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2. Ticagrelor alone versus ticagrelor plus aspirin from month 1 to month 12 after percutaneous coronary intervention in patients with acute coronary syndromes (ULTIMATE-DAPT): a randomised, placebo-controlled, double-blind clinical trial

Author

Li, Xiaobo, Ge, Zhen, Kan, Jing, Anjum, Muhammed, Ye, Fei, Gao, Xiaofei, Jalal, Anjum, Xie, Ping, Tao, Ling, Chen, Xiang, Khan, Hamid S, Javed, Asim, Shao, Yibin, Guo, Xiaomei, Li, Feng, Saghir, Tahir, Mengal, Naeem, Nie, Shaoping, Qu, Hong, Qian, Xuesong, Yang, Song, Chen, Jing, Gao, Dasheng, Liu, Lijun, Wang, Mingliang, Chen, Lianglong, Liu, Fan, Xu, Tan, Liu, Yinwu, Gill, Badar Ul Ahad, Yang, Qing, Guo, Nin, Wen, Shangyu, Cong, Hongliang, Hong, Lang, Sheiban, Imad, Raza, Afsar, Wei, Yongyue, Chen, Feng, Mintz, Gary S, Zhang, Jun-Jie, Stone, Gregg W, Chen, Shao-Liang, Mohydin, Bilal S, Gao, Fentang, Shao, Yibing, Wang, Yan, Zeng, Hesong, and Khan, Hamid Sharif

Published
2024
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3. Intravascular ultrasound-guided versus angiography-guided percutaneous coronary intervention in acute coronary syndromes (IVUS-ACS): a two-stage, multicentre, randomised trial

Author

Li, Xiaobo, Ge, Zhen, Kan, Jing, Anjum, Muhammed, Ye, Fei, Gao, Xiaofei, Jalal, Anjum, Xie, Ping, Tao, Ling, Chen, Xiang, Khan, Hamid S, Javed, Asim, Shao, Yibin, Guo, Xiaomei, Li, Feng, Saghir, Tahir, Mengal, Naeem, Nie, Shaoping, Qu, Hong, Qian, Xuesong, Yang, Song, Chen, Jing, Gao, Dasheng, Liu, Lijun, Wang, Mingliang, Chen, Lianglong, Liu, Fan, Xu, Tan, Liu, Yinwu, Gill, Badar Ul Ahad, Yang, Qing, Guo, Nin, Wen, Shangyu, Cong, Hongliang, Hong, Lang, Sheiban, Imad, Raza, Afsar, Wei, Yongyue, Chen, Feng, Mintz, Gary S, Zhang, Jun-Jie, Stone, Gregg W, Chen, Shao-Liang, Khan, Hamid Sharif, and Guo, Ning

Published
2024
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4. Long-term impact of intravascular ultrasound-guidance for percutaneous coronary intervention on unprotected left main. The IMPACTUS-LM, an observational, multicentric study

Author

Bruno, Francesco, de Filippo, Ovidio, Sardone, Andrea, Capranzano, Piera, Conrotto, Federico, Sheiban, Imad, Giacobbe, Federico, Laudani, Claudio, Burzotta, Francesco, Saia, Francesco, Escaned, Javier, Raposeiras Roubin, Sergio, Mancone, Massimo, Templin, Christian, Candreva, Alessandro, Trabattoni, Daniela, Wanha, Wojciech, Stefanini, Giulio, Chieffo, Alaide, Cortese, Bernardo, Casella, Gianni, Wojakowski, Wojciech, Colombo, Francesco, De Ferrari, Gaetano Maria, Boccuzzi, Giacomo, D'Ascenzo, Fabrizio, and Iannaccone, Mario

Published
2024
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5. Benefit of Extended Dual Antiplatelet Therapy Duration in Acute Coronary Syndrome Patients Treated with Drug Eluting Stents for Coronary Bifurcation Lesions (from the BIFURCAT Registry)

Author

De Filippo, Ovidio, Kang, Jeehoon, Bruno, Francesco, Han, Jung-Kyu, Saglietto, Andrea, Yang, Han-Mo, Patti, Giuseppe, Park, Kyung-Woo, Parma, Radoslaw, Kim, Hyo-Soo, De Luca, Leonardo, Gwon, Hyeon-Cheol, Iannaccone, Mario, Chun, Woo Jung, Smolka, Grzegorz, Hur, Seung-Ho, Cerrato, Enrico, Han, Seung Hwan, di Mario, Carlo, Song, Young Bin, Escaned, Javier, Choi, Ki Hong, Helft, Gerard, Doh, Joon-Hyung, Truffa Giachet, Alessandra, Hong, Soon-Jun, Muscoli, Saverio, Nam, Chang-Wook, Gallone, Guglielmo, Capodanno, Davide, Trabattoni, Daniela, Imori, Yoichi, Dusi, Veronica, Cortese, Bernardo, Montefusco, Antonio, Conrotto, Federico, Colonnelli, Iacopo, Sheiban, Imad, de Ferrari, Gaetano Maria, Koo, Bon-Kwon, and D'Ascenzo, Fabrizio

Published
2021
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6. Long-term (≥15 years) Follow-up of Percutaneous Coronary Intervention of Unprotected Left Main (From the GRAVITY Registry)

Author

D'Ascenzo, Fabrizio, Elia, Edoardo, Marengo, Giorgio, Wańha, Wojciech, González Ferreiro, R., Truffa, Alessandra, Trabattoni, Daniela, Figini, Filippo, Verardi, Roberto, Di Palma, G., Infusino, Fabio, Pivato, Carlo, Ochała, Andrzej, Omedè, Pierluigi, Milewski, Marek, Estevez, Roi, Raporeiras Roubin, S., De Filippo, O., Conrotto, Federico, Montefusco, Antonio, Gili, Sebastiano, Cortese, Bernardo, Dusi, Veronica, Gallone, Guglielmo, Manfredi, Roberto, Mancone, Massimo, Biondi Zoccai, G., Casella, Gianni, Templin, Christian, Stefanini, Giulio, Wojakowski, Wojciech, Sheiban, Imad, and De Ferrari, G.M.

