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Your search keyword '"Sharifian, Ramezanali"' showing total 7 results
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7 results on '"Sharifian, Ramezanali"'

1. Down-regulation of immune checkpoints by doxorubicin and carboplatin-containing neoadjuvant regimens in a murine breast cancer model

Author

Sadighi, Sanambar, Sharifian, Ramezanali, Kazemimanesh, Monireh, Muhammadnejad, Ahad, Shahosseini, Zahra, Amanpour, Saeid, and Muhammadnejad, Samad

Subjects
lymphocytes, animal model breast neoplasms immune checkpoints neoadjuvant chemotherapy tumor, infiltrating, lcsh:R, Immune checkpoints, lcsh:Medicine, Original Article, Animal model, Tumor-infiltrating - lymphocytes, Breast neoplasms, Neoadjuvant chemotherapy
Abstract

Objective(s): Immune checkpoint expression on tumor-infiltrating lymphocytes (TILs) has a correlation with the outcome of neoadjuvant chemotherapy (NAC) in breast cancer. However, the reciprocal effect of these regimens on the quality and quantity of immune checkpoints has hitherto not been addressed. We aimed to evaluate the impact of three NAC regimens on TILs and immune checkpoints in a murine triple-negative breast cancer model.Materials and Methods: Syngeneic model of locally-advanced breast cancer was established in immunocompetent mice using a 4T1 cell line. Tumor-bearing animals were treated with human-equivalent dosages of doxorubicin, paclitaxel, paclitaxel and carboplatin combination, and placebo. Infiltration of CD3+, CD8+, and FoxP3+ cells into the tumor was assessed by immunohistochemistry. Expression of immune checkpoints, including PD-1, CTLA-4, and TIM-3, was evaluated by real-time PCR.Results: Doxorubicin led to a significant (p

Published
2021

6. A study of Bernard-Soulier syndrome in Tehran, Iran.

Author

Toogeh, Gholamreza, Keyhani, Manochehr, Sharifian, Ramezanali, Safaee, Reza, Emami, Amirhossein, and Dalili, Hossein

Abstract

BACKGROUND: Bernard-Soulier Syndrome (BSS) is a hemorrhagic disorder with an autosomal recessive pattern of inheritance. We describe the demographic and clinical characteristics of Iranian patients with BSS followed in a major teaching and tertiary care hospital in Tehran, Iran. METHODS: We performed a retrospective medical record review of 97 patients with BSS who received care at the Imam Khomeini Hospital between 1969 and 2001. We collected data on the family history, clinical presentation, bleeding episodes, and lab profiles of these patients. RESULTS: Among all patients, 78 (81%) had a family history of consanguinity. The most common presenting symptom was epistaxis, seen in 62 (63.9%) patients. Peripheral blood smears demonstrated giant platelets on 67 (68.7%) of patients. Complete blood count demonstrated decreased platelets in 85 (87.4%) of patients ranging from 20,000/?L to 130,000/?L. Anemia was seen in 62 (64%) and 91 (93.8%) had prolonged bleeding time. The majority of patients (60%) had mild bleeding episodes, but 39 (40%) had at least one episode of severe bleeding in their past history. CONCLUSION: Our data are consistent with other reports regarding clinical presentation of BSS, but consanguinity seems to be more common. [ABSTRACT FROM AUTHOR]

Published
2010

7. The relation of bone marrow scintigraphy and unilateral bone marrow biopsy in malignant lymphoma.

Author

Esmaili J, Safaee SR, Sharifian R, Shoeybi S, and Gholamrezanezhad A

Subjects
Adolescent, Adult, Female, Humans, Male, Middle Aged, Radionuclide Imaging, Radiopharmaceuticals, Reproducibility of Results, Sensitivity and Specificity, Statistics as Topic, Bone Marrow diagnostic imaging, Bone Marrow pathology, Lymphoma diagnostic imaging, Lymphoma pathology, Technetium Tc 99m Sulfur Colloid
Abstract

To assess the diagnostic role of bone marrow scintigraphy (BMS) for detecting bone marrow infiltration by malignant lymphomas, 47 patients, 14 with malignant Hodgkin's and 33 with non-Hodgkin's lymphoma underwent BMS with 99mTc-sulphur-colloid and also unilateral iliac crest bone marrow biopsy (BMB). BM involvement in BMB was observed in 11 of the 47 patients. Four of these patients also had BMS lesions. Eight patients had BMS lesions not detected by BMB. There was poor agreement between the two modalities (kappa=0.137). Considering BMB as the gold standard, sensitivity, specificity, positive predictive value, negative predictive value and accuracy of BMS were 36%, 77%, 33%, 80%, and 68% respectively. In conclusion, BMS has a high negative predictive value and may be used as a complementary screening test for lymphoma to assess the extent of BM involvement, especially if magnetic resonance imaging-guided biopsy or positron emission tomography studies are not available, as is the case in developing countries.

Published
2005

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