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193 results on '"Sharma, Jyotika"'

2. Improving Performance and Quality of Service in 5G Technology

Author

Jain, Stuti, Jain, Ritika, Sharma, Jyotika, Sharma, Ashish, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Marriwala, Nikhil, editor, Tripathi, C.C, editor, Jain, Shruti, editor, and Kumar, Dinesh, editor

Published
2022
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14. Significance of Immunohistochemical Biomarker in Breast Carcinoma from a Single Tertiary Care Hospital of Southern Assam

Author

Choudhury Biswadeep, Sharma Jyotika, Deuri Biman, Naiding Momota, Bezbaruah Babul, and Nivedita Dasgupta

Subjects
Oncology, medicine.medical_specialty, business.industry, Internal medicine, medicine, Biomarker (medicine), Immunohistochemistry, Tertiary care hospital, skin and connective tissue diseases, Breast carcinoma, business
Abstract

Background: Breast carcinoma is the most common malignancy in female worldwide, leading cause of death in women.immunohistochemistry plays a very important role in the prognostication and treatment determination of breast carcinoma patients. Objective: To analyze the immunohistochemical markers in invasive carcinoma of breast and to correlate the expression of hormonal receptors with age of the patient, tumor size, histological grade and lymph node metastasis.Materials and method: The study was conducted on 88 infiltrating ductal breast carcinoma sample in a tertiary care hospital of Southern Assam for a period of two year (January2018- December 2019). Data including age, tumor size, and histologic grade and lymph node status retrieved from pathology department. Chi- square was used to determine the statistical significance between ER/PR status HER2/neu status along with their correlation with various clinicopathological parametres with respect to infiltrating ductal breast carcinoma.Result: The mean age of the patients was 56.6 years. We observed correlation between ER and PR expression with age, tumor size, tumor grade. There was correlation between HER2/neu expression and age only. None of the markers showed correlation with lymph node involvement (P>0.05).Conclusion: Our findings showed the importance of biomarkers (ER, PR, HER2/neu) expression as prognostic factors for therapeutic decision.

Published
2021

16. Antimicrobial Activity of Ficus Religiosa Against Some Pathogenic Microorganisms

Author

Pathania Singh Mamta, Sankhyan Poonam, Sharma Jyotika, Bhardwaj Payal, Pathania Singh Dhirendra, Pathania Singh Mamta, Sankhyan Poonam, Sharma Jyotika, Bhardwaj Payal, and Pathania Singh Dhirendra

Abstract

In the present study, we have chosen Ficus religiosa as herbal medicine to determine their antimicrobial property. Evidently, there are most efficient studies that confirm the antimicrobial property of this plant. This study looks into the in vitro antimicrobial activity of the plant for different solvent extracts against some gram positive and gram negative pathogenic microorganisms that causes most common cases of infectious diseases. Aqueous and ethanolic extracts of F. religiosa leaves showed antibacterial effect against Staphylococcus aureus, Salmonella paratyphi, Shigella dysenteriae, S. typhimurium, Pseudomonas aeruginosa, Bacillus subtillis, Escherichia coli, S. typhi. The extracts of F. religiosa were also found to be active against Aspergillus niger and Penicillium notatum.

Published
2021

18. Sialylation on O-linked glycans protects von Willebrand factor from macrophage galactose lectin-mediated clearance

Author

Ward, Soracha E., primary, O’Sullivan, Jamie M., additional, Moran, Alan B., additional, Spencer, Daniel I. R., additional, Gardner, Richard A., additional, Sharma, Jyotika, additional, Fazavana, Judicael, additional, Monopoli, Marco, additional, McKinnon, Thomas A.J., additional, Chion, Alain, additional, Haberichter, Sandra, additional, and O’Donnell, James S., additional

Published
2021
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29. Macrophage galactose-type lectin-1 (MGL1) deficiency is associated with increased neutrophilia and hyper inflammation in Gram-Negative pneumonia

Author

Jondle, Christopher N., Sharma, Atul, Simonson, Tanner J., Larson, Benjamin, Mishra, Bibhuti B., and Sharma, Jyotika

Subjects
Mice, Knockout, Leukocytosis, Neutrophils, Macrophages, Asialoglycoproteins, Gene Expression, Membrane Proteins, Adoptive Transfer, Extracellular Traps, Article, Disease Models, Animal, Klebsiella pneumoniae, Mice, Neutrophil Infiltration, Phagocytosis, Pneumonia, Bacterial, Animals, Genetic Predisposition to Disease, Lectins, C-Type, Inflammation Mediators, Gram-Negative Bacterial Infections
Abstract

