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1. Changes in the global hospitalisation burden of respiratory syncytial virus in young children during the COVID-19 pandemic: a systematic analysis

Author

Mrčela, Dina, Milić, Petra, Veljačić Visković, Daniela, Torres-Fernandez, David, Urchueguía, Arantxa, Díez-Domingo, Javier, Orrico-Sánchez, Alejandro, Walaza, Sibongile, Gottberg, Anne von, Reubenson, Gary, Dawood, Halima, Mekgoe, Omphile, Plessis, Mignon du, Baute, Neydis, Naby, Fathima, Keck, James W, Dobson, Jennifer, Hartman, Rachel, Sandoval, Marqia, Bressler, Sara S, Bruden, Dana, Karseladze, Irakli, Shchomak, Zakhar, Barreto, Rosário, Murunga, Nickson, Mutunga, Martin, Casalegno, Jean-Sebastien, Horvat, Come, Cong, Bingbing, Koç, Uğurcan, Bandeira, Teresa, Bassat, Quique, Bont, Louis, Chakhunashvili, Giorgi, Cohen, Cheryl, Desnoyers, Christine, Hammitt, Laura L, Heikkinen, Terho, Huang, Q Sue, Markić, Joško, Mira-Iglesias, Ainara, Moyes, Jocelyn, Nokes, D James, Ploin, Dominique, Seo, Euri, Singleton, Rosalyn, Wolter, Nicole, Fu Yung, Chee, Zar, Heather J, Feikin, Daniel R, Sparrow, Erin G, Nair, Harish, and Li, You

Published
2024
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2. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis

Author

Abram, Michael, Aerssens, Jeroen, Alafaci, Annette, Balmaseda, Angel, Bandeira, Teresa, Barr, Ian, Batinović, Ena, Beutels, Philippe, Bhiman, Jinal, Blyth, Christopher C, Bont, Louis, Bressler, Sara S, Cohen, Cheryl, Cohen, Rachel, Costa, Anna-Maria, Crow, Rowena, Daley, Andrew, Dang, Duc-Anh, Demont, Clarisse, Desnoyers, Christine, Díez-Domingo, Javier, Divarathna, Maduja, du Plessis, Mignon, Edgoose, Madeleine, Ferolla, Fausto Martín, Fischer, Thea K, Gebremedhin, Amanuel, Giaquinto, Carlo, Gillet, Yves, Hernandez, Roger, Horvat, Come, Javouhey, Etienne, Karseladze, Irakli, Kubale, John, Kumar, Rakesh, Lina, Bruno, Lucion, Florencia, MacGinty, Rae, Martinon-Torres, Federico, McMinn, Alissa, Meijer, Adam, Milić, Petra, Morel, Adrian, Mulholland, Kim, Mungun, Tuya, Murunga, Nickson, Newbern, Claire, Nicol, Mark P, Odoom, John Kofi, Openshaw, Peter, Ploin, Dominique, Polack, Fernando P, Pollard, Andrew J, Prasad, Namrata, Puig-Barberà, Joan, Reiche, Janine, Reyes, Noelia, Rizkalla, Bishoy, Satao, Shilpa, Shi, Ting, Sistla, Sujatha, Snape, Matthew, Song, Yanran, Soto, Giselle, Tavakoli, Forough, Toizumi, Michiko, Tsedenbal, Naranzul, van den Berge, Maarten, Vernhes, Charlotte, von Mollendorf, Claire, Walaza, Sibongile, Walker, Gregory, Li, You, Wang, Xin, Blau, Dianna M, Caballero, Mauricio T, Feikin, Daniel R, Gill, Christopher J, Madhi, Shabir A, Omer, Saad B, Simões, Eric A F, Campbell, Harry, Pariente, Ana Bermejo, Bardach, Darmaa, Bassat, Quique, Casalegno, Jean-Sebastien, Chakhunashvili, Giorgi, Crawford, Nigel, Danilenko, Daria, Do, Lien Anh Ha, Echavarria, Marcela, Gentile, Angela, Gordon, Aubree, Heikkinen, Terho, Huang, Q Sue, Jullien, Sophie, Krishnan, Anand, Lopez, Eduardo Luis, Markić, Joško, Mira-Iglesias, Ainara, Moore, Hannah C, Moyes, Jocelyn, Mwananyanda, Lawrence, Nokes, D James, Noordeen, Faseeha, Obodai, Evangeline, Palani, Nandhini, Romero, Candice, Salimi, Vahid, Satav, Ashish, Seo, Euri, Shchomak, Zakhar, Singleton, Rosalyn, Stolyarov, Kirill, Stoszek, Sonia K, von Gottberg, Anne, Wurzel, Danielle, Yoshida, Lay-Myint, Yung, Chee Fu, Zar, Heather J, and Nair, Harish

Published
2022
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3. Endobronchial lesion in a premature neonate.

