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Hepatic fibrosis is a reversible pathological phenomenon, in the early and middle stages, but but no satisfactory intervention drugs have been available so far. Recent studies have suggested that microcirculation disturbance of liver is one of the important pathogenesis of chronic liver disease, the improvement of microcirculation is beneficial to the recovery of liver function and the delay of liver fibrosis. Hepatic stellate cells are the core cells of hepatic fibrosis, and also the most critical cells that affect the microcirculation of the liver. While TLR4/MyD88/NF-K.B and TLR4/MyD88/MAPKs which are based on the action of hepatic stellate cells are two pathways that have very important influence on the inflammatory response of liver, the proliferation and apoptosis of hepatic stellate cells, and the secretion of fibrogenic cytokines. It was found that Plumbapin, the active ingredient of Guangxi specialty ethnic medicine, has the definite effect of promoting blood circulation and removing blood stasis and anti-hepatic fibrosis, but its mechanism is not clear. In this study, the research progress of the above problems was reviewed, and further research ideas were derived as follows: the pharmacological effect of Plumbapin on anti-hepatic fibrosis, promoting blood circulation and removing stasis was based on the influence of TLR4/MyD88/NF-K.B and MAPKs signal pathway. [ABSTRACT FROM AUTHOR]

Hepatic sinusoidal endothelial cells (HSEC) are the most important cells that constitute the microcirculation barrier of liver. Clinically, W-P bodies have been detected in the HSEC cells of most patients with liver fibrosis, and these bodies have become the synthesis and storage sites of vW factor, ET-1 and other factors of liver fibrosis; during pathological stimulation, W-P bodies will excrete the above factors into the cytoplasm, which can make the structure and function of HSEC maladjusted, cause the disturbance of liver microcirculation, and aggravate the process of liver fibrosis. However, previous studies have found that Plumbagin, the active ingredient of Guangxi specialty ethnic medicine, has the definite function of promoting blood circulation and removing blood stasis and anti-liver fibrosis, but its mechanism is not clear. In this study, the research progress of the above problems was reviewed, and further research ideas were derived from it as follows: the role of Plumbagin in promoting blood circulation and removing blood stasis and anti-liver fibrosis is produced by affecting the formation quantity of W-P bodies, affecting the synthesis and storage of the contents of W-P bodies, and interfering with their exocytosis ability. [ABSTRACT FROM AUTHOR]