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The advancement of biomedical technologies has introduced a promising approach for targeted drug delivery—utilizing nano and microscale systems. These compounds provide the potential for precise drug delivery to specific tissues, enhancing diagnostic accuracy and therapeutic efficacy, thereby minimizing off-target effects and improving site-specific accumulation. They enable controlled release of therapeutic agents, reducing the systemic toxicity often associated with conventional drugs. This review particularly highlights the critical role of cell membrane-decorated nanocompounds (CDCs), which represent a significant innovation in this field. Artificial Intelligence (AI) plays a pivotal role in enhancing the precision of CDCs, utilizing advanced algorithms to predict optimal delivery routes and release mechanisms. Moreover, AI-driven analytics are instrumental in the real-time monitoring and adjustment of drug release rates, ensuring maximum efficacy and patient safety. This review delves into the applications of CDCs, exploring their characterization, drug delivery potential, and future prospects, with a specific focus on how cell membrane coatings can revolutionize the landscape of drug delivery. Furthermore, the integration of AI in these processes is emphasized, particularly in how it can significantly impact future therapeutic strategies.

Interrupted cooling experiments of FGH97 nickel-based powder metallurgy (PM) superalloy with different cooling rates were carried out using a DIL805A quenching dilatometer. The microstructural evolution of the γ′ precipitates during cooling after solution heat-treatment was investigated by means of field emission scanning electron microscopy (FE-SEM), energy dispersive spectrometer (EDS), transmission electron microscopy (TEM), and X-ray diffraction (XRD). Vickers microhardness tests were performed on the samples that were interrupted at different temperatures to establish a relationship between microstructure and mechanical properties. The results revealed that the secondary γ′ precipitates preferentially nucleated at a higher temperature, and gradually grew during the cooling stage. Meanwhile, the morphology of the secondary γ′ precipitates transitioned from spherical to cubic, to rounded cuboidal, to a butterfly-like shape, and ultimately splitting into octo-cubes, whose driving force was attributed to the mutual competition between surface energy and elastic strain energy. During the initial stages of the cooling process, the microhardness decreased due to the growth and coarsening of the secondary γ′ precipitates. As the temperature decreased, the supersaturation within the matrix became sufficient to overcome the energy barrier for a second burst of nucleation, the tertiary γ′ phases precipitated, resulting in an increase in microhardness.

Objective: To provide a comprehensive overview of existing evidence, research gaps, and future research priorities concerning the treatment of myasthenia gravis (MG) using exercise therapies. Method: Clinical studies on exercise treatment for MG were searched in nine databases to conduct a scoping review. Two independent researchers screened the literature and comprehensively analyzed the characteristics and limitations of the included articles. Results: A total of 5725 studies were retrieved, of which 24 were included. The included studies were conducted in 16 different countries/regions and 456 patients were enrolled. Study designs included both interventional and observational studies. Exercise interventions included aerobic exercise, resistance exercise, balance training, and stretch training, and are typically administered in conjunction with medication, usual care, or some other interventions. The intensity, frequency, and duration of exercise interventions varied hugely among studies. Six-minute walk test, adverse events, muscle strength, MG quality of life-15 scale, forced vital capacity, quantitative MG scale, and MG activities of daily living scale were the most frequently used outcomes. All studies reported results in favor of the efficacy and safety of exercise in MG, and exercise-related adverse events were reported in two studies. Conclusion: This scoping review provides an overview of the evidence concerning exercise treatment for MG. Key gaps in evidence include a limited number of participants, complex interventions, variability in outcome selection, and insufficient reporting in publications. The promotion of exercise treatment for MG still encounters several obstacles. A larger population, rigorous study design and conduction, standardized interventions and outcomes, and standardized reporting are essential.