Author

Shchomak, Zakhar, Oliveira, Lia, Saianda, Ana, and Bandeira, Teresa

Abstract

Endobronchial and endotracheal tumours are rare in the paediatric population, especially in neonates. The common presentation is respiratory distress with persistent lung collapse or hyperinflation. Treatment usually involves endoscopic or surgical lobar resection. This case presents a preterm neonate who developed acute respiratory distress with persistent right upper lobe atelectasis. A flexible bronchoscopy showed a pediculate violaceous endobronchial lesion in the right main bronchus. Endoscopic resection was not possible due to the patient’s low weight and the decision was made to support the patient with continuous positive airway pressure (CPAP) at home, while monitoring her closely. Remarkably, the lesion spontaneously resolved, and CPAP support was discontinued successfully. The case emphasises the importance of early bronchoscopy, continuous monitoring and the possibility of using CPAP support until conditions are reunited for an eventual resection. This unique case also demonstrates the potential for spontaneous resolution in some cases. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2019:a systematic analysis

Author

Li, You, Wang, Xin, Blau, Dianna, Caballero, Mauricio, Feikin, Daniel R., Gill, Christopher, Madhi, Shabir A., Omer, Saad B, Simoes, Eric A. F., Campbell, Harry, Bermejo Pariente, Ana, Bardach, Darmaa, Bassat, Quique, Casalegno, Jean-Sebastien, Chakhunashvili, Giorgi, Crawford, NIgel, Danilenko, Daria, Do, Anh N., Echavarria, Marcela, Gentile, Angela, Gordon, Aubree, Heikkinen, Terho, Huang, Sue, Jullien, Sophie, Krishnan, Anand, Lopez, E., Markic, JOsko, Mira-Iglesias , Ainara, Moore, Hannah, Moyes, Jocelyn, Mwananyanda, Lawrence, Nokes, D. James, Noordeen, Faseeha, Obodai, Evangeline, Palani, Nandhini, Romero, Candice, Salimi, Vahid, Satav, Ashish, Seo, Euri, Shchomak, Zakhar, Singleton, Rosalyn, Stolyarov, Kirill, Stoszek, Sonia, von Gottberg, Anne, Wurzel, Danielle, Yoshida, Lay-Myint, Yung, Chee Fu, Zar, Heather, and Nair, Harish

Subjects
Hospitalization, Cost of Illness, Child, Preschool, Respiratory Syncytial Virus, Human, Humans, Infant, Hospital Mortality, Respiratory Tract Infections/epidemiology, Child, Global Health, Respiratory Syncytial Virus Infections/epidemiology
Abstract

