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137 results on '"Shen, Mingzhi"'

14. Efficacy and safety of Oral LL‐37 against the Omicron BA.5.1.3 variant of SARS‐COV‐2: A randomized trial

Author

Zhao, Yiming, primary, Zhang, Hanlin, additional, Zhao, Zhizhuang, additional, Liu, Fangfang, additional, Dong, Meng, additional, Chen, Li, additional, Shen, Mingzhi, additional, Luan, Zhe, additional, Zhang, Hanwen, additional, Wu, Junling, additional, Li, Congyong, additional, Chen, Jun, additional, Li, Chao, additional, Liu, Zhiwei, additional, Chen, Yi, additional, Zheng, Aihua, additional, Li, Huiling, additional, Wang, Shufang, additional, Jin, Wanzhu, additional, and Sun, Gang, additional

Published
2023
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15. The role of epicardial fat radiomic profiles for atrial fibrillation identification and recurrence risk with coronary CT angiography.

Author

Wu, Jingping, Li, Yuwei, Wu, Dan, Schoepf, Uwe-Joseph, Zhao, Pengfei, Goller, Markus, Li, Junhuan, Tian, Jinwen, Shen, Mingzhi, Cao, Kunlin, Yang, Li, and Zhang, Fan

Subjects
PULMONARY veins, EPICARDIAL adipose tissue, ATRIAL fibrillation, CORONARY angiography, RECEIVER operating characteristic curves, FAT, LEFT heart atrium
Abstract

Objectives Fat radiomic profile (FRP) was a promising imaging biomarker for identifying increased cardiac risk. We hypothesize FRP can be extended to fat regions around pulmonary veins (PV), left atrium (LA), and left atrial appendage (LAA) to investigate their usefulness in identifying atrial fibrillation (AF) and the risk of AF recurrence. Methods We analysed 300 individuals and grouped patients according to the occurrence and types of AF. We used receiver operating characteristic and survival curves analyses to evaluate the value of imaging biomarkers, including fat attenuation index (FAI) and FRP, in distinguishing AF from sinus rhythm and predicting post-ablation recurrence. Results FRPs from AF-relevant fat regions showed significant performance in distinguishing AF and non-AF with higher AUC values than FAI (peri-PV: FRP = 0.961 vs FAI = 0.579, peri-LA: FRP = 0.923 vs FAI = 0.575, peri-LAA: FRP = 0.900 vs FAI = 0.665). FRPs from peri-PV, peri-LA, and peri-LAA were able to differentiate persistent and paroxysmal AF with AUC values of 0.804, 0.819, and 0.694. FRP from these regions improved AF recurrence prediction with an AUC of 0.929, 0.732, and 0.794. Patients with FRP cut-off values of ≥0.16, 0.38, and 0.26 had a 7.22-, 5.15-, and 4.25-fold higher risk of post-procedure recurrence, respectively. Conclusions FRP demonstrated potential in identifying AF, distinguishing AF types, and predicting AF recurrence risk after ablation. FRP from peri-PV fat depot exhibited a strong correlation with AF. Therefore, evaluating epicardial fat using FRP was a promising approach to enhance AF clinical management. Advances in knowledge The role of epicardial adipose tissue (EAT) in AF had been confirmed, we focussed on the relationship between EAT around pulmonary arteries and LAA in AF which was still unknown. Meanwhile, we used the FRP to excavate more information of EAT in AF. [ABSTRACT FROM AUTHOR]

Published
2024
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17. (Nano)platforms in breast cancer therapy: Drug/gene delivery, advanced nanocarriers and immunotherapy

Author

Ashrafizadeh, Milad, primary, Zarrabi, Ali, additional, Bigham, Ashkan, additional, Taheriazam, Afshin, additional, Saghari, Yalda, additional, Mirzaei, Sepideh, additional, Hashemi, Mehrdad, additional, Hushmandi, Kiavash, additional, Karimi‐Maleh, Hassan, additional, Nazarzadeh Zare, Ehsan, additional, Sharifi, Esmaeel, additional, Ertas, Yavuz Nuri, additional, Rabiee, Navid, additional, Sethi, Gautam, additional, and Shen, Mingzhi, additional

Published
2023
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18. IntraCoronary Artery Retrograde Thrombolysis vs. Thrombus Aspiration in ST-Segment Elevation Myocardial Infarction: Study Protocol for a Randomized Controlled Trial

