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3. CCR2 is a potential therapeutic target in peri‐implantitis

Author

Yuan, Shasha, primary, Wei, Yiping, additional, Jiang, Wenting, additional, Sun, Fei, additional, Li, Siqi, additional, Li, Qingqing, additional, Song, Zhanming, additional, Liu, Zhongtian, additional, Mo, Yaqian, additional, Wang, Xuekang, additional, Li, Ning, additional, Lv, Ping, additional, She, Shaoping, additional, Wang, Cui, additional, Zhang, Yu, additional, Wang, Ying, additional, and Hu, Wenjie, additional

Published
2023
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4. CCR2 is a potential therapeutic target in peri‐implantitis.

Author

Yuan, Shasha, Wei, Yiping, Jiang, Wenting, Sun, Fei, Li, Siqi, Li, Qingqing, Song, Zhanming, Liu, Zhongtian, Mo, Yaqian, Wang, Xuekang, Li, Ning, Lv, Ping, She, Shaoping, Wang, Cui, Zhang, Yu, Wang, Ying, and Hu, Wenjie

Subjects
INFLAMMATION prevention, DENTAL implants, BIOLOGICAL models, CYTOKINES, IN vivo studies, OSTEOCLASTS, BONE resorption, PERIODONTITIS, ANIMAL experimentation, CHEMOKINE receptors, MACROPHAGES, RISK assessment, IMIDAZOLES, RESEARCH funding, IMMUNITY, PERI-implantitis, MICE, MONOCYTES, PHARMACODYNAMICS, CHEMICAL inhibitors, DISEASE risk factors
Abstract

Aim: CCR2 (C‐C chemokine receptor type 2) plays a crucial role in inflammatory and bone metabolic diseases; however, its role in peri‐implantitis remains unclear. This study aimed to explore whether CCR2 contributes to peri‐implantitis and the treatment effects of cenicriviroc (CVC) on peri‐implant inflammation and bone resorption. Materials and Methods: The expression of CCR2 was studied using clinical tissue analysis and an in vivo peri‐implantitis model. The role of CCR2 in promoting inflammation and bone resorption in peri‐implantitis was evaluated in Ccr2−/− mice and wild‐type mice. The effect of CVC on peri‐implantitis was evaluated using systemic and local dosage forms. Results: Human peri‐implantitis tissues showed increased CCR2 and CCL2 levels, which were positively correlated with bone loss around the implants. Knocking out Ccr2 in an experimental model of peri‐implantitis resulted in decreased monocyte and macrophage infiltration, reduced pro‐inflammatory cytokine generation and impaired osteoclast activity, leading to reduced inflammation and bone loss around the implants. Treatment with CVC ameliorated bone loss in experimental peri‐implantitis. Conclusions: CCR2 may be a potential target for peri‐implantitis treatment by harnessing the immune‐inflammatory response to modulate the local inflammation and osteoclast activity. [ABSTRACT FROM AUTHOR]

Published
2024
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5. FAM3D is essential for colon homeostasis and host defense against inflammation associated carcinogenesis

Author

Liang, Weiwei, Peng, Xinjian, Li, Qingqing, Wang, Pingzhang, Lv, Ping, Song, Quansheng, She, Shaoping, Huang, Shiyang, Chen, Keqiang, Gong, Wanghua, Yuan, Wuxing, Thovarai, Vishal, Yoshimura, Teizo, O’huigin, Colm, Trinchieri, Giorgio, Huang, Jiaqiang, Lin, Shuye, Yao, Xiaohong, Bian, Xiuwu, Kong, Wei, Xi, Jianzhong, Wang, Ji Ming, and Wang, Ying

Published
2020
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7. Dominant neoantigen verification in hepatocellular carcinoma by a single-plasmid system coexpressing patient HLA and antigen

Author

Chen, Pu, primary, Chen, Dongbo, additional, Bu, Dechao, additional, Gao, Jie, additional, Qin, Wanying, additional, Deng, Kangjian, additional, Ren, Liying, additional, She, Shaoping, additional, Xu, Wentao, additional, Yang, Yao, additional, Xie, Xingwang, additional, Liao, Weijia, additional, and Chen, Hongsong, additional

Published
2023
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9. Critical roles for CCR2 and the therapeutic potential of cenicriviroc in periodontitis: A pre‐clinical study