BACKGROUND: Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory infection in young children. We previously estimated that in 2015, 33·1 million episodes of RSV-associated acute lower respiratory infection occurred in children aged 0-60 months, resulting in a total of 118 200 deaths worldwide. Since then, several community surveillance studies have been done to obtain a more precise estimation of RSV associated community deaths. We aimed to update RSV-associated acute lower respiratory infection morbidity and mortality at global, regional, and national levels in children aged 0-60 months for 2019, with focus on overall mortality and narrower infant age groups that are targeted by RSV prophylactics in development.METHODS: In this systematic analysis, we expanded our global RSV disease burden dataset by obtaining new data from an updated search for papers published between Jan 1, 2017, and Dec 31, 2020, from MEDLINE, Embase, Global Health, CINAHL, Web of Science, LILACS, OpenGrey, CNKI, Wanfang, and ChongqingVIP. We also included unpublished data from RSV GEN collaborators. Eligible studies reported data for children aged 0-60 months with RSV as primary infection with acute lower respiratory infection in community settings, or acute lower respiratory infection necessitating hospital admission; reported data for at least 12 consecutive months, except for in-hospital case fatality ratio (CFR) or for where RSV seasonality is well-defined; and reported incidence rate, hospital admission rate, RSV positive proportion in acute lower respiratory infection hospital admission, or in-hospital CFR. Studies were excluded if case definition was not clearly defined or not consistently applied, RSV infection was not laboratory confirmed or based on serology alone, or if the report included fewer than 50 cases of acute lower respiratory infection. We applied a generalised linear mixed-effects model (GLMM) to estimate RSV-associated acute lower respiratory infection incidence, hospital admission, and in-hospital mortality both globally and regionally (by country development status and by World Bank Income Classification) in 2019. We estimated country-level RSV-associated acute lower respiratory infection incidence through a risk-factor based model. We developed new models (through GLMM) that incorporated the latest RSV community mortality data for estimating overall RSV mortality. This review was registered in PROSPERO (CRD42021252400).FINDINGS: In addition to 317 studies included in our previous review, we identified and included 113 new eligible studies and unpublished data from 51 studies, for a total of 481 studies. We estimated that globally in 2019, there were 33·0 million RSV-associated acute lower respiratory infection episodes (uncertainty range [UR] 25·4-44·6 million), 3·6 million RSV-associated acute lower respiratory infection hospital admissions (2·9-4·6 million), 26 300 RSV-associated acute lower respiratory infection in-hospital deaths (15 100-49 100), and 101 400 RSV-attributable overall deaths (84 500-125 200) in children aged 0-60 months. In infants aged 0-6 months, we estimated that there were 6·6 million RSV-associated acute lower respiratory infection episodes (4·6-9·7 million), 1·4 million RSV-associated acute lower respiratory infection hospital admissions (1·0-2·0 million), 13 300 RSV-associated acute lower respiratory infection in-hospital deaths (6800-28 100), and 45 700 RSV-attributable overall deaths (38 400-55 900). 2·0% of deaths in children aged 0-60 months (UR 1·6-2·4) and 3·6% of deaths in children aged 28 days to 6 months (3·0-4·4) were attributable to RSV. More than 95% of RSV-associated acute lower respiratory infection episodes and more than 97% of RSV-attributable deaths across all age bands were in low-income and middle-income countries (LMICs).INTERPRETATION: RSV contributes substantially to morbidity and mortality burden globally in children aged 0-60 months, especially during the first 6 months of life and in LMICs. We highlight the striking overall mortality burden of RSV disease worldwide, with one in every 50 deaths in children aged 0-60 months and one in every 28 deaths in children aged 28 days to 6 months attributable to RSV. For every RSV-associated acute lower respiratory infection in-hospital death, we estimate approximately three more deaths attributable to RSV in the community. RSV passive immunisation programmes targeting protection during the first 6 months of life could have a substantial effect on reducing RSV disease burden, although more data are needed to understand the implications of the potential age-shifts in peak RSV burden to older age when these are implemented.FUNDING: EU Innovative Medicines Initiative Respiratory Syncytial Virus Consortium in Europe (RESCEU).

Published
2022

6. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis

Author

Li, You, primary, Wang, Xin, additional, Blau, Dianna M, additional, Caballero, Mauricio T, additional, Feikin, Daniel R, additional, Gill, Christopher J, additional, Madhi, Shabir A, additional, Omer, Saad B, additional, Simões, Eric A F, additional, Campbell, Harry, additional, Pariente, Ana Bermejo, additional, Bardach, Darmaa, additional, Bassat, Quique, additional, Casalegno, Jean-Sebastien, additional, Chakhunashvili, Giorgi, additional, Crawford, Nigel, additional, Danilenko, Daria, additional, Do, Lien Anh Ha, additional, Echavarria, Marcela, additional, Gentile, Angela, additional, Gordon, Aubree, additional, Heikkinen, Terho, additional, Huang, Q Sue, additional, Jullien, Sophie, additional, Krishnan, Anand, additional, Lopez, Eduardo Luis, additional, Markić, Joško, additional, Mira-Iglesias, Ainara, additional, Moore, Hannah C, additional, Moyes, Jocelyn, additional, Mwananyanda, Lawrence, additional, Nokes, D James, additional, Noordeen, Faseeha, additional, Obodai, Evangeline, additional, Palani, Nandhini, additional, Romero, Candice, additional, Salimi, Vahid, additional, Satav, Ashish, additional, Seo, Euri, additional, Shchomak, Zakhar, additional, Singleton, Rosalyn, additional, Stolyarov, Kirill, additional, Stoszek, Sonia K, additional, von Gottberg, Anne, additional, Wurzel, Danielle, additional, Yoshida, Lay-Myint, additional, Yung, Chee Fu, additional, Zar, Heather J, additional, Nair, Harish, additional, Abram, Michael, additional, Aerssens, Jeroen, additional, Alafaci, Annette, additional, Balmaseda, Angel, additional, Bandeira, Teresa, additional, Barr, Ian, additional, Batinović, Ena, additional, Beutels, Philippe, additional, Bhiman, Jinal, additional, Blyth, Christopher C, additional, Bont, Louis, additional, Bressler, Sara S, additional, Cohen, Cheryl, additional, Cohen, Rachel, additional, Costa, Anna-Maria, additional, Crow, Rowena, additional, Daley, Andrew, additional, Dang, Duc-Anh, additional, Demont, Clarisse, additional, Desnoyers, Christine, additional, Díez-Domingo, Javier, additional, Divarathna, Maduja, additional, du Plessis, Mignon, additional, Edgoose, Madeleine, additional, Ferolla, Fausto Martín, additional, Fischer, Thea K, additional, Gebremedhin, Amanuel, additional, Giaquinto, Carlo, additional, Gillet, Yves, additional, Hernandez, Roger, additional, Horvat, Come, additional, Javouhey, Etienne, additional, Karseladze, Irakli, additional, Kubale, John, additional, Kumar, Rakesh, additional, Lina, Bruno, additional, Lucion, Florencia, additional, MacGinty, Rae, additional, Martinon-Torres, Federico, additional, McMinn, Alissa, additional, Meijer, Adam, additional, Milić, Petra, additional, Morel, Adrian, additional, Mulholland, Kim, additional, Mungun, Tuya, additional, Murunga, Nickson, additional, Newbern, Claire, additional, Nicol, Mark P, additional, Odoom, John Kofi, additional, Openshaw, Peter, additional, Ploin, Dominique, additional, Polack, Fernando P, additional, Pollard, Andrew J, additional, Prasad, Namrata, additional, Puig-Barberà, Joan, additional, Reiche, Janine, additional, Reyes, Noelia, additional, Rizkalla, Bishoy, additional, Satao, Shilpa, additional, Shi, Ting, additional, Sistla, Sujatha, additional, Snape, Matthew, additional, Song, Yanran, additional, Soto, Giselle, additional, Tavakoli, Forough, additional, Toizumi, Michiko, additional, Tsedenbal, Naranzul, additional, van den Berge, Maarten, additional, Vernhes, Charlotte, additional, von Mollendorf, Claire, additional, Walaza, Sibongile, additional, and Walker, Gregory, additional

