34 results on '"Shaya M"'
Search Results
2. Major histocompatibility class I antigens in the Lebanese population
- Author
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Salti, N. N., primary and Shaya, M., additional
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- 2021
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3. Limited mobility of dioxins near San Jacinto super fund site (waste pit) in the Houston Ship Channel, Texas due to strong sediment sorption
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Gerard Cornelissen, Shaya M. Seward, Kevin M. Yeager, Peter H. Santschi, Robin Brinkmeyer, Hans Petter Heinrich Arp, and Patrick Louchouarn
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Geologic Sediments ,Polychlorinated Dibenzodioxins ,010504 meteorology & atmospheric sciences ,Financial Management ,Health, Toxicology and Mutagenesis ,010501 environmental sciences ,Toxicology ,Dioxins ,01 natural sciences ,Sedimentary depositional environment ,chemistry.chemical_compound ,Pore water pressure ,Rivers ,Polycyclic Aromatic Hydrocarbons ,Ships ,0105 earth and related environmental sciences ,Levoglucosan ,Sediment ,Sorption ,General Medicine ,Contamination ,Pollution ,Texas ,Carbon ,chemistry ,Environmental chemistry ,Hazardous Waste Sites ,Petroleum ,Environmental science ,Bay ,Water Pollutants, Chemical ,Environmental Monitoring - Abstract
Sediments from a waste pit in Houston Ship Channel (HSC) were characterized using a number of molecular markers of natural organic matter fractions (e.g., pyrogenic carbon residues, PAHs, lignins), in addition to dioxins, in order to test the hypothesis that the dispersal and mobility of dioxins from the waste pit in the San Jacinto River is minimal. Station SG-6, sampled at the site of the submerged waste pit, had the highest dioxin/furan concentrations reported for the Houston Ship Channel/Galveston Bay (HSC/GB) system (10,000e46,000 pg/g), which translated into some of the highest reported World Health Organization Toxic Equivalents (TEQs: 2000e11,000 pg/g) in HSC sediments. Using a multi-tracer approach, this study confirmed our hypothesis that sludges from chlorinated pulps are a very likely source of dioxins/furans to this pit. However, this material also contained large quantities of additional hydrophobic organic contaminants (PAHs) and pyrogenic markers (soot-BC, levoglucosan), pointing to the co-occurrence of petroleum hydrocarbons and combustion byproducts. Comparison of dioxin/furan signatures in the waste pit with those from sediments of the HSC and a control site suggests that the remobilization of contaminated particles did not occur beyond the close vicinity of the pit itself. The dioxins/furans in sediments outside the waste pit within the HSC are rather from other diffuse inputs, entering the sedimentary environment through the air and water, and which are comprised of a mixture of industrial and municipal sources. Fingerprinting of waste pit dioxins indicates that their composition is typical of pulp and paper sources. Measured pore water concentrations were 1 order of magnitude lower than estimated values, calculated from a multiphase sorption model, indicating low mobility of dioxins within the waste pit. This is likely accomplished by co-occurring and strong sorbing pyrogenic and petrogenic residues in the waste pit, which tend to keep dioxins strongly sorbed to particles. © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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- 2018
4. Limited mobility of dioxins near San Jacinto super fund site (waste pit) in the Houston Ship Channel, Texas due to strong sediment sorption
- Author
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Louchouarn, Patrick, primary, Seward, Shaya M., additional, Cornelissen, Gerard, additional, Arp, Hans Peter H., additional, Yeager, Kevin M., additional, Brinkmeyer, Robin, additional, and Santschi, Peter H., additional
- Published
- 2018
- Full Text
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5. Analysis of lignin-derived phenols in standard reference materials and ocean dissolved organic matter by gas chromatography/tandem mass spectrometry
- Author
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Noah White, Shuiwang Duan, Rainer M. W. Amon, Shaya M. Seward, Patrick Louchouarn, and Christina Pondell
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Total organic carbon ,Chromatography ,Gas Chromatography/Tandem Mass Spectrometry ,General Chemistry ,Oceanography ,Mass spectrometry ,Tandem mass spectrometry ,chemistry.chemical_compound ,chemistry ,Environmental chemistry ,Dissolved organic carbon ,Environmental Chemistry ,Lignin ,Gas chromatography ,Phenols ,Water Science and Technology - Abstract
A series of reference materials are proposed for intercomparison and quality control purposes during the quantification of lignin oxidation products (LOP) from diverse environmental matrices. These materials are all easily accessible and certified for diverse organic constituents (NIST and IHSS). They represent a suite of natural environmental matrices (from solids to aqueous) and are characterized by a wide range of organic carbon and lignin concentrations with abundant proportions of all major LOP. The variability of LOP concentrations and signatures for all these materials averages 3–5% and does not exceed 10%. Using these standards, a new quantification method was developed and validated for the determination of low-level CuO oxidation products using capillary gas chromatography–tandem mass spectrometry (GC/MS–MS). Tandem mass spectrometry provides both the high sensitivity and selectivity required for the identification and quantification of trace levels of dissolved lignin. The method is particularly useful for removing interference from co-eluting isotopes generated from the DOM matrix and during glucose amendment procedures of low-carbon samples. Such glucose amendment is not necessary, however, when the CuO to organic carbon weight-to-weight ratio can be kept at a value
- Published
- 2010
6. Novel N-substituted indole hydrazones as potential antiplatelet agents: synthesis, biological evaluations, and molecular docking studies
- Author
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Navid Tavili, Shaya Mokhtari, Hafezeh Salehabadi, Marjan Esfahanizadeh, and Shohreh Mohebbi
- Subjects
antiplatelet aggregation ,indole ,synthesis ,turbidimetric assay. ,Pharmacy and materia medica ,RS1-441 - Abstract
Background and purpose: Antiplatelet agents can diminish the chance of coronary heart diseases due to the prevention of unusual clotting in the arteries by inhibiting platelet aggregation and avoiding the formation of a blood clot. This mechanism can help to prevent ischemic stroke likewise. To improve the activity of these drugs and reduce their side effects, further studies are required. Experimental approach: Based on the previous studies representing the promising antiplatelet activity of indole hydrazones, a series of their homologs containing twenty-one compounds were prepared in two steps. First, alkylation reaction on the nitrogen of the indole ring, and second, chiff base formation by condensation of a primary amine and N-substituted indole-3 carbaldehyde. Consequently, their platelet anti-aggregation activity was evaluated based on the Born turbidimetric method. Findings/Results: Most of the compounds exhibited noticeable activity against platelet aggregation induced by arachidonic acid. Amongst them, two compounds 2e and 2f showed higher activity with IC50 values that made comparable to indomethacin and acetylsalicylic acid as standard drugs and had no toxicity on platelets. Conclusion and implications: The synthesized compounds exhibited promising activity against arachidonic acid-induced aggregation; however, none of them showed noticeable antiplatelet activity induced by adenosine di-phosphate. Chemical structure comparison of the prepared derivatives indicated the existence of a lipophilic medium-sized group on the phenyl ring increased their activity. In addition, the docking studies confirmed this hydrophobic interaction in the lipophilic pocket of cyclooxygenase-1 enzyme suggesting that hydrophobicity of this region plays a pivotal role in the anti-platelet activity of these compounds. To prove this finding, the enzymatic evaluation with the target enzyme is required.
