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1. IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition

Author

Ozonoff, Al, Ehrlich, Lauren IR, Melamed, Esther, Sesma, Ana Fernandez, Simon, Viviana, Pulendran, Bali, Nadeau, Kari C, Davis, Mark M, McCoey, Grace A, Sekaly, Rafick, Baden, Lindsey R, Levy, Ofer, Schaenman, Joanna, Reed, Elaine F, Shaw, Albert C, Hafler, David A, Montgomery, Ruth R, Kleinstein, Steven H, Becker, Patrice M, Augustine, Alison D, Calfee, Carolyn S, Erle, David J, DeBakey, Michael E, Corry, David B, Kheradmand, Farrah, Atkinson, Mark A, Brakenridge, Scott C, Higuita, Nelson I Agudelo, Metcalf, Jordan P, Hough, Catherine L, Messer, William B, Kraft, Monica, Bime, Chris, Peters, Bjoern, Milliren, Carly E, Syphurs, Caitlin, McEnaney, Kerry, Barton, Brenda, Lentucci, Claudia, Saluvan, Mehmet, Chang, Ana C, Hoch, Annmarie, Albert, Marisa, Shaheen, Tanzia, Kho, Alvin T, Liu, Shanshan, Thomas, Sanya, Chen, Jing, Murphy, Maimouna D, Cooney, Mitchell, Hayati, Arash Nemati, Bryant, Robert, Abraham, James, Jayavelu, Naresh Doni, Presnell, Scott, Jancsyk, Tomasz, Maguire, Cole, Qi, Jingjing, Lee, Brian, Fourati, Slim, Esserman, Denise A, Guan, Leying, Gygi, Jeremy, Pawar, Shrikant, Brito, Anderson, Fragiadakis, Gabriela K, Patel, Ravi, Overton, James A, Vita, Randi, Westendorf, Kerstin, Shannon, Casey P, Tebbutt, Scott J, Thyagarajan, Rama V, Rousseau, Justin F, Wylie, Dennis, Triplett, Todd A, Kojic, Erna, Chinthrajah, Sharon, Ahuja, Neera, Rogers, Angela J, Artandi, Maja, Geng, Linda, Yendewa, George, Powell, Debra L, Kim, James N, Simmons, Brent, Goonewardene, I Michael, Smith, Cecilia M, Martens, Mark, Sherman, Amy C, Walsh, Stephen R, Issa, Nicolas C, Salehi-Rad, Ramin, Dela Cruz, Charles, Farhadian, Shelli, Iwasaki, Akiko, Ko, Albert I, Anderson, Evan J, Mehta, Aneesh K, and Sevransky, Jonathan E

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Immunology, Infectious Diseases, Coronaviruses, Lung, Emerging Infectious Diseases, Inflammatory and immune system, Good Health and Well Being, Humans, COVID-19, Glycosylation, SARS-CoV-2, Glycosyltransferases, Complement System Proteins, Immunoglobulin M, IMPACC Network
Abstract

The glycosylation of IgG plays a critical role during human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, activating immune cells and inducing cytokine production. However, the role of IgM N-glycosylation has not been studied during human acute viral infection. The analysis of IgM N-glycosylation from healthy controls and hospitalized coronavirus disease 2019 (COVID-19) patients reveals increased high-mannose and sialylation that correlates with COVID-19 severity. These trends are confirmed within SARS-CoV-2-specific immunoglobulin N-glycan profiles. Moreover, the degree of total IgM mannosylation and sialylation correlate significantly with markers of disease severity. We link the changes of IgM N-glycosylation with the expression of Golgi glycosyltransferases. Lastly, we observe antigen-specific IgM antibody-dependent complement deposition is elevated in severe COVID-19 patients and modulated by exoglycosidase digestion. Taken together, this work links the IgM N-glycosylation with COVID-19 severity and highlights the need to understand IgM glycosylation and downstream immune function during human disease.

Published
2024

2. Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

Author

Ozonoff, Al, Jayavelu, Naresh Doni, Liu, Shanshan, Melamed, Esther, Milliren, Carly E., Qi, Jingjing, Geng, Linda N., McComsey, Grace A., Cairns, Charles B., Baden, Lindsey R., Schaenman, Joanna, Shaw, Albert C., Samaha, Hady, Seyfert-Margolis, Vicki, Krammer, Florian, Rosen, Lindsey B., Steen, Hanno, Syphurs, Caitlin, Dandekar, Ravi, Shannon, Casey P., Sekaly, Rafick P., Ehrlich, Lauren I. R., Corry, David B., Kheradmand, Farrah, Atkinson, Mark A., Brakenridge, Scott C., Higuita, Nelson I. Agudelo, Metcalf, Jordan P., Hough, Catherine L., Messer, William B., Pulendran, Bali, Nadeau, Kari C., Davis, Mark M., Sesma, Ana Fernandez, Simon, Viviana, van Bakel, Harm, Kim-Schulze, Seunghee, Hafler, David A., Levy, Ofer, Kraft, Monica, Bime, Chris, Haddad, Elias K., Calfee, Carolyn S., Erle, David J., Langelier, Charles R., Eckalbar, Walter, Bosinger, Steven E., Peters, Bjoern, Kleinstein, Steven H., Reed, Elaine F., Augustine, Alison D., Diray-Arce, Joann, Maecker, Holden T., Altman, Matthew C., Montgomery, Ruth R., Becker, Patrice M., and Rouphael, Nadine

Published
2024
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3. Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study

Author

Ozonoff, Al, Schaenman, Joanna, Jayavelu, Naresh Doni, Milliren, Carly E, Calfee, Carolyn S, Cairns, Charles B, Kraft, Monica, Baden, Lindsey R, Shaw, Albert C, Krammer, Florian, van Bakel, Harm, Esserman, Denise A, Liu, Shanshan, Sesma, Ana Fernandez, Simon, Viviana, Hafler, David A, Montgomery, Ruth R, Kleinstein, Steven H, Levy, Ofer, Bime, Christian, Haddad, Elias K, Erle, David J, Pulendran, Bali, Nadeau, Kari C, Davis, Mark M, Hough, Catherine L, Messer, William B, Higuita, Nelson I Agudelo, Metcalf, Jordan P, Atkinson, Mark A, Brakenridge, Scott C, Corry, David, Kheradmand, Farrah, Ehrlich, Lauren IR, Melamed, Esther, McComsey, Grace A, Sekaly, Rafick, Diray-Arce, Joann, Peters, Bjoern, Augustine, Alison D, Reed, Elaine F, Altman, Matthew C, Becker, Patrice M, Rouphael, Nadine, Bime, Chris, McEnaney, Kerry, Barton, Brenda, Lentucci, Claudia, Saluvan, Mehmet, Chang, Ana C, Hoch, Annmarie, Albert, Marisa, Shaheen, Tanzia, Kho, Alvin T, Thomas, Sanya, Chen, Jing, Murphy, Maimouna D, Cooney, Mitchell, Presnell, Scott, and Fragiadakis, Gabriela K

