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14 results on '"Shaw, Rosemarie"'

1. Manufacture, Immunological Characterization and Clinical Response of GMP Grade Sars-COV-2 Cytotoxic T Lymphocytes (CTLs) Utilizing the Clinimacs® Cytokine Capture System

Author

Chu, Yaya, primary, Lamb, Margaret, additional, Maryamchik, Elena, additional, Rigot, Olivia, additional, Ayello, Janet, additional, Harrison, Lauren, additional, Mintzer, Elizabeth, additional, Shaw, Rosemarie, additional, Behbehani, Gregory, additional, Mardis, Elaine, additional, Miller, Katherine, additional, Rao Venkata, Lakshmi Prakruthi, additional, Chang, Hsiaochi, additional, Lee, Dean A., additional, Rosenthal, Elana Y., additional, Kadauke, Stephan, additional, Bunin, Nancy J., additional, Talano, Julie, additional, Johnson, Bryon D, additional, Wang, Yongping, additional, and Cairo, Mitchell S., additional

Published
2023
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2. Manufacture and Characterization of Good Manufacturing Practice-Compliant SARS-COV-2 Cytotoxic T Lymphocytes

Author

Chu, Yaya, primary, Milner, Jordan, additional, Lamb, Margaret, additional, Maryamchik, Elena, additional, Rigot, Olivia, additional, Ayello, Janet, additional, Harrison, Lauren, additional, Shaw, Rosemarie, additional, Behbehani, Gregory K, additional, Mardis, Elaine R, additional, Miller, Katherine, additional, Prakruthi Rao Venkata, Lakshmi, additional, Chang, Hsiaochi, additional, Lee, Dean, additional, Rosenthal, Elana, additional, Kadauke, Stephan, additional, Bunin, Nancy, additional, Talano, Julie-An, additional, Johnson, Bryon, additional, Wang, Yongping, additional, and Cairo, Mitchell S, additional

Published
2022
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3. 320 - Safety and Efficacy of High Dose Granulocyte Colony Stimulating Factor Mobilization in Familial Haploidentical Adult Donors with Sickle Cell Trait Followed By CD34+ Cell Enrichment and Mononuclear Cell Add-Back Prior to Haploidentical Allogeneic Transplantation in High-Risk Sickle Cell Disease Recipients

Author

Milner, Jordan, Flower, Allyson, Schulman, Stephanie, Keever-Taylor, Carolyn A, Fabricatore, Sandra, Morris, Erin, Mahanti, Harshini, Shi, Qiuhu, Shaw, Rosemarie, Weinberg, Rona Singer, Grossman, Brenda, Talano, Julie-An, Shenoy, Shalini, Moore, Theodore B., Ayello, Janet, van de Ven, Carmella, and Cairo, Mitch S.

Published
2022
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4. Safety and Efficacy of High Dose Granulocyte Colony Stimulating Factor Mobilization in Familial Haploidentical Adult Donors with Sickle Cell Trait Followed By CD34+ Cell Enrichment and Mononuclear Cell Add-Back Prior to Haploidentical Allogeneic Transplantation in High-Risk Sickle Cell Disease Recipients

Author

Milner, Jordan, primary, Flower, Allyson, additional, Schulman, Stephanie, additional, Keever-Taylor, Carolyn A, additional, Fabricatore, Sandra, additional, Morris, Erin, additional, Mahanti, Harshini, additional, Shi, Qiuhu, additional, Shaw, Rosemarie, additional, Weinberg, Rona Singer, additional, Grossman, Brenda, additional, Talano, Julie-An, additional, Shenoy, Shalini, additional, Moore, Theodore B., additional, Ayello, Janet, additional, van de Ven, Carmella, additional, and Cairo, Mitch S., additional

Published
2022
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5. Manufacture and Characterization of Good Manufacturing Practice-Compliant SARS-COV-2 Cytotoxic T Lymphocytes.