Published
2021
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7. Incidence of Adverse Events at 3 Months Versus at 12 Months After Dual Antiplatelet Therapy Cessation in Patients Treated With Thin Stents With Unprotected Left Main or Coronary Bifurcations

Author

D'Ascenzo, Fabrizio, Barbero, Umberto, Abdirashid, Mohamed, Trabattoni, Daniela, Boccuzzi, Giacomo, Ryan, Nicola, Quadri, Giorgio, Capodanno, Davide, Venuti, Giuseppe, Muscoli, Saverio, Tomassini, Francesco, Autelli, Michele, Montabone, Andrea, Wojakowski, Wojciech, Rognoni, Andrea, Gallo, Diego, Parma, Radoslaw, De Luca, Leonardo, Figini, Filippo, Mitomo, Satoru, Montefusco, Antonio, Mattesini, Alessio, Wańha, Wojciech, Protasiewicz, Marcin, Smolka, Grzegorz, Huczek, Zenon, Rolfo, Cristina, Cortese, Bernardo, Chieffo, Alaide, Kuliczowki, Wiktor, Nuñez-Gil, Ivan, Morbiducci, Umberto, Ugo, Fabrizio, Marengo, Giorgio, Iannaccone, Mario, Cerrato, Enrico, Mario, Carlo di, Moretti, Claudio, D'Amico, Maurizio, Varbella, Ferdinando, Lüscher, Thomas F., Sheiban, Imad, Escaned, Javier, Romeo, Francesco, Rinaldi, Mauro, De Ferrari, Gaetano Maria, and Helft, Gerard

Published
2020
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10. Daily risk of adverse outcomes in patients undergoing complex lesions revascularization: A subgroup analysis from the RAIN-CARDIOGROUP VII study (veRy thin stents for patients with left mAIn or bifurcatioN in real life)

Author

Biolè, Carloalberto, Huczek, Zenon, Nuñez-Gil, Ivan, Boccuzzi, Giacomo, Autelli, Michele, Montefusco, Antonio, Trabattoni, Daniela, Ryan, Nicola, Venuti, Giuseppe, Imori, Yoichi, Takano, Hitoshi, Matsuda, Junya, Shimizu, Wataru, Muscoli, Saverio, Montabone, Andrea, Wojakowski, Wojciech, Rognoni, Andrea, Helft, Gerard, Gallo, Diego, Parma, Radoslaw, De Luca, Leonardo, Figini, Filippo, Mitomo, Satoru, Pennone, Mauro, Mattesini, Alessio, Templin, Christian, Quadri, Giorgio, Wańha, Wojciech, Cerrato, Enrico, Smolka, Grzegorz, Protasiewicz, Marcin, Kuliczkowski, Wiktor, Rolfo, Cristina, Cortese, Bernardo, Capodanno, Davide, Chieffo, Alaide, Morbiducci, Umberto, Iannaccone, Mario, Gili, Sebastiano, di Mario, Carlo, D'Amico, Maurizio, Romeo, Francesco, Lüscher, Thomas F., Sheiban, Imad, Escaned, Javier, Varbella, Ferdinando, and D'Ascenzo, Fabrizio

Published
2019
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11. Impact of Final Kissing Balloon and of Imaging on Patients Treated on Unprotected Left Main Coronary Artery With Thin-Strut Stents (From the RAIN-CARDIOGROUP VII Study)

Author

D'Ascenzo, Fabrizio, Omedè, Pierluigi, De Filippo, Ovidio, Cerrato, Enrico, Autelli, Michele, Trabattoni, Daniela, Ryan, Nicola, Venuti, Giuseppe, Muscoli, Saverio, Montabone, Andrea, Wojakowski, Wojciech, Rognoni, Andrea, Helft, Gerard, Gallo, Diego, Parma, Radoslaw, De Luca, Leonardo, Figini, Filippo, Mitomo, Satoru, Boccuzzi, Giacomo, Mattesini, Alessio, Wańha, Wojciech, Smolka, Grzegorz, Huczek, Zenon, Cortese, Bernardo, Sheiban, Imad, Escaned, Javier, Biolè, Carloalberto, Conrotto, Federico, Templin, Christian, Quadri, Giorgio, Rolfo, Cristina, Capodanno, Davide, Chieffo, Alaide, Nuñez-Gil, Ivan, Morbiducci, Umberto, Iannaccone, Mario, Gili, Sebastiano, Mario, Carlo di, Moretti, Claudio, D'Amico, Maurizio, Varbella, Ferdinando, Romeo, Francesco, and Lüscher, Thomas F.

