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1. Implementation of the updated Sydney system biopsy protocol improves the diagnostic yield of gastric preneoplastic conditions: Results from a real-world study

Author

Latorre, Gonzalo, Vargas, José Ignacio, Shah, Shailja C., Ivanovic-Zuvic, Danisa, Achurra, Pablo, Fritzsche, Martín, Leung, Jai-Sen, Ramos, Bernardita, Jensen, Elisa, Uribe, Javier, Montero, Isabella, Gandara, Vicente, Robles, Camila, Bustamante, Miguel, Silva, Felipe, Dukes, Eitan, Corsi, Oscar, Martínez, Francisca, Binder, Victoria, Candia, Roberto, González, Robinson, Espino, Alberto, Agüero, Carlos, Sharp, Allan, Torres, Javiera, Roa, Juan Carlos, Pizarro, Margarita, Corvalan, Alejandro H., Rabkin, Charles S., Camargo, M. Constanza, and Riquelme, Arnoldo

Published
2024
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2. Clinical features and prognosis of malignant small bowel tumors: Experience from a university hospital in Chile

Author

Silva, Felipe, Bustamante, Miguel, Latorre, Gonzalo, Flandez, Jorge, Montero, Isabella, Dukes, Eitan, Gandara, Vicente, Robles, Camila, Uribe, Javier, Iglesias, Andrés, Bellolio, Felipe, Molina, María Elena, Migueles, Rodrigo, Urrejola, Gonzalo, Larach, Tomás, Besser, Nicolas, Sharp, Allan, Agüero, Carlos, Riquelme, Arnoldo, Vargas, José Ignacio, Candia, Roberto, Monrroy, Hugo, De Simone, Federico, and Espino, Alberto

Published
2024
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3. Evaluation of trefoil factor 3 as a non-invasive biomarker of gastric intestinal metaplasia and gastric cancer in a high-risk population

Author

Latorre, Gonzalo, Pizarro, Margarita, Ford, James Stephen, Gándara, Vicente, Muñoz, Gonzalo, Araya, Juan Carlos, Bellolio, Enrique, Villaseca, Miguel, Fuentes-López, Eduardo, Cortés, Pablo, Rollán, Antonio, Bufadel, María Ester, Araya, Raúl, Vargas, José Ignacio, Espino, Alberto, Sharp, Allan, Agüero, Carlos, Donoso, Andrés, Bresky, Gustavo, Pedrero, Pamela, Rueda, Carlos, Calvo, Alfonso, Odagaki, Tomoyuki, Moriyama, Tomohiko, Ishida, Tsukasa, Parra-Blanco, Adolfo, Camargo, M. Constanza, González, Robinson, Corvalán, Alejandro H., and Riquelme, Arnoldo

Published
2023
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5. Implementation of the Updated Sydney System biopsy protocol improves the diagnostic yield of gastric preneoplastic conditions: results from a real-world study

Author

Latorre, Gonzalo, primary, Ignacio Vargas, José, additional, Shah, Shailja C., additional, Ivanovic-Zuvic, Danisa, additional, Achurra, Pablo, additional, Fritzsche, Martín, additional, Leung, Jai-Sen, additional, Ramos, Bernardita, additional, Jensen, Elisa, additional, Uribe, Javier, additional, Montero, Isabella, additional, Gandara, Vicente, additional, Robles, Camila, additional, Bustamante, Miguel, additional, Silva, Felipe, additional, Dukes, Eitan, additional, Corsi, Oscar, additional, Martínez, Francisca, additional, Binder, Victoria, additional, Candia, Roberto, additional, González, Robinson, additional, Espino, Alberto, additional, Agüero, Carlos, additional, Sharp, Allan, additional, Torres, Javiera, additional, Roa, Juan Carlos, additional, Pizarro, Margarita, additional, Corvalan, Alejandro H., additional, Rabkin, Charles S., additional, Constanza Camargo, M., additional, and Riquelme, Arnoldo, additional

Published
2023
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12. Miotomía endoscópica por vía oral (POEM) en un paciente pediátrico para tratamiento de la acalasia esofágica

