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1. A Web-Based Time-Use Application to Assess Diet and Movement Behavior in Asian Schoolchildren: Development and Usability Study of My E-Diary for Activities and Lifestyle (MEDAL)

Author

Chia, Airu, Chew, Muhammad Naeem Jia Sheng, Tan, Sarah Yi Xuan, Chan, Mei Jun, T Colega, Marjorelee, Toh, Jia Ying, Natarajan, Padmapriya, Lança, Carla, Shek, Lynette P, Saw, Seang-Mei, Müller-Riemenschneider, Falk, and Chong, Mary Foong-Fong

Subjects
Computer applications to medicine. Medical informatics, R858-859.7, Public aspects of medicine, RA1-1270
Abstract

BackgroundWeb-based time-use diaries for schoolchildren are limited, and existing studies focus mostly on capturing physical activities and sedentary behaviors but less comprehensively on dietary behaviors. ObjectiveThis study aims to describe the development of My E-Diary for Activities and Lifestyle (MEDAL)—a self-administered, web-based time-use application to assess diet and movement behavior—and to evaluate its usability in schoolchildren in Singapore. MethodsMEDAL was developed through formative research and an iterative user-centric design approach involving small groups of schoolchildren (ranging from n=5 to n=15, aged 7-13 years). To test the usability, children aged 10-11 years were recruited from 2 primary schools in Singapore to complete MEDAL for 2 weekdays and 2 weekend days and complete a 10-item usability questionnaire. ResultsThe development process revealed that younger children (aged

Published
2021
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6. A machine-learning exploration of the exposome from preconception in early childhood atopic eczema, rhinitis and wheeze development

Author

Dong, Yizhi, Lau, Hui Xing, Suaini, Noor Hidayatul Aini, Kee, Michelle Zhi Ling, Ooi, Delicia Shu Qin, Shek, Lynette Pei-chi, Lee, Bee Wah, Godfrey, Keith M., Tham, Elizabeth Huiwen, Ong, Marcus Eng Hock, Liu, Nan, Wong, Limsoon, Tan, Kok Hian, Chan, Jerry Kok Yen, Yap, Fabian Kok Peng, Chong, Yap Seng, Eriksson, Johan Gunnar, Feng, Mengling, and Loo, Evelyn Xiu Ling

Published
2024
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8. The prospective associations of fetal growth-related pregnancy complications with subsequent breastfeeding duration and markers of human milk production

Author

Pang, Wei Wei, Geddes, Donna T, Lai, Ching-Tat, Michael, Navin, Huang, Jonathan, Chan, Yiong Huak, Cheong, Clara Y, Fok, Doris, Pundir, Shikha, Ng, Sharon, Vickers, Mark H, Chua, Mei Chien, Tan, Kok Hian, Godfrey, Keith M, Shek, Lynette P, Chong, Yap-Seng, Eriksson, Johan G, Chan, Shiao-Yng, and Wlodek, Mary E

Published
2024
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9. Plasma lipidomic profiling reveals metabolic adaptations to pregnancy and signatures of cardiometabolic risk: a preconception and longitudinal cohort study

Author

Chen, Li, Mir, Sartaj Ahmad, Bendt, Anne K., Chua, Esther W. L., Narasimhan, Kothandaraman, Tan, Karen Mei-Ling, Loy, See Ling, Tan, Kok Hian, Shek, Lynette P., Chan, Jerry, Yap, Fabian, Meaney, Michael J., Chan, Shiao-Yng, Chong, Yap Seng, Gluckman, Peter D., Eriksson, Johan G., Karnani, Neerja, and Wenk, Markus R.

