Search

Your search keyword '"Shaul Shohat"' showing total 3 results
Start Over Author "Shaul Shohat"
3 results on '"Shaul Shohat"'

1. Assessment of Bioprotect’s Biodegradable Balloon System as a Rectal Spacer in Radiotherapy: An Animal Study on Tissue Response and Biocompatibility

Author

Yuval Ramot, Tal Levin-Harrus, Adva Ezratty, Michal Steiner, Nati Ezov, Abraham J. Domb, Muhammad Abdel-Haq, Shaul Shohat, Liron Aperman, Lee Adler, Oleg Dolkart, and Abraham Nyska

Subjects
prostate cancer, rectal spacer, Bioprotect balloon, radiotherapy, biodegradable balloon, tissue response, Pharmacy and materia medica, RS1-441
Abstract

Prostate cancer is a significant health concern for men, emphasizing the need for effective treatment strategies. Dose-escalated external beam radiotherapy shows promise in improving outcomes but presents challenges due to radiation effects on nearby structures, such as the rectum. Innovative techniques, including rectal spacers, have emerged to mitigate these effects. This study comprehensively assessed tissue responses following the implantation of the Bioprotect biodegradable fillable balloon as a rectal spacer in a rat model. Evaluation occurred at multiple time points (4, 26, and 52 weeks) post-implantation. Results revealed localized tissue responses consistent with the expected reaction to biodegradable materials, characterized by mild to moderate fibrotic reactions and encapsulation, underscoring the safety and biocompatibility of the balloon. Importantly, no other adverse events occurred, and the animals remained healthy throughout the study. These findings support its potential clinical utility in radiotherapy treatments to enhance patient outcomes and minimize long-term implant-related complications, serving as a benchmark for future similar studies and offering valuable insights for researchers in the field. In conclusion, the findings from this study highlight the safety, biocompatibility, and potential clinical applicability of the Bioprotect biodegradable fillable balloon as a promising rectal spacer in mitigating radiation-induced complications during prostate cancer radiotherapy.

Published
2023
Full Text
View/download PDF

2. A novel device for protecting rectum during prostate cancer irradiation: in vivo data on a large mammal model

Author

Yair Levy, Avi Domb, Rahamim Ben-Yosef, Adrian Paz, Shlomi Alani, Shaul Shohat, Yossi Muncher, and Ben Corn

Subjects
Male, medicine.medical_specialty, Swine, Urology, medicine.medical_treatment, Rectum, Context (language use), Biocompatible Materials, Balloon, Prostate cancer, Radiation Protection, Prostate, In vivo, medicine, Animals, business.industry, Prostatic Neoplasms, Equipment Design, Prostheses and Implants, medicine.disease, Surgery, Radiation therapy, Disease Models, Animal, medicine.anatomical_structure, Histopathology, business, Nuclear medicine
Abstract

Hypofractionation schemes and associated higher rectal doses have evoked the need for improved protection of the rectum during prostate cancer irradiation.An implantable, biodegradable, inflatable, preshaped triangular balloon of commercially used poly(L-lactide-co-epsilon-caprolactone) co-polymer material was developed to provide separation between prostate and rectum. Biocompatibility and degradability of the balloon implanted subcutaneously or perineally, and in the context of transperineal implantation and local irradiation were evaluated in several in vivo studies.The device was found to be biocompatible in subcutaneously implanted rabbits up to 42 days, in a transperineally implanted dog up to 12 months and in 8 transperineally implanted pigs up to 6 months. Upon inflation in situ the balloon separated the tissues, remained inflated for several months and subsequently biodegraded. No systemic or local toxicity was noted, as shown by histopathology. Device insertion into the perineal area using a dedicated introductory kit was convenient and feasible. Three-month followup in irradiated pigs that received 15 Gy in 3 fractions 1 week apart showed a stable balloon position with no local or systemic side effects.This novel device was safe and effective for its intended use of separating tissues for a desired duration. A clinical study will commence to evaluate the safety and efficacy of this device during irradiation in patients with prostate cancer.

Published
2008

3. Liquid chromatographic analysis of organic additives in copper plating baths

Author

Eli Grushka, Shaul Shohat, and S. Glikberg

Subjects
Chromatography, Isocratic elution, chemistry, Ion pairing, Scientific method, Organic Chemistry, Extraction (chemistry), Copper plating, chemistry.chemical_element, General Medicine, Biochemistry, Copper, Analytical Chemistry
Abstract

A new method is described for the analysis of organic additives in copper plating baths. Liquid chromatography, utilizing an ion-pair reversed-phase technique, was found to be most suited for this purpose. Ion pairing neutralizes the brightener components, thereby enabling the use of moderate conditions during analysis, I.e. , a pH of 4–5 and isocratic elution. Preceding the chromatography, a solid-phase extraction process was used to decrease the copper ion concentration and the acidity of the bath. Active copper plating baths were investigated and the results are given and explained.

Published
1988

Catalog

Books, media, physical & digital resources
See catalog results