Author

Chu, Yaya, Milner, Jordan, Lamb, Margaret, Maryamchik, Elena, Rigot, Olivia, Ayello, Janet, Harrison, Lauren, Shaw, Rosemarie, Behbehani, Gregory K, Mardis, Elaine R, Miller, Katherine, Venkata, Lakshmi Prakruthi Rao, Chang, Hsiaochi, Lee, Dean, Rosenthal, Elana, Kadauke, Stephan, Bunin, Nancy, Talano, Julie-An, Johnson, Bryon, and Wang, Yongping

Subjects
CYTOTOXIC T cells, SARS-CoV-2, MONONUCLEAR leukocytes, TUMOR necrosis factors, COVID-19
Abstract

Background Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 virus-specific cytotoxic T-cell lymphocytes (vCTLs) could provide a promising modality in COVID-19 treatment. We aimed to screen, manufacture, and characterize SARS-CoV-2–vCTLs generated from convalescent COVID-19 donors using the CliniMACS Cytokine Capture System (CCS). Methods Donor screening was done by stimulation of convalescent COVID-19 donor peripheral blood mononuclear cells with viral peptides and identification of interferonγ (IFN-γ)+ CD4 and CD8 T cells using flow cytometry. Clinical-grade SARS-CoV-2–vCTLs were manufactured using the CliniMACS CCS. The enriched SARS-CoV-2–vCTLs were characterized by T-cell receptor sequencing, mass cytometry, and transcriptome analysis. Results Of the convalescent donor blood samples, 93% passed the screening criteria for clinical manufacture. Three validation runs resulted in enriched T cells that were 79% (standard error of the mean 21%) IFN-γ+ T cells. SARS-CoV-2–vCTLs displayed a highly diverse T-cell receptor repertoire with enhancement of both memory CD8 and CD4 T cells, especially in CD8 TEM, CD4 TCM, and CD4 TEMRA cell subsets. SARS-CoV-2–vCTLs were polyfunctional with increased gene expression in T-cell function, interleukin, pathogen defense, and tumor necrosis factor superfamily pathways. Conclusions Highly functional SARS-CoV-2–vCTLs can be rapidly generated by direct cytokine enrichment (12 hours) from convalescent donors. Clinical Trials Registration NCT04896606. [ABSTRACT FROM AUTHOR]

Published
2023
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6. Manufacture and Immunological Characterization of GMP-Compliant Functional Sars-COV-2 Cytotoxic T Lymphocytes (CTLs) Utilizing the Clinimacs ® Cytokine Capture System

Author

Chu, Yaya, primary, Milner, Jordan, additional, Lamb, Margaret, additional, Maryamchik, Elena, additional, Rigot, Olivia, additional, Ayello, Janet, additional, Harrison, Lauren, additional, Shaw, Rosemarie, additional, Behbehani, Greg K., additional, Mardis, Elaine R., additional, Miller, Katherine E, additional, Venkata, Lakshmi Prakruthi Rao, additional, Chang, Hsiaochi, additional, Lee, Dean Anthony, additional, Rosenthal, Elana Y., additional, Kadauke, Stephan, additional, Bunin, Nancy, additional, Talano, Julie-An, additional, Johnson, Bryon, additional, Wang, Yongping, additional, and Cairo, Mitchell S., additional

Published
2021
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7. Optimization of Gating of IFN-Gamma Positive Viral Specific Cytotoxic T-Cells (vCTLs) Following Viral Peptivators® Stimulation Utilizing the Cytokine Capture System on the Clinimacs® Prodigy: Quality Control of the Viral CTL Consortium (VIRCTL)

Author

Rigot, Olivia, primary, Ayello, Janet, additional, Fallon, Bernadette, additional, Colon, Lin Marie, additional, Kuhns, Robert, additional, Harrison, Lauren, additional, Shaw, Rosemarie, additional, Fabricatore, Sandra, additional, Gonzalez, Isabel D, additional, Flower, Allyson, additional, Johnson, Bryon D, additional, Wang, Yongping, additional, and Cairo, Mitchell S., additional

Published
2021
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8. Safety and Efficacy of GMP Clinical Grade Manufacturing of Virus Specific Cytotoxic T Lymphocytes (vCTLS) Against Cytomegalovirus (CMV), Epstein Barr Virus ( EBV), Adenovirus (ADV) and BKV to Treat Medically Refractory Viral Infections Post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT) in Children, Adolescents and Young Adults (CAYA) (IND# 17449)