Published
2023
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10. Cross-sectional and prospective associations between children's 24-h time use and their health-related quality of life: a compositional isotemporal substitution approach

Author

Tan, Sarah Yi Xuan, Padmapriya, Natarajan, Bernard, Jonathan Y., Toh, Jia Ying, Wee, Hwee-Lin, Tan, Kok Hian, Yap, Fabian Kok Peng, Lee, Yung Seng, Chong, Yap-Seng, Godfrey, Keith, Eriksson, Johan Gunnar, Shek, Lynette Pei-Chi, Tan, Chuen Seng, Chong, Mary Foong-Fong, and Müller-Riemenschneider, Falk

Published
2023
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12. Preconception sleep quality moderates the association between preconception hair cortisol levels and mental health in pregnant women

Author

Abdul Jafar, Nur K., Tham, Elaine K.H., Eng, Derric Z.H., Yeo, Sherwynn, Rifkin-Graboi, Anne, Gooley, Joshua J., Loy, See Ling, Eriksson, Johan G., Chong, Yap-Seng, Tan, Kok Hian, Chan, Jerry Kok Yen, Chen, Helen, Shek, Lynette Pei-Chi, Gluckman, Peter D., Yap, Fabian, Meaney, Michael J., Broekman, Birit F.P., Kee, Michelle Z.L., and Cai, Shirong

Published
2023
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13. Time-to-conception and clinical pregnancy rate with a myo-inositol, probiotics, and micronutrient supplement: secondary outcomes of the NiPPeR randomized trial

Author

Albert, Ben, Cai, Shirong, Calder, Philip C., Carvalho, Ryan, Guiao Castro, Julie Ann, Cavanagh, Mary, Chan, Jerry KY., Chang, Mei Ling, Chi, Claudia, Childs, Caroline E., Choh, Mei Kit, Chong, Mary FF., Chu, Anne HY., Conlon, Cathryn, Paula Costello, Cyrus Cooper, Cox, Vanessa, Galani, Sevasti, Hammond, Judith, Harvey, Nicholas C., Holt, Richard, Inskip, Hazel M., Jagtap, Mrunalini, Jeon, Gene, Karnani, Neerja, Nembrini, Chiara, Lillycrop, Karen A., Müller-Riemenschneider, Falk, Natarajan, Padmapriya, Ng, Sharon, Ramasamy, Adaikalavan, Tham, Elizabeth, Tint, Mya Thway, O’Sullivan, Justin M., Satianegara, Gernalia, Shek, Lynette PC., Silva-Zolezzi, Irma, Sim, Wendy, Soh, Shu E., Tay, Vicky, Taylor, Rachel, Theodosia, Salika, Wall, Clare, Woon, Gladys, Vickers, Mark, Ying, Wei, Chan, Shiao-Yng, Barton, Sheila J., Loy, See Ling, Chang, Hsin Fang, Titcombe, Philip, Wong, Jui-Tsung, Ebreo, Marilou, Ong, Judith, Tan, Karen ML., Nield, Heidi, El-Heis, Sarah, Kenealy, Timothy, Chong, Yap-Seng, Baker, Philip N., Cutfield, Wayne S., and Godfrey, Keith M.

Published
2023
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14. Sensitive LC-MS/MS method for the temporal profiling of bile acids, fatty acids and branched-chain alpha-keto acids in maternal plasma during pregnancy and cord blood plasma at delivery

Author

Ng, Daniel Zhi Wei, Lee, Sean Xian Yu, Ooi, Delicia Shu Qin, Ta, Le Duc Huy, Yap, Gaik Chin, Tay, Carina Jing Xuan, Huang, Chiung-Hui, Tham, Elizabeth Huiwen, Loo, Evelyn Xiu Ling, Shek, Lynette P.C., Goh, Anne, Bever, Hugo P.S. Van, Teoh, Oon Hoe, Lee, Yung Seng, Yap, Fabian, Tan, Kok Hian, Chong, Yap-Seng, Chan, Shiao Yng, Eriksson, Johan Gunnar, Godfrey, Keith M., Lee, Bee Wah, and Chan, Eric Chun Yong

Published
2023
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15. Breastfeeding may benefit cardiometabolic health of children exposed to increased gestational glycemia in utero

Author

Ong, Yi Ying, Pang, Wei Wei, Huang, Jonathan Y., Aris, Izzuddin M., Sadananthan, Suresh Anand, Tint, Mya-Thway, Yuan, Wen Lun, Chen, Ling-Wei, Chan, Yiong Huak, Karnani, Neerja, Velan, S. Sendhil, Fortier, Marielle V., Choo, Jonathan, Ling, Lieng Hsi, Shek, Lynette, Tan, Kok Hian, Gluckman, Peter D., Yap, Fabian, Chong, Yap-Seng, Godfrey, Keith M., Chong, Mary F-F., Chan, Shiao-Yng, Eriksson, Johan G., Wlodek, Mary E., Lee, Yung Seng, and Michael, Navin

Published
2022
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17. Asian birth cohort studies on allergic diseases: The A2BC network initiative.

