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The formation of predictions is essential to our ability to build models of the world and use them for intelligent decision-making. Here we challenge the dominant assumption that humans form only forward predictions, which specify what future events are likely to follow a given present event. We demonstrate that in some environments, it is more efficient to use backward prediction, which specifies what present events are likely to precede a given future event. This is particularly the case in diverging environments, where possible future events outnumber possible present events. Correspondingly, in six preregistered experiments (n = 1,299) involving both simple decision-making and more challenging planning tasks, we find that humans engage in backward prediction in divergent environments and use forward prediction in convergent environments. We thus establish that humans adaptively deploy forward and backward prediction in the service of efficient decision-making., (© 2024. The Author(s), under exclusive licence to Springer Nature Limited.)

The finding that human decision-making is systematically biased continues to have an immense impact on both research and policymaking. Prevailing views ascribe biases to limited computational resources, which require humans to resort to less costly resource-rational heuristics. Here, we propose that many biases in fact arise due to a computationally costly way of coping with uncertainty-namely, hierarchical inference-which by nature incorporates information that can seem irrelevant. We show how, in uncertain situations, Bayesian inference may avail of the environment's hierarchical structure to reduce uncertainty at the cost of introducing bias. We illustrate how this account can explain a range of familiar biases, focusing in detail on the halo effect and on the neglect of base rates. In each case, we show how a hierarchical-inference account takes the characterization of a bias beyond phenomenological description by revealing the computations and assumptions it might reflect. Furthermore, we highlight new predictions entailed by our account concerning factors that could mitigate or exacerbate bias, some of which have already garnered empirical support. We conclude that a hierarchical inference account may inform scientists and policy makers with a richer understanding of the adaptive and maladaptive aspects of human decision-making., (© 2022. The Psychonomic Society, Inc.)

Background: Disorders involving compulsivity, fear, and anxiety are linked to beliefs that the world is less predictable. We lack a mechanistic explanation for how such beliefs arise. Here, we test a hypothesis that in people with compulsivity, fear, and anxiety, learning a probabilistic mapping between actions and environmental states is compromised., Methods: In Study 1 ( n = 174), we designed a novel online task that isolated state transition learning from other facets of learning and planning. To determine whether this impairment is due to learning that is too fast or too slow, we estimated state transition learning rates by fitting computational models to two independent datasets, which tested learning in environments in which state transitions were either stable (Study 2: n = 1413) or changing (Study 3: n = 192)., Results: Study 1 established that individuals with higher levels of compulsivity are more likely to demonstrate an impairment in state transition learning. Preliminary evidence here linked this impairment to a common factor comprising compulsivity and fear. Studies 2 and 3 showed that compulsivity is associated with learning that is too fast when it should be slow (i.e. when state transition are stable) and too slow when it should be fast (i.e. when state transitions change)., Conclusions: Together, these findings indicate that compulsivity is associated with a dysregulation of state transition learning, wherein the rate of learning is not well adapted to the task environment. Thus, dysregulated state transition learning might provide a key target for therapeutic intervention in compulsivity.

Many decision-making studies have demonstrated that humans learn either expected values or relative preferences among choice options, yet little is known about what environmental conditions promote one strategy over the other. Here, we test the novel hypothesis that humans adapt the degree to which they form absolute values to the diversity of the learning environment. Since absolute values generalize better to new sets of options, we predicted that the more options a person learns about the more likely they would be to form absolute values. To test this, we designed a multi-day learning experiment comprising twenty learning sessions in which subjects chose among pairs of images each associated with a different probability of reward. We assessed the degree to which subjects formed absolute values and relative preferences by asking them to choose between images they learned about in separate sessions. We found that concurrently learning about more images within a session enhanced absolute-value, and suppressed relative-preference, learning. Conversely, cumulatively pitting each image against a larger number of other images across multiple sessions did not impact the form of learning. These results show that the way humans encode preferences is adapted to the diversity of experiences offered by the immediate learning context., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2022 Solomyak et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

