Search

Your search keyword '"Shen, Xiuli"' showing total 253 results
Start Over Author "Shen, Xiuli"
253 results on '"Shen, Xiuli"'

24. Proteomic analysis of plasma in healthy adults receiving recombinant vaccinia virus provides novel insights into HIV‐1 neutralizing antibodies.

Author

Chen, Ran, Fu, Yuyu, Li, Dan, Wang, Shuhui, Ruan, Yuhua, Ren, Li, Wang, Shuo, Shen, Xiuli, Shi, Yutao, Shao, Yiming, and Liu, Ying

Subjects
VACCINIA, RECOMBINANT viruses, PROTEOMICS, IMMUNOGLOBULINS, BLOOD proteins
Abstract

Human immunodeficiency virus (HIV) infection is still a global public health issue, and the development of an effective prophylactic vaccine inducing potent neutralizing antibodies remains a significant challenge. This study aims to explore the inflammation‐related proteins associated with the neutralizing antibodies induced by the DNA/rTV vaccine. In this study, we employed the Olink chip to analyze the inflammation‐related proteins in plasma in healthy individuals receiving HIV candidate vaccine (DNA priming and recombinant vaccinia virus rTV boosting) and compared the differences between neutralizing antibody‐positive (nab +) and –negative(nab‐) groups. We identified 25 differentially expressed factors and conducted enrichment and correlation analysis on them. Our results revealed that significant expression differences in artemin (ARTN) and C‐C motif chemokine ligand 23 (CCL23) between nab+ and –nab‐ groups. Notably, the expression of CCL23 was negatively corelated to the ID50 of neutralizing antibodies and the intensity of the CD4+ T cell responses. This study enriches our understanding of the immune picture induced by the DNA/rTV vaccine, and provides insights for future HIV vaccine development. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

45. Retroviruses: Reversing the dogma of life - A review

Author

Potlakayala Shobha, Miles Andrew, Patel Shrina, Patel Aayushi, Wolbrette Gregory, Kane Shriya, Lookfong Nicole, Noble Abigayle, Shen Xiuli, and Rudrabhatla Sairam

Subjects
General Medicine
Abstract

Retroviruses replicate by means of reverse transcription, utilizing an enzyme, reverse transcriptase, in conjunction with integrase. Their elements have been found in humans, animals, fungi, plants, and bacteria alike. For millions of years, these elements are continuing to integrate into the eukaryotic genomes and affecting these organisms to date. Specifically, endogenous retroviruses have been shown to comprise a large portion of vertebrate genomes. Studies have shown that these microscopic viral elements within the genome are influencing gene expression and in turn evolution, by affecting adjacent gene expression patterns. In the medical field, these retroviruses can present illnesses for many, such as those living with Human Immunodeficiency Virus or Human T Cell Lymphotropic Viruses. With modern advances in bioinformatics, genomics, and drug design, retroviruses are being understood much better. A multitude of new discoveries is advancing the scientific communities to mitigate, prevent, and hopefully cure serious medical ailments caused by retroviruses.

Published
2022

Catalog

Books, media, physical & digital resources
See catalog results