Author

Jiang, Wenting, primary, Xu, Tao, additional, Yuan, Shasha, additional, Wei, Yiping, additional, Song, Zhanming, additional, Li, Qingqing, additional, She, Shaoping, additional, Wang, Xuekang, additional, Wang, Cui, additional, Yang, Gang, additional, Cao, Jie, additional, Sun, Fei, additional, Shi, Meng, additional, Li, Siqi, additional, Liu, Zhongtian, additional, Mo, Yaqian, additional, Lv, Ping, additional, Zhang, Yu, additional, Wang, Ying, additional, and Hu, Wenjie, additional

Published
2022
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12. A signature based on NKG2D ligands to predict the recurrence of hepatocellular carcinoma after radical resection.

Author

Chen, Dongbo, Gao, Jie, Ren, Liying, Chen, Pu, Yang, Yao, She, Shaoping, Xie, Yong, Liao, Weijia, and Chen, Hongsong

Subjects
HEPATOCELLULAR carcinoma, LIGANDS (Biochemistry), RADICALS (Chemistry), GENE expression, PROTEIN expression
Abstract

Introduction: Due to the high recurrence, the HCC prognosis remains poor. Yet, the biomarkers for predicting the recurrence of high‐risk patients are currently lacking. We aimed to develop a signature to predict the recurrence of HCC based on NKG2D ligands. Methods: The multivariate Cox proportional hazards regression was used to select recurrence‐related variables of NKG2D ligands in HCC patients from The Cancer Genome Atlas (TCGA). HCC patients from the OEP000321 dataset and Guilin cohort were used to validate the predictive signature. The mRNA expression of NKG2D ligands was measured by QRT‐PCR. Immunohistochemistry analysis of HCC tissue microarray samples was used to identify the expression of NKG2D ligands. Results: In this study, NKG2D ligands expression in the mRNA and protein level was both abnormally expressed in HCC and associated with recurrence‐free survival (RFS). Then, the recurrence‐related variables of NKG2D ligands in HCC were selected by the multivariate Cox proportional hazards regression. Among the eight NKG2D ligands, MICA (HR = 1.347; 95% CI = 1.012–1.793; p = 0.041), ULBP3 (HR = 0.453; 95% CI = 0.231–0.889; p = 0.021) and ULBP5 (HR = 3.617; 95% CI = 1.819–7.194; p < 0.001) were significantly correlated with RFS in the TCGA‐LIHC cohort. Then, the signature was constructed by the three NKG2D ligands. The predictive effectiveness of this signature was also validated in the OEP000321 dataset and Guilin cohort. Further, HCC patients were classified into low‐risk and high‐risk subgroups by the predictive score. Compared with the low‐risk group, the high‐risk group had poor RFS in both training and validation cohorts. Importantly, compared with the low‐risk patients with the G1‐G2 stage, the levels of infiltrated NK‐activated cells and NKG2D expression were both lower in the high‐risk patients. Conclusions: The signature based on MICA, ULBP3, and ULBP5 could predict HCC recurrence. [ABSTRACT FROM AUTHOR]

Published
2023
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15. FAM19A5/TAFA5, a novel neurokine, plays a crucial role in depressive-like and spatial memory-related behaviors in mice

Author

Huang, Shiyang, primary, Zheng, Can, additional, Xie, Guoguang, additional, Song, Zhanming, additional, Wang, Pingzhang, additional, Bai, Yun, additional, Chen, Dixin, additional, Zhang, Yan, additional, Lv, Ping, additional, Liang, Weiwei, additional, She, Shaoping, additional, Li, Qingqing, additional, Liu, Zhongtian, additional, Wang, Yun, additional, Xing, Guo-Gang, additional, and Wang, Ying, additional

Published
2020
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16. PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target

Author

She, Shaoping, primary, Wu, Xiaoning, additional, Zheng, Danfeng, additional, Pei, Xiaolei, additional, Ma, Jing, additional, Sun, Yameng, additional, Zhou, Jialing, additional, Nong, Lin, additional, Guo, Changyuan, additional, Lv, Ping, additional, Song, Quansheng, additional, Zheng, Can, additional, Liang, Weiwei, additional, Huang, Shiyang, additional, Li, Qingqing, additional, Liu, Zhongtian, additional, Song, Zhanming, additional, Li, Yuzi, additional, Zhang, Yu, additional, Kong, Wei, additional, You, Hong, additional, Xi, Jianzhong, additional, and Wang, Ying, additional