Abstract Malignancy is a major public health problem and among the leading lethal diseases worldwide. Although the current tumor treatment methods have therapeutic effect to a certain extent, they still have some shortcomings such as poor water solubility, short half-life, local and systemic toxicity. Therefore, how to deliver therapeutic agent so as to realize safe and effective anti-tumor therapy become a problem urgently to be solved in this field. As a medium of information exchange and material transport between cells, exosomes are considered to be a promising drug delivery carrier due to their nano-size, good biocompatibility, natural targeting, and easy modification. In this review, we summarize recent advances in the isolation, identification, drug loading, and modification of exosomes as drug carriers for tumor therapy alongside their application in tumor therapy. Basic knowledge of exosomes, such as their biogenesis, sources, and characterization methods, is also introduced herein. In addition, challenges related to the use of exosomes as drug delivery vehicles are discussed, along with future trends. This review provides a scientific basis for the application of exosome delivery systems in oncological therapy. Graphical Abstract

The service life of hot work die steel is significantly influenced by its microstructure and thermal fatigue properties. This paper explores the impact of deep cryogenic treatment (DCT) on H13 hot work die steel's microstructural evolution and mechanical as well as thermal fatigue properties. The results demonstrate that a portion of unstable retained austenite transforms into martensite during deep cryogenic treatment and numerous finely dispersed carbides precipitate from the matrix, thereby enhancing hardness. Analysis of the average crack length and distribution of thermal fatigue test samples reveals that the average crack length and crack density of DCT-treated samples are lower than those of non-DCT-treated samples. Thermal fatigue cracks in the specimens primarily originated from trigeminal grain boundaries and the carbides are found at the crack tips. DCT facilitates the precipitation of fine and dispersed carbides, imparting a robust pinning effect on boundary migration and thereby impeding the initiation and propagation of thermal fatigue cracks. Furthermore, deep cryogenic treatment results in a reduction in the number of M23C6 type carbides with large particles and an increase in smaller M6C type carbides during the thermal fatigue test. This indicates a positive influence on the carbide distribution and further contributes to the improved thermal fatigue resistance of the hot work die steel.

Wildfire risk prediction is a critical component of disaster prevention and mitigation, often closely associated with local human activities in most regions. Recent studies demonstrate that employing joint modeling techniques using diverse datasets alongside Convolutional Neural Networks-Long Short-Term Memory Networks (ConvLSTM) produces favorable predictive results. However, previous research inadequately explored the different impact of factors across different categories and spatial orientations, and neglected the impact of fuels and human activities inside the samples. This study focuses on the six eastern provinces of China, utilizing a multi-source dataset comprising satellite-monitored wildfire products from 2012 to 2022, along with various factors indicating terrestrial and human activities, simulated meteorological elements and high-resolution vegetation imagery. By introducing channel and spatial attention mechanisms and visual transformer mode, this research optimizes the ConvLSTM wildfire prediction model. Results indicate a noteworthy enhancement, elevating accuracy, Kappa coefficient, and AUC of ROC curves from 91.15%, 80.87%, and 97.01% to 92.79%, 84.48%, and 97.90%, respectively. Consequently, it reinforces the accuracy by increase of the structural features within samples and quantifying the differences in the importance of different factors, which is also validated by prediction application of the samples in the entire year of 2023. Sensitivity analysis reveals that the current model is still highly dependent on the meteorological factors. Notably, the impact of structural features significantly surpasses the influence of terrain and terrestrial ecology elements, which should be considered in further models. Thus, this study has developed a methodology integrating multiple attention mechanisms and sample structural features, which could furnish high-precision daily kilometer-level wildfire risk prediction products. This method could improve the efficiency of prevention and control by improving the accuracy and narrowing the high-risk areas.

IntroductionResearch on myasthenia gravis (MG) has undergone rapid development in recent years. This article aimed to elucidate the characteristics of MG publications over the past 20 years and analyze emerging trends using bibliometric methods.MethodsInformation on MG articles was obtained from the Web of Science Core Collection and stored in Excel for quantitative analyses. Bibliometric analyses were performed using CiteSpace and VOSviewer to visualize publications according to countries/regions, institutions, journals, and authors.ResultsA total of 3,610 publications were included in the analysis. The USA had the highest number of publications (NP) and H-index. Among the institutions, the University of Oxford had the highest NP, followed by the University of Toronto and Duke University. Close cooperation was observed among countries and institutions. The most productive author was Renato Mantegazza, followed by Jan J. Verschuuren, and Amelia Evoli. Muscle & Nerve published the most articles on MG, followed by the Journal of Neuroimmunology and Neuromuscular Disorders. The keyword with the highest strength is “neuromuscular transmission,” followed by “safety” and “rituximab.” Co-citation analysis includes 103 publications cited at least 65 times, categorized into four clusters. Additionally, 123 keywords cited more than 40 times were analyzed and divided into five clusters.ConclusionThis bibliometric analysis shows the framework of research over the past 20 years by mapping the scholarly contributions of various countries or regions, institutions, journals, and authors in MG. The analysis also explores future trends and prospective directions, emphasizing individualized treatment based on subtypes, novel immunotherapeutic approaches, and thymectomy.