Published
2019
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13. The EUROpean and Chinese cardiac and renal Remote Ischemic Preconditioning Study (EURO-CRIPS CardioGroup I): A randomized controlled trial

Author

Moretti, Claudio, Cerrato, Enrico, Cavallero, Erika, Lin, Song, Rossi, Marco Luciano, Picchi, Andrea, Sanguineti, Francesca, Ugo, Fabrizio, Palazzuoli, Alberto, Bertaina, Maurizio, Presbitero, Patrizia, Shao-liang, Chen, Pozzi, Roberto, Giammaria, Massimo, Limbruno, Ugo, Lefèvre, Thierry, Gasparetto, Valeria, Garbo, Roberto, Omedè, Pierluigi, Sheiban, Imad, Escaned, Javier, Biondi-Zoccai, Giuseppe, Gaita, Fiorenzo, Perl, Leor, and D'Ascenzo, Fabrizio

Published
2018
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14. Unprotected Left Main Coronary Disease and ST-Segment Elevation Myocardial Infarction A Contemporary Review and Argument for Percutaneous Coronary Intervention

Author

Lee, Michael S, Bokhoor, Pooya, Park, Seung-Jung, Kim, Young-Hak, Stone, Gregg W, Sheiban, Imad, Biondi-Zoccai, Giuseppe, Sillano, Dario, Tobis, Jonathan, and Kandzari, David E

Subjects
Heart Disease, Atherosclerosis, Heart Disease - Coronary Heart Disease, Cardiovascular, Angioplasty, Balloon, Coronary, Comorbidity, Coronary Artery Bypass, Coronary Artery Disease, Coronary Circulation, Evidence-Based Medicine, Humans, Myocardial Infarction, Patient Selection, Practice Guidelines as Topic, Risk Assessment, Risk Factors, Treatment Outcome, acute myocardial infarction, drug-eluting stent(s), left main disease, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology
Abstract

Acute occlusion involving the unprotected left main coronary artery (ULMCA) is a clinically catastrophic event, often leading to abrupt and severe circulatory failure, lethal arrhythmias, and sudden cardiac death. Although coronary artery bypass grafting (CABG) is the standard of care for ULMCA disease in patients with stable ischemic heart disease, uncertainty surrounds the optimal revascularization strategy for patients with ST-elevation myocardial infarction (MI) and ULMCA occlusion who survive to hospitalization, and treatment guidelines in this setting are vague. Percutaneous coronary intervention (PCI) is technically feasible in most patients, has the advantage of providing more rapid reperfusion compared with CABG with acceptable short- and long-term outcomes, and is associated with a lower risk of stroke. PCI of the ULMCA should be considered as a viable alternative to CABG for selected patients with MI, including those with ULMCA occlusion and less than Thrombolysis In Myocardial Infarction flow grade 3, cardiogenic shock, persistent ventricular arrhythmias, and significant comorbidities. The higher risk of target vessel revascularization associated with ULMCA PCI compared with CABG is an acceptable tradeoff given the primary need for rapid reperfusion to enhance survival.

Published
2010

15. Incidence and Management of Restenosis After Treatment of Unprotected Left Main Disease With Drug-Eluting Stents 70 Restenotic Cases From a Cohort of 718 Patients: FAILS (Failure in Left Main Study)

Author

Sheiban, Imad, Sillano, Dario, Biondi-Zoccai, Giuseppe, Chieffo, Alaide, Colombo, Antonio, Vecchio, Sabine, Margheri, Massimo, Gunn, Julian P, Raina, Tushar, Liistro, Francesco, Bolognese, Leonardo, Lee, Michael S, Tobis, Jonathan, and Moretti, Claudio

Subjects
Assistive Technology, Atherosclerosis, Bioengineering, Heart Disease, Clinical Research, Heart Disease - Coronary Heart Disease, Cardiovascular, Aged, Aged, 80 and over, Angioplasty, Balloon, Coronary, Cohort Studies, Coronary Artery Bypass, Coronary Restenosis, Drug-Eluting Stents, Female, Graft Occlusion, Vascular, Humans, Incidence, Male, Middle Aged, Retrospective Studies, Treatment Failure, coronary artery disease, drug-eluting stent, left main coronary artery, percutaneous coronary intervention, restenosis, Cardiorespiratory Medicine and Haematology, Public Health and Health Services, Cardiovascular System & Hematology
Abstract

ObjectivesThis study sought to retrospectively appraise the incidence and management of restenosis after drug-eluting stent (DES) implantation for unprotected left main (ULM) disease.BackgroundThe promising role of DES for ULM has been reported. However, no detailed data are available on subsequent restenosis.MethodsFrom the total sample of patients with ULM treated with DES, we identified those presenting with angiographic ULM restenosis. The primary end point was the long-term rate of major adverse cardiac events (MACE), that is, death, myocardial infarction (MI), or target lesion revascularization (TLR). We also adjudicated stent thrombosis according to the Academic Research Consortium.ResultsPost-DES restenosis in ULM occurred in 70 of 718 patients (9.7%). Of these, 59 (84.3%) were treated percutaneously (34 [48.6%] with additional DES, 22 [31.4%] with standard or cutting balloons, 2 [2.9%] with rotational atherectomy, and 1 [1.4%] with a bare-metal stent), whereas 7 (10%) patients underwent bypass surgery and 4 (5.7%) were treated medically. In-hospital MACE included no periprocedural MI and only 1 (1.4%) death. After 27.2 +/- 15.4 months, MACE occurred cumulatively in 18 (25.7%) patients, with death in 4 (5.7%), MI in 2 (2.9%), and TLR in 15 (21.4%). Patients treated with medical, interventional, and surgical therapy had the following MACE rates, respectively: 50%, 25.4%, and 14.3%. Definite, probable, and possible stent thrombosis occurred in 0 (0%), 1 (1.4%), and 1 (1.4%) patient, respectively.ConclusionsDES restenosis in the ULM artery can be managed in most cases with a minimally invasive approach, achieving favorable early and late results.

