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Quality of any manufactured product is closely associated with to maintenance of manufacturing systems of any organization. To achieve a world class manufacturing system, two new manufacturing paradigm Total Productive Maintenance (TPM) and Total Quality Management (TQM) have emerged over the period along with other widely used concepts. In this paper, a case study related to implementation of Total Productive Maintenance is shared for a packaging material manufacturing organization. TPM Concept is implemented in the business flexible unit equipped with various flexographic printing machines. Overall Equipment Effectiveness (OEE) is used as the key performance measure of success of TPM implementation. The losses associated with equipment effectiveness are identified and all the pillars of TPM are implemented in a phased manner eliminating the losses and thus improving the utilization of flexographic printing machines.