Author

Lee, So‐Yeon, Nakano, Taiji, Shimojo, Naoki, Yamamoto‐Hanada, Kiwako, Fukuie, Tatsuki, Ohya, Yukihiro, Tham, Elizabeth Huiwen, Van Bever, Hugo, Shek, Lynette Pei‐Chi, Lee, Bee Wah, Leung, Ting‐Fan, Leung, Agnes Sze Yin, Wong, Gary W. K., Huang, Jing‐Long, Yeh, Kuo‐Wei, Fikri, Bahrul, Suratannon, Narissara, Chatchatee, Pantipa, Peters, Rachel, and Hong, Soo‐Jong

Abstract

The Asia Allergy Birth Cohort (A2BC) network consolidates data from multiple independently established birth cohorts across Asia to enhance research on host–environment interactions in allergic diseases. These cohorts, established at different times with various methodologies, are reliable data sources. Our aim is to introduce the content, variables, and outcomes of these cohorts while highlighting their differences, laying the groundwork for future collaborative research. The A2BC network includes 10 cohort studies on allergic diseases from six Asian countries. Enrollment criteria, study aims, and an initial inventory were discussed and confirmed through five business meetings. A common database was developed to assess the study characteristics of these observational cohorts on allergic diseases, though harmonization efforts are retrospective. Five studies collected data on specific immunoglobulin E responses to various inhalant and food allergens, while six cohorts conducted skin prick tests. Lung function measurements were included in some studies, but without standardized procedures across cohorts. Asthma and allergic rhinitis were primarily assessed using questionnaires or doctor diagnoses, while assessments of eczema and food allergies varied across studies. The A2BC network also examines early‐life environmental factors such as delivery mode, antibiotic usage, diet, and air pollutants, although these exposures were measured differently across the cohorts. Despite differences in the origins, methods, and objectives of each cohort, pooling data and conducting joint analyses offer valuable insights into the relationship between environmental exposures and allergic disease outcomes in Asian children. This approach can serve as a foundation for future collaborative research. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Tracking of dietary patterns between pregnancy and 6 years post-pregnancy in a multiethnic Asian cohort: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) study

Author

Lee, Yu Qi, Colega, Marjorelee, Sugianto, Ray, Lai, Jun Shi, Godfrey, Keith M., Tan, Kok Hian, Shek, Lynette Pei-Chi, Loy, See Ling, Müller‑Riemenschneider, Falk, Padmapriya, Natarajan, Chong, Yap Seng, Eriksson, Johan Gunnar, Chan, Jerry Kok Yen, Chan, Shiao-Yng, Tai, Bee Choo, and Chong, Mary Foong-Fong

Published
2022
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20. Family-focused contextual factors associated with lifestyle patterns in young children from two mother-offspring cohorts: GUSTO and EDEN

Author

Chia, Airu, Descarpentrie, Alexandra, Cheong, Rene N., Toh, Jia Ying, Natarajan, Padmapriya, Sugianto, Ray, Cai, Shirong, Saldanha-Gomes, Cécilia, Dargent-Molina, Patricia, de Lauzon-Guillain, Blandine, Plancoulaine, Sabine, Lança, Carla, Saw, Seang Mei, Godfrey, Keith M., Shek, Lynette P., Tan, Kok Hian, Charles, Marie-Aline, Chong, Yap Seng, Heude, Barbara, Eriksson, Johan G., Müller-Riemenschneider, Falk, Lioret, Sandrine, Chong, Mary F.-F., and Bernard, Jonathan Y.