Published
2009

17. Multicenter international registry of unprotected left main coronary artery percutaneous coronary intervention with drug‐eluting stents in patients with myocardial infarction

Author

Lee, Michael S, Sillano, Dario, Latib, Azeem, Chieffo, Alaide, Zoccai, Giuseppe Biondi, Bhatia, Ravi, Sheiban, Imad, Colombo, Antonio, and Tobis, Jonathan

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Cardiovascular, Clinical Trials and Supportive Activities, Bioengineering, Heart Disease - Coronary Heart Disease, Clinical Research, Atherosclerosis, Heart Disease, Assistive Technology, Prevention, Good Health and Well Being, Aged, Aged, 80 and over, Angioplasty, Balloon, Coronary, California, Cardiovascular Agents, Cardiovascular Diseases, Coronary Angiography, Coronary Artery Disease, Critical Illness, Drug-Eluting Stents, Feasibility Studies, Female, Hospital Mortality, Humans, Italy, Kaplan-Meier Estimate, Male, Myocardial Infarction, Paclitaxel, Proportional Hazards Models, Registries, Retrospective Studies, Risk Assessment, Risk Factors, Severity of Illness Index, Sirolimus, Time Factors, Treatment Outcome, drug-eluting stents, left main coronary artery, myocardial infarction, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Abstract

BackgroundPatients who present with myocardial infarction (MI) and unprotected left main coronary artery (ULMCA) disease represent an extremely high-risk subset of patients. ULMCA percutaneous coronary intervention (PCI) with drug-eluting stents (DES) in MI patients has not been extensively studied.MethodsIn this retrospective multicenter international registry, we evaluated the clinical outcomes of 62 consecutive patients with MI who underwent ULMCA PCI with DES (23 ST-elevation MI [STEMI] and 39 non-ST-elevation MI [NSTEMI]) from 2002 to 2006.ResultsThe mean age was 70 +/- 12 years. Cardiogenic shock was present in 24%. The mean EuroSCORE was 10 +/- 8. Angiographic success was achieved in all patients. Overall in-hospital major adverse cardiac event (MACE) rate was 10%, mortality was 8%, all due to cardiac deaths from cardiogenic shock, and one patient suffered a periprocedural MI. At 586 +/- 431 days, 18 patients (29%) experienced MACE, 12 patients (19%) died (the mortality rate was 47% in patients with cardiogenic shock), and target vessel revascularization was performed in four patients, all of whom had distal bifurcation involvement (two patients underwent repeat PCI and two patients underwent bypass surgery). There was no additional MI. Two patients had probable stent thrombosis and one had possible stent thrombosis. Diabetes [hazard ratio (HR) 4.22, 95% confidence interval (CI) (1.07-17.36), P = 0.04), left ventricular ejection fraction [HR 0.94, 95% CI (0.90-0.98), P = 0.005), and intubation [HR 7.00, 95% CI (1.62-30.21), P = 0.009) were significantly associated with increased mortality.ConclusionsPatients with MI and ULMCA disease represent a very high-risk subgroup of patients who are critically ill. PCI with DES appears to be technically feasible, associated with acceptable long-term outcomes, and a reasonable alternative to surgical revascularization for MI patients with ULMCA disease. Randomized trials are needed to determine the ideal revascularization strategy for these patients.

Published
2009

18. Ticagrelor alone versus ticagrelor plus aspirin from month 1 to month 12 after percutaneous coronary intervention in patients with acute coronary syndromes (ULTIMATE-DAPT): a randomised, placebo-controlled, double-blind clinical trial

Author

Ge, Zhen, Kan, Jing, Gao, Xiaofei, Raza, Afsar, Zhang, Jun-Jie, Mohydin, Bilal S, Gao, Fentang, Shao, Yibing, Wang, Yan, Zeng, Hesong, Li, Feng, Khan, Hamid Sharif, Mengal, Naeem, Cong, Hongliang, Wang, Mingliang, Chen, Lianglong, Wei, Yongyue, Chen, Feng, Stone, Gregg W, Chen, Shao-Liang, Li, Xiaobo, Ge, Zhen, Kan, Jing, Anjum, Muhammed, Ye, Fei, Gao, Xiaofei, Jalal, Anjum, Xie, Ping, Tao, Ling, Chen, Xiang, Khan, Hamid S, Javed, Asim, Shao, Yibin, Guo, Xiaomei, Li, Feng, Saghir, Tahir, Mengal, Naeem, Nie, Shaoping, Qu, Hong, Qian, Xuesong, Yang, Song, Chen, Jing, Gao, Dasheng, Liu, Lijun, Wang, Mingliang, Chen, Lianglong, Liu, Fan, Xu, Tan, Liu, Yinwu, Gill, Badar Ul Ahad, Yang, Qing, Guo, Nin, Wen, Shangyu, Cong, Hongliang, Hong, Lang, Sheiban, Imad, Raza, Afsar, Wei, Yongyue, Chen, Feng, Mintz, Gary S, Zhang, Jun-Jie, Stone, Gregg W, and Chen, Shao-Liang

Abstract

Following percutaneous coronary intervention with stent placement to treat acute coronary syndromes, international clinical guidelines generally recommend dual antiplatelet therapy with aspirin plus a P2Y12receptor inhibitor for 12 months to prevent myocardial infarction and stent thrombosis. However, data on single antiplatelet therapy with a potent P2Y12inhibitor earlier than 12 months after percutaneous coronary intervention for patients with an acute coronary syndrome are scarce. The aim of this trial was to assess whether the use of ticagrelor alone, compared with ticagrelor plus aspirin, could reduce the incidence of clinically relevant bleeding events without an accompanying increase in major adverse cardiovascular or cerebrovascular events (MACCE).