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Genetics, Clinical Research, Infectious Diseases, Lung, Emerging Infectious Diseases, Prevention, Coronaviruses, Good Health and Well Being, COVID-19, Creatinine, Female, Hospitalization, Humans, Male, Phenotype, Prospective Studies, RNA, Viral, SARS-CoV-2, Severity of Illness Index, Troponin, Post-Acute COVID-19 Syndrome, Viral load, Antibody, IMPACC study group members, Public Health and Health Services, Clinical sciences, Epidemiology
Abstract

BackgroundBetter understanding of the association between characteristics of patients hospitalized with coronavirus disease 2019 (COVID-19) and outcome is needed to further improve upon patient management.MethodsImmunophenotyping Assessment in a COVID-19 Cohort (IMPACC) is a prospective, observational study of 1164 patients from 20 hospitals across the United States. Disease severity was assessed using a 7-point ordinal scale based on degree of respiratory illness. Patients were prospectively surveyed for 1 year after discharge for post-acute sequalae of COVID-19 (PASC) through quarterly surveys. Demographics, comorbidities, radiographic findings, clinical laboratory values, SARS-CoV-2 PCR and serology were captured over a 28-day period. Multivariable logistic regression was performed.FindingsThe median age was 59 years (interquartile range [IQR] 20); 711 (61%) were men; overall mortality was 14%, and 228 (20%) required invasive mechanical ventilation. Unsupervised clustering of ordinal score over time revealed distinct disease course trajectories. Risk factors associated with prolonged hospitalization or death by day 28 included age ≥ 65 years (odds ratio [OR], 2.01; 95% CI 1.28-3.17), Hispanic ethnicity (OR, 1.71; 95% CI 1.13-2.57), elevated baseline creatinine (OR 2.80; 95% CI 1.63- 4.80) or troponin (OR 1.89; 95% 1.03-3.47), baseline lymphopenia (OR 2.19; 95% CI 1.61-2.97), presence of infiltrate by chest imaging (OR 3.16; 95% CI 1.96-5.10), and high SARS-CoV2 viral load (OR 1.53; 95% CI 1.17-2.00). Fatal cases had the lowest ratio of SARS-CoV-2 antibody to viral load levels compared to other trajectories over time (p=0.001). 589 survivors (51%) completed at least one survey at follow-up with 305 (52%) having at least one symptom consistent with PASC, most commonly dyspnea (56% among symptomatic patients). Female sex was the only associated risk factor for PASC.InterpretationIntegration of PCR cycle threshold, and antibody values with demographics, comorbidities, and laboratory/radiographic findings identified risk factors for 28-day outcome severity, though only female sex was associated with PASC. Longitudinal clinical phenotyping offers important insights, and provides a framework for immunophenotyping for acute and long COVID-19.FundingNIH.

Published
2022

5. Immunophenotyping assessment in a COVID-19 cohort (IMPACC): A prospective longitudinal study

Author

Rouphael, Nadine, Maecker, Holden, Montgomery, Ruth R, Diray-Arce, Joann, Kleinstein, Steven H, Altman, Matthew C, Bosinger, Steven E, Eckalbar, Walter, Guan, Leying, Hough, Catherine L, Krammer, Florian, Langelier, Charles, Levy, Ofer, McEnaney, Kerry, Peters, Bjoern, Rahman, Adeeb, Rajan, Jayant V, Sigelman, Steven, Steen, Hanno, van Bakel, Harm, Ward, Alyssa, Wilson, Michael R, Woodruff, Prescott, Zamecnik, Colin R, Augustine, Alison D, Ozonoff, Al, Reed, Elaine F, Becker, Patrice M, Higuita, Nelson Agudelo, Atkinson, Mark A, Baden, Lindsey R, Bime, Christian, Brakenridge, Scott C, Calfee, Carolyn S, Cairns, Charles B, Corry, David, Davis, Mark M, Ehrlich, Lauren IR, Haddad, Elias K, Erle, David J, Fernandez-Sesma, Ana, Hafler, David A, Kheradmand, Farrah, Kraft, Monica, McComsey, Grace A, Melamed, Esther, Messer, William, Metcalf, Jordan, Nadeau, Kari C, Pulendran, Bali, Sarwal, Minnie, Schaenman, Joanna, Sekaly, Rafick, Shaw, Albert C, and Simon, Viviana

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Biomarkers, COVID-19, Computational Biology, Data Analysis, Gene Expression Profiling, Hospitalization, Humans, Immunophenotyping, Longitudinal Studies, Molecular Diagnostic Techniques, Prospective Studies, Proteomics, SARS-CoV-2, United States, IMPACC Manuscript Writing Team, IMPACC Network Steering Committee, Clinical sciences, Immunology
Abstract

The IMmunoPhenotyping Assessment in a COVID-19 Cohort (IMPACC) is a prospective longitudinal study designed to enroll 1000 hospitalized patients with COVID-19 (NCT04378777). IMPACC collects detailed clinical, laboratory and radiographic data along with longitudinal biologic sampling of blood and respiratory secretions for in depth testing. Clinical and lab data are integrated to identify immunologic, virologic, proteomic, metabolomic and genomic features of COVID-19-related susceptibility, severity and disease progression. The goals of IMPACC are to better understand the contributions of pathogen dynamics and host immune responses to the severity and course of COVID-19 and to generate hypotheses for identification of biomarkers and effective therapeutics, including optimal timing of such interventions. In this report we summarize the IMPACC study design and protocols including clinical criteria and recruitment, multi-site standardized sample collection and processing, virologic and immunologic assays, harmonization of assay protocols, high-level analyses and the data sharing plans.

