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Background: Acute ischemic stroke and thyroid conditions have complicated interactions. With mixed findings, earlier research has suggested a link between thyroid function and the severity and outcome of strokes. Aim: Toevaluate the impact of thyroid function on acute ischemic stroke patient's functional outcome and stroke severity. Patients and methods: This prospective cohort study, which comprised 70 patients admitted within 48 hours of the beginning of their first acute ischemic stroke, was carried out at the Stroke and Critical Care Units of the Neurology Department at Zagazig University Hospitals. On admission, routine laboratory tests and thyroid hormone levels were examined. Modified Rankin scales [mRS] and the National Institute of Health and Stroke scale [NIHSS] were used to measure the severity of the stroke and the functional outcome, respectively. Results: In 41% of patients, abnormal thyroid function was found. Nonthyroid sickness syndrome was the thyroid anomaly that was most frequently noted [low FT3]. Stroke severity and a poor outcome were substantially correlated with high TSH and low FT3. Conclusion: The severity and functional prognosis of an ischemic stroke may be predicted by abnormal thyroid hormone levels at presentation. [ABSTRACT FROM AUTHOR]

Background: Post-stroke fatigue (PSF) is a common symptom that can have debilitating effects. Furthermore, it is cited as one of the worse symptoms by up to 40% of stroke survivors. Numerous risk factors for PSF, including clinical, laboratory, and hormonal variables, particularly thyroid hormones, were investigated. We aimed To assess the prevalence and contributing factors of post-stroke fatigue in AIS patients. Patients and Methods: This prospective cohort study, which included 70 patients with their first-ever AIS, conducted from August 2022 to January 2023 in the stroke units of the Zagazig neurology department. Patients were evaluated using the fatigue severity scale (scale 7-item version) one month after the stroke's onset. At admission to stroke units, routine laboratory and specialized hormonal assays for thyroid function were performed. Results: 16% of our patients reported post-stroke fatigue. Low T3, high TSH, and dyslipidemia were the three most frequently seen predictors. Conclusions: Dyslipidemia and altered thyroid function are linked to post-stroke fatigue, pointing to a potential role for neuroendocrine responses in PSF. [ABSTRACT FROM AUTHOR]

Background: One of the heterogeneous chronic diseases affecting the kidneys is chronic kidney disease (CKD). Patients with chronic kidney disease, which is associated with high morbidity and mortality, are more likely to experience nervous system problems. Objective: This work was performed to estimate the prevalence and predictors of peripheral neuropathy in children with End Stage Renal Disease (ESRD) on hemodialysis. Patient and methods: A total of 80 children from Egypt were recruited and divided into 2 separate groups. As a first step, a case group of 40 children (5-18 years old) with ESRD who were receiving regular hemodialysis was established. Besides the control group of 40 healthy children matched by age and gender to the case group. We subjected all the participants to detailed history taking stressing on duration of dialysis, family history of renal diseases, consanguinity and history of neuromuscular symptoms such as distal paresthesia, or muscle weakness. General examination for weight, height, blood pressure, vital signs, systemic examination including: Heart examination, chest, abdominal and neurological examination. Routine laboratory investigations and nerve conduction studies were done. Results: We found a statistically significant difference in weight and height between the two studied groups. 40% of patients had polyneuropathy. Multivariate analysis showed that longer disease duration (7 years), high parathyroid hormone level and high ferritin were independent predictors of polyneuropathy. Conclusion: Peripheral neuropathy is a common complication among children with end stage renal disease. Longer dialysis duration, high ferritin and parathormone levels were considered strong predictors of polyneuropathy among CKD patients. [ABSTRACT FROM AUTHOR]