Published
2022
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21. Publisher Correction: Correlates of protection against symptomatic SARS-CoV-2 in vaccinated children

Author

Zhong, Youjia, primary, Kang, Alicia Y. H., additional, Tay, Carina J. X., additional, Li, Hui’ En, additional, Elyana, Nurul, additional, Tan, Chee Wah, additional, Yap, Wee Chee, additional, Lim, Joey M. E., additional, Le Bert, Nina, additional, Chan, Kuan Rong, additional, Ong, Eugenia Z., additional, Low, Jenny G., additional, Shek, Lynette P., additional, Tham, Elizabeth Huiwen, additional, and Ooi, Eng Eong, additional

Published
2024
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23. Longitudinal Analysis of Patterns and Correlates of Physical Activity and Sedentary Behavior in Women From Preconception to Postpartum: The Singapore Preconception Study of Long-Term Maternal and Child Outcomes Cohort.

Author

Chu, Anne H.Y., Padmapriya, Natarajan, Tan, Shuen Lin, Goh, Claire Marie J.L., Chong, Yap-Seng, Shek, Lynette P., Tan, Kok Hian, Gluckman, Peter D., Yap, Fabian K.P., Lee, Yung Seng, Loy, See Ling, Chan, Jerry K.Y., Godfrey, Keith M., Eriksson, Johan G., Chan, Shiao-Yng, Bernard, Jonathan Y., and Müller-Riemenschneider, Falk

Subjects
SEDENTARY behavior, PHYSICAL activity, SCREEN time, PUERPERIUM, BODY mass index
Abstract

Objective: Longitudinal changes in physical activity (PA) and sedentary behavior patterns from preconception to postpartum are not fully characterized. We examined changes and baseline sociodemographic/clinical correlates of PA and sedentary behavior in women from preconception to postpartum. Methods: The Singapore Preconception Study of Long-Term Maternal and Child Outcomes cohort recruited 1032 women planning pregnancy. Participants completed questionnaires at preconception, 34 to 36 weeks gestation, and 12 months postpartum. Repeated-measures linear regression models were used to analyze changes in walking, moderate to vigorous PA (MVPA), screen time, and total sedentary time, and to identify sociodemographic/clinical correlates associated with these changes. Results: Of the 373 women who delivered singleton live births, 281 provided questionnaires for all time points. Walking time increased from preconception to late pregnancy but decreased postpartum (adjusted means [95% CI]: 454 [333–575], 542 [433–651], and 434 [320–547] min/wk, respectively). Vigorous-intensity PA and MVPA decreased from preconception to late pregnancy but increased postpartum (vigorous-intensity PA: 44 [11–76], 1 [−3–5], and 11 [4–19] min/wk, MVPA: 273 [174–372], 165 [95–234], and 226 [126–325] min/wk, respectively). Screen time and total sedentary time remained consistent from preconception to pregnancy but decreased postpartum (screen: 238 [199–277], 244 [211–277], and 162 [136–189] min/d, total: 552 [506–598], 555 [514–596], and 454 [410–498] min/d, respectively). Individual characteristics of ethnicity, body mass index, employment, parity, and self-rated general health significantly influenced women's activity patterns. Conclusion: During late pregnancy, walking time increased, while MVPA declined significantly, and partially returned to preconception levels postpartum. Sedentary time remained stable during pregnancy but decreased postpartum. The identified set of sociodemographic/clinical correlates underscores need for targeted strategies. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Maternal height, gestational diabetes mellitus and pregnancy complications

Author

Chu, Anne H.Y., Yuan, Wen Lun, Loy, See Ling, Soh, Shu E., Bernard, Jonathan Y., Tint, Mya-Thway, Ho-Lim, Sarah S.T., Goh, Huecin, Ramasamy, Adaikalavan, Kumar, Mukkesh, Goh, Claire, Ang, Li Ting, Shek, Lynette Pei-Chi, Chong, Yap Seng, Tan, Kok Hian, Su, Lin Lin, Biswas, Arijit, Yap, Fabian, Lee, Yung Seng, Chi, Claudia, Godfrey, Keith M., Eriksson, Johan Gunnar, and Chan, Shiao-Yng

Published
2021
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27. The longitudinal association between early-life screen viewing and abdominal adiposity—findings from a multiethnic birth cohort study