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- 2022
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7. Role of phosphatidylinositol 3‐kinase signaling pathway in radiation‐induced liver injury
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Lei Xiao, Hua Zhang, Xin Yang, Shaya Mahati, Ge Wu, Yiliyaer Xiaheding, Yong‐Xing Bao, and Hui Xiao
- Subjects
hepatic stellate cells ,PI3K/Akt pathway ,radiation‐induced liver injury ,TGF‐β1 ,Medicine (General) ,R5-920 - Abstract
Abstract Transforming growth factor‐β1 (TGF‐β1) is one of critical cytokines in radiation‐induced liver injury. Hepatic stellate cells (HSC) are activated in the early stage of radiation‐induced liver injury. However, it is currently unclear whether phosphatidylinositol 3‐kinase (PI3K/Akt) signal pathway is activated in radiation‐induced liver injury. Herein, male Sprague‐Dawley rats were irradiated with 6 MV X‐rays (30 Gy) on the right liver. Next, Hematoxylin and eosin staining, Masson staining, and electron microscopy were performed to examine pathological changes. Immunohistochemistry was performed to assess the expression of TGF‐β1, α‐SMA, and p‐Akt (S473) in liver tissues. In vitro, rat HSC cell line HSC‐T6 cells were given different doses of 6 MV X‐ray irradiation (10 and 20 Gy) and treated with LY294002. The expression of α‐SMA and p‐Akt in mRNA and protein levels were measured by reverse transcription‐polymerase chain reactioin (RT‐PCR) and Western blot. TGF‐β1 expression was detected by enzyme‐linked immuno sorbent assay (ELISA). After irradiation, the liver tissues showed obvious pathological changes, indicating the establishment of the radiation‐induced liver injury. Expression levels of TGF‐β1, α‐SMA, and p‐Akt (S473) protein in liver tissues were significantly increased after irradiation, and this increase was in a time‐dependent manner, suggesting the activation of HSC and PI3K/Akt signal pathway. in vitro experiments showed that the TGF‐β1 secreted by HSCs, and the expression of Akt and α‐SMA at mRNA and protein levels were significantly increased in irradiation groups. However, the expression of TGF‐β1, Akt, and α‐SMA were significantly decreased in PI3K/Akt signal pathway inhibitor LY294002‐treated group. Our results suggest that during radiation‐induced liver injury, HSCs are activated by TGF‐β1‐mediated PI3K/Akt signal pathway.
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- 2020
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8. Delivery of miR-26a Using an Exosomes-Based Nanosystem Inhibited Proliferation of Hepatocellular Carcinoma
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Shaya Mahati, Xiangjun Fu, Xuexian Ma, Hua Zhang, and Lei Xiao
- Subjects
drug delivery ,Glypican 3 ,exosomes ,miR-26a ,nanosystem ,Biology (General) ,QH301-705.5 - Abstract
Background: MicroRNA (abbreviated miRNA)-based treatment holds great promise for application as clinical antitumor therapy, but good carriers for delivery of the miRNA drug are lacking. Exosomes secreted by mesenchymal stem cells (MSCs) have proved to be safe, and exogenously modified exosomes may potentially represent an excellent drug delivery vehicle.Methods: In this study, we designed a delivery nano system using single-stranded variable fragment (scFv)-modified exosomes derived from human cord blood MSCs. Genetic engineering technology was used to obtain anti-Glypican 3 (GPC3) scFv-modified exosomes, which were then loaded with miR-26a mimics through electroporation.Results: Results of electron microscopy and dynamic light scattering indicated that the diameter of the drug-carrying exosomes was about 160 nm. Furthermore, anti-GPC3 scFv-modified exosomes effectively delivered miR-26a to GPC3-positive hepatocellular carcinoma cells, thereby inhibiting cell proliferation and migration by regulating the expression of downstream target genes of miR-26a. The exosomes-based nano system displayed favorable anti-tumor effect in vivo with no obvious side effects.Conclusion: Our data provided a new perspective for the use of exosome delivery systems for miRNA-based antitumor therapy.
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- 2021
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9. The Tumorigenic Properties of EZH2 are Mediated by MiR-26a in Uveal Melanoma
- Author
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Yao Li, Mingmei Zhang, Huayin Feng, and Shaya Mahati
- Subjects
microRNA-26a ,EZH2 ,uveal melanoma ,tumor progression ,cell proliferation ,Biology (General) ,QH301-705.5 - Abstract
Background: The polycomb group protein enhancer of zeste homolog 2 (EZH2) has been found to be highly expressed in various tumors, and microRNA-26a (miR-26a) is often unmodulated in cancers. However, the functions of these two molecules in uveal melanoma (UM) and their relationships have not been reported.Methods: We explored the effects of the miR-26a–EZH2 axis in UM by examining the levels of miR-26a and EZH2. The EZH2 levels in various tumor types and the correlations between EZH2 levels and overall survival and disease-free survival were reanalyzed. The binding of miR-26a to the 3′-untranslated region of EZH2 mRNA was measured using the luciferase reporter assay. The regulation of EZH2 gene expression by miR-26a was also identified, and the effect of elevated EZH2 expression on UM cell function was further examined. Results: miR-26a was downregulated and EZH2 was upregulated in UM cells. Overexpression of miR-26a inhibited cell proliferation, and knockdown of EZH2 suppressed cell growth. EZH2 was a direct target of miR-26a in UM cells. The knockout of EZH2 mimicked the tumor inhibition of miR-26a in UM cells, whereas the reintroduction of EZH2 abolished this effect. In addition, a network of EZH2 and its interacting proteins (UBC, CDK1, HDAC1, SUZ12, EED) was found to participate in miR-26a-mediated tumor progression.Conclusion: The newly identified miR-26a–EZH2 axis may be a potential target for the development of treatment strategies for UM.
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- 2021
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10. Mortality risk assessment of maternal birth complications
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Grisaru-Granovsky, S, primary, Shaya, M, additional, Hersch, M, additional, and Samueloff, A, additional
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- 2003
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11. A sero-epidemiological study of herpes virus type 1 and 2 infection in Israel
- Author
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Isacsohn, M., Smetana, Z., Rones, Z. Z., Raveh, D., Diamant, Y., Samueloff, A., Shaya, M., Mendelson, E., Slater, P., and Rudenski, B.