Published
2020
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18. FAM19A1 is a new ligand for GPR1 that modulates neural stem‐cell proliferation and differentiation

Author

Zheng, Can, primary, Chen, Dixin, additional, Zhang, Yan, additional, Bai, Yun, additional, Huang, Shiyang, additional, Zheng, Danfeng, additional, Liang, Weiwei, additional, She, Shaoping, additional, Peng, Xinjian, additional, Wang, Pingzhang, additional, Mo, Xiaoning, additional, Song, Quansheng, additional, Lv, Ping, additional, Huang, Jing, additional, Ye, Richard D., additional, and Wang, Ying, additional

Published
2018
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20. PSMP, a novel chemotactic cytokine, triggers inflammatory Ly6ChiCCR2+ monocyte migration and promotes colitis in a CCR2-dependent manner

Author

She, Shaoping, primary, Pei, Xiaolei, additional, Zheng, Danfeng, additional, Ma, Jing, additional, Guo, Changyuan, additional, Zhang, Yan, additional, Peng, Xinjian, additional, Chen, Dixin, additional, Wang, Pingzhang, additional, Mo, Xiaoning, additional, Zhang, Yingmei, additional, Song, Quansheng, additional, Ma, Dalong, additional, and Wang, Ying, additional

Published
2016
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21. Identification of FAM3D as a novel endogenous chemotaxis agonist for the FPRs (formyl peptide receptors)

Author

Peng, Xinjian, primary, Xu, Enquan, additional, Liang, Weiwei, additional, Pei, Xiaolei, additional, Chen, Dixin, additional, Zheng, Danfeng, additional, Zhang, Yang, additional, Zheng, Can, additional, Wang, Pingzhang, additional, She, Shaoping, additional, Zhang, Yan, additional, Ma, Jing, additional, Mo, Xiaoning, additional, Zhang, Yingmei, additional, Ma, Dalong, additional, and Wang, Ying, additional

Published
2016
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22. Identification of FAM3D as a new endogenous chemotaxis agonist for the formyl peptide receptors.

Author

Peng X, Xu E, Liang W, Pei X, Chen D, Zheng D, Zhang Y, Zheng C, Wang P, She S, Zhang Y, Ma J, Mo X, Zhang Y, Ma D, and Wang Y

Subjects
Animals, Colitis genetics, Colitis pathology, Cytokines genetics, Dextran Sulfate toxicity, Extracellular Signal-Regulated MAP Kinases genetics, Extracellular Signal-Regulated MAP Kinases metabolism, HEK293 Cells, Humans, Mice, Monocytes pathology, Neutrophils pathology, Chemotaxis, Colitis metabolism, Cytokines metabolism, MAP Kinase Signaling System, Monocytes metabolism, Neutrophils metabolism, Receptors, Formyl Peptide agonists, Receptors, Formyl Peptide genetics, Receptors, Formyl Peptide metabolism, Receptors, Lipoxin agonists, Receptors, Lipoxin genetics, Receptors, Lipoxin metabolism
Abstract

The family with sequence similarity 3 (FAM3) gene family is a cytokine-like gene family with four members FAM3A, FAM3B, FAM3C and FAM3D. In this study, we found that FAM3D strongly chemoattracted human peripheral blood neutrophils and monocytes. To identify the FAM3D receptor, we used chemotaxis, receptor internalization, Ca(2+) flux and radioligand-binding assays in FAM3D-stimulated HEK293 cells that transiently expressed formyl peptide receptor (FPR)1 or FPR2 to show that FAM3D was a high affinity ligand of these receptors, both of which were highly expressed on the surface of neutrophils, and monocytes and macrophages. After being injected into the mouse peritoneal cavity, FAM3D chemoattracted CD11b+ Ly6G+ neutrophils in a short time. In response to FAM3D stimulation, phosphorylated ERK1/2 and phosphorylated p38 MAPK family proteins were upregulated in the mouse neutrophils, and this increase was inhibited upon treatment with an inhibitor of FPR1 or FPR2. FAM3D has been reported to be constitutively expressed in the gastrointestinal tract. We found that FAM3D expression increased significantly during colitis induced by dextran sulfate sodium. Taken together, we propose that FAM3D plays a role in gastrointestinal homeostasis and inflammation through its receptors FPR1 and FPR2., (© 2016. Published by The Company of Biologists Ltd.)

Published
2016
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