Author

Shen, Mingzhi, primary, Wang, Jihang, additional, Li, Dongyun, additional, Zhou, Xinger, additional, Guo, Yuting, additional, Zhang, Wei, additional, Guo, Yi, additional, Wang, Jian, additional, Liu, Jie, additional, Zhao, Guang, additional, Zhao, Shihao, additional, and Tian, Jinwen, additional

Published
2022
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20. Intracoronary artery retrograde thrombolysis for ST-segment elevation myocardial infarction with a tortuous coronary artery: A case report and review of the literature

Author

Shen, Mingzhi, primary, Lu, Haihui, additional, Liao, Yichao, additional, Wang, Jian, additional, Guo, Yi, additional, Zhou, Xinger, additional, Nong, Yingqiao, additional, Fu, Zhenhong, additional, Wang, Jihang, additional, Guo, Yuting, additional, Zhao, Shihao, additional, Fan, Li, additional, and Tian, Jinwen, additional

Published
2022
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21. Intracoronary artery retrograde thrombolysis combined with percutaneous coronary interventions for ST-segment elevation myocardial infarction complicated with diabetes mellitus: A case report and literature review

Author

Shen, Mingzhi, primary, Liao, Yichao, additional, Wang, Jian, additional, Zhou, Xinger, additional, Guo, Yuting, additional, Nong, Yingqiao, additional, Guo, Yi, additional, Lu, Haihui, additional, Jin, Rongjie, additional, Wang, Jihang, additional, Fu, Zhenhong, additional, Li, Dongyun, additional, Zhao, Shihao, additional, and Tian, Jinwen, additional

Published
2022
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22. Roles of Ferroptosis in Cardiovascular Diseases

Author

Guo, Yuting, primary, Zhang, Wei, additional, Zhou, Xinger, additional, Zhao, Shihao, additional, Wang, Jian, additional, Guo, Yi, additional, Liao, Yichao, additional, Lu, Haihui, additional, Liu, Jie, additional, Cai, Yanbin, additional, Wu, Jiao, additional, and Shen, Mingzhi, additional

Published
2022
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25. Targeting STAT3: A crucial modulator of sepsis

Author

Lei, Wangrui, primary, Liu, Dianxiao, additional, Sun, Meng, additional, Lu, Chenxi, additional, Yang, Wenwen, additional, Wang, Changyu, additional, Cheng, Ye, additional, Zhang, Meng, additional, Shen, Mingzhi, additional, Yang, Zhi, additional, Chen, Yin, additional, Deng, Chao, additional, and Yang, Yang, additional

Published
2021
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31. The roles of liver X receptor α in inflammation and inflammation‐associated diseases.

Author

Zhao, Lin, Lei, Wangrui, Deng, Chao, Wu, Zhen, Sun, Meng, Jin, Zhenxiao, Song, Yanbin, Yang, Zhi, Jiang, Shuai, Shen, Mingzhi, and Yang, Yang

Subjects
NUCLEAR receptors (Biochemistry), INFLAMMATION, NUCLEAR families, ALZHEIMER'S disease, TRANSCRIPTION factors, ATHEROSCLEROSIS, LIVER
Abstract

Liver X receptor α (LXRα; also known as NR1H3), an isoform of LXRs, is a member of the nuclear receptor family of transcription factors and plays essential roles in the transcriptional control of cholesterol homeostasis. Previous in‐depth phenotypic analyses of mouse models with deficient LXRα have also demonstrated various physiological functions of this receptor within inflammatory responses. LXRα activation exerts a combination of metabolic and anti‐inflammatory actions resulting in the modulation and the amelioration of inflammatory disorders. The tight "repercussions" between LXRα and inflammation, as well as cholesterol homeostasis, have suggested that LXRα could be pharmacologically targeted in pathologies such as atherosclerosis, acute lung injury, and Alzheimer's disease. This review gives an overview of the recent advances in understanding the roles of LXRα in inflammation and inflammation‐associated diseases, which will help in the design of future experimental researches on the potential of LXRα and advance the investigation of LXRα as pharmacological inflammatory targets. [ABSTRACT FROM AUTHOR]

Published
2021
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33. Prognostic ability of cystatin C and homocysteine plasma levels for long-term outcomes in very old acute myocardial infarction patients

