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13 results on '"Shehata, Hussam"'

5. Abstract P6-02-01: Frequency of pathogenic germline mutations beyond Germline BRCA gene mutations among Saudi patients with breast cancer

Author

Alolayan, Ashwaq, primary, Sabatin, Fouad, additional, algarni, Mohammed, additional, Mabsout, Nadine, additional, Zaher, Horya, additional, Shehata, Hussam, additional, Alturki, Saeed, additional, Alshalhoub, Abdulaziz, additional, Alturki, Fatimah, additional, Refaea, Sadal, additional, Abdelhafiz, Nafisah, additional, Alfayea, Turki, additional, Alshammari, Kanan, additional, and Albalwi, Mohammed, additional

Published
2023
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7. Reducing Futile Acute Care Services for Terminally Ill Patients With Cancer: The Dignity Project

Author

Salama, Hind, primary, Al Mutairi, Nashmia, additional, Damlaj, Moussab, additional, Alolayan, Ashwaq, additional, Binahmed, Ahmed, additional, Salama, Hagir, additional, Tlayjeh, Haytham, additional, Alhejazi, Ayman, additional, Lawrence, Myer, additional, Shehata, Hussam, additional, Shami, Mona, additional, Alkaiyat, Mohammad, additional, and Jazieh, Abdul Rahman, additional

Published
2021
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8. Implementation of care near home model (CNH) for cancer patients in response to COVID-19 pandemic.

Author

Jazieh, Abdul-Rahman, primary, Al Mutairi, Nashmia, additional, Al Hadab, Abdulrahman, additional, Al Olayan, Ashwaq, additional, Al Hejazi, Ayman, additional, Al Qarni, Abdullah, additional, Al Zahrani, Mohsen, additional, Shehata, Hussam, additional, Al Shami, Mona, additional, Al Raizah, Abdulrahman, additional, Gadallah, Azzah, additional, Musumadi, Luhanga, additional, Al Rabeeah, Fawaz, additional, Alotaibi, Thamer, additional, and Al Ajlan, Abdulaziz, additional

Published
2020
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10. Reducing futile acute care services (ACS) for terminally ill cancer patients (Dignity Project).

Author

Salama, Hind, primary, Al Mutairi, Nashmia, additional, Damlaj, Moussab, additional, Alolayan, Ashwaq Aman Mohammed, additional, Binahmed, Ahmed, additional, Salama, Hagir, additional, Tlayjeh, Haytham, additional, Lawrence, Myer, additional, Shehata, Hussam, additional, Al Shami, Mona, additional, Alkaiyat, Mohammad, additional, and Jazieh, Abdul-Rahman, additional

Published
2020
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13. Prevalence of BRCA1 and BRCA2 Mutations Among High-Risk Saudi Patients With Breast Cancer.

Author

Abulkhair, Omalkhair, Al Balwi, Mohammed, Makram, Ola, Alsubaie, Lamia, Faris, Medhat, Shehata, Hussam, Hashim, Ahmed, Arun, Banu, Saadeddin, Ahmed, and Ibrahim, Ezzeldin

Subjects
BREAST cancer, CANCER patients, BRCA genes, LONGITUDINAL method
Abstract

Purpose: Over the past three decades, the incidence rate of breast cancer (BC) among Arab women has continually increased. However, data on the prevalence of BRCA1/2 mutations are scarce. Although the population in Saudi Arabia is at large homogeneous and consanguinity is common, especially in the central, eastern, and southern regions of the country, the prevalence of BRCA1 and BRCA2 mutations and the characteristics of BC are not well studied in the country. Methods: This prospective observational study intended to determine the prevalence of BRCA1 and BRCA2 mutations and sought to examine the clinicopathologic features of BC associated with these mutations. Results: Of 310 patients, 270 (87%) had no mutation. BRCA mutations were identified in 40 patients; BRCA1 mutations were found in 11% of patients, and BRCA2 mutations were found in 2% of patients. Variants of unknown significance were found in 15% of patients (45 patients). Triple-negative BC (TNBC) accounted for 86% of all patients with BC and mutations. The following three recurrent deleterious founder BRCA1 mutations were observed: c.4136_4137delCT was observed in five unrelated patients, c.5530delC was observed in three unrelated patients, and c.4524G>A mutations were observed in five unrelated patients. One novel mutation was identified in the BRCA1 gene (c.5512 dup [p.Glu1838Glyfs*42]). Conclusion: Among high-risk Saudi patients with BC, BRCA1 mutations are prevalent (11%). TNBC is the most common BC subtype. Furthermore, age alone does not have a significant association with mutation, but a combination of risk factors such as age, familial history, and TNBC has a significant association with BRCA mutation. [ABSTRACT FROM AUTHOR]

Published
2017
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