Author

Padmapriya, Natarajan, Tint, Mya-Thway, Sadananthan, Suresh Anand, Michael, Navin, Chen, Bozhi, Cai, Shirong, Toh, Jia Ying, Lanca, Carla, Tan, Kok Hian, Saw, Seang Mei, Shek, Lynette Pei-Chi, Chong, Yap Seng, Gluckman, Peter D., Lee, Yung Seng, Yap, Fabian, Fortier, Marielle V., Chong, Mary Foong-Fong, Godfrey, Keith M., Eriksson, Johan G., Velan, S. Sendhil, Kramer, Michael S., Bernard, Jonathan Y., and Müller-Riemenschneider, Falk

Published
2021
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29. The prospective associations of 24-hour movement behaviors and domain-specific activities with executive function and academic achievement among school-aged children in Singapore.

Author

Padmapriya, Natarajan, Bernard, Jonathan Y., Yi Xuan Tan, Sarah, Chu, Anne H. Y., Jie Lin Goh, Claire Marie, Shuen Lin Tan, Shek, Lynette P., Yap Seng Chong, Kok Hian Tan, Shiao-Yng Chan, Yap, Fabian, Godfrey, Keith M., Yung Seng Lee, Meaney, Michael J., Eriksson, Johan G., Chuen Seng Tan, Law, Evelyn C., and Müller-Riemenschneider, Falk

Published
2024
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30. Climate change from the Asia‐Pacific perspective: What an allergist needs to know and do.

Author

Zain, Amanda, Yeo, Inez, Wong, Lydia, and Shek, Lynette P.

Subjects
GREENHOUSE gas mitigation, HEAT waves (Meteorology), METERED-dose inhalers, CLIMATE change mitigation, FOOD allergy
Abstract

Allergic diseases such as asthma, atopic dermatitis, and food allergies are a burgeoning health challenge in the Asia‐Pacific region. Compounding this, the region has become increasingly susceptible to the impacts of climate change. The region has weathered extreme precipitation, intense heat waves, and dust storms over the recent decades. While the effects of environmental and genetic factors on allergic diseases are well understood, prevailing gaps in understanding the complex interactions between climate change and these factors remain. We aim to provide insights into the various pathways by which climate change influences allergic diseases in the Asia‐Pacific population. We outline practical steps that allergists can take to reduce the carbon footprint of their practice on both a systemic and patient‐specific level. We recommend that allergists optimize disease control to reduce the resources required for each patient's care, which contributes to reducing greenhouse gas emissions. We encourage the responsible prescription of metered dose inhalers by promoting the switch to dry powder inhalers for certain patients, at each clinician's discretion. We also recommend the utilization of virtual consultations to reduce patient travel while ensuring that evidence‐based guidelines for rational allergy management are closely adhered to. Finally, eliminating unnecessary testing and medications will also reduce greenhouse gas emissions in many areas of medical care. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Multiple modifiable lifestyle factors and the risk of perinatal depression during pregnancy: Findings from the GUSTO cohort

Author

van Lee, Linde, Chia, Airu, Phua, Desiree, Colega, Marjorelee, Padmapriya, Natarajan, Bernard, Jonathan Y., Cai, Shirong, Tham, Elaine K.H., Teoh, Oon Hoe, Goh, Daniel, Gooley, Joshua J., Gluckman, Peter D., Yap, Fabian, Shek, Lynette P.C., Godfrey, Keith M., Tan, Kok Hian, Chong, Yap-Seng, Müller-Riemenschneider, Falk, Broekman, Birit, Meaney, Michael, Chen, Helen, and Chong, Mary F.F.

Published
2020
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33. Is breastfeeding associated with later child eating behaviours?