Managing multiple goals is essential to adaptation, yet we are only beginning to understand computations by which we navigate the resource demands entailed in so doing. Here, we sought to elucidate how humans balance reward seeking and punishment avoidance goals, and relate this to variation in its expression within anxious individuals. To do so, we developed a novel multigoal pursuit task that includes trial-specific instructed goals to either pursue reward (without risk of punishment) or avoid punishment (without the opportunity for reward). We constructed a computational model of multigoal pursuit to quantify the degree to which participants could disengage from the pursuit goals when instructed to, as well as devote less model-based resources toward goals that were less abundant. In general, participants ( n = 192) were less flexible in avoiding punishment than in pursuing reward. Thus, when instructed to pursue reward, participants often persisted in avoiding features that had previously been associated with punishment, even though at decision time these features were unambiguously benign. In a similar vein, participants showed no significant downregulation of avoidance when punishment avoidance goals were less abundant in the task. Importantly, we show preliminary evidence that individuals with chronic worry may have difficulty disengaging from punishment avoidance when instructed to seek reward. Taken together, the findings demonstrate that people avoid punishment less flexibly than they pursue reward. Future studies should test in larger samples whether a difficulty to disengage from punishment avoidance contributes to chronic worry., Competing Interests: PS, ER, QH, RD, EE No competing interests declared, (© 2022, Sharp et al.)

Objective : A novel brief intervention was used to investigate how empathic support and expectation can induce changes in mood, anxiety, and perceived stress. Method : Seventy-six undergraduates with high negative affect were assigned to three conditions of a program involving tasks with no known therapeutic benefit. In Group 1: Expectation Only, participants were given a deceptive description of the benefits of the program to quantify the magnitude of symptom change due to expectation alone. In Group 2: Empathic Support + Expectation, participants were also instructed to write about past and current sources of distress and provided with supportive notes each week to quantify the role of empathic support plus expectation. In Group 3: Control, participants were told they were "norming" the instruments. Results : Participants in Groups 1 and 2 demonstrated decreases in depression, anxiety, and rumination, with significant medium effect reductions found in the empathic support plus expectation condition. Conclusions : Evidence suggests that empathic support and expectation cause reduction of symptoms spanning depression and anxiety.

Recent mechanistic models of cognitive control define the normative level of control deployment as a function of the effort cost of exerting control balanced against the reward that can be attained by exerting control. Despite these models explaining empirical findings in adults, prior literature has suggested that adolescents may not adaptively integrate value into estimates of how much cognitive control they should deploy. Moreover, much work in adolescent neurodevelopment casts social valuation processes as competing with, and in many cases overwhelming, cognitive control in adolescence. Here, we test whether social incentives can adaptively increase cognitive control. Adolescents (M age  = 14.64, 44 male, N = 87) completed an incentivized cognitive control task in which they could exert cognitive control to receive rewards on behalf of real peers who were rated by all peers in their school grade as being of either high- or low-status. Using Bayesian modeling, we find robust evidence that adolescents exert more cognitive control for high- relative to low-status peers. Moreover, we demonstrate that social incentives, irrespective of their high- or low-status, boost adolescent cognitive control above baseline control where no incentives are offered. Findings support the hypothesis that the cognitive control system in early adolescence is flexibly modulated by social value., (© 2021 John Wiley & Sons Ltd.)

Background: A dominant methodology in contemporary clinical neuroscience is the use of dimensional self-report questionnaires to measure features such as psychological traits (e.g., trait anxiety) and states (e.g., depressed mood). These dimensions are then mapped to biological measures and computational parameters. Researchers pursuing this approach tend to equate a symptom inventory score (plus noise) with some latent psychological trait., Main Text: We argue this approach implies weak, tacit, models of traits that provide fixed predictions of individual symptoms, and thus cannot account for symptom trajectories within individuals. This problem persists because (1) researchers are not familiarized with formal models that relate internal traits to within-subject symptom variation and (2) rely on an assumption that trait self-report inventories accurately indicate latent traits. To address these concerns, we offer a computational model of trait depression that demonstrates how parameters instantiating a given trait remain stable while manifest symptom expression varies predictably. We simulate patterns of mood variation from both the computational model and the standard self-report model and describe how to quantify the relative validity of each model using a Bayesian procedure., Conclusions: Ultimately, we would urge a tempering of a reliance on self-report inventories and recommend a shift towards developing mechanistic trait models that can explain within-subject symptom dynamics.

