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Background Patients with cirrhosis and coronavirus disease-2019 (COVID-19) have high in-hospital mortality. The information on outcome of cirrhosis patients in post-hospitalization period are limited. Aims We aimed to study the outcome of cirrhosis patients with COVID-19 after hospital discharge. Methods The records of the cirrhosis patients discharged after COVID-19 were reviewed. Their data were compared with a similar number of cirrhosis patients without COVID-19 after propensity score matching for age, sex, etiology of cirrhosis, and model for end-stage liver disease (MELD) score. Results Cirrhosis patients with (n=92) or without (n=92) COVID-19 were included in 1:1 ratio. The mortality among COVID-19 (22; 23.9%) and non-COVID-19 (19; 20.7%) were comparable (HR 1.224; 95% CI 0.663-2.263, P=0.520), over a similar duration of follow-up [186 (86-271) vs 183 (103-274)]. Among COVID-19 patients, 45; 48.9% developed a new acute decompensation-increased ascites (40; 43.5%), hepatic encephalopathy (20; 21.7%), or variceal bleeding (8; 8.7%) whereas 25 (27.2%) patients needed re-hospitalization. A proportion of participants continued to have either fatigue/weakness (24/80; 30.0%), sleep disturbances (11/80; 13.7%), or joint pains (16/80; 20.0%). The most common causes of death in patients of both groups were end-stage liver disease: 16 (72.7%) vs 9 (47.4%), followed by multiorgan dysfunction: 4 (18.2%) vs 6 (31.6%), GI bleeding: 2 (9.1%) vs. 4 (21.0%), P=0.484. A lower albumin level, higher international normalized ratio, bilirubin, Child-Turcotte-Pugh, and MELD scores at discharge predicted mortality in the COVID-19 group. Conclusion Short-term outcomes of patients with cirrhosis who survive the initial insult of COVID-19 are not different from patients without COVID-19, and survival is determined by the severity of liver disease at discharge.

Objective: The main objective of the study was to measure the association of quality of life between anxiety and depression in patients with chronic rheumatic heart disease. Methodology: Psychometric assessment (anxiety and depression) of the subjects was measured using HADS. Clinical data were collected from the Department of Cardiology OPD of Safdarjung Hospital, New Delhi. A total of 500 RHD patients and 100 healthy controls were included in the study based on inclusion and exclusion criteria. Data analysis was performed with Chi square test and ANOVA using IBM SPSS version 22. Findings: Almost 80% of the subjects were suffering from moderate RHD, and 20% were suffering from Severe RHD. Most cases of RHD were suffering from moderate anxiety and depression levels. Among all the variables of SF-36 questionnaire, only pain was only variable associated with anxiety. None of the SF-36 variables was associated with depression in patients with RHD. Conclusion: It was seen that high levels of anxiety and depression levels are present in patients with RHD. It was also observed that the high anxiety levels in the RHD patients can also be a major cause of depression in patients. The factors related to the disease like physical pain, social functioning, and general health causes high anxiety and depression in the patients when the disease prevails over a long time., Mediterranean Journal of Clinical Psychology, Vol 7, No 2 (2019)