The Richards’ equation is widely used in the simulation of unsaturated flow and related fields. In the numerical solution process, the finite difference method can be used to carry out numerical discretization and iterative calculation. However, in order to obtain a more reliable numerical solution, the space step size of a conventional uniform grid is often small. For some unfavorable numerical conditions, such as infiltration into dry soil, iterative calculation is time-consuming and even the accuracy cannot be improved very well. Therefore, an improved method is proposed by using the Chebyshev space grid, which combines the finite difference method to numerically discretize the Richards’ equation to obtain linear equations. Then the classic Picard iterative method is used to iteratively solve the linear equations to obtain the numerical solutions of the Richards’ equations. Through two examples of unsaturated flow under unfavorable conditions for homogeneous soil and layered soil, combined with the analytical solution of the model and the software Hydrus-1D, the accuracy of the numerical solution obtained by the improved grid method and the uniform grid method is compared and examined. The results show that the proposed Chebyshev grid method can obtain higher numerical accuracy with a smaller number of nodes than the traditional uniform grid, and the computational cost is smaller. This method has a good application prospect.

We report a ∼5.2 σ detection of the kinetic Sunyaev–Zel’dovich (kSZ) effect in Fourier space, by combining the DESI galaxy groups and the Planck data. We use the density-weighted pairwise kSZ power spectrum as the summary statistic, and the detailed procedure of its measurement is presented in this paper. Meanwhile, we analyze the redshift space group density power spectrum to constrain its bias parameters and photo- z uncertainties. These best-fitted parameters are substituted to a nonlinear kSZ model, and we fit the measured kSZ power spectrum with this model to constrain the group optical depth $\bar{\tau }$ . Selected by a varying lower mass threshold M _th , the galaxy group catalogs with different median masses ( $\tilde{M}$ ) are constructed from the Data Release 9 data of the DESI Legacy Imaging Surveys. $\tilde{M}$ spans a wide range of ∼10 ^13 –10 ^14 M _⊙ / h and the heaviest $\tilde{M}\sim {10}^{14}\ {M}_{\odot }/h$ is larger than those of most other kSZ detections. When the aperture photometric filter radius θ _AP is set to be 4.′2, the $\tilde{M}=1.75\times {10}^{13}\ {M}_{\odot }/h$ group sample at the median redshift $\tilde{z}=0.64$ has the highest kSZ detection signal-to-noise ratio = 5.2. By fitting $\bar{\tau }{\rm{s}}$ from various samples against their $\tilde{M}$ s, we obtain a linear $\mathrm{log}\bar{\tau }-\mathrm{log}\tilde{M}$ relation: $\mathrm{log}\bar{\tau }=\gamma (\mathrm{log}\tilde{M}-14)+\mathrm{log}\beta $ , in which γ = 0.55 ± 0.1. We also vary the aperture photometric filter radius and measure the $\bar{\tau }$ profiles of group samples, whose constraints on the baryon distribution within and around dark matter halos will be discussed in a companion paper.

We investigate the feasibility of using the comoving Lagrangian acceleration ( COLA ) technique to efficiently generate galaxy mock catalogs that can accurately reproduce the statistical properties of observed galaxies. Our proposed scheme combines the subhalo abundance-matching (SHAM) procedure with COLA simulations, using only three free parameters: the scatter magnitude ( σ _scat ) in SHAM, the initial redshift ( z _init ) of the COLA simulation, and the time stride ( da ) used by COLA . In this proof-of-concept study, we focus on a subset of BOSS CMASS NGC galaxies within the redshift range z ∈ [0.45, 0.55]. We perform GADGET simulation and low-resolution COLA simulations with various combinations of ( z _init , da ), each using 1024 ^3 particles in an 800 h ^−1 Mpc box. By minimizing the difference between COLA mock and CMASS NGC galaxies for the monopole of the two-point correlation function (2PCF), we obtain the optimal σ _scat . We have found that by setting z _init = 29 and da = 1/30, we achieve a good agreement between COLA mock and CMASS NGC galaxies within the range of 4–20 h ^−1 Mpc, with a computational cost lower by 2 orders of magnitude than that of the GADGET N -body code. Moreover, a detailed verification is performed by comparing various statistical properties, such as anisotropic 2PCF, three-point clustering, and power spectrum multipoles, which shows a similar performance of the GADGET mock and COLA mock catalogs with the CMASS NGC galaxies. Furthermore, we assess the robustness of the COLA mock catalogs for different cosmological models, demonstrating consistent results in the resulting 2PCFs. Our findings suggest that COLA simulations are a promising tool for efficiently generating mock catalogs for emulators and machine-learning analyses to explore the large-scale structure of the Universe.