Author

Ayello, Janet, primary, Flower, Allyson, additional, Kuhns, Robert, additional, Colon, Lin Marie, additional, Fallon, Bernadette, additional, Rigot, Olivia, additional, Shaw, Rosemarie, additional, Harrison, Lauren, additional, Morris, Erin, additional, Sturhahn, Meghan, additional, Gonzalez, Isabel D, additional, Wang, Yongping, additional, O’Donnell, Lynn C., additional, Lee, Dean Anthony, additional, Talano, Julie-An, additional, Johnson, Bryon D, additional, Bunin, Nancy J., additional, and Cairo, Mitchell S., additional

Published
2021
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9. Rapid Engraftment, Immune Cell Reconstitution and Sustained Donor Chimerism in Patients Receiving G-CSF Mobilized Peripheral Blood Stem Cells (PB-SC) from Related or Unrelated Donors Undergoing CD34 Enrichment with Mononuclear Cell (T cell) Addback in Children, Adolescents, and Adults with Malignant and Nonmalignant Diseases

Author

Milner, Jordan, primary, Nichols, Cydney, additional, Ayello, Janet, additional, Seiter, Karen P., additional, Liu, Delong, additional, Morris, Erin, additional, Fabricatore, Sandra, additional, Chu, Yaya, additional, Shaw, Rosemarie, additional, van de Ven, Carmella, additional, Flower, Allyson M., additional, and Cairo, Mitchell S, additional

Published
2020
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10. Enrichment of CD34+ Hematopoietic Progenitor STEM CELLS and Depletion of CD3 CELLS Utilizing the Clinimacs®: Comparison of Immediate Versus Next Day Processing

Author

Rigot, Olivia Caunday, primary, Ayello, Janet, additional, Colon, Lin Marie, additional, Kuhns, Ed, additional, Wade, Cheryl, additional, Shaw, Rosemarie, additional, Harrison, Lauren, additional, Fabricatore, Sandra, additional, Sturhahn, Meghan, additional, Kretschmer, Patricia, additional, McHale, Patricia, additional, Flower, Allyson, additional, Liu, Delong, additional, Seiter, Karen, additional, and Cairo, Mitchell S., additional

Published
2020
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11. 432 - Optimization of Gating of IFN-Gamma Positive Viral Specific Cytotoxic T-Cells (vCTLs) Following Viral Peptivators® Stimulation Utilizing the Cytokine Capture System on the Clinimacs® Prodigy: Quality Control of the Viral CTL Consortium (VIRCTL)

Author

Rigot, Olivia, Ayello, Janet, Fallon, Bernadette, Colon, Lin Marie, Kuhns, Robert, Harrison, Lauren, Shaw, Rosemarie, Fabricatore, Sandra, Gonzalez, Isabel D, Flower, Allyson, Johnson, Bryon D, Wang, Yongping, and Cairo, Mitchell S.

Published
2021
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12. 409 - Safety and Efficacy of GMP Clinical Grade Manufacturing of Virus Specific Cytotoxic T Lymphocytes (vCTLS) Against Cytomegalovirus (CMV), Epstein Barr Virus ( EBV), Adenovirus (ADV) and BKV to Treat Medically Refractory Viral Infections Post Allogeneic Hematopoietic Stem Cell Transplantation (AlloHSCT) in Children, Adolescents and Young Adults (CAYA) (IND# 17449)

Author

Ayello, Janet, Flower, Allyson, Kuhns, Robert, Colon, Lin Marie, Fallon, Bernadette, Rigot, Olivia, Shaw, Rosemarie, Harrison, Lauren, Morris, Erin, Sturhahn, Meghan, Gonzalez, Isabel D, Wang, Yongping, O’Donnell, Lynn C., Lee, Dean Anthony, Talano, Julie-An, Johnson, Bryon D, Bunin, Nancy J., and Cairo, Mitchell S.

Published
2021
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