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Your search keyword '"Shemo, Bryna C."' showing total 7 results
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7 results on '"Shemo, Bryna C."'

1. Tγδ LGLL identifies a subset with more symptomatic disease: analysis of an international cohort of 137 patients

Author

Barilà, Gregorio, Grassi, Angela, Cheon, HeeJin, Teramo, Antonella, Calabretto, Giulia, Chahal, Jasmanet, Vicenzetto, Cristina, Almeida, Julia, Shemo, Bryna C., Shi, Min, Gasparini, Vanessa Rebecca, Munoz-Garcia, Noemi, Pastoret, Cédric, Nakazawa, Hideyuki, Oshimi, Kazuo, Sokol, Lubomir, Ishida, Fumihiro, Lamy, Thierry, Orfao, Alberto, Morice, William G., Loughran, Thomas P., Jr., Semenzato, Gianpietro, and Zambello, Renato

Published
2023
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4. Tγδ LGL LEUKEMIA IDENTIFIES A SUBSET WITH MORE SYMPTOMATIC DISEASE: ANALYSIS OF AN INTERNATIONAL COHORT OF 137 PATIENTS

Author

Barila', Gregorio, primary, Grassi, Angela, additional, Cheon, HeeJin, additional, Teramo, Antonella, additional, Calabretto, Giulia, additional, Chahal, Jasmanet Singh, additional, Vicenzetto, Cristina, additional, Almeida, Julia, additional, Shemo, Bryna C, additional, Shi, Min, additional, Gasparini, Vanessa Rebecca Rebecca, additional, Munoz-Garcia, Noemi, additional, Pastoret, Cedric, additional, Nakazawa, Hideyuki, additional, Oshimi, Kazuo, additional, Sokol, Lubomir, additional, Ishida, Fumihiro, additional, Lamy, Thierry, additional, Orfao, Alberto, additional, Morice, William George, additional, Loughran, Thomas, additional, Semenzato, Gianpietro, additional, and Zambello, Renato, additional

Published
2022
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6. Frequent somatic TET2 mutations in chronic NK-LGL leukemia with distinct patterns of cytopenias

Author

Olson, Thomas L., primary, Cheon, HeeJin, additional, Xing, Jeffrey C., additional, Olson, Kristine C., additional, Paila, Umadevi, additional, Hamele, Cait E., additional, Neelamraju, Yaseswini, additional, Shemo, Bryna C., additional, Schmachtenberg, Matt, additional, Sundararaman, Shriram K., additional, Toro, Mariella F., additional, Keller, Cheryl A., additional, Farber, Emily A., additional, Onengut-Gumuscu, Suna, additional, Garrett-Bakelman, Francine E., additional, Hardison, Ross C., additional, Feith, David J., additional, Ratan, Aakrosh, additional, and Loughran, Thomas P., additional

Published
2021
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7. Frequent Somatic TET2Mutations in Chronic NK-LGL Leukemia with Distinct Patterns of Cytopenias

Author

Olson, Thomas L., Cheon, HeeJin, Xing, Jeffrey C., Olson, Kristine C., Paila, Umadevi, Hamele, Cait E., Neelamraju, Yaseswini, Shemo, Bryna C., Schmachtenberg, Matt, Sundararaman, Shriram K., Toro, Mariella F., Keller, Cheryl A., Farber, Emily A., Onengut-Gumuscu, Suna, Garrett-Bakelman, Francine E., Hardison, Ross C., Feith, David J., Ratan, Aakrosh, and Loughran, Thomas P

Abstract

Chronic natural killer large granular lymphocyte (NK-LGL) leukemia, also referred to as chronic lymphoproliferative disorder of NK cells (CLPD-NK), is a rare disorder defined by prolonged expansion of clonal NK cells. Similar prevalence of STAT3mutations in chronic T- and NK-LGL leukemia is suggestive of common pathogenesis. We undertook whole genome sequencing to identify mutations unique to NK-LGL leukemia. We analyzed the results to develop a resequencing panel and applied it to 58 patients. PI3K pathway gene mutations (PIK3CD/PIK3AP1) and TNFAIP3mutations were seen in 5% and 10% of patients, respectively. TET2was exceptional in that mutations were present in 16/58 (28%) of patient samples, with evidence that TET2mutations can be dominant and exclusive to the NK compartment. Reduced-representation bisulfite sequencing (RRBS) demonstrated that methylation patterns were significantly altered in TET2-mutant samples. The promoter of TET2and that of PTPRD, a negative regulator of STAT3, were found to be methylated in additional cohort samples, largely confined to the TET2 mutant group. Mutations in STAT3were observed in 19/58 (33%) of patient samples, seven of which had concurrent TET2mutations. Thrombocytopenia and resistance to immunosuppressives were uniquely observed in those patients with only TET2mutation (Games-Howell p=0.0074, Fisher’s exact p=0.00466, respectively). Patients with STAT3mutation, inclusive of those with TET2co-mutation, had lower hematocrit (HCT), hemoglobin (HGB), and absolute neutrophil count (ANC) compared to STAT3wild-type patients (Welch’s t-test, p<=0.015). We present the discovery of TET2mutations in chronic NK-LGL leukemia and evidence that it identifies a unique molecular subtype.

Published
2021
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