Author

Mejía, Ricardo, Sáez, Josefina, Aranda, Francisco, Pattillo, Juan Carlos, Vuletin, José Fernando, Gattini, Daniela, Jaime, María Francisca, and Sharp, Allan

Subjects
therapeutic endoscopy, Heller myotomy, Esophageal achalasia, POEM, Acalasia esofágica, miotomía de Heller, endoscopía terapéutica
Abstract

Resumen: Introducción: La acalasia es el trastorno motor primario más frecuente del esófago. Su incidencia reportada es baja, aún más en pacientes pediátricos. La miotomía de Heller laparoscópica corres ponde al estándar actual de tratamiento. Durante los últimos años la miotomía endoscópica por vía oral (POEM) se ha posicionado como una alternativa terapéutica segura y tan efectiva como el Heller para la acalasia esofágica. Objetivo: Describir la técnica de POEM y reportar el primer caso pediátrico en nuestro país. Caso clínico: Paciente de 11 años, previamente sano, que se presentó con disfagia ilógica progresiva y baja de peso. El estudio concluyó una acalasia tipo II. Fue sometido a POEM y cursó un postoperatorio sin incidentes. A un año de la intervención se ha documentado resolución de la sintomatología, seguimiento endoscópico y manométrico sin complicaciones. Con clusiones: El caso descrito corresponde al primer POEM en un paciente pediátrico en nuestro país. La acalasia esofágica es infrecuente en pediatría y el POEM ha demostrado éxito clínico y seguridad comparables a la miotomía de Heller laparoscópica en el corto y mediano plazo. El seguimiento a largo plazo permitirá determinar su rol definitivo en el tratamiento de pacientes pediátricos con acalasia esofágica. Abstract: Introduction: Achalasia is the most common primary motor disorder of the esophagus. Its reported incidence is low, even more in pediatric patients. Laparoscopic Heller myotomy is the current stan dard of treatment. During the last years, per-oral endoscopic myotomy (POEM) has been positioned as a safe and effective therapeutic alternative as the Heller procedure for esophageal achalasia. Ob jective: To describe the POEM technique and report the first pediatric case in our country. Clinical Case: 11-year-old patient, previously healthy, who presented with progressive dysphagia for solids and liquids and weight loss. The study concluded a type II achalasia. The patient underwent a POEM and had a postoperative course without incidents. One year after the intervention, symptomatic, endoscopic and manometric resolution have been documented. Conclusions: The described case is the first POEM in a pediatric patient in our country. Esophageal achalasia is uncommon in pediatrics and POEM has demonstrated clinical success and safety comparable to laparoscopic Heller myotomy in short and medium term. Long-term follow-up will determine its definitive role in the treatment of pediatric patients with esophageal achalasia.

Published
2019

13. News from the interface: the molecular structures of triacylglyceride lipases

Author

Derewenda, Zygmunt S. and Sharp, Allan M.

Subjects
Triglycerides -- Research, Lipase -- Research, Molecular structure -- Analysis, Biological sciences, Chemistry
Abstract

Neutral lipases constitute one of the most ubiquitous and diverse families of enzymes. The recently solved crystal structures of three lipases show that enzymatic hydrolysis occurs with the assistance of a catalytic triad, which is structurally reminiscent of serine proteinases. However, these lipases only become active at the oil--water interface through a conformational change that exposes the active centre of the enzyme., The reports on the crystal structures of triacylglyceride lipases RmL,derived from Rhizomucor meihei, human pancreatic lipase (hPL) and GcL, derived from the Geotrichum candidum, provide insight into protein-lipid interactions and lipid degradation. The three non-homologous enzymes are alpha/beta-type proteins having central, predominantly parallel beta-sheet. In addition, the carboxy-terminal side of the central sheet was found to be the catalytic site of the enzymes. These data provide the molecular basis of interfacial activation which is a unique property of true lipases.

