Search

Comprehensive Summary: Herein, we reported a precise de novo synthesis of chiral 3,4‐dihydroquinazoline frameworks via a one‐pot anionic stereogenic‐at‐cobalt(III) complex‐catalyzed enantioselective Ugi‐azide/Pd‐catalyzed cyclization sequence. This powerful protocol involves 5 components and 2 catalytic systems, delivering chiral 3,4‐dihydroquinazolines with excellent enantioselectivities (up to 94% ee). The preliminary antifungal experiments suggest that both Ugi‐adducts and 3,4‐dihydroquinazolines have great potential in inhibiting plant pathogens such as Trichoderma viride and Fusarium graminearum. [ABSTRACT FROM AUTHOR]

Allylamines are important building blocks in the synthesis of bioactive compounds. The direct coupling of allylic C−H bonds and commonly available amines is a major synthetic challenge. An allylic C−H amination of 1,4‐dienes has been accomplished by palladium catalysis. With aromatic amines, branch‐selective allylic aminations are favored to generate thermodynamically unstable Z‐allylamines. In addition, more basic aliphatic cyclic amines can also engage in the reaction, but linear dienyl allylic amines are the major products. [ABSTRACT FROM AUTHOR]

As one of intriguing physical results of electronic reconstruction, the metal–insulator transition plays an important role in exploring new electronic devices. In this study, the density functional theory is employed to investigate the metal–insulator transition in (LaTiO3)m/(CaVO3)n superlattices. Herein, three kinds of physical avenues, i.e., stacking orientation, epitaxial strain, and thickness periods, are used to tune the metal–insulator transition. Our calculations find that the [001]- and [110]-oriented (LaTiO3)1/(CaVO3)1 superlattices on SrTiO3 substrate are insulating, while [111]-oriented case is metallic. Such metallic behavior in [111] orientation can also be modulated by epitaxial strain. Besides the structural orientation and strain effect, the highly probable metal–insulator transition is presented in (LaTiO3)m/(CaVO3)n superlattices with increasing thickness. In addition, several interesting physical phenomena have also been revealed, such as selective charge transfer, charge ordering, and orbital ordering. [ABSTRACT FROM AUTHOR]

Comprehensive Summary: Herein, we reported a precise de novo synthesis of chiral 3,4‐dihydroquinazoline frameworks via a one‐pot anionic stereogenic‐at‐cobalt(III) complex‐catalyzed enantioselective Ugi‐azide/Pd‐catalyzed cyclization sequence. This powerful protocol involves 5 components and 2 catalytic systems, delivering chiral 3,4‐dihydroquinazolines with excellent enantioselectivities (up to 94% ee). The preliminary antifungal experiments suggest that both Ugi‐adducts and 3,4‐dihydroquinazolines have great potential in inhibiting plant pathogens such as Trichoderma viride and Fusarium graminearum. [ABSTRACT FROM AUTHOR]

A palladium-catalyzed asymmetric intramolecular allylic C-H amination controlled by a chiral phosphoramidite ligand was established for the preparation of various substituted chiral hydropyrimidinones, the precursors of hydropyrimidines, in high yields with high enantioselectivities. In particular, dienyl sodium N-sulfonyl amides bearing an arylethene-1-sulfonyl group underwent a sequential allylic C-H amination and intramolecular Diels-Alder (IMDA) reaction to produce chiral fused tricyclic tetrahydropyrimidinone frameworks in high yields and with high levels of stereoselectivity. Significantly, this method was used as the key step in an asymmetric synthesis of letermovir., (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)