C-type lectin receptors (CLRs), the carbohydrate-recognizing molecules, orchestrate host immune response in homeostasis and in inflammation. In the present study we examined the function of macrophage galactose-type lectin-1 (MGL1), a mammalian CLR, in pneumonic sepsis, a deadly immune disorder frequently associated with a nonresolving hyperinflammation. In a murine model of pneumonic sepsis using pulmonary infection with Klebsiella pneumoniae, the expression of MGL1 was upregulated in the lungs of K. pneumoniae-infected mice, and the deficiency of this CLR in MGL1(-/-) mice resulted in significantly increased mortality to infection than in the MGL1-sufficient wild-type mice, despite a similar bacterial burden. The phagocytic cells from MGL1(-/-) mice did not exhibit any defects in bacterial uptake and intracellular killing and were fully competent in neutrophil extracellular trap formation, a recently identified extracellular killing modality of neutrophils. Instead, the increased susceptibility of MGL1(-/-) mice seemed to correlate with severe lung pathology, indicating that MGL1 is required for resolution of pulmonary inflammation. Indeed, the MGL1(-/-) mice exhibited a hyperinflammatory response, massive pulmonary neutrophilia, and an increase in neutrophil-associated immune mediators. Concomitantly, MGL1-deficient neutrophils exhibited an increased influx in pneumonic lungs of K. pneumoniae-infected mice. Taken together, these results show a previously undetermined role of MGL1 in controlling neutrophilia during pneumonic infection, thus playing an important role in resolution of inflammation. To our knowledge, this is the first study depicting a protective function of MGL1 in an acute pneumonic bacterial infection.

Published
2016

30. Mechanism of neutrophil extracellular trap formation: role of Mincle as autophagy regulator

Author

Sharma, Atul, Simonson, Tanner, Jondle, Christopher N., Mishra, Bibhuti B., and Sharma, Jyotika

Subjects
Autophagy (Cytology) -- Health aspects, Neutrophils -- Health aspects, Science and technology
Abstract

Neutrophil extracellular traps (NETs) constitute antimicrobial function of neutrophils but have also been linked to perpetuation of inflammation. It's important but difficult to control NETs because of underdeveloped knowledge about the major regulating components. In the current study we examined the mechanism by which Mincle, a C-type lectin receptor, regulates NET formation. We found that Mincle mediates NET formation in response to several activation stimuli in-vitro and in-vivo during pneumoseptic infection with Klebsiella pneumoniae, indicating its regulatory role in NET formation. Mechanistically, we show that attenuated NET formation in Mincle-/- neutrophils correlates with an impaired autophagy activation in-vitro and in-vivo, while reactive oxygen species (ROS) formation in these neutrophils remained intact. The requirement of autophagy in Mincle-mediated NET formation was further supported by exogenous treatment with autophagy inducer tamoxifen, which rescued the NET formation defect in Mincle-/- neutrophils. This identification of novel role of Mincle as a regulator of autophagy addresses a major challenge in the field by positing this pathway to be targeted for modulation of NETs, while preserving ROS production, an important innate immune defense., Atul Sharma * (P), Tanner Simonson, Christopher N Jondle, Bibhuti B Mishra, and Jyotika Sharma Department of Biomedical Sciences, University of North Dakota, School of Medicine and Health Sciences, 1301 [...]

Published
2017

37. Galectin-3 in M2 Macrophages Plays a Protective Role in Resolution of Neuropathology in Brain Parasitic Infection by Regulating Neutrophil Turnover.

Author

Zangbede, NFredice O. Quenum, Chauhan, Arun, Sharma, Jyotika, and Mishra, Bibhuti B.

Subjects
GALECTINS, MACROPHAGE activation, GENE expression, CELL death, LABORATORY mice
Abstract

Macrophages/microglia with M2-activation phenotype are thought to play important anti-inflammatory and tissue reparative functions in the brain, yet the molecular bases of their functions in the CNS remain to be clearly defined. In a preclinical model of neurocysticercosis using brain infection with a parasite Mesocestoides corti, we previously reported the presence of large numbers of M2 cells in the CNS. In this study using female mice, we report that M2 macrophages in the parasite-infected brain display abundant galectin-3 expression. Disease severity was increased in Galectin-3-/- mice correlating with increased neurological defects, augmented cell death and, importantly, massive accumulation of neutrophils and M2 macrophages in the CNS of these mice. Because neutrophil clearance by efferocytosis is an important function of M2 macrophages, we investigated a possible role of galectin-3 in this process. Indeed, galectin-3-deficient M2 macrophages exhibited a defect in efferocytic clearance of neutrophils in vitro. Furthermore, adoptive transfer of M2 macrophages from galectin-3-sufficient WT mice reduced neutrophilia in the CNS and ameliorated disease severity in parasite-infected Galectin-3-/- mice. Together, these results demonstrate, for the first time, a novel role ofgalectin-3 in M2 macrophage function in neutrophil turnover and resolution of inflammatory pathology in the CNS. This likely will have implications in neurocysticercosis and neuroinflammatory diseases. [ABSTRACT FROM AUTHOR]

Published
2018
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