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Pseudomyxoma peritonei (PMP) is a poorly understood uncommon condition with an estimated incidence of one to two per million (worldwide) per year. It is characterized by the peritoneal deposition of mucinous implants, diffusely involving the peritoneal surfaces, most commonly of the appendix, and occasionally from the ovary, coupled with mucinous ascites. PMP associated with primary ovarian mucinous tumor was very rare. This is a case report of a 45-year-old female presented with large ovarian mass with gross ascites which was operated and diagnosed as primary atypical proliferative mucinous tumor with pseudomyxoma ovarii with disseminated peritoneal adenomucinosis.

Malignant Brenner tumors of the ovary are very rare, and their definition, biology and treatment modality have not been established. Most Brenner tumors are benign, with only 1–2% being malignant. We present a case of 57-year-old women with a rare malignant Brenner tumor. She presented with complaint of abdominal pain and postmenopausal bleeding. Imaging revealed large complex solid cystic pelvic mass. She underwent staging ovarian laparotomy, and the specimen was sent for histopathological study. Histopathology revealed malignant Brenner tumor. On immunohistochemistry, tumor cells were immunoreactive for uroplakin, CK7, WT1, GATA-3 and Ki67 60% and nonimmunoreactive for CK20, favouring urothelial differentiation.

Background: Various histopathological changes have been observed following neoadjuvant chemotherapy in individual tumors in the literature. Aims and Objectives: To observe histopathologic changes seen after neoadjuvant chemotherapy in breast malignancies, squamous cell carcinomas, adenocarcinomas, and Wilms' tumor using breast cancer predominantly as the model. Materials and Methods: The present prospective study was carried out on 60 patients including 40 patients with carcinoma breast and 20 patients with other malignancies who received neoadjuvant chemotherapy. Results: Post neoadjuvant chemotherapy, mastectomy specimens revealed nuclear enlargement, nuclear shrinkage, necrosis, vacuolation of nucleus, vacuolation of cytoplasm, dyscohesion, and shrinkage of tumor cells with nuclear changes of nonviability like karyorrhexis, karyolysis, and pyknosis. Stromal reactions manifested as fibrosis, elastosis, collagenization, hyalinization, microcalcification, and neovascularization. Areas of necrosis included both vascular and avascular pattern. The stroma also revealed fibrinoid necrosis and mucinous change. Hyalinization of the blood vessel wall was a common finding. The most common inflammatory host response observed in the present study was lymphocytic; others included mixed inflammation, plasmacytic, prominent histiocytic, and giant cell types. Giant cell reaction was significantly correlated to all types of tumor responses (P < 0.05). Similar changes were also observed in other malignancies. A detailed review of the literature has also been done and presented. Conclusion: The tumor grade decreases and differentiation improves, in addition to the retrogressive changes and increase in stromal component, as a result of chemotherapy in carcinoma breast as well as in other malignancies.

Approximately 60% of all ovarian tumors are epithelial in origin, and these neoplasms are thought to arise from the ovarian surface epithelium or small epithelial inclusion cysts. Surface epithelium is capable of differentiating into serous (tubal), mucinous, endometrioid or transitional epithelium. Serous and mucinous cystadenomas are the most common epithelial tumors and, together, account for about 30% of ovarian tumors We report a case of a 29-year-old lady P1L1 presenting with the chief complaints of pain abdomen off and on since the last 1 year. Ultrasonography revealed normal uterus with enlarged right ovary, with a cyst measuring 46 mm × 36 mm × 55 mm showing internal echoes with volume of 50 cc., left ovary also enlarged with multiple well-defined cysts measuring 34 mm × 44 mm × 69 mm with volume of 55 cc and the largest cyst measuring 37 mm. Bilateral ovarian cystectomy was done and sent for histopathology. To our surprise, both the ovaries revealed different histopathological pictures, with the right ovary revealing serous cystadenoma and the left ovary showing mucinous cystadenoma. This rare occurrence has never been reported so far in the literature to the best of our knowledge.

Background: Lymph nodes serve as site of immunologic expansion of lymphocyte populations. Enlargement of nodes may be caused by spread and growth of cancer cells or it can be due to reactive hyperplasia of lymph nodes. Aim : To study the pattern of reaction in involved and uninvolved lymph nodes draining breast carcinoma and correlate different patterns of hyperplasia with other morphological parameters in modified radical mastectomy (MRM) specimens. Material and Methods: Histopathological examination of 734 lymph nodes isolated from MRM specimens over a period of 2 years was performed on routine microsections. Results: Mixed pattern of hyperplasia was the most widespread followed by the diffuse pattern, the follicular hyperplasia, sinus histiocytosis, and paracortical hyperplasia in decreasing order. Follicular hyperplasia was seen in 23.44% of the ductal carcinomas and 36.36% of the malignant phylloides tumor. Sinus histiocytosis was seen in 23.53% of the metaplastic carcinomas, 22.22% of the medullary carcinomas with a decline to 12.10% amongst the ductal carcinomas. However, mixed pattern of hyperplasia was seen in 28.57% of the papillary carcinomas, 26.31% of the lobular and 27.41% of the ductal carcinomas. The incidence of sinus histiocytosis increased from 10.96 to 23.68% with the grade of tumor. There was a decline in the incidence of sinus histiocytosis, paracortical hyperplasia with the increase in the size of the tumor. Conclusions: The assessment of the reactive behavior of lymph nodes serves as an indicator to the histologic immunostaging of malignant tumors. This data indicate that the lymph node reaction to cancer and their incidence and prognostic significance may vary depending upon the stage and type of tumor.

Mediastinal masses in children comprise a heterogeneous group of malignant and benign neoplasms. The majority of malignant tumors of mediastinum are Hodgkins and non-Hodgkins lymphomas, germ cell tumors, and neuroblastomas. Thymomas, thymic carcinoid, and thymic carcinomas constitute thymic epithelial neoplasms (TEN). Thymoma is a primary tumor of the thymus epithelial cells and one of the most common neoplasms in the anterosuperior mediastinum, especially in middle-aged or older adults. Thymic epithelial neoplasms are usually seen in the latter decades of life and rarely occur in children. We hereby report a case of 13-year-old girl presenting with thymoma.

Angiomyolipoma (AML) is a benign renal neoplasm derived from perivascular epithelioid cells and composed of fat, and vascular and smooth muscle element besides spindle cells. It has an incidence of 0.3 - 3% and has increased due to advances in imaging modalities. The overall female to male ratio is approximately 4:1 which is suggesting hormonal component to tumor growth. It can occur sporadically or may be associated with tuberous sclerosis complex. We present a case of renal angiomyolipoma in a 28 year old woman who presented with symptoms of pain off and on and the diagnosis was based on the computed tomography and was confirmed on histopathology.

Giant-cell tumor (GCT) is a histologically benign, locally aggressive tumor that typically affects the ends of long bones, most commonly involving distal femur, proximal tibia, distal radius, and proximal humerus in the order of frequency. The involvement of flat bones of pelvis is extremely rare. We herein describe the unusual case of histologically benign GCT at ilium distinguished by marked destructive features on X-ray, CT, MRI, and histological examination necessitating hemi-pelvectomy in a 15-year-old female. Characteristics features of the giant cell tumor and its treatment options are reviewed.