Author

Fu,Zhenhong, Yang,Xia, Shen,Mingzhi, Xue,Hao, Qian,Geng, Cao,Feng, Guo,Jun, Dong,Wei, Chen,Yundai, Fu,Zhenhong, Yang,Xia, Shen,Mingzhi, Xue,Hao, Qian,Geng, Cao,Feng, Guo,Jun, Dong,Wei, and Chen,Yundai

Abstract

Zhenhong Fu,1,* Xia Yang,1,* Mingzhi Shen,2,* Hao Xue,1,* Geng Qian,1 Feng Cao,1 Jun Guo,1 Wei Dong,1 Yundai Chen1 1Department of Cardiology, Chinese People’s Liberation Army General Hospital, Beijing, China; 2Department of Cardiology, Hainan Branch of Chinese People’s Liberation Army General Hospital, Sanya, Hainan, China *These authors contributed equally to this work Background and aims: This study sought to evaluate the prognostic powers of combined use of cystatin C (Cys C) and homocysteine (Hcy) at predicting adverse events of patients >80 years old with acute myocardial infarction (AMI).Patients and methods: The analysis involved 753 patients >80 years old undergoing coronary angiography for chest pain in China from January 2006 to December 2012. Kaplan–Meier method was used for survival and major adverse cardiac events (MACE) rates. Multivariate Cox regression was performed to identify mortality predictors. Receiver operating characteristic curve analysis was performed to predict the cutoff values of Cys C and Hcy for all-cause mortality.Results: The duration of follow-up was 40–116 months (median, 63 months; interquartile range, 51–74 months). The long-term survival and event-free survival rates of AMI patients were significantly lower than those of unstable angina pectoris patients (P<0.05), and were significantly different according to the tertile concentration of Cys C of AMI patients (P<0.01). Cys C and Hcy were independent risk factors for long-term all-cause mortality (odds ratio [OR] =3.72 [2.27–6.09]; OR =1.59 [1.04–2.61]) and MACE (OR =2.83 [1.82–4.40]; OR =1.09 [1.04–1.21]) of AMI patients. The predictive cutoff value of Cys C was 1.815 mg/L (82.8%, 86.4%) and that of Hcy was 15.06 µmol/L (84.4%, 83.1%) in AMI patients. Combined use of both biomarker’s cutoff values further increased the sensitivity and specific

Published
2018

38. Hyperhomocysteinemia is an independent predictor of long-term clinical outcomes in Chinese octogenarians with acute coronary syndrome

Author

Fu,Zhenhong, Qian,Geng, Xue,Hao, Guo,Jun, Chen,Lian, Yang,Xia, Shen,Mingzhi, Dong,Wei, Chen,Yundai, Fu,Zhenhong, Qian,Geng, Xue,Hao, Guo,Jun, Chen,Lian, Yang,Xia, Shen,Mingzhi, Dong,Wei, and Chen,Yundai

Abstract

Zhenhong Fu,1,* Geng Qian,1,* Hao Xue,1,* Jun Guo,1 Lian Chen,1 Xia Yang,1 Mingzhi Shen,2 Wei Dong,1 Yundai Chen11Department of Cardiology, Chinese People’s Liberation Army General Hospital, Beijing, People’s Republic of China; 2Department of Cardiology, Hainai Branch of Chinese People’s Liberation Army General Hospital, Sanya, Hainan, People’s Republic of China*These authors contributed equally to this workObjective: To evaluate the prognostic value of homocysteine (Hcy) in Chinese acute coronary syndrome (ACS) octogenarians.Methods: The study cohort comprised 660 consecutive ACS octogenarians who underwent coronary angiography. We classified the patients into three groups according to Hcy tertiles. Kaplan–Meier method was performed for survival and major adverse cardiac events (MACE) rates. Multivariate Cox regression was performed to identify mortality predictors. Receiver operating characteristic curve analysis was performed to predict the cutoff value of Hcy for all-cause mortality.Results: The follow-up period was 28 (inter-quartile range: 16–38) months. Diastolic blood pressure, ratios of male, renal failure and old myocardial infarction in high plasma level Hcy (H-Hcy) group were higher than those in low (L-Hcy) and middle (M-Hcy) plasma level of Hcy groups (P<0.05). The Hcy level was positively correlated with uric acid level (r=0.211, P=0.001) and Cystatin C (Cys C) level (r=0.212, P=0.001) and negatively correlated with estimated glomerular filtration rate (r=−0.148, P=0.018). For the long-term outcomes, the cumulative survival rate of H-Hcy group was significantly lower than that of L-Hcy and M-Hcy groups (P=0.006). All-cause mortality and MACE of H-Hcy group were higher than those of L-Hcy and M-Hcy group (P=0.0001, P=0.0008). Hcy is an independent predictor for long-term all-cause mortality (odds ratio =2.26, 95% CI=1.23–4.16, P=0.023) and MACE (odds ratio =