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- 2002
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12. Mortality risk assessment of maternal birth complications
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Grisaru-Granovsky, S., Shaya, M., Hersch, M., and Samueloff, A.
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- 2004
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13. Making meaning of narratives: Everyday life philosophers (book review)
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Shaya M
- Published
- 2000
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14. Impression of the stomach wall at gastroscopy may be due to giant a. lienalis aneurysm.
- Author
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Shaya M and Løve US
- Subjects
- Female, Humans, Aged, Stomach, Tomography, X-Ray Computed, Abdomen, Gastroscopy, Aneurysm diagnostic imaging
- Abstract
Splenic artery aneurysms are rare but can be fatal. The majority are asymptomatic and small (less-than 2cm). The diagnosis is often incidental on abdominal CT, but this case report presents of a 78-year-old woman who was diagnosed with a splenic artery aneurysm through a gastroscopy. The posterior gastric wall in the fundus-corpus junction showed a 7 cm area that was bulging into the lumen. The subsequent CT showed a gigantic splenic artery aneurysm measuring 9 cm in diameter. EUS is recommended because it has a high precision in diagnosing subepithelial lesions compared to abdominal CT scan.
- Published
- 2023
15. Varenicline Treatment for Waterpipe Smoking Cessation.
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Chami HA, Zaouk N, Makki M, Tamim H, Shaya M, and Talih F
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- Female, Humans, Adult, Male, Varenicline therapeutic use, Carbon Monoxide, Cotinine, Nicotinic Agonists therapeutic use, Smoking Cessation, Water Pipe Smoking
- Abstract
Background: Waterpipe smoking is increasing worldwide with no proven interventions for cessation. We compared abstinence rates with 12-week varenicline therapy versus placebo among habitual waterpipe smokers willing to quit., Methods: This double-blind placebo-controlled single-center trial, randomized waterpipe smokers from Lebanon who did not smoke other tobacco products to receive varenicline or placebo for 12 weeks. All participants also received three structured 30-minute individual behavioral intervention sessions. The primary outcome was repeated point prevalence abstinence assessed by self-report and verified by exhaled carbon monoxide three times during 12 weeks and analyzed with the intention to treat. End of treatment urine cotinine, weight, blood pressure, anxiety, depression, withdrawal, and adverse symptoms were also assessed., Results: In total, 152 waterpipe smokers (mean age 38 years [SD = 13], 39% females) willing to quit, who smoked waterpipe exclusively (average 2.3 per day [SD = 1.6] for 16.8 years [SD = 10.8]) were randomized. Seventy-nine participants (52%) with any missing abstinence assessment were considered to have relapsed. Repeat point prevalence abstinence rate was numerically higher among the varenicline group compared to placebo, but the difference did not reach statistical significance when assessed by self-report (16.9 vs. 13.6%, respectively, p = .6) and when further verified by exhaled carbon monoxide (14.1% vs. 9.9%, respectively, p = .4). Abstinence rates were similar in both groups when further verified by urine cotinine at end of treatment. No serious adverse events were reported, adverse symptoms and other outcomes were similar in the varenicline and placebo arms., Conclusions: Varenicline for 12 weeks was not more effective than placebo to achieve abstinence among daily waterpipe smokers., Implications: Varenicline in combination with a behavioral intervention did not significantly enhance the quit rate among exclusive waterpipe smokers compared to behavioral intervention plus placebo. We experienced difficulty enrolling exclusive waterpipe smokers willing to quit and observed high dropout rates among participants demonstrating the difficulties of waterpipe smoking cessation., (© The Author(s) 2022. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
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- 2023
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16. A circular RNA derived from GLIS3 accelerates the proliferation of glioblastoma cells through competitively binding with miR-449c-5p to upregulate CAPG and GLIS3.
- Author
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Zhou Q, Shaya M, Kugeluke Y, Fu Q, Li S, and Dilimulati Y
- Subjects
- Cell Proliferation genetics, DNA-Binding Proteins, Humans, Microfilament Proteins, Nuclear Proteins, Repressor Proteins, Trans-Activators, Brain Neoplasms metabolism, Glioblastoma genetics, MicroRNAs genetics, MicroRNAs metabolism, RNA, Circular metabolism
- Abstract
Background: Glioblastoma (GBM) is an aggressive and malignant brain tumor with extremely poor prognosis. Despite advances in treatment, the pathogenesis of GBM remains elusive. Mounting studies have revealed the critical role of circular RNAs (circRNAs) in the development and progression of human cancers including GBM, but the comprehension of their functions is still insufficient. In this study, we investigated the expression profile of a circRNA derived from GLIS family zinc finger 3 (GLIS3) in GBM and normal astrocytes. CircGLIS3 expression was detected through quantitative real-time polymerase chain reaction (qRT-PCR) analysis. Functional experiments were performed to analyze the influence of circGLIS3 on GBM cell proliferation and apoptosis. In addition, mechanism assays were to uncover the potential regulatory mechanism of circGLIS3., Results: CircGLIS3 was up-regulated in GBM cells and knockdown of circGLIS3 significantly hampered proliferation and promoted apoptosis of GBM cells. Furthermore, circGLIS3 positively regulated CAPG and GLIS3 by sponging miR-449c-5p to affect GBM cell proliferation and apoptosis., Conclusions: In summary, our study identified that circGLIS3 could promote proliferation and inhibit apoptosis of GBM cells via targeting miR-449c-5p/GLIS3/CAPG axis in vitro. This study could offer a novel molecular perspective for further investigation into mechanisms essential to GBM progression., (© 2022. The Author(s).)
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- 2022
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17. Knockdown of circ_0055412 promotes cisplatin sensitivity of glioma cells through modulation of CAPG and Wnt/β-catenin signaling pathway.