Published
2021

6. Perfect timing: circadian rhythms, sleep, and immunity — an NIH workshop summary

Author

Haspel, Jeffrey A, Anafi, Ron, Brown, Marishka K, Cermakian, Nicolas, Depner, Christopher, Desplats, Paula, Gelman, Andrew E, Haack, Monika, Jelic, Sanja, Kim, Brian S, Laposky, Aaron D, Lee, Yvonne C, Mongodin, Emmanuel, Prather, Aric A, Prendergast, Brian, Reardon, Colin, Shaw, Albert C, Sengupta, Shaon, Szentirmai, Éva, Thakkar, Mahesh, Walker, Wendy E, and Solt, Laura A

Subjects
Biomedical and Clinical Sciences, Immunology, Sleep Research, Neurosciences, Underpinning research, 1.1 Normal biological development and functioning, Inflammatory and immune system, Animals, Cell Differentiation, Circadian Rhythm, Education, Humans, Immune System, Immunity, Microbiota, National Institutes of Health (U.S.), Sleep, T-Lymphocytes, United States, Biomedical and clinical sciences, Health sciences
Abstract

Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune system homeostasis. Both innate and adaptive immune responses - ranging from leukocyte mobilization, trafficking, and chemotaxis to cytokine release and T cell differentiation -are mediated in a time of day-dependent manner. The National Institutes of Health (NIH) recently sponsored an interdisciplinary workshop, "Sleep Insufficiency, Circadian Misalignment, and the Immune Response," to highlight new research linking sleep and circadian biology to immune function and to identify areas of high translational potential. This Review summarizes topics discussed and highlights immediate opportunities for delineating clinically relevant connections among biological rhythms, sleep, and immune regulation.

Published
2020

8. Multi-omic longitudinal study reveals immune correlates of clinical course among hospitalized COVID-19 patients

Author

Abraham, James, Adkisson, Michael, Albert, Marisa, Altamirano, Luz Torres, Alvarenga, Bonny, Anderson, Matthew L., Anderson, Evan J., Arnett, Azlann, Asashima, Hiromitsu, Atkinson, Mark A., Baden, Lindsey R., Barton, Brenda, Beach, Katherine, Beagle, Elizabeth, Becker, Patrice M., Bell, Matthew R., Bernui, Mariana, Bime, Christian, Boddapati, Arun Kumar, Booth, J. Leland, Borresen, Brittney, Brakenridge, Scott C., Bristow, Laurel, Bryant, Robert, Calfee, Carolyn S., Carreño, Juan Manuel, Carrillo, Sidney, Chak, Suzanna, Chang, Iris, Connors, Jennifer, Conway, Michelle, Corry, David B., Cowan, David, Croen, Brett, Dela Cruz, Charles S., Cusimano, Gina, Eaker, Lily, Edwards, Carolyn, Ehrlich, Lauren I.R., Elashoff, David, Erickson, Heidi, Erle, David J., Farhadian, Shelli, Farrugia, Keith, Fatou, Benoit, Fernandes, Andrea, Fernandez-Sesma, Ana, Fragiadakis, Gabriela K., Furukawa, Sara, Geltman, Janelle N., Ghale, Rajani, Bermúdez González, Maria Carolina, Goonewardene, I. Michael, Guerrero, Estella Sanchez, Guirgis, Faheem W., Hafler, David A., Hamilton, Sydney, Harris, Paul, Hayati, Arash Nemati, Hendrickson, Carolyn M., Agudelo Higuita, Nelson I., Hodder, Thomas, Holland, Steven M., Hough, Catherine L., Huerta, Christopher, Hurley, Kerin C., Hutton, Scott R., Iwasaki, Akiko, Jauregui, Alejandra, Jha, Meenakshi, Johnson, Brandi, Joyner, David, Kangelaris, Kirsten N., Kelly, Geoffrey, Khalil, Zain, Khan, Zenab, Kheradmand, Farrah, Kim, James N., Kimura, Hiroki, Ko, Albert I., Kohr, Bernard, Kraft, Monica, Krummel, Matthew, Kutzler, Michele A., Lasky-Su, Jessica, Lee, Serena, Lee, Deanna, Leipold, Michael, Lentucci, Claudia, Leroux, Carolyn, Lin, Edward, Liu, Shanshan, Love, Christina, Lu, Zhengchun, Maliskova, Lenka, Manning, Brittany Roth, Manohar, Monali, Martens, Mark, McComsey, Grace A., McEnaney, Kerry, McLin, Renee, Melamed, Esther, Melnyk, Nataliya, Mendez, Kevin, Messer, William B., Metcalf, Jordan P., Michelotti, Gregory, Mick, Eran, Mohanty, Subhasis, Mosier, Jarrod, Mulder, Lubbertus C.F., Murphy, Maimouna, Nadeau, Kari R.C., Nelson, Ebony, Nelson, Allison, Nguyen, Viet, Oberhaus, Jordan, Panganiban, Bernadine, Pellegrini, Kathryn L., Pickering, Harry C., Powell, Debra L., Presnell, Scott, Pulendran, Bali, Rahman, Adeeb H., Rashid, Ahmad Sadeed, Raskin, Ariel, Reed, Elaine F., Ribeiro, Susan Pereira, Rivera, Adreanne M., Rogers, Jacob E., Rogers, Angela, Rogowski, Brandon, Rooks, Rebecca, Rosenberg-Hasson, Yael, Rothman, Jessica, Rousseau, Justin F., Salehi-Rad, Ramin, Saluvan, Mehmet, Samaha, Hady, Schaenman, Joanna, Schunk, Ron, Semenza, Nicholas C., Sen, Subha, Sevransky, Jonathan, Seyfert-Margolis, Vicki, Shaheen, Tanzia, Shaw, Albert C., Sieg, Scott, Siegel, Sarah A.R., Sigal, Natalia, Siles, Nadia, Simmons, Brent, Simon, Viviana, Singh, Gagandeep, Sinko, Lauren, Smith, Cecilia M., Smolen, Kinga K., Song, Li-Zhen, Srivastava, Komal, Sullivan, Peter, Syphurs, Caitlin, Tcheou, Johnstone, Tegos, George P., Tharp, Greg K., Tong, Alexandra, Tsitsiklis, Alexandra, Ungaro, Ricardo F., Vaysman, Tatyana, Viode, Arthur, Vita, Randi, Wang, Xiaomei, Ward, Alyssa, Ward, Dawn C., Willmore, Andrew, Woloszczuk, Kyra, Wong, Kari, Woodruff, Prescott G., Xu, Leqi, van Haren, Simon, van de Guchte, Adriana, Zhao, Yujiao, Diray-Arce, Joann, Fourati, Slim, Doni Jayavelu, Naresh, Patel, Ravi, Maguire, Cole, Chang, Ana C., Dandekar, Ravi, Qi, Jingjing, Lee, Brian H., van Zalm, Patrick, Schroeder, Andrew, Chen, Ernie, Konstorum, Anna, Brito, Anderson, Gygi, Jeremy P., Kho, Alvin, Chen, Jing, Pawar, Shrikant, Gonzalez-Reiche, Ana Silvia, Hoch, Annmarie, Milliren, Carly E., Overton, James A., Westendorf, Kerstin, Cairns, Charles B., Rouphael, Nadine, Bosinger, Steven E., Kim-Schulze, Seunghee, Krammer, Florian, Rosen, Lindsey, Grubaugh, Nathan D., van Bakel, Harm, Wilson, Michael, Rajan, Jayant, Steen, Hanno, Eckalbar, Walter, Cotsapas, Chris, Langelier, Charles R., Levy, Ofer, Altman, Matthew C., Maecker, Holden, Montgomery, Ruth R., Haddad, Elias K., Sekaly, Rafick P., Esserman, Denise, Ozonoff, Al, Augustine, Alison D., Guan, Leying, Peters, Bjoern, and Kleinstein, Steven H.