Published
2015

43. A novel protective mechanism for mitochondrial aldehyde dehydrogenase (ALDH2) in type i diabetes-induced cardiac dysfunction: Role of AMPK-regulated autophagy

Author

Guo, Yuli, primary, Yu, Wenjun, additional, Sun, Dongdong, additional, Wang, Jiaxing, additional, Li, Congye, additional, Zhang, Rongqing, additional, Babcock, Sara A., additional, Li, Yan, additional, Liu, Min, additional, Ma, Meijuan, additional, Shen, Mingzhi, additional, Zeng, Chao, additional, Li, Na, additional, He, Wei, additional, Zou, Qian, additional, Zhang, Yingmei, additional, and Wang, Haichang, additional

Published
2015
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47. Baicalin Protects the Cardiomyocytes from ER Stress-Induced Apoptosis: Inhibition of CHOP through Induction of Endothelial Nitric Oxide Synthase

Author

Shen, Mingzhi, primary, Wang, Lin, additional, Yang, Guodong, additional, Gao, Lei, additional, Wang, Bo, additional, Guo, Xiaowang, additional, Zeng, Chao, additional, Xu, Yong, additional, Shen, Liangliang, additional, Cheng, Ke, additional, Xia, Yuesheng, additional, Li, Xiumin, additional, Wang, Haichang, additional, Fan, Li, additional, and Wang, Xiaoming, additional

Published
2014
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50. GW24-e3729 ERK5 Mediates advanced glycation end products-induced impairment of angiogenic capacity in cardiac endothelial cells under hypoxia condition through regulation of VEGF expression

Author

Yu Qiujun, Li Yan, Wang Hai-chang, Shen Mingzhi, Cheng Jin, and Yin Tao

Subjects
Matrigel, business.industry, Angiogenesis, Stimulation, Hypoxia (medical), Pharmacology, Endothelial stem cell, Downregulation and upregulation, Glycation, Immunology, Medicine, Phosphorylation, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract

Objectives Diabetes-induced impairment of collateral formation in ischaemic myocardium has been demonstrated both in experimental and clinical studies, which may contribute to unfavorableprognosis among diabetic individuals. However, the underlying mechanism remains to be defined. Endothelial cell (EC) is thought to be one of the important elements in the development and maturation of coronary collaterals. Since ERK5 is a novel regulator of angiogenesis and closely related with VEGF, in present study we aim to determine whether ERK5 exerts a causative effect on advanced glycation end products (AGEs)-induced impairment of angiogenic capacity in cardiac ECs under hypoxia condition, and to identify the down streamtarget molecule. Methods Cardiac ECs were isolated from left ventricle of Sprague-Dawley rats with a enzyme digestion procedure described in our previous publications. Cells were treated with or without AGEs and then exposed to hypoxia or normoxia. Proliferation, migration and tube-forming of endothelial cells were detected by MTT, Transwell and Matrigel assay respectively. Protein of interest were further validated using ELISA and Western-blot techniques. Results Hypoxia promoted proliferation, migration and tube-forming capacity in cardiac ECs, which was inhibited significantly by combined administration of AGEs. Incubation with AGEs induced decrease of VEGF secretion and increase of ERK5 phosphorylation after hypoxia stimulation. XMD8-92, a inhibitor of ERK5 phosphorylation, treatment caused elevation of VEGF secretion, and counteracted AGEs-induced impairment of angiogenic capacity in cardiac ECs under hypoxia condition, which has a similar effect with supplementation of exogenous VEGF. Conclusions Our study demonstrated for the first time that hypoxia-induced enhancement of angiogenic capacity in cardiac ECs was inhibited in the presence of AGEs, which was related with downregulation of VEGF expression caused by ERK5 phosphorylation. Thus ERK5 may function as an important regulator in diabetes-induced impairment of angiogenesis and thereby exacerbated myocardial ischaemic injury through coordinately targeting VEGF in cardiac ECs. Intervention of ERK5 pathway mayrepresent an avenue for therapeutic exploitation to improve prognosis in diabetic individuals with coronary artery disease.

Published
2013

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