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Zhou Q, Fu Q, Shaya M, Kugeluke Y, Li S, and Dilimulati Y
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- Animals, Cell Line, Tumor, Cell Proliferation genetics, Cisplatin metabolism, Cisplatin pharmacology, Cisplatin therapeutic use, Gene Expression Regulation, Neoplastic, RNA, Messenger, Wnt Signaling Pathway genetics, beta Catenin metabolism, Glioma drug therapy, Glioma genetics, MicroRNAs genetics, MicroRNAs metabolism
- Abstract
Introduction: Glioma is the most frequent primary cerebral tumor in adults. Recent evidence has suggested that circular RNAs (circRNAs) are associated with the pathological processes in glioma. In our study, we aimed to investigate the function and mechanism of circ_CAPG (circ_0055412) in glioma., Methods: Firstly, circ_0055412 expression was examined through RT-qPCR analysis. Loss-of-function assays and animal experiments were implemented to evaluate the role of circ_0055412 on cisplatin resistance of glioma cells. Moreover, mechanism assays were done to probe into the regulatory mechanism of circ_0055412 in glioma cells., Results: Circ_0055412 was found to be notably upregulated in glioma cells. Moreover, depletion of circ_0055412 enhanced cisplatin sensitivity of glioma cells in vitro and in vivo. Moreover, circ_0055412 recruited eukaryotic translation initiation factor 4A3 (EIF4A3) protein to stabilize capping actin protein, gelsolin like (CAPG) mRNA. Furthermore, circ_0055412 served as a sponge for microRNA-330-3p (miR-330-3p) and regulated nuclear factor of activated T cells 3 (NFATC3) expression to activate the transcription of catenin beta 1 (CTNNB1), thus participating in the activation of Wnt/β-catenin signaling pathway., Conclusion: Circ_0055412 contributed to cisplatin resistance of glioma cells via stabilizing CAPG mRNA and modulating Wnt/β-catenin signaling pathway. This finding might provide novel information for the treatment of glioma., (© 2022 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd.)
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- 2022
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18. Analysis of clinical characteristics of macrophage capping protein (CAPG) gene expressed in glioma based on TCGA data and clinical experiments.
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Fu Q, Shaya M, Li S, Kugeluke Y, Dilimulati Y, Liu B, and Zhou Q
- Abstract
Macrophage capping protein (CAPG) genes were investigated based on The Cancer Genome Atlas (TCGA) database and clinical experiments. Glioblastoma (GBM) genes expression profiling chip of 529 disease samples and 10 normal samples selected from TCGA database were used for analysis, 25 brain glioma tissue samples and 15 normal brain tissues were collected in the Department of Neurosurgery of the First Affiliated Hospital of Xinjiang Medical University in China from 2016 to 2017 to analyze CAPG genes. TCGA results showed that the expression level of CAPG genes in GBM was higher than that in normal tissues, and the expression level of men, aged over 46 years and high grade gliomas in pathological stages was higher than that of women, aged ≤46 and low grade gliomas in pathological stages, and the survival time of high expression was shorter than that of low expression. The expression level of CAPG in glioma tissues was higher than that in normal tissues, and the expression level of CAPG in males was higher than that in females, as males had lymphatic transfer and low differentiation compared with females, but the expression level was not related to age. Survival analysis showed that higher expression level indicated shorter survival time, they were positively correlated. The expression of CAPG in glioma is high, and it is highly expressed with the severity of the disease, and it is also obviously related to the prognosis. Therefore, CAPG could be used as a biomarker for pathological grade and prognosis in glioma. However, the related studies are not consistent on the expression of different sex and ages, so further study is needed.
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- 2019
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19. Maternal and neonatal outcomes following a proactive peripartum multidisciplinary management protocol for placenta creta spectrum as compared to the urgent delivery.
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Stanleigh J, Michaeli J, Armon S, Khatib F, Zuckerman B, Shaya M, Ioscovitch A, Shenfeld O, Greenblat D, Farkash R, Tevet A, Samueloff A, and Grisaru Granovsky S
- Subjects
- Adult, Cesarean Section, Female, Humans, Hysterectomy, Peripartum Period, Placenta Accreta surgery, Pregnancy, Prospective Studies, Delivery, Obstetric, Patient Care Team, Placenta Accreta therapy, Pregnancy Outcome
- Abstract
Background: Adherent and invasive placenta, termed Placenta Creta Spectrum (PCS), is associated with increased maternal morbidity and mortality. Incidence and risk factors for Placenta Creta are on the rise and call to optimize the obstetric care for this condition., Objectives: We sought to compare maternal and neonatal outcomes between a ProActive Peripartum Multidisciplinary Approach (PAMA) as compared to the urgent management of the Placenta Creta Spectrum patients., Study Design: We conducted a single-center prospective observational study between 2005-2016. PCS patients registered with the implementation of a PAMA protocol 2014-2016 epoch(E2) were compared with the pre-PAMA 2005-2013 epoch(E1), managed by urgent team recruitment. The PAMA protocol is grounded on a continuum of care; A. Antenatal: PCS risk assessment based on clinical history and imaging, surgical, anesthesia, urological consults and designation of a dedicated team to be present at planned surgery; B. Delivery: planned at 34-35 weeks, massive transfusion protocol activation, insertion of ureteral catheters, vertical uterine incision, placement of vessel loops on the iliac vessels, avoidance of active placenta delivery, followed by the decision of hysterectomy or uterine repair; C. Post-operative care: intensive care admission. We evaluated maternal and neonatal outcomes., Results: During the study period 158,438 deliveries were registered in our institution; we identified a total of 72 PCS cases (0.05%): 50(69.4%) in E1 and 22 (30.6%) in E2. Patient characteristics were comparable among epochs. Significantly, patients in E2 vs. E1 had fewer events of massive blood transfusion 36.0% vs. 13.6%, p = 0.05; were transfused less RBC units: median 4 vs. 1.5, p = 0.012, had no transfusion-related respiratory complications and hemorrhage control re-laparotomies. Hysterectomy and hollow visceral injury rates were comparable (72% vs. 63.7%, 26% vs. 22%; respectively). The hysterectomy pathology assessment was available for the majority of the cases in both epochs; percreta diagnosis rate significantly increased in E2. The neonatal outcome was similar among the epochs., Conclusions: Institution of a PAMA protocol for PCS resulted in eliminating the urgent deliveries and in reducing the associated significant hemorrhagic related maternal morbidity, with no increase in the rate of hysterectomy or adverse neonatal outcome., (Copyright © 2019 Elsevier B.V. All rights reserved.)
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- 2019
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20. A natural agonist of mosquito TRPA1 from the medicinal plant Cinnamosma fragrans that is toxic, antifeedant, and repellent to the yellow fever mosquito Aedes aegypti.
