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31 results on '"Shen, HongZhang"'

7. LC3-dependent extracellular vesicles (LDEVs) promote M-MDSC accumulation and immunosuppression in colorectal cancer.

Author

Gu, Ye, primary, Liu, Qiang, additional, He, Qiaoxian, additional, Wu, Qiangsheng, additional, Li, Lingyun, additional, Xu, Dongchao, additional, Zheng, Liyun, additional, Xie, Lu, additional, Cheng, Sile, additional, Shen, Hongzhang, additional, Zhou, Yifeng, additional, Yang, Jianfeng, additional, Jin, Hangbin, additional, and Zhang, Xiaofeng, additional

Published
2024
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10. Cuproptosis-related genes establishment score system to assess the prognosis and immune microenvironment in cholangiocarcinoma

Author

Liu, Qiang, primary, Zhu, Jianpeng, additional, Huang, Zhicheng, additional, Bian, Ying, additional, Liu, Xiaodie, additional, Zhang, Jinglei, additional, Zheng, Liyun, additional, Gu, Ye, additional, Chen, Yan, additional, Xu, Dongchao, additional, Zhang, Xiaofeng, additional, Yang, Jianfeng, additional, Shen, Hongzhang, additional, and Jin, Hangbin, additional

Published
2023
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13. Identification of novel immune-related targets mediating disease progression in acute pancreatitis

Author

Liu, Qiang, Li, Lingyun, Xu, Dongchao, Zhu, Jianpeng, Huang, Zhicheng, Yang, Jianfeng, Cheng, Sile, Gu, Ye, Zheng, Liyun, Zhang, Xiaofeng, and Shen, Hongzhang

Subjects
Microbiology (medical), Immunology, Anti-Inflammatory Agents, Lipase, Microbiology, Toll-Like Receptor 2, Systemic Inflammatory Response Syndrome, Mice, Inbred C57BL, Mice, Disease Models, Animal, Infectious Diseases, Pancreatitis, Acute Disease, Amylases, Disease Progression, Animals, Ceruletide
Abstract

IntroductionAcute pancreatitis (AP) is an inflammatory disease with very poor outcomes. However, the order of induction and coordinated interactions of systemic inflammatory response syndrome (SIRS) and compensatory anti-inflammatory response syndrome (CARS) and the potential mechanisms in AP are still unclear.MethodsAn integrative analysis was performed based on transcripts of blood from patients with different severity levels of AP (GSE194331), as well as impaired lung (GSE151572), liver (GSE151927) and pancreas (GSE65146) samples from an AP experimental model to identify inflammatory signals and immune response-associated susceptibility genes. An AP animal model was established in wild-type (WT) mice and Tlr2-deficient mice by repeated intraperitoneal injection of cerulein. Serum lipase and amylase, pancreas impairment and neutrophil infiltration were evaluated to assess the effects of Tlr2 in vivo.ResultsThe numbers of anti-inflammatory response-related cells, such as M2 macrophages (P = 3.2 × 10–3), were increased with worsening AP progression, while the numbers of pro-inflammatory response-related cells, such as neutrophils (P = 3.0 × 10–8), also increased. Then, 10 immune-related AP susceptibility genes (SOSC3, ITGAM, CAMP, FPR1, IL1R1, TLR2, S100A8/9, HK3 and MMP9) were identified. Finally, compared with WT mice, Tlr2-deficient mice exhibited not only significantly reduced serum lipase and amylase levels after cerulein induction but also alleviated pancreatic inflammation and neutrophil accumulation.DiscussionIn summary, we discovered SIRS and CARS were stimulated in parallel, not activated consecutively. In addition, among the novel susceptibility genes, TLR2might be a novel therapeutic target that mediates dysregulation of inflammatory responses during AP progression.

Published
2022
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15. Reduced Adenoma Miss Rate With 9-Minute vs 6-Minute Withdrawal Times for Screening Colonoscopy: A Multicenter Randomized Tandem Trial

Author

Zhao, Shengbing, primary, Song, Yihang, additional, Wang, Shuling, additional, Wang, Rong, additional, Feng, Zhijie, additional, Gong, Aixia, additional, Yang, Xia, additional, Pan, Peng, additional, Yao, Dongmei, additional, Zhang, Jingwen, additional, Zhu, Yaqin, additional, Li, Tao, additional, Bi, Junhua, additional, Ren, Xu, additional, Tang, Xiufen, additional, Li, Qiang, additional, Yu, Dan, additional, Zheng, Jinghua, additional, Song, Bo, additional, Wang, Ping, additional, Chen, Weigang, additional, Shang, Guochen, additional, Xu, Yanqiu, additional, Xu, Ping, additional, Lai, Yuexing, additional, Xu, Huanhai, additional, Yang, Xiaomin, additional, Sheng, Jianqiu, additional, Tao, Yurong, additional, Li, Xinghua, additional, Zhu, Yangbei, additional, Zhang, Xiaofeng, additional, Shen, Hongzhang, additional, Ma, Yingcai, additional, Wang, Fangyu, additional, Wu, Lin, additional, Wang, Xianfei, additional, Li, Zhaoshen, additional, and Bai, Yu, additional

Published
2022
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18. Risk Factors for Carbapenem Resistant Gram Negative Bacteria (CR-GNB) Carriage Upon Admission to the Gastroenterology Department in a Tertiary First Class Hospital of China: Development and Assessment of a New Predictive Nomogram