Published
2023
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9. Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19

Author

Unterman, Avraham, Sumida, Tomokazu S., Nouri, Nima, Yan, Xiting, Zhao, Amy Y., Gasque, Victor, Schupp, Jonas C., Asashima, Hiromitsu, Liu, Yunqing, Cosme, Jr., Carlos, Deng, Wenxuan, Chen, Ming, Raredon, Micha Sam Brickman, Hoehn, Kenneth B., Wang, Guilin, Wang, Zuoheng, DeIuliis, Giuseppe, Ravindra, Neal G., Li, Ningshan, Castaldi, Christopher, Wong, Patrick, Fournier, John, Bermejo, Santos, Sharma, Lokesh, Casanovas-Massana, Arnau, Vogels, Chantal B. F., Wyllie, Anne L., Grubaugh, Nathan D., Melillo, Anthony, Meng, Hailong, Stein, Yan, Minasyan, Maksym, Mohanty, Subhasis, Ruff, William E., Cohen, Inessa, Raddassi, Khadir, Niklason, Laura E., Ko, Albert I., Montgomery, Ruth R., Farhadian, Shelli F., Iwasaki, Akiko, Shaw, Albert C., van Dijk, David, Zhao, Hongyu, Kleinstein, Steven H., Hafler, David A., Kaminski, Naftali, and Dela Cruz, Charles S.

Published
2022
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10. Impact of circulating SARS-CoV-2 variants on mRNA vaccine-induced immunity

Author

Lucas, Carolina, Vogels, Chantal B. F., Yildirim, Inci, Rothman, Jessica E., Lu, Peiwen, Monteiro, Valter, Gehlhausen, Jeff R., Campbell, Melissa, Silva, Julio, Tabachnikova, Alexandra, Peña-Hernandez, Mario A., Muenker, M. Catherine, Breban, Mallery I., Fauver, Joseph R., Mohanty, Subhasis, Huang, Jiefang, Shaw, Albert C., Ko, Albert I., Omer, Saad B., Grubaugh, Nathan D., and Iwasaki, Akiko

Published
2021
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11. SalivaDirect: A simplified and flexible platform to enhance SARS-CoV-2 testing capacity

Author

Anastasio, Kelly, Askenase, Michael H., Batsu, Maria, Bickerton, Sean, Brower, Kristina, Bucklin, Molly L., Cahill, Staci, Cao, Yiyun, Courchaine, Edward, DeIuliis, Giuseppe, Earnest, Rebecca, Geng, Bertie, Goldman-Israelow, Benjamin, Handoko, Ryan, Khoury-Hanold, William, Kim, Daniel, Knaggs, Lynda, Kuang, Maxine, Lapidus, Sarah, Lim, Joseph, Linehan, Melissa, Lu-Culligan, Alice, Martin, Anjelica, Matos, Irene, McDonald, David, Minasyan, Maksym, Nakahata, Maura, Naushad, Nida, Nouws, Jessica, Obaid, Abeer, Odio, Camila, Oh, Ji Eun, Omer, Saad, Park, Annsea, Park, Hong-Jai, Peng, Xiaohua, Petrone, Mary, Prophet, Sarah, Rice, Tyler, Rose, Kadi-Ann, Sewanan, Lorenzo, Sharma, Lokesh, Shaw, Albert C., Shepard, Denise, Smolgovsky, Mikhail, Sonnert, Nicole, Strong, Yvette, Todeasa, Codruta, Valdez, Jordan, Velazquez, Sofia, Vijayakumar, Pavithra, White, Elizabeth B., Yang, Yexin, Vogels, Chantal B.F., Watkins, Anne E., Harden, Christina A., Brackney, Doug E., Shafer, Jared, Wang, Jianhui, Caraballo, César, Kalinich, Chaney C., Ott, Isabel M., Fauver, Joseph R., Kudo, Eriko, Lu, Peiwen, Venkataraman, Arvind, Tokuyama, Maria, Moore, Adam J., Muenker, M. Catherine, Casanovas-Massana, Arnau, Fournier, John, Bermejo, Santos, Campbell, Melissa, Datta, Rupak, Nelson, Allison, Dela Cruz, Charles S., Ko, Albert I., Iwasaki, Akiko, Krumholz, Harlan M., Matheus, J.D., Hui, Pei, Liu, Chen, Farhadian, Shelli F., Sikka, Robby, Wyllie, Anne L., and Grubaugh, Nathan D.

Published
2021
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13. The human CD47 checkpoint is targeted by an immunosuppressive Aedes aegypti salivary factor to enhance arboviral skin infectivity.