Determining the characteristic stress intensity according to the rock stress-strain curve is significant significance for rock engineering. Nowadays, there are relatively mature methods for determining peak stress and damage stress. However, the crack volume strain method, axial strain method, and strain response method are more subjective to determine rock’s closure stress and initiation stress. The closure rock stress and crack initiation stress refined value method are proposed based on these methods, which are based on the discreteness of the rock stress and strain point. Through optimizing the stress characteristics by an objective function (variance function), the subjectivity of artificial observation is avoided; Based on the trend of rock stress-strain curve, an empirical method for determining rock closure stress and crack initiation stress is proposed. The test results indicate that the two proposed methods that calculate closure rock stress and crack initiation stress can obtain reasonable results. These methods can be used as a supplement to the characteristics of the rock stress determination method and can be used in actual engineering.

BackgroundCOVID-19 vaccines are required for individuals with myasthenia gravis (MG), as these patients are more likely to experience severe pneumonia, myasthenia crises, and higher mortality rate. However, direct data on the safety of COVID-19 vaccines in patients with MG are lacking, which results in hesitation in vaccination. This scoping was conducted to collect and summarize the existing evidence on this issue.MethodsPubMed, Cochrane Library, and Web of Science were searched for studies using inclusion and exclusion criteria. Article titles, authors, study designs, demographics of patients, vaccination information, adverse events (AEs), significant findings, and conclusions of included studies were recorded and summarized.ResultsTwenty-nine studies conducted in 16 different countries in 2021 and 2022 were included. Study designs included case report, case series, cohort study, cross-sectional study, survey-based study, chart review, and systemic review. A total of 1347 patients were included. The vaccines used included BNT162b2, mRNA-1273, ChAdOx1 nCoV-19, inactivated vaccines, and recombinant subunit vaccines. Fifteen case studies included 48 patients reported that 23 experienced new-onset, and five patients experienced flare of symptoms. Eleven other types of studies included 1299 patients reported that nine patients experienced new-onset, and 60 participants experienced flare of symptoms. Common AEs included local pain, fatigue, asthenia, cephalalgia, fever, and myalgia. Most patients responded well to treatment without severe sequelae. Evidence gaps include limited strength of study designs, type and dose of vaccines varied, inconsistent window of risk and exacerbation criteria, limited number of participants, and lack of efficacy evaluation.ConclusionCOVID-19 vaccines may cause new-onset or worsening of MG in a small proportion of population. Large-scale, multicenter, prospective, and rigorous studies are required to verify their safety.

Black carbon (BC) is one of the main factors in global climate change and human health. Based on reanalysis data from the Modern-Era Retrospective Analysis for Research and Applications Version 2 (MERRA-2), the historical trends in the variation of BC and the factors affecting this were investigated in core city of Central Plains Economic Zone in China-Zhengzhou. Based on correlation analysis with ground measurements of BC concentration, it was determined that the MERRA-2 reanalysis data could be used to reveal the variations in ground-level BC concentrations. According to the variation trends of BC concentration in 1980–2020 and typical fossil fuel consumption in 2008–2017, two periods of rapidly increasing BC concentration were identified in 1980–1989 and 1999–2006. The increase in BC concentration then slowed from 2007. Since 2012, due to the adjustment of the Zhengzhou strategy and the implementation of an emission control strategy throughout Henan Province, the consumption of coal and coke decreased by 4% every year, resulting in a downward trend in the total BC emissions. However, coal and coke were still the main factors affecting the BC concentration in Zhengzhou. The contribution of transportation to BC in Zhengzhou has been particularly important since 2016. Analysis of BC seasonal variation revealed that the highest BC concentration was in winter, mainly due to the increase in industry and residential emissions. Additionally, based on the local and regional emission inventories and combined with potential source contribution function (PSCF), concentration weighted trajectory (CWT), this study revealed the potential sources regions and source types of BC in Zhengzhou, and found that the intensification of energy consumption and BC emissions in Zhengzhou and the surrounding regions of Henan Province might be the reasons for the high BC loading in Zhengzhou through regional transport.

