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Abstract Background Some research found that elevated plasma cell-free DNA (cfDNA) concentrations and poor prognosis are associated in non-small cell lung cancer (NSCLC). However, more studies need to be carried out to verify this conclusion. Therefore, this study investigated the relationship between cfDNA concentration and treatment outcomes including prognosis in patients with advanced NSCLC. Methods We retrospectively collected medical records and cfDNA data from 160 patients with advanced NSCLC. Progression-free survival (PFS) were calculated using the Kaplan-Meier method and were compared between groups using the log rank test. Cox regression analysis was used for estimating the independent predictors of PFS. And we used logistic regression to evaluate the relationship between baseline biomarkers and efficacy. In our study, BT1 cfDNA, BT2 cfDNA, and BT3 cfDNA were defined as cfDNA concentration before the first treatment (baseline cfDNA concentration), cfDNA concentration before the second treatment, and cfDNA concentration before the third treatment, respectively. Results Patients with low cfDNA (BT1 cfDNA

Security assurance (SA) is a technique that helps organizations to appraise the trust and confidence that a system can be operated correctly and securely. To foster effective SA, there must be systematic techniques to reflect the fact that the system meets its security requirements and, at the same time, is resilient against security vulnerabilities and failures. Quantitative SA evaluation applies computational and mathematical techniques for deriving a set of SA metrics to express the assurance level that a system reaches. Such metrics are intended to quantify the strength and weaknesses of the system that can be used to support improved decision making and strategic planning initiatives. Utilizing metrics to capture and evaluate a system’s security posture has gained attention in recent years. However, scarce work has described how to combine SA evaluation while taking into account both SA metrics modeling and analysis. This paper aims to develop a novel approach for the modeling, calculation, and analysis of SA metrics that could ultimately enhance quantitative SA evaluation.

Sexual health and well-being are important components of overall well-being and quality of life. Yet, little is known about autistic persons' self-reported sexual health and well-being in Canada. In the current study, 3,551 youth aged 16–24 from across Canada were surveyed, including 419 youth who reported an autism diagnosis or self-identified as autistic. We examined demographic and sexual health data from autistic youth and assessed differences/similarities with non-autistic youth on key indicators. A significantly greater percentage of autistic youth reported a transgender identity (22.5% vs. 1.9%), an asexual identity (7.0% vs. 2.7%), and an LGBQ+ sexual orientation (55.6% vs. 22.3%), compared to non-autistic youth. Autistic youth were just as likely as non-autistic youth to value sexual pleasure. On average, autistic youth rated their sexual health as "good," and many were happy with their sexual lives. Half were in a committed relationship, and autistic youth in relationships were generally sexually and emotionally satisfied in their relationships. Many had engaged in partnered sexual behaviours (e.g., touching genitals, oral sex, penis–vagina sex), with a higher percentage of autistic youth reporting that they had ever had penis–anal sex (30.8% vs. 22.6%). Autistic youth and non-autistic youth reported similar condom/barrier use for most sexual behaviours. The implications of these findings for sexual health promotion with autistic youth are discussed. [ABSTRACT FROM AUTHOR]

Lithium‐sulfur (Li‐S) battery shows promising development potential in secondary lithium‐ion batteries. However, the shuttle effect of polysulfides, uncontrollable lithium dendrite growth, and safety hazards in conventional liquid electrolytes limit the popularity of Li‐S batteries in the future commercial market. In this work, a high‐performance gel electrolyte (GPE) was prepared in situ by initiating the ring‐opening polymerization of 1,3‐dioxolane (DOL) with aluminum trifluoromethanesulfonate (Al(OTf)3) and using diethylene glycol dimethyl ether (DME) as a plasticizer, which can effectively improve the interfacial compatibility between sulfur cathode and the electrolyte, as well as the stability of lithium anode. The electrochemical performance of the poly‐DOL (PDOL) GPE was optimized by adjusting the concentration ratio of the initiator. When the concentration of Al(OTf)3 is 4 mM, the PDOL GPE has a high ionic conductivity up to 3.81 × 10−4 S cm−1 and a lithium ion migration number of 0.57. The assembled quasi‐solid‐state Li‐S batteries shows an initial discharge specific capacity of 908.1 mAh g−1 at 0.1 C with a capacity retention of 68% after 240 cycles, and its average Coulombic efficiency is maintained at 96.1%. This gel electrolyte design provides a feasible practical idea in quasi‐solid‐state Li‐S batteries. [ABSTRACT FROM AUTHOR]

This research presents a rigorous comparative analysis of high‐pressure homogenization (HPH) and microfluidization (MF) for the production of krill oil (KO) emulsions, scrutinizing their impact on oxidative stability, bioaccessibility, and the behavior under in vitro simulated digestion. Our findings revealed that MF emulsions possessed a distinct advantage, with a droplet size and distribution that promoted exceptional oxidative stability, evidenced by a sustained reduction in oxidative markers and enhanced retention of bioactive components, including EPA and DHA, and the potent antioxidant astaxanthin. In contrast, HPH yielded larger and less uniform particles, correlating with diminished stability. The in vitro digestion studies underscored the superior bioaccessibility of MF emulsions, with a pronounced release of free fatty acids during the intestinal phase, indicative of an optimized digestion and absorption process due to the smaller droplet size of the emulsions. The study's insights advocate for the adoption of microfluidization in the food industry for the development of advanced delivery systems for n‐3 fatty acids, particularly in the context of KO‐based products. The technique shows promise in enhancing the quality, stability, and bioavailability of these products, which are rich in health‐promoting lipids. The microfluidization technique emerges as a promising avenue for the fortification of a diverse range of commercial food, beverage, and pharmaceutical products with lipids that contribute to health and wellness. [ABSTRACT FROM AUTHOR]

Software security is an ongoing problem, largely due to a lack of security knowledge among software developers from diverse backgrounds. To counter this, security experts are attempting to offer a broad range of knowledge resources to enlighten developers about increasing cybersecurity threats. Unfortunately, the abundance of knowledge resources does not seem to have much of an impact on reducing the issue of software security. The ineffective teaching and learning approaches for software security have created difficulties for developers in learning security knowledge. This research employs a four-cycle of Design Science Research Methodology (DSRM) to integrate necessary elements in the development of a context-based learning system for security education and learning. The final artifact is an ontology-based web application that facilitates a contextualized learning process by providing security knowledge through contextual software cases. Through evaluation in pedagogical and software development environments, it is proven to contribute a viable solution to the problem domain. While these results are positive, the innovative context-based artifact benefits not only the domain of software engineering but also other educational fields, such as information security and computer security.