- Author
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Inocente EA, Shaya M, Acosta N, Rakotondraibe LH, and Piermarini PM
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- Aedes metabolism, Animals, Benzaldehydes chemistry, Benzaldehydes pharmacology, Larva drug effects, Mosquito Control, Mosquito Vectors metabolism, Plants, Medicinal chemistry, Sesquiterpenes isolation & purification, Sesquiterpenes pharmacology, TRPA1 Cation Channel genetics, Yellow Fever transmission, Yellow Fever virology, Aedes drug effects, Insect Repellents pharmacology, Insecticides pharmacology, Magnoliopsida chemistry, Mosquito Vectors drug effects, Plant Extracts pharmacology, TRPA1 Cation Channel agonists
- Abstract
Plants produce various secondary metabolites that offer a potential source of novel insecticides and repellents for the control of mosquito vectors. Plants of the genus Cinnamosma are endemic to, and widely-distributed throughout, the island of Madagascar. The barks of these species are commonly used in traditional medicines for treating a wide range of maladies. The therapeutic nature of the bark is thought to be associated with its enrichment of pungent drimane sesquiterpenes, which elicit antifeedant and toxic effects in some insects. Here we test the hypothesis that a bark extract of Cinnamosma fragrans (CINEX) and its major drimane sesquiterpenes are insecticidal, antifeedant, and repellent to Aedes aegypti, the principal mosquito vector of chikungunya, dengue, yellow fever, and Zika viruses. We demonstrate that CINEX is 1) toxic to larval and adult female mosquitoes, and 2) antifeedant and repellent to adult female mosquitoes. Moreover, we show that cinnamodial (CDIAL), a sesquiterpene dialdehyde isolated from CINEX, duplicates these bioactivities and exhibits similar toxic potency against pyrethroid-susceptible and -resistant strains of Ae. aegypti. Importantly, we show that CDIAL is an agonist of heterologously-expressed mosquito Transient Receptor Potential A1 (TRPA1) channels, and the antifeedant activity of CDIAL is dampened in a TRPA1-deficient strain of Ae. aegypti (TRPA1-/-). Intriguingly, TRPA1-/- mosquitoes do not exhibit toxic resistance to CDIAL. The data indicate that modulation of TRPA1 is required for the sensory detection and avoidance of CDIAL by mosquitoes, but not for inducing the molecule's toxicity. Our study suggests that CDIAL may serve as a novel chemical platform for the development of natural product-based insecticides and repellents for controlling mosquito vectors.
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- 2018
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21. Attitudes of Lebanese university students towards surgical hymen reconstruction.
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Awwad J, Nassar A, Usta I, Shaya M, Younes Z, and Ghazeeri G
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- Adult, Cross-Sectional Studies, Culture, Female, Gender Identity, Gynecologic Surgical Procedures methods, Humans, Lebanon, Logistic Models, Male, Multivariate Analysis, Religion, Sexual Partners, Sexuality, Surveys and Questionnaires, Universities, Women's Rights, Attitude, Hymen surgery, Marriage ethnology, Sexual Abstinence ethnology, Sexual Behavior ethnology, Students psychology
- Abstract
Many cultural and religious beliefs place virginity at a high level of social significance, in that women who lose their virginity before marriage may face humiliation, ostracism, divorce, and extreme violence. This led to an increase in the demand for virginity restoration through surgical hymen reconstruction among these cultures. However, data regarding the acceptance of hymenoplasty in societies that consider sexuality a taboo are scarce. In this cross-sectional study, we investigated the effects of gender and religion on sexual attitudes towards hymenoplasty, premarital sex, and virginity in a sample of 600 Lebanese university students. Our findings showed that approval of hymenoplasty was low among participants regardless of gender (25.7 % men vs. 19.1 % women) and religious affiliations (22.5 % Muslims vs. 22.3 % Christians). Arguments for rejection were rooted in moral ethics and personal convictions: "form of deceiving and cheating" (80.7 %) and "betrayal of honesty in the relationship" (80.4 %). Reasons for acceptance included: personal belief in "women's rights, autonomy, and freedom" (72.2 %) and "physical harm and death" (63.5 %).Male participants were more likely to approve premarital coital sex than females (61.0 vs. 27.3 %). Muslims were also more likely to reject marrying a non-virgin than Christians (39.9 vs. 18.0 %). Female participants expressed more tolerance towards marrying a non-virgin male partner (78.3 vs. 57.3 %). Low acceptance of hymenoplasty among Lebanese university students was found to be related to moral ethics and personal convictions independently from gender and religious affiliation. Differences in sexual attitudes towards premarital coital sex and virginity, however, were more significantly influenced by culture and religion.
- Published
- 2013
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22. Complications of posterior cranial fossa surgery--an institutional experience of 500 patients.
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Dubey A, Sung WS, Shaya M, Patwardhan R, Willis B, Smith D, and Nanda A
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- Adolescent, Adult, Aged, Arnold-Chiari Malformation pathology, Arnold-Chiari Malformation surgery, Brain Neoplasms pathology, Brain Neoplasms surgery, Cerebellopontine Angle pathology, Cerebellopontine Angle surgery, Child, Chordoma pathology, Chordoma surgery, Cranial Fossa, Posterior blood supply, Cranial Fossa, Posterior pathology, Decompression, Surgical adverse effects, Decompression, Surgical methods, Female, Hemifacial Spasm pathology, Hemifacial Spasm surgery, Humans, Length of Stay, Male, Microsurgery adverse effects, Microsurgery methods, Middle Aged, Neurosurgical Procedures methods, Postoperative Complications physiopathology, Postoperative Complications prevention & control, Retrospective Studies, Vascular Surgical Procedures methods, Young Adult, Cranial Fossa, Posterior surgery, Neurosurgical Procedures adverse effects, Postoperative Complications epidemiology, Vascular Surgical Procedures adverse effects
- Abstract
Background: The complication of the posterior fossa surgery is seldom described in the literature. The purposes of this retrospective study are to draw attention to the potential complications associated with posterior fossa surgery and to critically review the predisposing factors that might influence the complication rate., Methods: We undertook a 10-year (1992-2002) retrospective study of all posterior fossa surgery performed at LSUHSC. A total of 500 patients were obtained from the operation database, and they were categorized into 5 groups based on the surgical approaches: (1) cerebellopontine angle lesion, (2) microvascular decompression for facial pain and spasm, (3) cerebellar lesions, (4) Chiari I decompression, and (5) petroclival lesions. Data collected for analysis included patient demographics, pathological characteristics of the lesions, and the postoperative complications that occurred as unexpected and undesirable events that prolonged hospital stay and may require surgical/medical intervention., Results: Of the 500 patients reviewed, 220 (44%) patients had tumor resections at the cerebellopontine angle; 110 (22%) patients had microvascular decompression for trigeminal neuralgia and hemifacial spasm; 86 (17.2%) patients had cerebellar lesions; 60 (12%) patients had Chiari I decompression; and 24 (4.8%) patients required transpetrosal approaches for petroclival lesions. The overall complication rate in our study was 31.8%, affecting 159 patients. Cerebrospinal fluid leaks were the most frequently encountered, presenting in 65 (13%) patients followed by meningitis in 46 (9.2%) patients, wound infection in 35 (7%) patients, and CN palsies in 24 (4.8%) patients. Other complications that were observed to develop almost exclusively in patients undergoing cerebellar parenchymal tumor resection included cerebellar edema in 25 (5%) patients, hydrocephalus in 23 (4.6%) patients, cerebellar hematoma in 15 (3%) patients, and cerebellar mutism in 6 (1.2%) patients. The overall mortality rate related to surgery was 2.6% occurring in 13 patients., Conclusion: Posterior fossa surgery involves greater morbidity and mortality and has a wider variety of complications than surgery in the supratentorial compartment. These complications may be avoided by careful perioperative planning, strict adherence to aseptic technique, meticulous microsurgical dissection, proper wound closure, and the judicious use of prophylactic agent. A thorough understanding of the patient's history, neurological findings, imaging studies, operative anatomy, as well as all potential adverse events associated with the procedure is also essential to minimize complications.