Significant quantities of plastic debris pollute nearly all the world's ecosystems, where it persists for decades and poses a considerable threat to flora and fauna. Much of the focus has been on the marine environment, with little information on the hazard posed by debris accumulating on beaches and adjacent vegetated areas. Here we investigate the potential for beach debris to disrupt terrestrial species and ecosystems on two remote islands. The significant quantities of debris on the beaches, and throughout the coastal vegetation, create a significant barrier which strawberry hermit crabs (Coenobita perlatus) encounter during their daily activities. Around 61,000 (2.447 crabs/m 2 ) and 508,000 crabs (1.117 crabs/m 2 ) are estimated to become entrapped in debris and die each year on Henderson Island and the Cocos (Keeling) Islands, respectively. Globally, there is an urgent need to establish a clear link between debris interactions and population persistence, as loss of biodiversity contributes to ecosystem degradation. Our findings show accumulating debris on these islands has the potential to seriously impact hermit crab populations. This is important for countless other islands worldwide where crabs and debris overlap, as crabs play a crucial role in the maintenance of tropical ecosystems., Competing Interests: Declaration of Competing Interest JLL: none. PBS: PBS is an employee of Two Hands Project. Two Hands Project provided support in the form of a salary for PBS, but did not have any other role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. SS: SS is an employee of Two Hands Project. Two Hands Project provided support in the form of a salary for SS, but did not have any other role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. ALB: none., (Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.)

Heightened risk taking in adolescence has long been attributed to valuation systems overwhelming the deployment of cognitive control. However, this explanation of why adolescents engage in risk taking is insufficient given increasing evidence that risk-taking behavior can be strategic and involve elevated cognitive control. We argue that applying the Expected Value of Control (EVC; Shenhav, Botvinick, & Cohen, 2013) computational model to adolescent risk taking can clarify under what conditions control is elevated or diminished during risky decision making. Through this lens, we review research examining when adolescent risk taking might be due to-rather than a failure of-effective cognitive control and suggest compelling ways to test such hypotheses. This effort can not only resolve when risk taking arises from an immaturity of the control system itself versus differences in what adolescents value relative to adults, but also identify promising avenues for channeling cognitive control towards adaptive outcomes in adolescence.

Familial stressors, such as weak familial connectedness, are associated with the development of maladaptive threat processing, yet little is known regarding how weak familial bonds impinge on biological mechanisms of threat processing. The present study leveraged multivoxel pattern analysis of fMRI data to compare the neural encoding of familial and nonfamilial threatening and non-threatening stimuli in adolescents who endorsed varying levels of connectedness to their families. Adolescents (N = 22, Mage = 14.38 years) reporting lower family connectedness 1 year earlier showed elevated sensitivity to familial threat, but not to nonfamilial threat in a neural network associated with threat processing, comprising left and right amygdala, and right inferior and middle temporal gyri. Results suggest that a learning history about one's social environment may shape neural mechanisms of threat processing by sensitizing them to risk-relevant stimuli. Such findings advance our understanding of how familial stressors contribute to disordered threat processing in adolescence.

Marine debris is pervasive worldwide, and affects biota negatively. We compared the characteristics of debris incorporated within brown booby (Sula leucogaster) nests throughout their pantropical distribution by assessing the type, colour and mass of debris items within nests and in beach transects at 18 sites, to determine if nests are indicators of the amount of debris in local marine environments. Debris was present in 14.4% of nests surveyed, with the proportion of nests with debris varying among sites (range: 0-100%). There was minimal overlap between the type or colour of debris found in nests and on adjacent beaches at individual sites. This suggests that brown boobies do not select debris uniformly across their distribution. We propose that the nests of brown boobies can be used as a sentinel of marine debris pollution of their local environment., (Copyright © 2018 Elsevier Ltd. All rights reserved.)

Although mindfulness meditation is known to provide a wealth of psychological benefits, the neural mechanisms involved in these effects remain to be well characterized. A central question is whether the observed benefits of mindfulness training derive from specific changes in the structural brain connectome that do not result from alternative forms of experimental intervention. Measures of whole-brain and node-level structural connectome changes induced by mindfulness training were compared with those induced by cognitive and physical fitness training within a large, multi-group intervention protocol (n = 86). Whole-brain analyses examined global graph-theoretical changes in structural network topology. A hypothesis-driven approach was taken to investigate connectivity changes within the insula, which was predicted here to mediate interoceptive awareness skills that have been shown to improve through mindfulness training. No global changes were observed in whole-brain network topology. However, node-level results confirmed a priori hypotheses, demonstrating significant increases in mean connection strength in right insula across all of its connections. Present findings suggest that mindfulness strengthens interoception, operationalized here as the mean insula connection strength within the overall connectome. This finding further elucidates the neural mechanisms of mindfulness meditation and motivates new perspectives about the unique benefits of mindfulness training compared to contemporary cognitive and physical fitness interventions.