Author

Zhang,Hongchen, Hu,Shanshan, Xu,Dongchao, Shen,Hongzhang, Jin,Hangbin, Yang,Jianfeng, Zhang,Xiaofeng, Zhang,Hongchen, Hu,Shanshan, Xu,Dongchao, Shen,Hongzhang, Jin,Hangbin, Yang,Jianfeng, and Zhang,Xiaofeng

Abstract

Hongchen Zhang,1– 3,* Shanshan Hu,1– 3,* Dongchao Xu,1– 3 Hongzhang Shen,1– 3 Hangbin Jin,1– 3 Jianfeng Yang,1– 3 Xiaofeng Zhang1– 3 1The Department of Gastroenterology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Zhejiang, People’s Republic of China; 2Key Laboratory of Integrated Traditional Chinese and Western Medicine for Biliary and Pancreatic Diseases of Zhejiang Province, Zhejiang, People’s Republic of China; 3Hangzhou Institute of Digestive Disease, Zhejiang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiaofeng Zhang, Department of Gastroenterology, Hangzhou First People’s Hospital, NO. 261 HuanSha Road, Hangzhou, 310006, People’s Republic of China, Tel +86-13588296257, Fax +86-571-56005600, Email moonshadowing@126.comBackground: With the increasing number of critically ill patients in the gastroenterology department (GED), infections associated with Carbapenem resistant gram-negative bacteria (CR-GNB) are of great concern in GED. As the turn-around time (TAT) for a positive screening culture result is slow, contact precaution and pre-emptive isolation, cohorting methods should be undertaken immediately on admission for high-risk patients. Accurate prediction tools for CR-GNB colonization in GED can help determine target populations upon admission. And thus, clinicians and nurses can implement preventive measures more timely and effectively.Objective: The purpose of the current study was to develop and internally validate a CR-GNB carrier risk predictive nomogram for a Chinese population in GED.Methods: Based on a training dataset of 400 GED patients collected between January 2020 and December 2021, we developed a model to predict CR-GNB carrier risk. A rectal swab was used to evaluate the patients’ CR-GNB colonization status microbiologically. We optimized features selection using the least absolute shrinkage and selection

Published
2022

30. Reduced Adenoma Miss Rate With 9-Minute vs 6-Minute Withdrawal Times for Screening Colonoscopy: A Multicenter Randomized Tandem Trial.

Author

Zhao S, Song Y, Wang S, Wang R, Feng Z, Gong A, Yang X, Pan P, Yao D, Zhang J, Zhu Y, Li T, Bi J, Ren X, Tang X, Li Q, Yu D, Zheng J, Song B, Wang P, Chen W, Shang G, Xu Y, Xu P, Lai Y, Xu H, Yang X, Sheng J, Tao Y, Li X, Zhu Y, Zhang X, Shen H, Ma Y, Wang F, Wu L, Wang X, Li Z, and Bai Y

Subjects
Humans, Colonoscopy, Adenoma diagnosis
Abstract

Introduction: Although the 9-minute mean withdrawal time (m-WT) is often reported to be associated with the optimal adenoma detection rate (ADR), no randomized trials of screening colonoscopy have confirmed the impact of a 9-minute m-WT on adenoma miss rate (AMR) and ADR., Methods: A multicenter tandem trial was conducted in 11 centers. Seven hundred thirty-three asymptomatic participants were randomized to receive segmental tandem screening colonoscopy with a 9-minute withdrawal, followed by a 6-minute withdrawal (9-minute-first group, 9MF, n = 366) or vice versa (6-minute-first group, 6MF, n = 367). The primary outcome was the lesion-level AMR., Results: The intention-to-treat analysis revealed that 9MF significantly reduced the lesion-level (14.5% vs 36.6%, P < 0.001) and participant-level AMR (10.9% vs 25.9%, P < 0.001), advanced adenoma miss rate (AAMR, 5.3% vs 46.9%, P = 0.002), multiple adenomas miss rate (20.7% vs 56.5%, P = 0.01), and high-risk adenomas miss rate (14.6% vs 39.5%, P = 0.01) of 6MF without compromising detection efficiency ( P = 0.79). In addition, a lower false-negative rate for adenomas ( P = 0.002) and high-risk adenomas ( P < 0.05), and a lower rate of shortening surveillance schedule ( P < 0.001) were also found in 9MF, accompanying with an improved ADR in the 9-minute vs 6-minute m-WT (42.3% vs 33.5%, P = 0.02). The independent inverse association between m-WT and AMR remained significant even after adjusting ADR, and meanwhile, 9-minute m-WT was identified as an independent protector for AMR and AAMR., Discussion: In addition to increasing ADR, 9-minute m-WT also significantly reduces the AMR and AAMR of screening colonoscopy without compromising detection efficiency., (Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.)

Published
2023
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31. Gastrointestinal bleeding as an initial manifestation in asymptomatic multiple myeloma: A case report and review of the literature.

Author

Lin M, Zhu J, Shen H, and Huang J

Abstract

Multiple myeloma (MM) is an uncommon type of malignant hematological neoplasm which, besides primarily involving the bone marrow, has a potent tendency to involve other organs and to present with various clinical manifestations. Involvement of the gastrointestinal (GI) system, particularly presenting with GI hemorrhage, in the course of MM is extremely rare. In the present study, we report a case of a middle-aged male who initially demonstrated GI bleeding and was finally diagnosed with MM. Further laboratory examinations, including analysis of globulin in the blood, bone marrow aspiration and radiogram, supported this diagnosis. This case may promote the possible involvement of plasma cell myeloma in the differential diagnosis of patients with unexplained and refractory GI bleeding. In this study we also present a thorough review of the literature with regard to the association between MM and GI hemorrhage.

Published
2013
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