Published
2024
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19. Late and very late stent thrombosis following drug-eluting stent implantation in unprotected left main coronary artery: a multicentre registry

Author

Chieffo, Alaide, Park, Seung-Jung, Meliga, Emanuele, Sheiban, Imad, Lee, Michael S, Latib, Azeem, Kim, Young-Hak, Valgimigli, Marco, Sillano, Dario, Magni, Valeria, Biondi-Zoccai, Giuseppe, Montorfano, Matteo, Airoldi, Flavio, Rogacka, Renata, Carlino, Mauro, Michev, Iassen, Lee, Cheol-Whan, Hong, Myeong-Ki, Park, Seong-Wook, Moretti, Claudio, Bonizzoni, Erminio, Sangiorgi, Giuseppe M, Tobis, Jonathan, Serruys, Patrick W, and Colombo, Antonio

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Heart Disease, Bioengineering, Cardiovascular, Assistive Technology, Atherosclerosis, Aged, Coronary Restenosis, Drug-Eluting Stents, Female, Graft Occlusion, Vascular, Hospitalization, Humans, Male, Middle Aged, Myocardial Revascularization, Paclitaxel, Registries, Sirolimus, Treatment Outcome, Tubulin Modulators, stent, left main coronary artery, drug-eluting stents, stent thrombosis, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

AimsTo evaluate the occurrence of late and very late stent thrombosis (ST) following elective drug-eluting stent (DES) implantation in unprotected left main coronary artery (LMCA) stenosis in a large multicentre registry.Methods and resultsAll 731 consecutive patients who had sirolimus- or paclitaxel-eluting stent electively implanted in de novo lesions on unprotected LMCA in five centres were included. ST was defined according to Academic Research Consortium definitions. Four (0.5%) patients had a definite ST: three early (two acute and one subacute) and one late ST, no cases of very late definite ST were recorded. All patients survived from the event. Three patients had a probable ST. Therefore, 7/731 (0.95%) patients had a definite or a probable ST and all were on dual antiplatelet therapy at the time of the event. Possible (eight late and 12 very late) ST occurred in 20 (2.7%) patients. At 29.5 ± 13.7 months follow-up, a total of 45 (6.2%) patients had died; 31 (4.2%) of cardiac death. Ninety five (12.9%) patients had a target-vessel and 76 (10.4%) a target-lesion revascularization. Angiographic follow-up was performed in 548 patients (75%): restenosis occurred in 77 (14.1%) patients.ConclusionElective treatment of LMCA stenosis with DES appears safe with a 0.9% incidence of definite and probable ST at 29.5 ± 13.7 months.

Published
2008

20. Incidence And Outlook Of Recurrent Restenosis After Treatment Of Unprotected Left Main Disease With Drug-Eluting Stents: Cohort Study On 718 Patients And 70 Restenotic Cases

Author

Sillano, Dario, Chieffo, Alaide, Colombo, Antonio, Vecchio, Sabine, Margheri, Massimo, Gunn, Julian, Liistro, France Sco, Bolognese, Leonardo, Lee, Michael S, Tobis, Jonothan, Moretti, Claudio, Biondi-Zoccai, Giuseppe, Omede, Pierluigi, Sciuto, Filippo, and Sheiban, Imad

Subjects
Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology
Published
2008

24. Comparison of bioresorbable vs durable polymer drug-eluting stents in unprotected left main (from the RAIN-CARDIOGROUP VII Study)

Author

Iannaccone, Mario, Barbero, Umberto, De Benedictis, Michele, Imori, Yoichi, Quadri, Giorgio, Trabattoni, Daniela, Ryan, Nicola, Venuti, Giuseppe, Montabone, Andrea, Wojakowski, Wojciech, Rognoni, Andrea, Helft, Gerard, Parma, Radoslaw, De Luca, Leonardo, Autelli, Michele, Boccuzzi, Giacomo, Mattesini, Alessio, Templin, Christian, Cerrato, Enrico, Wańha, Wojciech, Smolka, Grzegorz, Huczek, Zenon, Tomassini, Francesco, Cortese, Bernardo, Capodanno, Davide, Chieffo, Alaide, Nuñez-Gil, Ivan, Gili, Sebastiano, Bassignana, Antonia, di Mario, Carlo, Doronzo, Baldassarre, Omedè, Pierluigi, D’Amico, Maurizio, Tedeschi, Delio, Varbella, Ferdinando, Luscher, Thomas, Sheiban, Imad, Escaned, Javier, Rinaldi, Mauro, and D’Ascenzo, Fabrizio

Published
2020
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25. Impact of stent thickness on clinical outcomes in small vessel and bifurcation lesions: a RAIN-CARDIOGROUP VII sub-study

Author

Franchin, Luca, Piroli, Francesco, D’Ascenzo, Fabrizio, Nuñez-Gil, Ivan, Wojakowski, Wojciech, Imori, Yoichi, Trabattoni, Daniela, Huczek, Zenon, Venuti, Giuseppe, Muscoli, Saverio, Montabone, Andrea, Rognoni, Andrea, Parma, Radoslaw, Figini, Filippo, Mitomo, Satoru, Quadri, Giorgio, Wańha, Wojciech, Cortese, Bernardo, De Filippo, Ovidio, Ryan, Nicola, Varbella, Ferdinando, Sheiban, Imad, Helft, Gerard, and De Ferrari, Gaetano M.

Published
2021
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26. Impact of Kissing Balloon in Patients Treated With Ultrathin Stents for Left Main Lesions and Bifurcations: An Analysis From the RAIN-CARDIOGROUP VII Study

Author

Gaido, Luca, D’Ascenzo, Fabrizio, Imori, Yoichi, Wojakowski, Wojciech, Saglietto, Andrea, Figini, Filippo, Mattesini, Alessio, Trabattoni, Daniela, Rognoni, Andrea, Tomassini, Francesco, Bernardi, Alessandro, Ryan, Nicola, Muscoli, Saverio, Helft, Gerard, De Filippo, Ovidio, Parma, Radoslaw, De Luca, Leonardo, Ugo, Fabrizio, Cerrato, Enrico, Montefusco, Antonio, Pennacchi, Mauro, Wańha, Wojciech, Smolka, Grzegorz, de Lio, Giulia, Bruno, Francesco, Huczek, Zenon, Boccuzzi, Giacomo, Cortese, Bernardo, Capodanno, Davide, Omedè, Pierluigi, Mancone, Massimo, Nuñez-Gil, Ivan, Romeo, Francesco, Varbella, Ferdiando, Rinaldi, Mauro, Escaned, Javier, Conrotto, Federico, Burzotta, Francesco, Chieffo, Alaide, Perl, Leor, D’Amico, Maurizio, di Mario, Carlo, Sheiban, Imad, Gagnor, Andrea, Giammaria, Massimo, and De Ferrari, Gaetano Maria