Published
2022
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7. Global, Regional, and National Disease Burden Estimates of Acute Lower Respiratory Infections Due to Respiratory Syncytial Virus in Young Children in 2019: A Systematic Analysis

Author

Li, You, primary, Wang, Xin, additional, Blau, Dianna M., additional, Caballero, Mauricio T., additional, Feikin, Daniel, additional, Gill, Christopher John, additional, Madhi, Shabir Ahmed, additional, Omer, Saad B., additional, Simões, Eric A.F., additional, Campbell, Harry, additional, Bermejo Pariente, Ana, additional, Bardach, Darmaa, additional, Bassat, Quique, additional, Casalegno, Jean-Sebastien, additional, Chakhunashvili, Giorgi, additional, Crawford, Nigel W., additional, Danilenko, Daria, additional, Do, Lien Anh Ha, additional, Echavarria, Marcela, additional, Gentile, Angela, additional, Gordon, Aubree, additional, Heikkinen, Terho, additional, Huang, Sue, additional, Jullien, Sophie, additional, Krishnan, Anand, additional, López, Eduardo Luis, additional, Markić, Joško, additional, Mira-Iglesias, Ainara, additional, Moore, Hannah C., additional, Moyes, Jocelyn, additional, Mwananyanda, Lawrence, additional, Nokes, D. James, additional, Noordeen, Faseeha, additional, Obodai, Evangeline, additional, Palani, Nandhini, additional, Romero, Candice, additional, Salimi, Vahid, additional, SATAV, ASHISH RAMBHAU, additional, Seo, Euri, additional, Shchomak, Zakhar, additional, Singleton, Rosalyn, additional, Stolyarov, Kirill, additional, Stoszek, Sonia K., additional, Von Gottberg, Ann, additional, Wurzel, Danielle, additional, Yoshida, Lay-Myint, additional, Yung, Chee Fu, additional, Zar, Heather, additional, Network Group, Respiratory Virus Global Epidemiolo, additional, Nair, Harish, additional, and Group, RESCEU Investigators, additional

Published
2022
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10. Surgical treatment of neovascular glaucoma : a systematic review and meta-analysis

Author

Shchomak, Zakhar and Pinto, Luís Alexandre Pereira Abegão

Subjects
Implante de Baerveldt, Cirurgia de implante de válvula de drenagem, Oftalmologia, Válvula de Ahmed, Ciências Médicas [Domínio/Área Científica], Tratamento cirúrgico, Glaucoma neovascular
Abstract

Trabalho Final do Curso de Mestrado Integrado em Medicina, Faculdade de Medicina, Universidade de Lisboa, 2017 Submitted by Biblioteca da Faculdade de Medicina da Universidade de Lisboa (repositorio@medicina.ulisboa.pt) on 2018-06-22T13:41:49Z No. of bitstreams: 1 ZakharShchomak.pdf: 949089 bytes, checksum: 85ad95d264136cdc2159a2a34cd93b40 (MD5) Made available in DSpace on 2018-07-17T10:42:32Z (GMT). No. of bitstreams: 1 ZakharShchomak.pdf: 949089 bytes, checksum: 85ad95d264136cdc2159a2a34cd93b40 (MD5) Previous issue date: 2017

Published
2017

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