Published
1993

14. Resección endoscópica por tunelización submucosa de un leiomioma de la unión gastroesofágica: reporte de un caso

Author

Mejía, Ricardo, Sharp, Joaquín, Sáez, Josefina, and Sharp, Allan

Subjects
resección endoscópica, endoscopic resection, submucosal tunnelization, submucosal tumor, tumor submucoso, tunelización submucosa
Abstract

Resumen Introducción Los tumores submucosos del tracto gastrointestinal alto tienen potencial de malignidad y también pueden ser una carga para el paciente, por lo que se requiere disponer de un tratamiento seguro y eficaz. El surgimiento de la técnica de resección endoscópica por tunelización submucosa (STER) en los últimos años ha mostrado resultados prometedores. Caso clínico Se presenta el caso de un hombre de 47 años asintomático, en quien, en el contexto de un estudio preoperatorio de cirugía bariátrica, se pesquisa una lesión subepitelial en la unión gastroesofágica. La endosonografía alta es compatible con un leiomioma esofágico. Se realiza STER con éxito y sin complicaciones; a las 48 h es dado de alta. El estudio histopatológico confirmó un leiomioma esofágico. Discusión La técnica STER ha demostrado consistentemente ser segura y eficaz en el tratamiento de los tumores submucosos de la unión gastroesofágica. El desafío es difundir la técnica por el resto del país, para mayor beneficio de los pacientes. Introduction Upper gastrointestinal submucosal tumors are potentially malignant lesions; so safe and efficient treatments are needed. In recent years, submucosal tunneling endoscopic resection (STER) has emerged as a novel therapeutic technique, with promising results. Case report 47-year-old male patient, previously asymptomatic, who was found to have a subepithelial lesion at the gastroesophageal junction. Upper endoscopic ultrasound was compatible with a leiomyoma. He underwent STER to remove the tumor and recovered with any complications. The biopsy confirmed an esophageal leiomyoma. Discussion STER has become a highly feasible and safe therapeutic option for submucosal tumors of the gastroesophageal junction. The challenge is to spread knowledge about this technique, to maximize patient's benefit.

Published
2018

20. Su1210 Epidemiology of Small Bowel Tumors: 16 Years of Experience at a Chilean University Center

Author

Flandez, Jorge, primary, Cruz, Rodrigo, additional, Calderon, Paula, additional, Aldana, Camila, additional, Vasquez, Martin, additional, Andrade, Rocio, additional, Jarufe, Nicolas, additional, Martinez, Jorge A., additional, Guerra, Juan Francisco, additional, Molina, Maria, additional, Bellolio, Felipe, additional, Migueles, Rodrigo, additional, Larach, Jose, additional, Pimentel, Fernando, additional, Sharp, Allan C., additional, Donoso, Andres, additional, Mejia, Ricardo, additional, Torres, Javiera, additional, Duarte, Ignacio, additional, Vargas, Jose Ignacio, additional, San Martin, Diego, additional, Alvarez-Lobos, Manuel, additional, Gonzalez, Robinson G., additional, and Espino, Alberto, additional

Published
2017
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22. Disección submucosa endoscópica en cáncer gástrico incipiente: experiencia inicial en el Hospital Clínico de la Pontificia Universidad Católica de Chile

Author

Donoso D, Andrés, Sharp, Allan, Parra-Blanco, Adolfo, Roa, Juan Carlos, Bächler, Jean Phillipe, Crovari, Fernando, Funke, Ricardo, Pimentel, Fernando, Ibáñez, Luis, and Guzmán, Sergio

Subjects
Minimally invasive surgical procedures, Early detection of cancer, Stomach neoplasms, Endoscopy, digestive system
Abstract

Background: Endoscopic submucosal dissection (ESD) is a minimally invasive procedure that allows curative treatment of early gastric cancer (EGC) in selected patients. Aim: To report our initial experience with ESD. Material and Methods: Analysis of prospective data from 16 patients aged 61 to 84 years, who underwent ESD between December 2011 and June 2014. Tumor type, operative time, hospitalization length, oncologic outcomes, complications and short-term follow up were registered. Results: En-block resection was achieved in all cases. The median operative time was 135 min (range: 50-320 min). Specimens' median size was 3.5 cm (range: 3-10). All the resections were R0. In 14 patients ESD was considered curative. In two patients, ESD was considered potentially non-curative due to the presence pathological risk factors for lymph-node metastases in the biopsy specimen. Both patients underwent laparoscopic gastrectomy with lymph-node dissection. There was one case of gastric wall perforation that was repaired by laparoscopic suture. There was no mortality. The median follow-up time was 15 months (range: 2-30 months). Conclusions: ESD is a feasible and safe procedure in our institution with good results in this initial experience.

