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Cleidocranial dysplasia (CCD) is an uncommon hereditary condition characterized by a range of skeletal and dental irregularities, primarily caused by mutations in the RUNX2 gene. This case report details a 19-year-old female patient who visited the Department of Oral and Maxillofacial Surgery with complaints of multiple supernumerary teeth and retained deciduous teeth. The patient exhibited several hallmark features of CCD, including frontal bossing, an underdeveloped maxilla, a concave head shape, a flattened malar region, short stature with a bell-shaped chest, and sloping shoulders. The clinical presentation and treatment plan, which involved a phased approach combining surgical and orthodontic procedures, are discussed. Virtual surgical planning played a critical role in Surgically Assisted Rapid Palatal Expansion (SARPE). The positive outcome of this case emphasizes the importance of a multidisciplinary strategy in treating CCD and suggests the need for further exploration into standardized treatment protocols for this rare disorder. [ABSTRACT FROM AUTHOR]

Background and Objectives: Transdermal opioids have emerged as an effective and efficient analgesic modality to reduce post-operative pain effectively without the associated side effects of conventional iv opioids. This study aimed to assess the analgesic effectiveness of transdermal Buprenorphine 10 mcg/hr patches and transdermal Fentanyl 25 mcg/hr patches for alleviating postoperative pain oral cancer patients undergoing surgical resection with modified radicle neck dissection (MRND III) with reconstruction. Materials and Methods: This prospective, double-blind, randomized study included adult patients diagnosed with squamous cell carcinoma in the maxillofacial region. Participants were randomly assigned to one of three groups: Group 1 (control) received 100 mg of intravenous tramadol in 100 ml of normal saline, Group 2 received a fentanyl patch (25 mcg/hr), and Group 3 received a transdermal buprenorphine patch (10 mcg/hr). All patients were provided with intravenous paracetamol (1g) as a rescue analgesic when necessary. The transdermal patches were applied immediately before surgery. The primary objective was to assess mean FLACC scores, while the secondary objective was to evaluate total rescue analgesic requirements. Results: Group 3 demonstrated the lowest median FLACC scores, with a statistically significant difference (P < 0.05) at 2, 4, 8, 12, and 24 hours postoperatively (Kruskal-Wallis test). In addition, the total consumption of rescue analgesics was significantly lower in Group 3 compared to the other groups, without a corresponding increase in adverse events. Conclusions: The study concluded that applying a 10 mcg/hr buprenorphine patch prior to surgery in patients undergoing oral cancer procedures provides effective postoperative pain relief with minimal adverse effects. [ABSTRACT FROM AUTHOR]