Author

Marin-Lopez, Alejandro, Huck, John D., Esterly, Allen T., Azcutia, Veronica, Rosen, Connor, Garcia-Milian, Rolando, Sefik, Esen, Vidal-Pedrola, Gemma, Raduwan, Hamidah, Chen, Tse-Yu, Arora, Gunjan, Halene, Stephanie, Shaw, Albert C., Palm, Noah W., Flavell, Richard A., Parkos, Charles A., Thangamani, Saravanan, Ring, Aaron M., and Fikrig, Erol

Subjects
SALIVARY proteins, ZIKA virus infections, ARBOVIRUS diseases, LEUCOCYTES, ARBOVIRUSES, ZIKA virus, AEDES aegypti
Abstract

The Aedes aegypti mosquito is a vector of many infectious agents, including flaviviruses such as Zika virus. Components of mosquito saliva have pleomorphic effects on the vertebrate host to enhance blood feeding, and these changes also create a favorable niche for pathogen replication and dissemination. Here, we demonstrate that human CD47, which is known to be involved in various immune processes, interacts with a 34-kilodalton mosquito salivary protein named Nest1. Nest1 is up-regulated in blood-fed female A. aegypti and facilitates Zika virus dissemination in human skin explants. Nest1 has a stronger affinity for CD47 than its natural ligand, signal regulatory protein α, competing for binding at the same interface. The interaction between Nest1 with CD47 suppresses phagocytosis by human macrophages and inhibits proinflammatory responses by white blood cells, thereby suppressing antiviral responses in the skin. This interaction elucidates how an arthropod protein alters the human response to promote arbovirus infectivity. Editor's summary: Aedes aegypti mosquitos can transmit arboviruses during blood feeding, and components of mosquito saliva may enhance both blood feeding and virus transmission. Marin-Lopez et al. identified a 34-kDa mosquito salivary protein called Nest1, highly expressed in the saliva of female A. aegypti mosquitos, as a high-affinity binder to human CD47. In human skin explants infected with Zika virus, Nest1 increased virus burden and inhibited some CD47-governed immune functions like phagocytosis and proinflammatory responses in immune cells, thus inhibiting antiviral responses. These findings provide insight into how mosquito salivary proteins can potentially facilitate arbovirus infection. —Christiana Fogg [ABSTRACT FROM AUTHOR]

Published
2024
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16. Corrigendum to “Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: results from the IMPACC study” [eBioMedicine 83 (2022) 104208]

Author

Ozonoff, Al, primary, Schaenman, Joanna, additional, Jayavelu, Naresh Doni, additional, Milliren, Carly E., additional, Calfee, Carolyn S., additional, Cairns, Charles B., additional, Kraft, Monica, additional, Baden, Lindsey R., additional, Shaw, Albert C., additional, Krammer, Florian, additional, van Bakel, Harm, additional, Esserman, Denise A., additional, Liu, Shanshan, additional, Sesma, Ana Fernandez, additional, Simon, Viviana, additional, Hafler, David A., additional, Montgomery, Ruth R., additional, Kleinstein, Steven H., additional, Levy, Ofer, additional, Bime, Chris, additional, Haddad, Elias K., additional, Erle, David J., additional, Pulendran, Bali, additional, Nadeau, Kari C., additional, Davis, Mark M., additional, Hough, Catherine L., additional, Messer, William B., additional, Agudelo Higuita, Nelson I., additional, Metcalf, Jordan P., additional, Atkinson, Mark A., additional, Brakenridge, Scott C., additional, Corry, David, additional, Kheradmand, Farrah, additional, Ehrlich, Lauren I.R., additional, Melamed, Esther, additional, McComsey, Grace A., additional, Sekaly, Rafick, additional, Diray-Arce, Joann, additional, Peters, Bjoern, additional, Augustine, Alison D., additional, Reed, Elaine F., additional, Altman, Matthew C., additional, Becker, Patrice M., additional, and Rouphael, Nadine, additional

Published
2023
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18. Discs Large (Dlg1) Complexes in Lymphocyte Activation

Author

Xavier, Ramnik, Rabizadeh, Shahrooz, Ishiguro, Kazuhiro, Andre, Niko, Ortiz, J. Bernabe, Wachtel, Heather, Morris, David G., Lopez-Ilasaca, Marco, Shaw, Albert C., Swat, Wojciech, and Seed, Brian

Published
2004

19. Prior cycles of anti-CD20 antibodies affect antibody responses after repeated SARS-CoV-2 mRNA vaccination

Author

Asashima, Hiromitsu, primary, Kim, Dongjoo, additional, Wang, Kaicheng, additional, Lele, Nikhil, additional, Buitrago-Pocasangre, Nicholas C., additional, Lutz, Rachel, additional, Cruz, Isabella, additional, Raddassi, Khadir, additional, Ruff, William E., additional, Racke, Michael K., additional, Wilson, JoDell E., additional, Givens, Tara S., additional, Grifoni, Alba, additional, Weiskopf, Daniela, additional, Sette, Alessandro, additional, Kleinstein, Steven H., additional, Montgomery, Ruth R., additional, Shaw, Albert C., additional, Li, Fangyong, additional, Fan, Rong, additional, Hafler, David A., additional, Tomayko, Mary M., additional, and Longbrake, Erin E., additional

Published
2023
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20. Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging

Author

Kumar, Archit, primary, Wang, Jiawei, additional, Esterly, Allen, additional, Radcliffe, Chris, additional, Zhou, Haowen, additional, Wyk, Brent Vander, additional, Allore, Heather G., additional, Tsang, Sui, additional, Barakat, Lydia, additional, Mohanty, Subhasis, additional, Zhao, Hongyu, additional, Shaw, Albert C., additional, and Zapata, Heidi J., additional

Published
2023
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24. Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease

Author

Pillai, Padmini S., Molony, Ryan D., Martinod, Kimberly, Dong, Huiping, Pang, Iris K., Tal, Michal C., Solis, Angel G., Bielecki, Piotr, Mohanty, Subhasis, Trentalange, Mark, Homer, Robert J., Flavell, Richard A., Wagner, Denisa D., Montgomery, Ruth R., Shaw, Albert C., Staeheli, Peter, and Iwasaki, Akiko