Published
2020
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27. Computing Methods for Composite Clinical Endpoints in Unprotected Left Main Coronary Artery Revascularization: A Post Hoc Analysis of the DELTA Registry

Author

Capodanno, Davide, Gargiulo, Giuseppe, Buccheri, Sergio, Chieffo, Alaide, Meliga, Emanuele, Latib, Azeem, Park, Seung-Jung, Onuma, Yoshinobu, Capranzano, Piera, Valgimigli, Marco, Narbute, Inga, Makkar, Raj R., Palacios, Igor F., Kim, Young-Hak, Buszman, Pawel E., Chakravarty, Tarun, Sheiban, Imad, Mehran, Roxana, Naber, Christoph, Margey, Ronan, Agnihotri, Arvind, Marra, Sebastiano, Leon, Martin B., Moses, Jeffrey W., Fajadet, Jean, Lefèvre, Thierry, Morice, Marie-Claude, Erglis, Andrejs, Alfieri, Ottavio, Serruys, Patrick W., Colombo, Antonio, and Tamburino, Corrado

Published
2016
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28. Design and rationale for the treatment effects of provisional side branch stenting and DK crush stenting techniques in patients with unprotected distal left main coronary artery bifurcation lesions (DKCRUSH V) Trial

Author

Chen, Shao-Liang, Han, Ya-Ling, Chen, Liang-Long, Qiu, Chun-Guang, Jiang, Tie-Min, Tao, Ling, Zeng, Hesong, Li, Li, Xia, Yong, Gao, Chuanyu, Santoso, Teguh, Paiboon, Chootopol, wang, Yan, Kwan, Tak W., Zhang, Jue-Jie, Ye, Fei, Tian, Nai-Liang, Liu, Zhi-Zhong, Lin, Song, Lu, ChengZhi, Wen, Shangyu, Hong, Lang, Zhang, Qi, Sheiban, Imad, Xu, Yawei, Wang, Lefeng, Chen, Shao-Yu, Li, Zhanquan, Cheng, Guanchang, and Cui, Lianqun

Published
2016
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29. Long-Term (≥10 Years) Safety of Percutaneous Treatment of Unprotected Left Main Stenosis With Drug-Eluting Stents

Author

Sheiban, Imad, Moretti, Claudio, D'Ascenzo, Fabrizio, Chieffo, Alaide, Taha, Salma, Connor, Stephen O., Chandran, SujaySubash, de la Torre Hernández, JM, Chen, Sl, Varbella, Ferdinando, Omedè, Pierluigi, Iannaccone, Mario, Meliga, Emanuele, Kawamoto, Hiroyoshi, Montefusco, Antonio, Mervyn, Chong, Garot, Philippe, Sin, Lin, Gasparetto, Valeria, Abdirashid, Mohamed, Cerrato, Enrico, Biondi Zoccai, Giuseppe, Gaita, Fiorenzo, Escaned, Javier, Hiddick Smith, David, Lefèvre, Thierry, and Colombo, Antonio

Published
2016
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30. A large, prospective, multicentre study of left main PCI using a latest-generation zotarolimus-eluting stent: the ROLEX study

Author

Tarantini, Giuseppe, primary, Fovino, Luca Nai, additional, Varbella, Ferdinando, additional, Trabattoni, Daniela, additional, Caramanno, Giuseppe, additional, Trani, Carlo, additional, De Cesare, Nicoletta, additional, Esposito, Giovanni, additional, Montorfano, Matteo, additional, Musto, Carmine, additional, Picchi, Andrea, additional, Sheiban, Imad, additional, Gasparetto, Valeria, additional, Ribichini, Flavio L., additional, Cardaioli, Francesco, additional, Saccà, Salvatore, additional, Cerrato, Enrico, additional, Napodano, Massimo, additional, Martinato, Matteo, additional, Azzolina, Danila, additional, Andò, Giuseppe, additional, Mugnolo, Antonio, additional, Caruso, Marco, additional, Rossini, Roberta, additional, Passamonti, Enrico, additional, Teles, Rui Campante, additional, Rigattieri, Stefano, additional, Gregori, Dario, additional, Tamburino, Corrado, additional, and Burzotta, Francesco, additional

Published
2023
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31. Clinical Outcome After DK Crush Versus Culotte Stenting of Distal Left Main Bifurcation Lesions: The 3-Year Follow-Up Results of the DKCRUSH-III Study

Author

Chen, Shao-Liang, Xu, Bo, Han, Ya-Ling, Sheiban, Imad, Zhang, Jun-Jie, Ye, Fei, Kwan, Tak W., Paiboon, Chitprapai, Zhou, Yu-Jie, Lv, Shu-Zheng, Dangas, George D., Xu, Ya-Wei, Wen, Shang-Yu, Hong, Lang, Zhang, Rui-Yan, Wang, Hai-Chang, Jiang, Tie-Ming, Wang, Yan, Sansoto, Teguh, Chen, Fang, Yuan, Zu-Yi, Li, Wei-Min, and Leon, Martin B.

