion and restraint stress-induced gastric ulcer in rats: roles of antioxidation, anti-inflammation, and pro-survival

Author

Guibo Sun, Xiaobo Sun, Shan Lu, Yun Luo, Jin Tan, Shen Yongmei, Daoshun Wu, and Geng Funeng

Subjects
Male, Restraint, Physical, medicine.medical_specialty, IGF-1/PTEN/Akt signalling, Anti-Inflammatory Agents, Pharmaceutical Science, Context (language use), RM1-950, 030226 pharmacology & pharmacy, 01 natural sciences, Gastroenterology, Antioxidants, Rats, Sprague-Dawley, KFX, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Drug Discovery, medicine, Periplaneta americana L, Animals, Stomach Ulcer, Pharmacology, Inflammation, Dose-Response Relationship, Drug, business.industry, digestive, oral, and skin physiology, Anti inflammation, gastric diseases, General Medicine, Anti-Ulcer Agents, Gastric Diseases, digestive system diseases, 0104 chemical sciences, Rats, Duodenal ulcer, 010404 medicinal & biomolecular chemistry, Disease Models, Animal, Oxidative Stress, Complementary and alternative medicine, Water immersion, Materia Medica, Molecular Medicine, Therapeutics. Pharmacology, Restraint stress, business, Omeprazole, Stress, Psychological, Research Article
Abstract

Context: Kangfuxin (KFX) is widely used for the treatment of gastric and duodenal ulcer; however, more research is needed to determine the protective mechanisms of KFX in ameliorating gastric ulcer. Objective: To investigate the efficacy and potential mechanism of Kangfuxin liquid (KFX) in water-immersion and restraint stress (WIRS)-induced gastric ulcer. Materials and methods: Seventy rats were randomly divided into seven groups (n = 10) as follows: the control group (normal saline, i.g.), the model group (normal saline, i.g.), the KFX groups (2.5, 5 and 10 mL/kg, i.g.), the omeprazole group (20 mg/kg, i.p.) and Sanjiuweitai Granules group (1850 mg/kg, i.g.). The WIRS model was applied to induce stress ulcers after 7 days of drug administration. Afterwards, rats were sacrificed at 10 h induced by WIRS. Results: Pre-treatment with KFX (5,10 mL/kg) could effectively reduce the area of gastric ulcers and improve the pathological changes of ulcerated tissue. Moreover, KFX (5,10 mL/kg) increased the prostaglandin E2 (52%) and cyclooxygenase-1 (30%) levels, and improved malondialdehyde (54%), superoxide dismutase (58%), catalase (39%), and nitric oxide (11%) and TNF-α (9%), IL-6 (11%), MMP-9 (54%) and MMP-2 (53%) of ulcer tissue. Furthermore, pre-treatment with KFX dramatically increased IGF-1, PTEN, and Akt protein expression. Conclusions: Our results suggest that KFX has protective effects on WIRS-induced gastric ulcer via inflammatory reactions, oxidative stress inhibition, and pro-survival action, which were the results of activating the IGF-1/PTEN/Akt signalling pathway. Our results provide evidence of KFX for treating gastric ulcer.

Published
2019

39. Comparative Transcriptomics Reveals the Expression Differences Between Four Developmental Stages of American Cockroach (Periplaneta americana)

Author

Zeng, Chenjuan, primary, Li, Wujiao, additional, Liao, Qi, additional, Yan, Tingting, additional, Wang, Kaisun, additional, Hu, Ye, additional, Shen, Yongmei, additional, Price, Megan, additional, Fan, Zhenxin, additional, Zhang, Xiuyue, additional, Yue, Bisong, additional, Geng, Funeng, additional, and Chen, Lijuan, additional

Published
2019
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41. Comparative Genomics Reveals the Genetic Mechanisms of Musk Secretion and Adaptive Immunity in Chinese Forest Musk Deer

Author

Zhou, Chuang, primary, Zhang, Wenbo, additional, Wen, Qinchao, additional, Bu, Ping, additional, Gao, Jie, additional, Wang, Guannan, additional, Jin, Jiazheng, additional, Song, Yinjie, additional, Sun, Xiaohong, additional, Zhang, Yifan, additional, Jiang, Xue, additional, Yu, Haoran, additional, Peng, Changjun, additional, Shen, Yongmei, additional, Price, Megan, additional, Li, Jing, additional, Zhang, Xiuyue, additional, Fan, Zhenxin, additional, and Yue, Bisong, additional

Published
2019
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46. The draft genome sequence of forest musk deer (Moschus berezovskii)

Author

Fan, Zhenxin, primary, Li, Wujiao, additional, Jin, Jiazheng, additional, Cui, Kai, additional, Yan, Chaochao, additional, Peng, Changjun, additional, Jian, Zuoyi, additional, Bu, Ping, additional, Price, Megan, additional, Zhang, Xiuyue, additional, Shen, Yongmei, additional, Li, Jing, additional, Qi, Wenhua, additional, and Yue, Bisong, additional

Published
2018
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48. Gastroprotective effects of Kangfuxin-against ethanol-induced gastric ulcer via attenuating oxidative stress and ER stress in mice

Author

Hongyu Zhang, Hongxue Shi, Fenzan Wu, Xiaokun Li, Geng Funeng, Jingjing Zhu, Zhengmao Li, Ma Xiuying, Tong Xiao, Bei-Bei Lin, Pian-Pian Chen, Shen Yongmei, and Jian Xiao

Subjects
0301 basic medicine, Pathology, medicine.medical_specialty, biology, business.industry, Caspase 3, General Medicine, Pharmacology, CHOP, Toxicology, medicine.disease_cause, digestive system diseases, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Apoptosis, medicine, Unfolded protein response, biology.protein, Gastric mucosa, Cimetidine, business, Oxidative stress, Caspase 12, medicine.drug
Abstract

Oxidative stress and ER stress play a role in the pathogenesis of gastric ulcer. Kangfuxin (KFX) has been used to treat gastric ulcer in patients. However, the underlying mechanisms of KFX action remain unclear. The current study was undertaken to evaluate the gastroprotective effects of KFX and to determine its potential mechanisms. Ethanol-induced gastric ulcer mouse model was employed. Ethanol pretreated mice were treated with low (0.02 g/kg) and high (0.05 g/kg) dose of KFX for 14 days. Cimetidine (0.8 g/kg) was used as positive control. Histological evaluation of the gastric mucosa revealed that mice treated with ethanol exhibited severe gastric mucosal damage. Ethanol treatment increased plasma and gastric MDA level, decreased plasma and gastric SOD activity, and reduced gastric HO-1 and GCL-c mRNA levels. ER stress markers (CHOP, GRP78, and caspase 12) were up-regulated upon ethanol administration. Moreover, increased cell apoptosis and pro-apoptotic protein Bax and caspase 3 were observed in ethanol treated mice, while the anti-apoptotic protein Bcl 2 was inhibited. Finally, KFX treatment reversed ethanol-induced phenotypes and ameliorated gastric ulcer. Our results demonstrated that the gastroprotective effects of KFX against ethanol-induced gastric ulcer could be attributed to its anti-oxidative stress, anti-ER stress and anti-apoptotic effects.

Published
2016

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