- Published
- 2009
- Full Text
- View/download PDF
23. [Musical hallucinations].
- Author
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Coebergh JA, Shaya M, Koopman JP, and Blom JD
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Hallucinations epidemiology, Hallucinations etiology, Humans, Male, Quality of Life, Substance-Related Disorders complications, Antimanic Agents therapeutic use, Hallucinations diagnosis, Hallucinations therapy
- Published
- 2009
24. The risk of malignancy in post-menopausal women presenting with adnexal torsion.
- Author
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Eitan R, Galoyan N, Zuckerman B, Shaya M, Shen O, and Beller U
- Subjects
- Adnexal Diseases diagnostic imaging, Adnexal Diseases pathology, Adnexal Diseases surgery, Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Middle Aged, Ovarian Neoplasms diagnostic imaging, Ovarian Neoplasms pathology, Ovarian Neoplasms surgery, Retrospective Studies, Risk Factors, Torsion Abnormality, Ultrasonography, Adnexal Diseases complications, Ovarian Neoplasms complications, Postmenopause
- Abstract
Objectives: Adnexal torsion is usually diagnosed in pre-menopausal women and is less common in post-menopausal patients. The risk of malignancy in cases of torsion in menopausal patients is not known. We set out to describe our experience with adnexal torsion in post-menopausal women and to discuss issues related to management in this situation., Methods: A retrospective chart review was conducted of all post-menopausal patients diagnosed with torsion of the adnexa from January 1990 through December 2005. Patient charts were reviewed for information regarding pre-operative signs and symptoms, pathology, demographics, surgical findings, procedure and outcome. As a control group, we chose a consecutive cohort of 29 pre-menopausal patients diagnosed with adnexal torsion during 2002., Results: Twenty-seven patients were found to be menopausal at the time of diagnosis of adnexal torsion. Median age at presentation was 63 years (range 43-93). A median delay of 40 h was found between the time of hospital admittance to surgery for post-menopausal patients in comparison to the pre-menopausal ones. The cause of torsion was benign in pre-menopausal patients whereas 22% of post-menopausal patients were diagnosed with malignant disease. More adnexas were found to be necrotic in menopausal patients and this resulted in under-diagnosis of malignancy on frozen section analysis., Conclusion: The diagnosis of adnexal torsion is less evident in post-menopausal patients leading to delayed treatment. The high risk of malignancy is of major importance and should be taken into account when counseling patients and when using frozen section during surgery.
- Published
- 2007
- Full Text
- View/download PDF
25. Glioblastoma multiforme in two non-nuclear family members.
- Author
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Daniels LB, Shaya M, Nordberg ML, Shorter CD, Fowler M, and Nanda A
- Subjects
- Aged, Brain Neoplasms genetics, Brain Neoplasms pathology, Chromosomes, Human, Pair 7, Chromosomes, Human, Pair 9, Female, Genetic Linkage, Glioblastoma genetics, Glioblastoma pathology, Humans, In Situ Hybridization, Fluorescence, Male, Middle Aged, Risk Factors, Brain Neoplasms diagnosis, Family, Glioblastoma diagnosis
- Abstract
Background: In spite of traditional and current epidemiological research, there have been few environmental risk factors identified for malignant brain tumors. It has been an equally difficult challenge to identify genetic causes for brain tumors because of the rarity of families with multiple affected individuals, which prevents the use of traditional methods of genetic analysis such as genetic linkage, sib-pair, or even population-based association studies. Thus, it is important to take advantage of rare occasions of familial brain tumors., Methods: Identification and careful study of such families may provide important clues about the etiology of brain malignancies. We studied one family of which two nonnuclear family members were affected with pathologically diagnosed glioblastoma multiforme. Fluorescence in situ hybridization (FISH) assays were used on archival sections from each patient's tumor to investigate the loss and/or gain of important allelic endpoints. Tissue sections were prepared and processed for FISH. DNA probes for targeted gene loci were used to assess allelic gain/loss. FISH probes targeted regions including 19q13, 1p36, 10q/phosphate and tensin homolog (PTEN), chromosome 3, chromosome 7, chromosome 17/17q and p53/17p., Results: FISH analyses identified distinct abnormalities in the two patients, suggesting that despite the familial connections and histologically similar tumors, genetic abnormalities are abundant and heterogeneous among these malignancies., Conclusion: These abnormalities, however, serve to contribute to valuable information regarding patient outcomes, albeit their precise roles in the etiology of this malignancy are yet to be determined.
- Published
- 2007
26. Role of stereotactic radiosurgery as a primary treatment option in the management of newly diagnosed multiple (3-6) intracranial metastases.
- Author
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Jawahar A, Shaya M, Campbell P, Ampil F, Willis BK, Smith D, and Nanda A
- Subjects
- Adult, Aged, Brain Neoplasms mortality, Breast Neoplasms mortality, Breast Neoplasms pathology, Breast Neoplasms prevention & control, Female, Follow-Up Studies, Gastrointestinal Neoplasms mortality, Gastrointestinal Neoplasms pathology, Gastrointestinal Neoplasms prevention & control, Humans, Karnofsky Performance Status, Kidney Neoplasms mortality, Kidney Neoplasms pathology, Kidney Neoplasms prevention & control, Lung Neoplasms mortality, Lung Neoplasms pathology, Lung Neoplasms prevention & control, Male, Melanoma mortality, Melanoma secondary, Melanoma surgery, Middle Aged, Retrospective Studies, Survival Rate, Treatment Outcome, Brain Neoplasms secondary, Brain Neoplasms surgery, Radiosurgery
- Abstract
Objective: The objective of this study was to assess the role of stereotactic radiosurgery in the management of newly diagnosed multiple intracranial metastases from known primary cancer locations., Methods: Fifty (29 women and 21 men) patients received radiosurgery for newly diagnosed 3 or more metastatic brain tumors. Their mean age was 53 years. Lung cancer was the most common primary cancer (66%)., Results: Arrest in the growth of irradiated tumors was achieved in 41 (82%) patients. Eight patients (16%) required further intervention for tumors in other brain locations. Mean survival after diagnosis of brain disease was 12 months and the brain disease-controlled period was 19 months. The period of brain disease control prolonged (P=.03) with decreasing tumor volumes (<10 mL). Control of treated tumors positively affected survival after diagnosis of brain disease (P=.0001)., Conclusion: Radiosurgery as an adjuvant improves survival in patients with cancer who have newly diagnosed multiple intracranial metastases by arresting the growth of tumors.