ObjectiveTo provide an overview of the range and characteristics of existing evidence, research gaps, and future research priorities in treating amyotrophic lateral sclerosis (ALS) with acupuncture.MethodClinical studies on acupuncture treatment for ALS were searched in 9 databases and two websites. Two independent researchers screened the literature according to the inclusion and exclusion criteria; extracted the demographic data, interventions, and significant findings of the studies; and comprehensively analyzed the characteristics and limitations of the included articles.ResultsA total of 2,326 studies were retrieved, of which 92 were included. Most of the studies were conducted in China, with the number increasing over time. Study designs included case reports, case series, randomized controlled trials (RCTs), and before-and-after studies, among which case reports were the most frequently used. A total of 1,388 patients were enrolled, of whom 1,031 had ALS, 274 had progressive bulbar palsy (PBP), 60 had progressive muscle atrophy (PMA), and 23 had primary lateral sclerosis (PLS). Acupuncture interventions included body acupuncture, electroacupuncture, acupoint injection, scalp acupuncture, acupoint massage, Sa-am acupuncture, needle-embedding therapy, auricular acupuncture, venom pharmacopuncture therapy, plum blossom needling, acupoint paste, electroacupuncture, and needle warming through moxibustion. The most frequently used acupoints were ST36, LI4, SP6, and LI11. Acupuncture is often applied in combination with other treatments, such as herbal or Western medicine. The frequency of treatment ranged from once a month to three times a day, and the duration of treatment ranged from 5 days to 3 years. Clinical symptoms, muscle strength, and effective rates were the most frequently used outcomes. Most studies reported significant efficacy, and only a few studies reported adverse events explicitly.ConclusionEvidence gaps include poor study design, complex interventions, limited significance of the selected outcomes, and limited study reporting. The promotion of acupuncture treatment for ALS still faces several obstacles. Rigorous study design and conduct, standardized intervention and outcome measurements, and normative reporting are needed to investigate the efficacy and safety of acupuncture treatment for ALS.

Soil-rock mixtures (S-RMs) composed of rock slope colluvium and landslide deposits are common in superficial hazards of bank slopes. The physical and mechanical properties of S-RMs are closely related to environmental conditions, especially reservoir water level fluctuation. Therefore, immersion-air dry (I-AD) circulations tests were carried out to simulate the phenomenon in this study. The macroscopic, mesoscopic, and microcosmic studies of S-RMs are carried out after experiencing cycles (N) of 0, 1, 5, and 10, respectively. Conventional triaxial tests, particle analysis tests, and scanning electron microscopy were performed to study the physical and mechanical properties of S-RMs. According to test results, the maximum deviator stress of S-RMs samples with confining pressures of 100, 200, 300, and 400 kPa after ten cycles is reduced by 41.13, 37.11, 32.17, and 30.20%. With the increase in N there is a significant trend towards reducing the strength of S-RMs, and the strength deterioration after the first I-AD circulation reached 15.73%. After I-AD circulations, the content of fine particles in S-RMs decreases, the grain-size characteristic and non-uniformity coefficient increase significantly, and the gradation of S-RMs shows discontinuity. Moreover, the repeated changes of water pressure have an irreversible impact on the microstructure of S-RMs, which will cause an increase in pore size and a higher pore disorder. In addition, it is found from the established strength parameter evolution equation that when N approaches infinity, S-RMs decomposes the weathering into cohesionless silt with an angle of repose of 0.90322φ0. The study results in this paper clarify the deterioration characteristics of wading S-RMs, and might be used in the bank slopes stability analysis.