Published
2016

25. Plasma collagen neoepitopes are associated with multiorgan disease in the ACCESS and GRADS sarcoidosis cohorts

Author

Sand, Jannie Marie Bu¨low, Jessen, Henrik, Leeming, Diana Julie, Yu, Sheeline, Lee, Chris J, Hu, Buqu, Sun, Ying, Adams, Taylor, Pivarnik, Taylor, Liu, Angela, Woo, Samuel, McGovern, John R, Fiorini, Vitória, Saber, Tina, Higuero-Sevilla, Jean Paul, Gulati, Mridu, Kaminski, Naftali, Damsky, William, Shaw, Albert C, Mohanty, Subhasis, Goobie, Gillian, Zhang, Yingze, Herzog, Erica Lyndrup, and Ryu, Changwan

Abstract

IntroductionThe pathogenesis of sarcoidosis involves tissue remodelling mediated by the accumulation of abnormal extracellular matrix, which is partly the result of an imbalance in collagen synthesis, cross-linking and degradation. During this process, collagen fragments or neoepitopes, are released into the circulation. The significance of these circulating collagen neoepitopes in sarcoidosis remains unknown.MethodsWe employed plasma samples from patients with sarcoidosis enrolled in A Case Control Etiologic Study of Sarcoidosis (ACCESS) and Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS), and healthy control patients recruited from the Yale community. Plasma concentrations of type III and VI collagen degradation (C3M and C6M) and formation (PRO-C3 and PRO-C6) were quantified via neoepitope-specific competitive ELISA, and statistical associations were sought with clinical phenotypes.ResultsRelative to healthy controls, the plasma of both sarcoidosis cohorts was enriched for C3M and C6M, irrespective of corticosteroid use and disease duration. While circulating collagen neoepitopes were independent of Scadding stage, there was a significant association between multiorgan disease and PRO-C3, PRO-C6 and C3M in the ACCESS cohort; PRO-C3 and C6M displayed this property in GRADS. These findings were unrelated to plasma levels of interleukin-4 (IL-4), IL-5, IL-6, IL-9, IL-10 and IL-13. Moreover, PRO-C3 was associated with dermatological disease in both cohorts.DiscussionIn two well-characterised sarcoidosis cohorts, we discovered that the plasma is enriched for neoepitopes of collagen degradation (C3M and C6M). In multiorgan disease, there was an association with circulating neoepitopes of type III formation (PRO-C3), perhaps mediated by dermatological sarcoidosis. Further investigation in this arena has the potential to foster new insights into the pathogenic mechanisms of this complex disease.

Published
2024
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27. Featured Cover

Author

Konstorum, Anna, primary, Mohanty, Subhasis, additional, Zhao, Yujiao, additional, Melillo, Anthony, additional, Vander Wyk, Brent, additional, Nelson, Allison, additional, Tsang, Sui, additional, Blevins, Tamara P., additional, Belshe, Robert B., additional, Chawla, Daniel G., additional, Rondina, Matthew T., additional, Gill, Thomas M., additional, Montgomery, Ruth R., additional, Allore, Heather G., additional, Kleinstein, Steven H., additional, and Shaw, Albert C., additional

Published
2023
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28. Platelet response to influenza vaccination reflects effects of aging

Author

Konstorum, Anna, primary, Mohanty, Subhasis, additional, Zhao, Yujiao, additional, Melillo, Anthony, additional, Vander Wyk, Brent, additional, Nelson, Allison, additional, Tsang, Sui, additional, Blevins, Tamara P., additional, Belshe, Robert B., additional, Chawla, Daniel G., additional, Rondina, Matthew T., additional, Gill, Thomas M., additional, Montgomery, Ruth R., additional, Allore, Heather G., additional, Kleinstein, Steven H., additional, and Shaw, Albert C., additional

Published
2023
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29. PD-1highCXCR5–CD4+ peripheral helper T cells promote CXCR3+ plasmablasts in human acute viral infection

Author

Asashima, Hiromitsu, primary, Mohanty, Subhasis, additional, Comi, Michela, additional, Ruff, William E., additional, Hoehn, Kenneth B., additional, Wong, Patrick, additional, Klein, Jon, additional, Lucas, Carolina, additional, Cohen, Inessa, additional, Coffey, Sarah, additional, Lele, Nikhil, additional, Greta, Leissa, additional, Raddassi, Khadir, additional, Chaudhary, Omkar, additional, Unterman, Avraham, additional, Emu, Brinda, additional, Kleinstein, Steven H., additional, Montgomery, Ruth R., additional, Iwasaki, Akiko, additional, Dela Cruz, Charles S., additional, Kaminski, Naftali, additional, Shaw, Albert C., additional, Hafler, David A., additional, and Sumida, Tomokazu S., additional

Published
2023
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30. Combining Cellular Immunology With RNAseq to Identify Novel Chlamydia T-Cell Subset Signatures

Author

Johnson, Raymond M, Asashima, Hiromitsu, Mohanty, Subhasis, and Shaw, Albert C

Subjects
CD4-Positive T-Lymphocytes, Mice, Inbred C57BL, Major Articles and Brief Reports, B-Lymphocytes, Mice, Infectious Diseases, T-Lymphocyte Subsets, Animals, Immunology and Allergy, Chlamydia trachomatis, Genitalia, Chlamydia Infections
Abstract

Chlamydia trachomatis serovars A–L cause important diseases of the eyes and reproductive tract by infecting epithelium lining those organs. A major hurdle for vaccine trials is finding a surrogate biomarker for protective immunity. Investigational data argues for T-cell biomarker(s) reflecting mucosal adaption, cytokine polarization, B-cell help, antibacterial effector mechanisms, or some combination thereof. A human investigation and 2 mouse studies link IL-13 to protection from infection/immunopathology. We performed RNAseq on T cells resident in spleens and genital tracts of naturally immune mice. CD4 signatures were consistent with helper function that differed by site including a genital tract-specific Fgl2 signal. The genital tract CD8 signature featured IL-10 and promotion of healing/scarring with a unique transcription of granzyme A. The RNAseq data was used to refine previously published CD4γ13 and CD8γ13 transcriptomes derived from protective T-cell clones, potentially identifying practicable T-cell subset signatures for assessing Chlamydia vaccine candidates.

