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3,842 results on '"Sharma, Ashok"'

12. An Interesting Case Of Acute Disseminated Encephalomyelitis

Author

Kumar, Satish, Sharma, Mohit, Sharma, Ashok, Raina, Rajiv, and Kakkilaya, Dr. Srinivas

Subjects
JOURNALS: Online Journal of Health and Allied Sciences, Online Journal of Health and Allied Sciences
Abstract

Acute disseminated encephalomyelitis (ADEM) is an uncommon inflammatory demyelinating disease of the central nervous system. The disease typically occurs after infections or vaccinations. However, in many patients with ADEM, no evidence of prior infection or vaccination can be found. We are reporting a patient who developed clinical and radiological features of acute disseminated encephalomyelitis after trauma of repeated attempts at lumber puncture for spinal anesthesia

Published
2008

35. An Implementation Case of Training and Education Pillar of TPM for Grinding Operations

Author

Sharma, Ashok Kumar, Sharma, Shudhanshu, Chaari, Fakher, Series Editor, Gherardini, Francesco, Series Editor, Ivanov, Vitalii, Series Editor, Haddar, Mohamed, Series Editor, Cavas-Martínez, Francisco, Editorial Board Member, di Mare, Francesca, Editorial Board Member, Kwon, Young W., Editorial Board Member, Tolio, Tullio A. M., Editorial Board Member, Trojanowska, Justyna, Editorial Board Member, Schmitt, Robert, Editorial Board Member, Xu, Jinyang, Editorial Board Member, Kumar, Ravinder, editor, Phanden, Rakesh Kumar, editor, Tyagi, R. K., editor, and Ramkumar, J., editor

Published
2024
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40. The role of intestine in metabolic dysregulation in murine Wilson disease

Author

Sarode, Gaurav V, Mazi, Tagreed A, Neier, Kari, Shibata, Noreene M, Jospin, Guillaume, Harder, Nathaniel HO, Caceres, Amanda, Heffern, Marie C, Sharma, Ashok K, More, Shyam K, Dave, Maneesh, Schroeder, Shannon M, Wang, Li, LaSalle, Janine M, Lutsenko, Svetlana, and Medici, Valentina

Subjects
Medical Biochemistry and Metabolomics, Biomedical and Clinical Sciences, Digestive Diseases, Liver Disease, Nutrition, Prevention, Chronic Liver Disease and Cirrhosis, Aetiology, 2.1 Biological and endogenous factors, Oral and gastrointestinal, Metabolic and endocrine, Animals, Mice, Hepatolenticular Degeneration, Lipid Metabolism, Disease Models, Animal, Sphingolipids, Intestines, Clinical sciences
Abstract

BackgroundThe clinical manifestations of Wilson disease (WD) are related to copper accumulation in the liver and the brain, but little is known about other tissue involvement regarding metabolic changes in WD. In vitro studies suggested that the loss of intestinal ATP7B affects metabolic dysregulation in WD. We tested this hypothesis by evaluating the gut microbiota and lipidome in 2 mouse models of WD and by characterizing a new mouse model with a targeted deletion of Atp7b in the intestine.MethodsCecal content 16S sequencing and untargeted hepatic and plasma lipidome analyses in the Jackson Laboratory toxic-milk and the Atp7b null global knockout mouse models of WD were profiled and integrated. Intestine-specific Atp7b knockout mice (Atp7bΔIEC) were generated and characterized using targeted lipidome analysis following a high-fat diet challenge.ResultsGut microbiota diversity was reduced in animal models of WD. Comparative prediction analysis revealed amino acid, carbohydrate, and lipid metabolism functions to be dysregulated in the WD gut microbial metagenome. Liver and plasma lipidomic profiles showed dysregulated triglyceride and diglyceride, phospholipid, and sphingolipid metabolism in WD models. However, Atp7bΔIEC mice did not show gut microbiome differences compared to wild type. When challenged with a high-fat diet, Atp7bΔIEC mice exhibited profound alterations to fatty acid desaturation and sphingolipid metabolism pathways as well as altered APOB48 distribution in intestinal epithelial cells.ConclusionsGut microbiome and lipidome underlie systemic metabolic manifestations in murine WD. Intestine-specific ATP7B deficiency affected both intestinal and systemic response to a high-fat challenge but not the microbiome profile, at least at early stages. WD is a systemic disease in which intestinal-specific ATP7B loss and diet influence the phenotype and the lipidome profile.

Published
2023

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