Background: Most graduate nursing education curricula naturally segregate students by role as they move into their role-specific coursework and clinical experiences. Segregation diminishes the opportunity for students to form important intraprofessional relationships. Intraprofessional collaboration can potentiate the influence of advanced practice nurses on individual patients, patient populations, and larger health care systems., Method: This pilot program paired clinical nurse specialists and nurse practitioner students in immersion clinical practicum experiences aimed to increase their understanding of each other's role and potential avenues for collaboration in future practice., Results: Students report increased levels of understanding of each other's roles and scope of practice. Pairing students in immersion experiences broadens their clinical reach and potentiates their influence on vulnerable patient populations., Conclusion: Findings indicate that this pilot program can be sustained. Benefits to early and focused intraprofessional educational experiences include increased awareness of advanced practice roles, scope of practice, and potential avenues for future collaboration. [J Nurs Educ. 2017;56(12):748-751.]., (Copyright 2017, SLACK Incorporated.)

An increasing number of studies highlight the risk of plastic pollution in the marine environment. However, systematic longitudinal data on the distribution and abundance of plastic debris remain sparse. Here we present the results of a two-year study of plastic pollution within the Tasman Sea, contrasted with a further year of data from the same region, in order to document how the density of debris varies across years in this area. Surface net tows were collected between Hobart, Tasmania and Sydney, Australia during the spring of 2013 and 2014 and compared with a subset of data from autumn 2012 from the same region. Substantial inter-annual variation in mean plastic abundance was observed over the three year period, ranging from to 248.04-3711.64pieceskm -2 , confirming the need for multiple years of sampling to fully estimate the extent of, and trends in, plastic pollution., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Etiological explanations of clinical anxiety can be advanced through understanding the neural mechanisms associated with anxiety in youth prior to the emergence of psychopathology. In this vein, the present study sought to investigate how trait anxiety is related to features of the structural connectome in early adolescence. 40 adolescents (21 female, mean age = 13.49 years) underwent a diffusion-weighted imaging scan. We hypothesized that the strength of several a priori defined structural connections would vary with anxious arousal based on previous work in human clinical neuroscience and adult rodent optogenetics. First, connection strength of caudate to rostral middle frontal gyrus was predicted to be anticorrelated with anxious arousal, predicated on extant work in clinically-diagnosed adolescents. Second, connection strength of amygdala to rostral anterior cingulate and to medial orbital frontal cortex would be positively and negatively correlated with anxious arousal, respectively, predicated on rodent optogenetics showing the former pathway is anxiogenic and the latter is anxiolytic. We also predicted that levels of anxiety would not vary with measures of global network topology, based on reported null findings. Results support that anxiety in early adolescence is associated with (1) the clinical biomarker connecting caudate to frontal cortex, and (2) the anxiogenic pathway connecting amygdala to rostral anterior cingulate, both in left but not right hemisphere. Findings support that in early adolescence, anxious arousal may be related to mechanisms that increase anxiogenesis, and not in a deficit in regulatory mechanisms that support anxiolysis.

Anthropogenic beach debris was recorded during beach surveys of 24 Caribbean islands during April 2014-April 2016. Beach debris was classified according to material type (e.g., polystyrene) and item use (e.g., fishing). Geophysical features (substrate type, beach direction, and human accessibility) of sample sites were recorded in order to investigate their relationship with debris density. Results suggest the density of macro debris (items >5mm) is highest on uninhabited, sandy beaches facing a leeward direction. Higher debris quantities on inaccessible beaches may be due to less frequent beach clean ups. Frequently accessed beaches exhibited lower macro, but higher micro debris (items 1-5mm) densities, possibly due to removal of macro debris during frequent beach clean ups. This suggests that while geophysical features have some influence on anthropogenic debris densities, high debris densities are occurring on all islands within the Caribbean region regardless of substrate, beach direction, or human accessibility., (Copyright © 2017 Elsevier Ltd. All rights reserved.)

Converging neuroscientific and psychological evidence points to several transdiagnostic factors that cut across DSM-defined disorders, which both affect and are affected by executive dysfunction. Two of these factors, anxious apprehension and anxious arousal, have helped bridge the gap between psychological and neurobiological models of anxiety. The present integration of diverse findings advances an understanding of the relationships between these transdiagnostic anxiety dimensions, their interactions with each other and executive function, and their neural mechanisms. Additionally, a discussion is provided concerning how these constructs fit within the Research Domain Criteria (RDoC) matrix developed by the National Institutes of Mental Health and how they relate to other anxiety constructs studied with different methods and at other units of analysis. Suggestions for future research are offered, including how to (1) improve measurement and delineation of these constructs, (2) use new neuroimaging methods and theoretical approaches of how the brain functions to build neural mechanistic models of these constructs, and (3) advance understanding of the relationships of these constructs to diverse emotional phenomena and executive functions., (Copyright © 2015 Elsevier B.V. All rights reserved.)