Isothermal compression behaviors of 5CrNiMoV steel were studied at temperatures of 870, 800, 750, and 700 °C, with strain rates of 0.001, 0.005, 0.01, 0.05, and 0.1 s−1, the compression temperatures 870 and 800 °C are above Ac3, as well as 750 and 700 °C below Ac3 temperature. The Modified Johnson–Cook (MJC) model and the Strain–Compensated Arrhenius (SCA) model were employed to demonstrate the relationship between the flow stress and the compression parameters. The correlation coefficient (R) and average absolute relative error (AARE) between the calculational and experimental flow stress were used to evaluate the accuracy of the two models. The results show that the effect of dynamic softening on flow stress is much more significant at higher temperatures and lower strain rates, while this effect is not obvious when the strain rate exceeds 0.005 s−1 with the temperature below Ac3. The MJC model has a good accuracy close to the reference conditions (0.001 s−1 and 700 °C), and it is suitable to predict the plastic behavior when the flow stress is lower than 200 Mpa. The unbiased AARE values were 6.82 and 5.71 for MJC model and SCA model, respectively, which implied the SCA model has a higher accuracy than the MJC model. The SCA model was believed to be capable of being used to illustrate the thermomechanical behavior of 5CrNiMoV tool steel in a wide range of plastic deformation conditions.

Although there are many existing analytical studies of tidal groundwater level fluctuations in coastal aquifer systems, few of them focus on an offshore submarine aquifer. Here, we consider tidal groundwater head fluctuations in a submarine leaky confined aquifer overlain by a semipermeable seabed. Both the seabed and the confined aquifer are assumed to extend horizontally infinitely. A one-dimensional mathematical model is established to describe the problem, and the analytical solution is derived. The impacts of the tidal loading efficiency, hydraulic conductivity and elastic storage of the semipermeable layer and aquifer on the groundwater head fluctuations in the aquifer system are analyzed and discussed. Solution analyses indicated that tidal loading effects tend to enhance the amplitude of the tidal groundwater fluctuation in the confined aquifer system and to reduce the phase shift between the groundwater head and the sea tide fluctuations.

Slope deformation prediction has important significance for slope prevention and control. Based on historical time series, the trend of displacement variation can be predicted in advance, and according to the development trend, risk warnings and treatment measures are proposed. The use of the mathematical model to predict slope deformation has been proved to be feasible by many studies; therefore, the choice of the predictive model and the practicability of the model are crucial issues in the prediction of slope deformation, and the mathematical prediction model used should be less complicated considering the practicality of the model. In view of slope deformation prediction, a fractional-order calculus gray model based on the coupling of gray theory and the fractional derivative method is proposed, which takes a deep foundation pit slope in Chongqing, Southwest China, as the study object. The fractional-order gray model is compared with the traditional gray models; therefore, the results show that the accuracy of slope deformation prediction based on the gray coupling model of cumulative displacement and fractional calculus is significantly higher than that of the conventional gray model, and its error is in the acceptable range compared with the actual monitoring data, which can meet the needs of engineering application. Compared with the traditional gray theory method, the gray coupling model of fractional-order calculus only increases the fractional derivative order, which is verified to be feasible, and can be used as a reference method for slope deformation prediction. It has a certain theoretical basis and a good application prospect in slope deformation prediction.

Introduction: Research on myasthenia gravis (MG) has undergone rapid development in recent years. This article aimed to elucidate the characteristics of MG publications over the past 20 years and analyze emerging trends using bibliometric methods. Methods: Information on MG articles was obtained from the Web of Science Core Collection and stored in Excel for quantitative analyses. Bibliometric analyses were performed using CiteSpace and VOSviewer to visualize publications according to countries/regions, institutions, journals, and authors. Results: A total of 3,610 publications were included in the analysis. The USA had the highest number of publications (NP) and H-index. Among the institutions, the University of Oxford had the highest NP, followed by the University of Toronto and Duke University. Close cooperation was observed among countries and institutions. The most productive author was Renato Mantegazza, followed by Jan J. Verschuuren, and Amelia Evoli. Muscle & Nerve published the most articles on MG, followed by the Journal of Neuroimmunology and Neuromuscular Disorders. The keyword with the highest strength is "neuromuscular transmission," followed by "safety" and "rituximab." Co-citation analysis includes 103 publications cited at least 65 times, categorized into four clusters. Additionally, 123 keywords cited more than 40 times were analyzed and divided into five clusters. Conclusion: This bibliometric analysis shows the framework of research over the past 20 years by mapping the scholarly contributions of various countries or regions, institutions, journals, and authors in MG. The analysis also explores future trends and prospective directions, emphasizing individualized treatment based on subtypes, novel immunotherapeutic approaches, and thymectomy. [ABSTRACT FROM AUTHOR]