Published
2015
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32. Comparison of Percutaneous Coronary Intervention (With Drug-Eluting Stents) Versus Coronary Artery Bypass Grafting in Women With Severe Narrowing of the Left Main Coronary Artery (from the Women–Drug-Eluting stent for LefT main coronary Artery disease Registry)

Author

Buchanan, Gill Louise, Chieffo, Alaide, Meliga, Emanuele, Mehran, Roxana, Park, Seung-Jung, Onuma, Yoshinobu, Capranzano, Piera, Valgimigli, Marco, Narbute, Inga, Makkar, Raj R., Palacios, Igor F., Kim, Young-Hak, Buszman, Piotr P., Chakravarty, Tarun, Sheiban, Imad, Naber, Christoph, Margey, Ronan, Agnihotri, Arvind, Marra, Sebastiano, Capodanno, Davide, Allgar, Victoria, Leon, Martin B., Moses, Jeffrey W., Fajadet, Jean, Lefevre, Thierry, Morice, Marie-Claude, Erglis, Andrejs, Tamburino, Corrado, Alfieri, Ottavio, Serruys, Patrick W., and Colombo, Antonio

Published
2014
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33. Percutaneous coronary intervention or coronary artery bypass graft in left main coronary artery disease: a comprehensive meta-analysis of adjusted observational studies and randomized controlled trials

Author

Bertaina, Maurizio, De Filippo, Ovidio, Iannaccone, Mario, Colombo, Antonio, Stone, Gregg, Serruys, Patrick, Mancone, Massimo, Omedè, Pierluigi, Conrotto, Federico, Pennone, Mauro, Kimura, Takeshi, Kawamoto, Hiroyoshi, Zoccai, Giuseppe Biondi, Sheiban, Imad, Templin, Christian, Benedetto, Umberto, Cavalcante, Rafael, D’Amico, Maurizio, Gaudino, Mario, Moretti, Claudio, Gaita, Fiorenzo, and D’Ascenzo, Fabrizio

Published
2018
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34. A large, prospective, multicentre study of left main PCI using a latest-generation zotarolimus-eluting stent: the ROLEX study

Author

Tarantini, Giuseppe, Fovino, Luca Nai, Varbella, Ferdinando, Trabattoni, Daniela, Caramanno, Giuseppe, Trani, Carlo, De Cesare, Nicoletta, Esposito, Giovanni, Montorfano, Matteo, Musto, Carmine, Picchi, Andrea, Sheiban, Imad, Gasparetto, Valeria, Ribichini, Flavio L, Cardaioli, Francesco, Saccà, Salvatore, Cerrato, Enrico, Napodano, Massimo, Martinato, Matteo, Azzolina, Danila, Andò, Giuseppe, Mugnolo, Antonio, Caruso, Marco, Rossini, Roberta, Passamonti, Enrico, Teles, Rui Campante, Rigattieri, Stefano, Gregori, Dario, Tamburino, Corrado, and Burzotta, Francesco

Subjects
cardiovascular disease, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, pci, stent, heart disease, Cardiology and Cardiovascular Medicine
Abstract

Data on left main (LM) percutaneous coronary interventions (PCI) have mostly been obtained in studies using drug-eluting stent (DES) platforms without dedicated large-vessel devices and with limited expansion capability.Our study aimed to investigate the safety and efficacy of LM PCI with the latest-generation Resolute Onyx DES.ROLEX (Revascularization Of LEft main with resolute onyX) is a prospective, multicentre study (ClinicalTrials.gov: NCT03316833) enrolling patients with unprotected LM coronary artery disease and a SYNTAX score33 undergoing PCI with the Resolute Onyx zotarolimus-eluting coronary stent, that includes dedicated extra-large vessel platforms. The primary endpoint (EP) was target lesion failure (TLF): a composite of cardiac death, target vessel myocardial infarction (TVMI) and ischaemia-driven target lesion revascularisation (ID-TLR), at 1 year. All events were adjudicated by an independent clinical event committee. An independent core lab analysed all procedural angiograms.A total of 450 patients (mean age 71.8 years, SYNTAX score 24.5±7.2, acute coronary syndrome in 53%) were enrolled in 26 centres. Of these, 77% of subjects underwent PCI with a single-stent and 23% with a 2-stent technique (8% double kissing [DK] crush, 6% culotte, 9% T/T and small protrusion [TAP] stenting). Intravascular imaging guidance was used in 45% (42% intravascular ultrasound [IVUS], 3% optical coherence tomography [OCT]). At 1 year, the primary EP incidence was 5.1% (cardiac death 2.7%, TVMI 2.7%, ID-TLR 2.0%). The definite/probable stent thrombosis rate was 1.1%. In a prespecified adjusted subanalysis, the primary EP incidence was significantly lower in patients undergoing IVUS/OCT-guided versus angio-guided PCI (2.0 vs 7.6%; hazard ratio [HR] 0.28, 95% confidence interval [CI]: 0.13-0.58; p0.001).In this large, multicentre, prospective registry, LM PCI with the Resolute Onyx DES showed good safety and efficacy at 1 year, particularly when guided by intracoronary imaging.

Published
2022

37. Drug eluting balloon versus drug eluting stent in percutaneous coronary interventions: Insights from a meta-analysis of 1462 patients

Author

Lupi, Alessandro, Rognoni, Andrea, Secco, Gioel Gabrio, Porto, Italo, Nardi, Federico, Lazzero, Maurizio, Rossi, Lidia, Parisi, Rosario, Fattori, Rossella, Genoni, Giulia, Rosso, Roberta, Stella, Pieter R., Sheiban, Imad, Bolognese, Leonardo, Liistro, Francesco, Bongo, Angelo Sante, and Agostoni, Pierfrancesco

Published
2013
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38. Early and long-term outlook of percutaneous coronary intervention for bifurcation lesions in young patients