Published
2022
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33. Dectin-1 Stimulation Promotes a Distinct Inflammatory Signature in the Setting of HIV-infection and Aging

Author

Kumar, Archit, primary, Wang, Jiawei, additional, Zhou, Haowen, additional, Radcliffe, Chris, additional, Wyk, Brent Vander, additional, Allore, Heather G., additional, Tsang, Sui, additional, Barakat, Lydia, additional, Mohanty, Subhasis, additional, Zhao, Hongyu, additional, Shaw, Albert C., additional, and Zapata, Heidi J., additional

Published
2022
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34. Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study

Author

Ozonoff, Al, primary, Schaenman, Joanna, additional, Jayavelu, Naresh Doni, additional, Milliren, Carly E., additional, Calfee, Carolyn S., additional, Cairns, Charles B., additional, Kraft, Monica, additional, Baden, Lindsey R., additional, Shaw, Albert C., additional, Krammer, Florian, additional, van Bakel, Harm, additional, Esserman, Denise A., additional, Liu, Shanshan, additional, Sesma, Ana Fernandez, additional, Simon, Viviana, additional, Hafler, David A., additional, Montgomery, Ruth R., additional, Kleinstein, Steven H., additional, Levy, Ofer, additional, Bime, Christian, additional, Haddad, Elias K., additional, Erle, David J., additional, Pulendran, Bali, additional, Nadeau, Kari C., additional, Davis, Mark M., additional, Hough, Catherine L., additional, Messer, William B., additional, Higuita, Nelson I. Agudelo, additional, Metcalf, Jordan P., additional, Atkinson, Mark A., additional, Brakenridge, Scott C., additional, Corry, David, additional, Kheradmand, Farrah, additional, Ehrlich, Lauren I.R., additional, Melamed, Esther, additional, McComsey, Grace A., additional, Sekaly, Rafick, additional, Diray-Arce, Joann, additional, Peters, Bjoern, additional, Augustine, Alison D., additional, Reed, Elaine F., additional, Altman, Matthew C., additional, Becker, Patrice M., additional, Rouphael, Nadine, additional, Ozonoff, Al, additional, Bime, Chris, additional, Davis, Mark M, additional, McEnaney, Kerry, additional, Barton, Brenda, additional, Lentucci, Claudia, additional, Saluvan, Mehmet, additional, Chang, Ana C., additional, Hoch, Annmarie, additional, Albert, Marisa, additional, Shaheen, Tanzia, additional, Kho, Alvin T., additional, Thomas, Sanya, additional, Chen, Jing, additional, Murphy, Maimouna D., additional, Cooney, Mitchell, additional, Presnell, Scott, additional, Fragiadakis, Gabriela K., additional, Patel, Ravi, additional, Guan, Leying, additional, Gygi, Jeremy, additional, Pawar, Shrikant, additional, Brito, Anderson, additional, Khalil, Zain, additional, Maguire, Cole, additional, Fourati, Slim, additional, Overton, James A., additional, Vita, Randi, additional, Westendorf, Kerstin, additional, Salehi-Rad, Ramin, additional, Leligdowicz, Aleksandra, additional, Matthay, Michael A., additional, Singer, Jonathan P., additional, Kangelaris, Kirsten N., additional, Hendrickson, Carolyn M., additional, Krummel, Matthew F., additional, Langelier, Charles R., additional, Woodruff, Prescott G., additional, Powell, Debra L., additional, Kim, James N., additional, Simmons, Brent, additional, Goonewardene, I. Michael, additional, Smith, Cecilia M., additional, Martens, Mark, additional, Mosier, Jarrod, additional, Kimura, Hiroki, additional, Sherman, Amy C., additional, Walsh, Stephen R., additional, Issa, Nicolas C., additional, Dela Cruz, Charles, additional, Farhadian, Shelli, additional, Iwasaki, Akiko, additional, Ko, Albert I., additional, Chinthrajah, Sharon, additional, Ahuja, Neera, additional, Rogers, Angela J., additional, Artandi, Maja, additional, Siegel, Sarah A.R., additional, Lu, Zhengchun, additional, Drevets, Douglas A., additional, Brown, Brent R., additional, Anderson, Matthew L., additional, Guirgis, Faheem W., additional, Thyagarajan, Rama V., additional, Rousseau, Justin F., additional, Wylie, Dennis, additional, Busch, Johanna, additional, Gandhi, Saurin, additional, Triplett, Todd A., additional, Yendewa, George, additional, Giddings, Olivia, additional, Anderson, Evan J., additional, Mehta, Aneesh K., additional, Sevransky, Jonathan E., additional, Khor, Bernard, additional, Rahman, Adeeb, additional, Stadlbauer, Daniel, additional, Dutta, Jayeeta, additional, Xie, Hui, additional, Kim-Schulze, Seunghee, additional, Gonzalez-Reiche, Ana Silvia, additional, van de Guchte, Adriana, additional, Farrugia, Keith, additional, Khan, Zenab, additional, Maecker, Holden T., additional, Elashoff, David, additional, Brook, Jenny, additional, Ramires-Sanchez, Estefania, additional, Llamas, Megan, additional, Rivera, Adreanne, additional, Perdomo, Claudia, additional, Ward, Dawn C., additional, Magyar, Clara E., additional, Fulcher, Jennifer A., additional, Abe-Jones, Yumiko, additional, Asthana, Saurabh, additional, Beagle, Alexander, additional, Bhide, Sharvari, additional, Carrillo, Sidney A., additional, Chak, Suzanna, additional, Ghale, Rajani, additional, Gonzalez, Ana, additional, Jauregui, Alejandra, additional, Jones, Norman, additional, Lea, Tasha, additional, Lee, Deanna, additional, Lota, Raphael, additional, Milush, Jeff, additional, Nguyen, Viet, additional, Pierce, Logan, additional, Prasad, Priya A., additional, Rao, Arjun, additional, Samad, Bushra, additional, Shaw, Cole, additional, Sigman, Austin, additional, Sinha, Pratik, additional, Ward, Alyssa, additional, Willmore, Andrew, additional, Zhan, Jenny, additional, Rashid, Sadeed, additional, Rodriguez, Nicklaus, additional, Tang, Kevin, additional, Altamirano, Luz Torres, additional, Betancourt, Legna, additional, Curiel, Cindy, additional, Sutter, Nicole, additional, Paz, Maria Tercero, additional, Tietje-Ulrich, Gayelan, additional, Leroux, Carolyn, additional, Connors, Jennifer, additional, Bernui, Mariana, additional, Kutzler, Michel A., additional, Edwards, Carolyn, additional, Lee, Edward, additional, Lin, Edward, additional, Croen, Brett, additional, Semenza, Nicholas C., additional, Rogowski, Brandon, additional, Melnyk, Nataliya, additional, Woloszczuk, Kyra, additional, Cusimano, Gina, additional, Bell, Mathew R., additional, Furukawa, Sara, additional, McLin, Renee, additional, Marrero, Pamela, additional, Sheidy, Julie, additional, Tegos, George P., additional, Nagle, Crystal, additional, Mege, Nathan, additional, Ulring, Kristen, additional, Seyfert-Margolis, Vicki, additional, Conway, Michelle, additional, Francisco, Dave, additional, Molzahn, Allyson, additional, Erickson, Heidi, additional, Wilson, Connie Cathleen, additional, Schunk, Ron, additional, Sierra, Bianca, additional, Hughes, Trina, additional, Smolen, Kinga, additional, Desjardins, Michael, additional, van Haren, Simon, additional, Mitre, Xhoi, additional, Cauley, Jessica, additional, Li, Xiaofang, additional, Tong, Alexandra, additional, Evans, Bethany, additional, Montesano, Christina, additional, Licona, Jose Humberto, additional, Krauss, Jonathan, additional, Chang, Jun Bai Park, additional, Izaguirre, Natalie, additional, Chaudhary, Omkar, additional, Coppi, Andreas, additional, Fournier, John, additional, Mohanty, Subhasis, additional, Muenker, M. Catherine, additional, Nelson, Allison, additional, Raddassi, Khadir, additional, Rainone, Michael, additional, Ruff, William E., additional, Salahuddin, Syim, additional, Schulz, Wade L., additional, Vijayakumar, Pavithra, additional, Wang, Haowei, additional, Wunder Jr., Elsio, additional, Young, H. Patrick, additional, Zhao, Yujiao, additional, Saksena, Miti, additional, Altman, Deena, additional, Kojic, Erna, additional, Srivastava, Komal, additional, Eaker, Lily Q., additional, Bermúdez-González, Maria C., additional, Beach, Katherine F., additional, Sominsky, Levy A., additional, Azad, Arman R., additional, Carreño, Juan Manuel, additional, Singh, Gagandeep, additional, Raskin, Ariel, additional, Tcheou, Johnstone, additional, Bielak, Dominika, additional, Kawabata, Hisaaki, additional, Mulder, Lubbertus CF, additional, Kleiner, Giulio, additional, Lee, Alexandra S., additional, Do, Evan Do, additional, Fernandes, Andrea, additional, Manohar, Monali, additional, Hagan, Thomas, additional, Blish, Catherine A., additional, Din, Hena Naz, additional, Roque, Jonasel, additional, Yang, Samuel, additional, Brunton, Amanda, additional, Sullivan, Peter E., additional, Strnad, Matthew, additional, Lyski, Zoe L., additional, Coulter, Felicity J., additional, Booth, J. Leland, additional, Sinko, Lauren A., additional, Moldawer, Lyle L., additional, Borresen, Brittany, additional, Roth-Manning, Brittney, additional, Song, Li-Zhen, additional, Nelson, Ebony, additional, Lewis-Smith, Megan, additional, Smith, Jacob, additional, Tipan, Pablo Guaman, additional, Siles, Nadia, additional, Bazzi, Sam, additional, Geltman, Janelle, additional, Hurley, Kerin, additional, Gabriele, Gio, additional, Sieg, Scott, additional, Vaysman, Tatyana, additional, Bristow, Laurel, additional, Hussaini, Laila, additional, Hellmeister, Kieffer, additional, Samaha, Hady, additional, Cheng, Andrew, additional, Spainhour, Christine, additional, Scherer, Erin M., additional, Johnson, Brandi, additional, Bechnak, Amer, additional, Ciric, Caroline R., additional, Hewitt, Lauren, additional, Carter, Erin, additional, Mcnair, Nina, additional, Panganiban, Bernadine, additional, Huerta, Christopher, additional, Usher, Jacob, additional, and Ribeiro, Susan Pereira, additional

