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Your search keyword '"Shao, Yongxiang"' showing total 10 results
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10 results on '"Shao, Yongxiang"'

2. Construction of EMT related prognostic signature for kidney renal clear cell carcinoma, through integrating bulk and single-cell gene expression profiles

Author

Huang, Qi, primary, Li, Feiyu, additional, Liu, Li, additional, Xu, Rui, additional, Yang, Tao, additional, Ma, Xiaoyun, additional, Zhang, Hongmei, additional, Zhou, Yan, additional, Shao, Yongxiang, additional, Wang, Qiaofeng, additional, Xi, Haifeng, additional, and Ding, Yancai, additional

Published
2023
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5. Recent Insight on Regulations of FBXW7 and Its Role in Immunotherapy

Author

Xing, Liangliang, Xu, Leidi, Zhang, Yong, Che, Yinggang, Wang, Min, Shao, Yongxiang, Qiu, Dan, Yu, Honglian, Zhao, Feng, and Zhang, Jian

Subjects
Cancer Research, Oncology
Abstract

SCFFBXW7 E3 ubiquitin ligase complex is a crucial enzyme of the ubiquitin proteasome system that participates in variant activities of cell process, and its component FBXW7 (F-box and WD repeat domain–containing 7) is responsible for recognizing and binding to substrates. The expression of FBXW7 is controlled by multiple pathways at different levels. FBXW7 facilitates the maturity and function maintenance of immune cells via functioning as a mediator of ubiquitination-dependent degradation of substrate proteins. FBXW7 deficiency or mutation results in the growth disturbance and dysfunction of immune cell, leads to the resistance against immunotherapy, and participates in multiple illnesses. It is likely that FBXW7 coordinating with its regulators and substrates could offer potential targets to improve the sensitivity and effects of immunotherapy. Here, we review the mechanisms of the regulation on FBXW7 and its tumor suppression role in immune filed among various diseases (mostly cancers) to explore novel immune targets and treatments.

Published
2022

10. Socioeconomic inequities in health care utilization in China.

Author

Zhang X, Wu Q, Shao Y, Fu W, Liu G, and Coyte PC

Subjects
Adolescent, Adult, Aged, China, Female, Health Care Surveys, Health Services Needs and Demand, Humans, Insurance, Health organization & administration, Male, Middle Aged, National Health Programs, Socioeconomic Factors, Young Adult, Ambulatory Care statistics & numerical data, Health Services statistics & numerical data, Healthcare Disparities statistics & numerical data, Hospitalization statistics & numerical data, Income statistics & numerical data
Abstract

The study assessed the present degree of inequity in health care utilization as well as the contributions of the main determinants in the context of expending health insurance coverage in China. Data were obtained from the 2008 National Health Services Survey (NHSS) in China. A concentration index was used to quantify the degree of income-related inequity in health care utilization. The need-standardized concentration indexes of outpatient care and inpatient care were 0.015 and 0.197, respectively. Income made the largest contribution to inequity favoring the better-off in the use of health care. The impacts of health insurance schemes on overall inequity varied according to the insurance memberships as well as types of services. The study revealed a pro-rich distribution of the probability of health care across income groups in China. Increased financial protection ability of medical insurance system remains a vital cornerstone to tackle the health care utilization inequity., (© 2015 APJPH.)

Published
2015
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