- Published
- 2005
- Full Text
- View/download PDF
27. Surgical management of intracranial cavernous malformations: the Louisiana State University Health Sciences Center, Shreveport experience.
- Author
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Berk C, Shaya M, Acharya R, and Nanda A
- Subjects
- Adolescent, Adult, Basal Ganglia blood supply, Brain Stem blood supply, Cavernous Sinus surgery, Central Nervous System Vascular Malformations diagnosis, Cerebral Hemorrhage diagnosis, Female, Follow-Up Studies, Headache diagnosis, Humans, Louisiana, Male, Middle Aged, Neuronavigation, Recovery of Function, Seizures diagnosis, Treatment Outcome, Ultrasonography, Interventional, Cavernous Sinus abnormalities, Central Nervous System Vascular Malformations surgery
- Abstract
Intracranial cavernous malformations are vascular anomalies consisting of endothelium-lined caverns filled with blood at various stages of thrombosis and organized and separated by a collagenous stroma devoid of mature vessel wall elements. They represent a clinical challenge both in diagnosis and management due to the variety of presenting symptoms and neuroradiological features. This study analyzes the clinical manifestations and surgical outcomes in 16 patients with cavernous malformations who were treated surgically at the Louisiana State University Health Sciences Center in Shreveport. The most common presenting features were headache, seizure, and focal neurologic deficits. Three patients had deep lesions (two in the brainstem and one in the basal ganglion), and 13 patients had superficial lesions. All patients underwent surgery and had complete excision of the lesion. The overall outcome was satisfactory for all patients with significant symptom relief over a mean follow-up period of 60 months. The optimal management of cavernous malformations should be determined on a case-by-case basis and, when indicated, surgery provides good outcome.
- Published
- 2005
- Full Text
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28. Factors influencing outcome in intracerebral hematoma: a simple, reliable, and accurate method to grade intracerebral hemorrhage.
- Author
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Shaya M, Dubey A, Berk C, Gonzalez-Toledo E, Zhang J, Caldito G, and Nanda A
- Subjects
- Adult, Aged, Aged, 80 and over, Female, Health Status, Hematoma etiology, Humans, Hydrocephalus, Hypertension complications, Intracranial Hemorrhages classification, Male, Middle Aged, Predictive Value of Tests, Retrospective Studies, Severity of Illness Index, Tomography, X-Ray Computed, Treatment Outcome, Hematoma therapy, Intracranial Hemorrhages pathology, Intracranial Hemorrhages therapy
- Abstract
Background: Intracerebral hemorrhage (ICH) is a major public health problem. This subset of stroke often coexists with other serious medical problems such as hypertension, diabetes, and obesity. Management of hemorrhagic stroke is controversial and there is no standardized system for assessing presentation and predicting outcome of this disease. We propose a new grading system based on clinical and radiologic factors important in influencing outcome in ICH that can be used by the entire health care team., Methods: We conducted a retrospective study of the last 50 patients who presented with hypertensive ICHs to Louisiana State University Health Sciences Center in Shreveport during 2001 to 2003. Significant predictors of outcome at 6 months as measured by the Glasgow outcome score (GOS) were determined and a grading system based on clot volume, hydrocephalus on initial computed tomographic scan, and focal neurologic deficit was formulated., Results: Three factors observed to have significant association with GOS were presence of a focal neurologic deficit on initial presentation (P = .003), presence of hydrocephalus on initial computed tomographic scan (P < .0001), and clot volume (P = .003). Patients were scored on these variables as follows: neurologically intact (0 point), any focal neurological deficit (1 point); absence of hydrocephalus (0 point), presence of hydrocephalus (1 point); and clot volume less than 20 mL (1 point), 20 to 50 mL (2 points), and greater than 50 mL (3 points) [corrected] The scores were summed to assign an ICH grade to each patient for predicting his GOS at 6 months. Given the nonsignificant difference between a patient's grade and his actual observed GOS (mean difference 0.04, P = .79), as well as their significant correlation (correlation coefficient = 0.76, P < .0001), we believe our grading system is useful for predicting a patient's GOS., Conclusion: An accurate and reliable grading scale for ICH is helpful in standardizing the management of ICH, improving communication of patient presentation among health care workers, and predicting outcomes.
- Published
- 2005
- Full Text
- View/download PDF
29. Transradial approach to coil embolization of an intracranial aneurysm.
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Schönholz C, Nanda A, Rodríguez J, Shaya M, and D'Agostino H
- Subjects
- Adult, Aneurysm, Ruptured complications, Humans, Intracranial Aneurysm complications, Male, Aneurysm, Ruptured therapy, Embolization, Therapeutic methods, Intracranial Aneurysm therapy, Obesity, Morbid complications, Radial Artery surgery
- Abstract
Purpose: To report the use of a transradial approach to coil embolization of an intracranial aneurysm in a morbidly obese patient., Technical Note: When the transfemoral approach was inaccessible in a morbidly obese patient with a ruptured intracranial aneurysm, coil embolization was performed via a 6-F sheath placed in the radial artery. Multiple platinum coils were delivered to exclude the 14-mm basilar tip aneurysm. Because heparin was not reversed, the sheath was left in the artery for 24 hours then removed. The radial artery was pulsatile, and blood supply to the hand was good., Conclusions: The radial artery appears to be a suitable route for access to the intracranial vessels when the femoral artery is not available.
- Published
- 2004
- Full Text
- View/download PDF
30. Quantification of the advantages of the extended frontal approach to skull base.
- Author
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Acharya R, Shaya M, Kumar R, Caldito GC, and Nanda A
- Abstract
This anatomic study evaluated the extent that a fronto-orbital osteotomy (FOO) added to a bilateral frontal craniotomy widened the exposure to the midline compartment of the anterior, middle, and posterior cranial fossae. The goal was to determine if osteotomy would significantly increase angles for two targets: the foramen magnum (FM) and anterior clinoid process (ACP). Stepwise dissections were performed on five cadaveric heads. A bilateral frontal craniotomy was made, followed by FOO. After the ethmoids were removed, the planum sphenoidale was drilled to enter the sphenoid sinus. Further drilling exposed the anterior clivus, which was drilled down to FM. Excellent exposure of the basilar artery, vertebral artery, and brain stem was achieved. With and without FOO, angles of exposure were measured for two targets: the ACP and FM. The angle of exposure after FOO increased markedly with an average gain of 76% for the ACP and of 80% for FM. Compared with a conventional bifrontal craniotomy, the addition of FOO increased the surgical exposure and minimized frontal lobe retraction for accessing lesions of the anterior, middle, and posterior cranial fossae.