Published
2015

23. Resección endoscópica por tunelización submucosa de un leiomioma de la unión gastroesofágica: reporte de un caso

Author

Mejía, Ricardo, Sharp, Joaquín, Sáez, Josefina, and Sharp, Allan

Abstract

Los tumores submucosos del tracto gastrointestinal alto tienen potencial de malignidad y también pueden ser una carga para el paciente, por lo que se requiere disponer de un tratamiento seguro y eficaz. El surgimiento de la técnica de resección endoscópica por tunelización submucosa (STER) en los últimos años ha mostrado resultados prometedores.

Published
2024
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26. Disección submucosa endoscópica en cáncer gástrico incipiente: experiencia inicial en el Hospital Clínico de la Pontificia Universidad Católica de Chile

Author

Donoso D, Andrés, primary, Sharp, Allan, additional, Parra-Blanco, Adolfo, additional, Roa, Juan Carlos, additional, Bächler, Jean Phillipe, additional, Crovari, Fernando, additional, Funke, Ricardo, additional, Pimentel, Fernando, additional, Ibáñez, Luis, additional, and Guzmán, Sergio, additional

Published
2015
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27. 589 Duodenojejunal Bypass Liner Increases Fasting and Postprandial Serum Levels of Bile Acids in Patients With Severe Obesity

Author

Munoz, Rodrigo, primary, Miquel, Juan F., additional, Arrese, Marco, additional, Irribarra, Veronica, additional, Pimentel, Fernando, additional, Sharp, Allan C., additional, Turiel, Dannae, additional, Pizarro, Palmenia, additional, Young, Andrew, additional, Brown, Kathleen, additional, Maggs, David, additional, Kaplan, Lee M., additional, and Escalona, Alex, additional

Published
2014
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29. Weight Loss and Metabolic Improvement in Morbidly Obese Subjects Implanted for 1 Year With an Endoscopic Duodenal-Jejunal Bypass Liner

Author

Escalona, Alex, primary, Pimentel, Fernando, additional, Sharp, Allan, additional, Becerra, Pablo, additional, Slako, Milenko, additional, Turiel, Dannae, additional, Muñoz, Rodrigo, additional, Bambs, Claudia, additional, Guzmán, Sergio, additional, Ibáñez, Luis, additional, and Gersin, Keith, additional

Published
2012
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30. 805 Complications of Gastrointestinal Endoscopy in 85,391 Procedures

Author

Espino, Alberto, primary, Garcia, Ximena, additional, Mac-Namara, Macarena, additional, Richter, Hugo, additional, Pimentel, Fernando, additional, Biel, Francisco, additional, Robles, Camila, additional, Callejas, Matías, additional, Sharp, Allan C., additional, Donoso, Andres, additional, Candia, Roberto, additional, Gonzalez, Robinson G., additional, Jarufe, Nicolas, additional, Arrese, Marco, additional, Alvarez-Lobos, Manuel, additional, and Padilla, Oslando, additional

Published
2012
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38. LETTERS.

Author

Sharp, Allan, Kouts, Phil, Allen, Marcus, and Yapi, Rex

Subjects
HELIUM, WAVELENGTHS, PHYSICISTS
Published
2019

43. [Experience with endoscopic submucosal dissection for the treatment of early neoplasms of the digestive tract].