Background and Research Objective: Participation in cardiac rehabilitation (CR) can result in positive outcomes for patients, but this population comprises only up to 20% of the total cardiac population. Thus, it is also necessary to examine the determinants of lifestyle behaviors in cardiac patients who do not attend CR programs. Studies have focused largely on physical health and outcomes of exercise participation, with less attention to dietary habits and the psychological determinants of behavior change. The purpose of this descriptive comparative study was to examine the differences in self-efficacy for and barriers to healthy dietary intake between CR participants and nonparticipants at 6 and 12 weeks after hospital discharge., Participants and Methods: A prospective longitudinal design was used. The sample consisted of 51 adults who (1) were diagnosed with/recovering from an acute cardiac event, treatment, or intervention; (2) received phase I CR; and (3) were physically able to participate in phase II CR. Participants were primarily male, elderly, married, and white; had more than a high school education; and had incomes more than $30,000. Analysis of covariance was used to determine differences over time in self-efficacy and barriers to healthy dietary intake between groups., Results and Conclusions: Although time 1 findings between groups were not significant, CR participants reported higher self-efficacy for healthy dietary intake than did nonparticipants. At time 2, CR participants also reported greater self-efficacy (F3,40 = 13.69, P ≤ .0001), indicating more confidence they could commit to a healthy diet. A significant difference was found in barriers to healthy dietary intake (t = 2.13, P = .04) at time 1, with CR participants reporting fewer barriers. At time 2, CR participants reported fewer barriers to healthy dietary intake (F3,39 = 18.19, P < .0001), indicating a more positive perception. Findings improve understanding of factors influencing adoption of healthy diet behaviors and are useful for designing interventions to assist individuals in sustaining secondary preventive efforts over time.

Critical-care settings have an opportunity to create healing environments (HEs). For the last decade, achieving this goal has been the task of the American Association of Critical Care Nurses. Today, several models used in these settings embrace synergistic care, healing therapies for patients, and the development of organizational models to improve the HEs for nurses themselves. Creating the HE is not impossible; however, researching the patient's experience within it is complex. This complexity requires researchers to consider biological, behavioral, and social variables on the unit. This article will describe biological and behavioral measures that may be used to examine the critically ill patient's response to an HE. Limitations of these measures are considerable. Future researchers will need to consider a multiplistic approach to the study of this construct.

1. 5-Phosphorylribose 1-pyrophosphate, in the presence of beta-mercaptoethanol, protected beta-galactosidase from heat inactivation. Many other substances, including 3':5'-cyclic-AMP, were without effect. 2. The efficiency of complementation in vitro of beta-galactosidase segments was decreased by 5-phosphorylribose 1-pyrophosphate but not by 3':5'-cyclic-AMP. Neither substance affected the activity of the complete enzyme. 3. Some indications as to the possible identity of the catabolite repression effector are presented.

1. Both permanent and transient catabolite repression of beta-galactosidase synthesis in Escherichia coli are abolished by 5mm-3':5'-cyclic-AMP when elicited by glucose, but not when caused by a mixture of glucose, glucose 6-phosphate, gluconate and casein hydrolysate (casamino acids). 2. Glucose uptake is slightly increased by 3':5'-cyclic-AMP. 3. No significant effects of the nucleotide were found on the synthesis of protein and RNA, either in exponential growth on one substrate, or during a growth shift from glycerol to glycerol plus glucose. 4. Marked changes in the soluble-protein profiles of cells growing in glycerol and glucose were caused by the presence of 3':5'-cyclic-AMP. 5. Measurements of (14)CO(2) release from specifically-labelled glucose showed that 3':5'-cyclic-AMP greatly stimulated glycolytic activity while having a minor depressing effect on the metabolic flow through the pentose phosphate cycle. 6. The concentrations of several metabolic intermediates, particularly fructose 1,6-diphosphate, were greatly affected by the presence of 3':5'-cyclic-AMP. 7. Several metabolites partially relieved glucose repression of beta-galactosidase synthesis in EDTA-treated cells; three out of five of these metabolites reversed the effect more effectively than did 3':5'-cyclic-AMP. 8. The evidence for and against a direct role for 3':5'-cyclic-AMP is discussed. It is concluded that the evidence for indirect action is at least as strong as that for direct action.