Author

Roversi, Sara, Biondi-Zoccai, Giuseppe, Romagnoli, Enrico, Sheiban, Imad, De Servi, Stefano, Tamburino, Corrado, Colombo, Antonio, Burzotta, Francesco, Presbitero, Patrizia, Bolognese, Leonardo, Paloscia, Leonardo, Rubino, Paolo, Sardella, Gennaro, Briguori, Carlo, Niccoli, Luigi, Franco, Gianfranco, Di Girolamo, Domenico, Piatti, Luigi, Greco, Cesare, Petronio, Sonia, Loi, Bruno, Lioy, Ernesto, Benassi, Alberto, Patti, Aldo, Gaspardone, Achille, Capodanno, Davide, Modena, Maria Grazia, and Sangiorgi, Giuseppe

Published
2013
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40. Incidence and predictors of coronary stent thrombosis: Evidence from an international collaborative meta-analysis including 30 studies, 221,066 patients, and 4276 thromboses

Author

D'Ascenzo, Fabrizio, Bollati, Mario, Clementi, Fabrizio, Castagno, Davide, Lagerqvist, Bo, de la Torre Hernandez, Jose M., ten Berg, Juriën M., Brodie, Bruce R., Urban, Philip, Jensen, Lisette Okkels, Sardi, Gabriel, Waksman, Ron, Lasala, John M., Schulz, Stefanie, Stone, Gregg W., Airoldi, Flavio, Colombo, Antonio, Lemesle, Gilles, Applegate, Robert J., Buonamici, Piergiovanni, Kirtane, Ajay J., Undas, Anetta, Sheiban, Imad, Gaita, Fiorenzo, Sangiorgi, Giuseppe, Modena, Maria Grazia, Frati, Giacomo, and Biondi-Zoccai, Giuseppe

Published
2013
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41. Three-year follow-up of the MULTIcentre evaluation of Single high-dose Bolus TiRofiban versus Abciximab with Sirolimus-eluting STEnt or Bare-Metal Stent in Acute Myocardial Infarction StudY (MULTISTRATEGY)

Author

Valgimigli, Marco, Campo, Gianluca, Gambetti, Stefania, Bolognese, Leonardo, Ribichini, Flavio, Colangelo, Salvatore, de Cesare, Nicoletta, Rodriguez, Alfredo E., Russo, Filippo, Moreno, Raul, Piva, Tommaso, Sheiban, Imad, Penzo, Carlo, Prati, Francesco, Nazzaro, Marco S., Díaz Fernández, José F., Vassanelli, Corrado, Parrinello, Giovanni, and Ferrari, Roberto

Published
2013
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44. Drug-Eluting Stent for Left Main Coronary Artery Disease: The DELTA Registry: A Multicenter Registry Evaluating Percutaneous Coronary Intervention Versus Coronary Artery Bypass Grafting for Left Main Treatment

Author

Chieffo, Alaide, Meliga, Emanuele, Latib, Azeem, Park, Seung-Jung, Onuma, Yoshinobu, Capranzano, Piera, Valgimigli, Marco, Jegere, Sanda, Makkar, Raj R., Palacios, Igor F., Kim, Young-Hak, Buszman, Pawel E., Chakravarty, Tarun, Sheiban, Imad, Mehran, Roxana, Naber, Christoph, Margey, Ronan, Agnihotri, Arvind, Marra, Sebastiano, Capodanno, Davide, Leon, Martin B., Moses, Jeffrey W., Fajadet, Jean, Lefevre, Thierry, Morice, Marie-Claude, Erglis, Andrejs, Tamburino, Corrado, Alfieri, Ottavio, Serruys, Patrick W., and Colombo, Antonio

Published
2012
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46. Sex-specific benefits of sirolimus-eluting stent on long-term outcomes in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention: Insights from the Multicenter Evaluation of Single High-Dose Bolus Tirofiban Versus Abciximab With Sirolimus-Eluting Stent or Bare-Metal Stent in Acute Myocardial Infarction Study trial

Author

Ferrante, Giuseppe, Presbitero, Patrizia, Corrada, Elena, Campo, Gianluca, Bolognese, Leonardo, Vassanelli, Corrado, Colangelo, Salvatore, De Cesare, Nicoletta, E. Rodriguez, Alfredo, Bramucci, Ezio, Moreno, Raul, Piva, Tommaso, Sheiban, Imad, Pasquetto, Giampaolo, Prati, Francesco, Nazzaro, Marco S., Ferrari, Roberto, and Valgimigli, Marco

Published
2012
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48. Prediction of All-Cause Mortality Following Percutaneous Coronary Intervention in Bifurcation Lesions Using Machine Learning Algorithms

Author

Burrello, Jacopo, primary, Gallone, Guglielmo, additional, Burrello, Alessio, additional, Jahier Pagliari, Daniele, additional, Ploumen, Eline H., additional, Iannaccone, Mario, additional, De Luca, Leonardo, additional, Zocca, Paolo, additional, Patti, Giuseppe, additional, Cerrato, Enrico, additional, Wojakowski, Wojciech, additional, Venuti, Giuseppe, additional, De Filippo, Ovidio, additional, Mattesini, Alessio, additional, Ryan, Nicola, additional, Helft, Gérard, additional, Muscoli, Saverio, additional, Kan, Jing, additional, Sheiban, Imad, additional, Parma, Radoslaw, additional, Trabattoni, Daniela, additional, Giammaria, Massimo, additional, Truffa, Alessandra, additional, Piroli, Francesco, additional, Imori, Yoichi, additional, Cortese, Bernardo, additional, Omedè, Pierluigi, additional, Conrotto, Federico, additional, Chen, Shao-Liang, additional, Escaned, Javier, additional, Buiten, Rosaly A., additional, Von Birgelen, Clemens, additional, Mulatero, Paolo, additional, De Ferrari, Gaetano Maria, additional, Monticone, Silvia, additional, and D’Ascenzo, Fabrizio, additional

Published
2022
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