Author

Mejía R, Sáez J, Briones P, Norero E, Ceroni M, Díaz A, and Sharp A

Subjects
Dissection, Gastrointestinal Tract, Humans, Neoplasm Recurrence, Local, Quality of Life, Retrospective Studies, Treatment Outcome, Endoscopic Mucosal Resection, Stomach Neoplasms
Abstract

Background: Endoscopic submucosal dissection (ESD) allows en-bloc resection of early gastro-intestinal neoplasms (EGIN) with healing potential., Aim: To describe the results of patients treated with ESD for EGIN by our team., Patients and Methods: Descriptive study of patients with EGIN who underwent ESD with curative intention between January 2008 and March 2020., Results: One hundred thirty-two ESD were performed in 127 patients. 77% were gastric lesions, 14% colorectal, 8% esophageal and 1% duodenal. En-bloc resection was achieved in 98.4% of ESDs. Eighty eight percent of patients met curative standards. Overall, cancer-specific, and recurrence-free survival were 95%, 100% and 98% respectively., Conclusions: ESD allows en-bloc resections with curative potential in selected patients, but with a significant reduction in morbidity and mortality and less impact on quality of life. Our results suggest the feasibility to perform ESD in our country with results comparable to those reported in the literature.

Published
2021
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44. Per oral endoscopic myotomy in a pediatric patient with achalasia.

Author

Mejía R, Sáez J, Aranda F, Pattillo JC, Vuletin JF, Gattini D, Jaime MF, and Sharp A

Subjects
Child, Humans, Male, Esophageal Achalasia surgery, Pyloromyotomy
Abstract

Introduction: Achalasia is the most common primary motor disorder of the esophagus. Its reported incidence is low, even more in pediatric patients. Laparoscopic Heller myotomy is the current stan dard of treatment. During the last years, per-oral endoscopic myotomy (POEM) has been positioned as a safe and effective therapeutic alternative as the Heller procedure for esophageal achalasia. Ob jective: To describe the POEM technique and report the first pediatric case in our country., Clinical Case: 11-year-old patient, previously healthy, who presented with progressive dysphagia for solids and liquids and weight loss. The study concluded a type II achalasia. The patient underwent a POEM and had a postoperative course without incidents. One year after the intervention, symptomatic, endoscopic and manometric resolution have been documented., Conclusions: The described case is the first POEM in a pediatric patient in our country. Esophageal achalasia is uncommon in pediatrics and POEM has demonstrated clinical success and safety comparable to laparoscopic Heller myotomy in short and medium term. Long-term follow-up will determine its definitive role in the treatment of pediatric patients with esophageal achalasia.

Published
2019
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45. [Endoscopic submucosal dissection in early gastric cancer: Experience in 16 patients].

Author

Donoso D A, Sharp A, Parra-Blanco A, Roa JC, Bächler JP, Crovari F, Funke R, Pimentel F, Ibáñez L, and Guzmán S

Subjects
Adenocarcinoma pathology, Aged, Disease-Free Survival, Early Detection of Cancer, Female, Follow-Up Studies, Gastric Mucosa pathology, Humans, Lymphatic Metastasis, Male, Middle Aged, Neoplasm Staging, Operative Time, Prospective Studies, Stomach Neoplasms pathology, Treatment Outcome, Adenocarcinoma surgery, Dissection methods, Gastrectomy methods, Gastric Mucosa surgery, Stomach Neoplasms surgery
Abstract

Background: Endoscopic submucosal dissection (ESD) is a minimally invasive procedure that allows curative treatment of early gastric cancer (EGC) in selected patients., Aim: To report our initial experience with ESD., Material and Methods: Analysis of prospective data from 16 patients aged 61 to 84 years, who underwent ESD between December 2011 and June 2014. Tumor type, operative time, hospitalization length, oncologic outcomes, complications and short-term follow up were registered., Results: En-block resection was achieved in all cases. The median operative time was 135 min (range: 50-320 min). Specimens' median size was 3.5 cm (range: 3-10). All the resections were R0. In 14 patients ESD was considered curative. In two patients, ESD was considered potentially non-curative due to the presence pathological risk factors for lymph-node metastases in the biopsy specimen. Both patients underwent laparoscopic gastrectomy with lymph-node dissection. There was one case of gastric wall perforation that was repaired by laparoscopic suture. There was no mortality. The median follow-up time was 15 months (range: 2-30 months)., Conclusions: ESD is a feasible and safe procedure in our institution with good results in this initial experience.

Published
2015
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