Published
2022
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36. Metabolomic and transcriptomic signatures of influenza vaccine response in healthy young and older adults

Author

Chou, Chih‐Hung, primary, Mohanty, Subhasis, additional, Kang, Heather A., additional, Kong, Lingjia, additional, Avila‐Pacheco, Julian, additional, Joshi, Samit R., additional, Ueda, Ikuyo, additional, Devine, Lesley, additional, Raddassi, Khadir, additional, Pierce, Kerry, additional, Jeanfavre, Sarah, additional, Bullock, Kevin, additional, Meng, Hailong, additional, Clish, Clary, additional, Santori, Fabio R., additional, Shaw, Albert C., additional, and Xavier, Ramnik J., additional

Published
2022
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38. No evidence of fetal defects or anti-syncytin-1 antibody induction following COVID-19 mRNA vaccination

Author

Lu-Culligan, Alice, primary, Tabachnikova, Alexandra, additional, Pérez-Then, Eddy, additional, Tokuyama, Maria, additional, Lee, Hannah J., additional, Lucas, Carolina, additional, Silva Monteiro, Valter, additional, Miric, Marija, additional, Brache, Vivian, additional, Cochon, Leila, additional, Muenker, M. Catherine, additional, Mohanty, Subhasis, additional, Huang, Jiefang, additional, Kang, Insoo, additional, Dela Cruz, Charles, additional, Farhadian, Shelli, additional, Campbell, Melissa, additional, Yildirim, Inci, additional, Shaw, Albert C., additional, Ma, Shuangge, additional, Vermund, Sten H., additional, Ko, Albert I., additional, Omer, Saad B., additional, and Iwasaki, Akiko, additional

Published
2022
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39. Platelet response to influenza vaccination reflects effects of aging

Author

Konstorum, Anna, primary, Mohanty, Subhasis, additional, Zhao, Yujiao, additional, Melillo, Anthony, additional, Vander Wyk, Brent, additional, Nelson, Allison, additional, Tsang, Sui, additional, Blevins, Tamara P., additional, Belshe, Robert B., additional, Chawla, Daniel G., additional, Rondina, Matthew T., additional, Montgomery, Ruth R., additional, Allore, Heather G., additional, Kleinstein, Steven H., additional, and Shaw, Albert C., additional

Published
2022
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