- Published
- 2004
- Full Text
- View/download PDF
31. Gamma knife radiosurgery for trigeminal neuralgia: a study of predictors of success, efficacy, safety, and outcome at LSUHSC.
- Author
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Shaya M, Jawahar A, Caldito G, Sin A, Willis BK, and Nanda A
- Subjects
- Adult, Aged, Aged, 80 and over, Brain pathology, Brain surgery, Female, Follow-Up Studies, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Pain Measurement, Retrospective Studies, Severity of Illness Index, Treatment Outcome, Trigeminal Neuralgia diagnosis, Radiosurgery adverse effects, Radiosurgery instrumentation, Trigeminal Neuralgia surgery
- Abstract
Background: Trigeminal neuralgia (TN) is a painful condition of controversial origin; however, vascular compression of the root entry zone of the trigeminal nerve is thought to be responsible in some cases. Recently, stereotactic radiosurgery has been established as an alternative treatment for medically intractable TN., Methods: Forty patients with medically refractory TN underwent gamma knife surgery for pain control at our institution. Dose planning was based on high-resolution, contrast-enhanced, axial, volume acquisition magnetic resonance images. Images were reviewed to detect vascular compression of the trigeminal nerve at the root entry zone by an observer blinded to the affected side and the outcome. Another observer, blinded to radiologic findings, conducted the patient follow-up. Results were classified as excellent and good (favorable outcomes) and failure (unfavorable) based upon the intensity of pain, frequency of episodes, pain medications, and need for additional interventions after radiosurgery., Results: Pain was left-sided in 22 patients and right-sided in 18 patients. Vascular compression of the affected nerve at the root entry zone was demonstrable in 14 patients. Prescription dose ranged from 70 to 90 Gy. At a median follow-up of 14 months (range, 3-31 months), 16 patients (40%) had excellent pain control, 12 (30%) had good control, while 12 (30%) had failed treatment. The Kaplan-Meier actuarial pain control rate at 15 months was 82.25 +/- 0.8% (95%CI). Magnetic resonance detectable vascular compression did not affect the outcome (p = 0.6). Increasing marginal dose (> or =40Gy) was a significant predictor of favorable outcome (p = 0.015)., Conclusions: gamma knife surgery is an effective and safe treatment for TN. In our study, we found that vascular compression of the nerve at the root entry zone was not a predictor of the outcome of gamma surgery for TN. The outcome improves with marginal prescription dose of 80 Gy or higher.
- Published
- 2004
- Full Text
- View/download PDF
32. Local cryoglobulin deposition in primary central nervous system lymphoma.
- Author
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Paueksakon P, Shaya M, Harper R, Hicks J, Truong L, Goodman JC, and Powell SZ
- Subjects
- Adult, Anticonvulsants, Antineoplastic Agents, Hormonal therapeutic use, Biomarkers, Tumor metabolism, Brain Neoplasms pathology, Brain Neoplasms surgery, Cell Nucleus ultrastructure, Chemotherapy, Adjuvant, Dexamethasone therapeutic use, Humans, Lymphoma, B-Cell pathology, Lymphoma, B-Cell surgery, Lymphoma, Large B-Cell, Diffuse pathology, Lymphoma, Large B-Cell, Diffuse surgery, Organelles ultrastructure, Phenytoin therapeutic use, Brain Neoplasms metabolism, Cryoglobulins metabolism, Lymphoma, B-Cell metabolism, Lymphoma, Large B-Cell, Diffuse metabolism
- Abstract
Primary central nervous system lymphomas (PCNSLs) represent malignant non-Hodgkin's B-cell lymphomas confined to the central nervous system. Recent years have brought a dramatic increase in the frequency of PCNSL in the immunocompromised and immunocompetent populations. Cryoglobulins are cold-precipitable immunoglobulins associated with a number of infectious, autoimmune, and neoplastic disorders. Although it is known that patients with hematologic malignancies (eg, B-cell lymphomas, chronic lymphocytic leukemia, plasma cell dyscrasias) may have cryoglobulinemias and cryoglobulin deposition in several organs (eg, kidney, liver skin, blood vessels, peripheral nervous system), PCNSL associated with cryoglobulin deposition has not been previously described. This report demonstrates localized cryoglobulin deposition within the tumor bed in an immunocompetent patient with PCNSL.
- Published
- 2003
- Full Text
- View/download PDF
33. Gastric carcinoma with metastasis to the placenta and amniotic fluid: case report and review of the literature.
- Author
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Khatib F, Shaya M, and Samueloff A
- Subjects
- Abdominal Pain, Adenocarcinoma pathology, Adult, Fatal Outcome, Female, Humans, Pregnancy, Stomach Neoplasms pathology, Adenocarcinoma diagnosis, Amniotic Fluid cytology, Neoplasm Metastasis, Placenta pathology, Pregnancy Complications, Neoplastic diagnosis, Stomach Neoplasms diagnosis
- Published
- 2003
- Full Text
- View/download PDF
34. The management of labor in women with more than one uterine scar: is a repeat cesarean section really the only "safe" option?
- Author
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Granovsky-Grisaru S, Shaya M, and Diamant YZ
- Subjects
- Case-Control Studies, Cicatrix, Female, Humans, Obstetric Labor Complications surgery, Parity, Pregnancy, Prospective Studies, Trial of Labor, Cesarean Section, Repeat statistics & numerical data, Obstetric Labor Complications therapy, Vaginal Birth after Cesarean statistics & numerical data
- Abstract
A prospective trial to investigate feasibility of vaginal delivery after more than one cesarean section, and the safety of vaginal delivery for mother and neonate. Twenty-six pregnant women with a history of two or more cesarean sections were admitted to the delivery room and accepted trial of labor under internal fetal and uterine monitoring. Epidural anesthesia and oxytocin were applied when needed. A similar group of patients (controls) preferred repeated cesarean section. Nineteen women (73%) were successfully delivered by the vaginal route. There were no cases of uterine rupture or perinatal loss. The maternal complication rate was lower than that of the control group. Trial of labor in selected cases of two or more low-segment cesarean sections may be considered safe for mother and fetus.
- Published
- 1994
- Full Text
- View/download PDF
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