Author

Pang, Wei Wei, McCrickerd, Keri, Quah, Phaik Ling, Fogel, Anna, Aris, Izzuddin M., Yuan, Wen Lun, Fok, Doris, Chua, Mei Chien, Lim, Sok Bee, Shek, Lynette P., Chan, Shiao-Yng, Tan, Kok Hian, Yap, Fabian, Godfrey, Keith M., Meaney, Michael J., Wlodek, Mary E., Eriksson, Johan G., Kramer, Michael S., Forde, Ciarán G., Chong, Mary FF, and Chong, Yap-Seng

Published
2020
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36. Early life Skin Microbiome and Metabolome Signatures Predict Atopic Dermatitis In An Asian Preconception Cohort

Author

Tham, Elizabeth, primary, Huy Ta, Le Duc, additional, Chia, Minghao, additional, Lim, Seong Soo, additional, Wearne, Stephen, additional, Chong, Kok Wee, additional, Goh, Anne, additional, Goh, Si Hui, additional, Teoh, Oon Hoe, additional, Cheng, Zai Ru, additional, Loo, Evelyn, additional, Shek, Lynette, additional, Lee, Bee Wah, additional, van Bever, Hugo, additional, Nagarajan, Niranjan, additional, and Common, John, additional

Published
2024
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37. Umbilical Cord Plasma Lysophospholipids and Triacylglycerols Associated with Birthweight Percentiles

Author

Wong, Gerard, primary, Narasimhan, Kothandaraman, additional, Cheong, Wei Fun, additional, Ng, Sharon, additional, Aris, Izzuddin M., additional, Loy, See Ling, additional, Bendt, Anne K., additional, Tan, Kok Hian, additional, Yap, Fabian K. P., additional, Shek, Lynette P., additional, Chong, Yap Seng, additional, Gluckman, Peter D., additional, Godfrey, Keith M., additional, Lee, Yung Seng, additional, Wenk, Markus R., additional, Karnani, Neerja, additional, and Chan, Shiao-Yng, additional

Published
2024
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38. Life stage impact on the human skin ecosystem: lipids and the microbial community

Author

Pagac, Martin Patrick, primary, Davient, Bala, additional, Ravikrishnan, Aarthi, additional, Chua, Ester, additional, Irudayaswamy, Antony, additional, Srinivas, Ramasamy, additional, Wearne, Stephen, additional, Muralidharan, Sneha, additional, Sridharan, Aishwarya, additional, Mohamed Naim, Ahmad Nazri, additional, Ho, Eliza, additional, Ng, Amanda, additional, Kwah, Junmei, additional, Png, Eileen, additional, Bendt, Anne, additional, Wenk, Markus, additional, Torta, Federico, additional, Nagarajan, Niranjan, additional, Common, John, additional, Chong, Yap Seng, additional, Tham, Elizabeth, additional, Shek, Lynette, additional, Loo, Evelyn, additional, Chambers, John, additional, Yew, Yik Weng, additional, Loh, Marie, additional, and Dawson, Thomas, additional

Published
2024
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40. High placental inositol content associated with suppressed pro-adipogenic effects of maternal glycaemia in offspring: the GUSTO cohort

Author

Chu, Anne H. Y., Tint, Mya T., Chang, Hsin F., Wong, Gerard, Yuan, Wen Lun, Tull, Dedreia, Nijagal, Brunda, Narayana, Vinod K., Meikle, Peter J., Chang, Kenneth T. E., Lewis, Rohan M., Chi, Claudia, Yap, Fabian K. P., Tan, Kok Hian, Shek, Lynette P., Chong, Yap-Seng, Gluckman, Peter D., Lee, Yung Seng, Fortier, Marielle V., Godfrey, Keith M., Eriksson, Johan G., Karnani, Neerja, and Chan, Shiao-Yng

Published
2021
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44. Determinants of intramyocellular lipid accumulation in early childhood

Author

Michael, Navin, Gupta, Varsha, Sadananthan, Suresh Anand, Sampathkumar, Aparna, Chen, Li, Pan, Hong, Tint, Mya Thway, Lee, Kuan Jin, Loy, See Ling, Aris, Izzuddin M., Shek, Lynette Pei-Chi, Yap, Fabian Kok Peng, Godfrey, Keith M., Leow, Melvin K.-S., Lee, Yung Seng, Kramer, Michael S., Henry, Christiani Jeyakumar, Fortier, Marielle Valerie, Seng Chong, Yap, Gluckman, Peter D., Karnani, Neerja, and Velan, S. Sendhil

Published
2020
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